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Drosophila melanogaster C3G guanyl-nucleotide exchange factor


LOCUS       NM_176694               7553 bp    mRNA    linear   INV 26-DEC-2023
            (C3G), transcript variant C, mRNA.
ACCESSION   NM_176694
VERSION     NM_176694.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 7553)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7553)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7553)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 7553)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 7553)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 7553)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 7553)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 7553)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 7553)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 7553)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 7553)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 7553)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 7553)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 7553)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 7553)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 7553)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 7553)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 7553)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 7553)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 7553)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 7553)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 7553)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 7553)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_176694.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7553
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..7553
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="C3G guanyl-nucleotide exchange factor"
                     /map="6D1-6D2"
                     /db_xref="FLYBASE:FBgn0259228"
                     /db_xref="GeneID:31618"
     CDS             1427..5989
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="CG42328 gene product from transcript CG42328-RC;
                     CG42328-PC; C3G-PC; C3G ortholog"
                     /codon_start=1
                     /product="C3G guanyl-nucleotide exchange factor, isoform
                     C"
                     /protein_id="NP_788867.1"
                     /db_xref="FLYBASE:FBpp0289069"
                     /db_xref="GeneID:31618"
                     /db_xref="FLYBASE:FBgn0259228"
                     /translation="MPQFDESFLSDCALADRWHFYSYTVKQLPPHPSPKPNRNRNPYP
                     SGASHDDHQHQLHHHHHQQHHHNHHRLWKTQRQSWSPRDTNNNHSLTSNNCNCNSSNT
                     CNSISATGNTLHSIKFHRRRKYKKLARLALSTPAIPLQMDVDVDVNVTVDREFDMEMD
                     TPVPLKNAVCHGSISSPSTPGTCSSGIGVGGGGCSSSSNNSINSGSYSTACTPPPPTH
                     QHHSQHQQLQGTPGGSSRVGGAGAGGGGGVPPAPPSAGSSGHKNSLKGTKLARRARSF
                     KDDLIEKISLMRTTNNTLGRSHSPHSPRTKHGTKAPPTTEEVLRSTQTLETHVKDISN
                     ALKHFRDVILKKKLEVLPGNGTVILETIASMYSVIQTYTLNENSAIMSSATLQVYQSL
                     GKLIKLCDEVMLSEDSGECASLSNENVREVIDLLEDAVRNLVTLAQGKLKEQDQCAFR
                     YSGSGLGGIGAAAEIMGAVTASPGASVPGTGVMRVSAAESAAQRTSLPDIALTPKERD
                     ILEQHNVNPMRGSHSTESILRDTSPPPKPPLPNRASNPPPLPPKRRSQPSASAGTVGV
                     GCSSSTSTSNQASPLPYAQSHNISLNSDLDCSSNISLLNYGVDRLSVRSRSPDENSQC
                     SFDSALNHSREEEDQQQQHQHLRSFPKLAAMMDEDMDKMVSYSFVSMREFRTSTQTTD
                     YSVQSSTKSSSSNSEIAFSISESTAVGSSSEYQQISQLVSHSQRHISSSSSSCTTTTT
                     SSSTTTGYGSSEVEQLQQQQQQQTTTTPADLAPALPPKSIQRSSLTRHDSPGVGDELD
                     EVQSSSGWASHRSSQSEVAELRQLSPLHHLNHHPHTASAGQLQQWHSKHHSLIEGPRL
                     QLAGSGSCSAFDQRHLDQEPPPLPIKKKHILAYMEICSASTRSIEQHRHTMHACNISR
                     NISHSQTMNIMPMSKELSPELEMPPALPPKNYKQRKATSMVASPTLQPVIVTTPPPSP
                     KPTLGENGSTGRPDSRMATVCEELNDAVASEDAMPEPRSPVLDSNENVSAVDDGQTFY
                     CHSHQLPAAEMEMSEDASSADNQPITTPQVLEEQEEPTAESRPLVAVHESVKPANVDE
                     DEEAERADMLINMLEEVNITRYLILKKREEDGPEVKGGYIDALIVHASRVQKVADNAF
                     CEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAAKETFALLVRVVNDLTSTD
                     LTSQLLSLLVEFVYQLVCSGQLYLAKLLRNKFVEKVTLYKEPKVYGFVGELGGAGSVG
                     GAGIAGSGGCSGTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKIEIPEVLLFAKDQC
                     EEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYL
                     ALLSALDSGPIRRLEWQKGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPYIGLI
                     LQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRFFDNF
                     KDFMGEEEMWQISEKIKPRGRRPVNY"
     misc_feature    4781..5191
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; Region: RasGEFN; smart00229"
                     /db_xref="CDD:214571"
     misc_feature    order(4838..4840,4973..4975,4985..4990,4997..4999,
                     5006..5011,5108..5110,5117..5119)
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:100121"
     misc_feature    5276..5947
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; Region: RasGEF; cd00155"
                     /db_xref="CDD:238087"
     misc_feature    order(5375..5383,5405..5410,5414..5422,5426..5431,
                     5438..5443,5450..5452,5549..5551,5558..5563,5567..5575,
                     5579..5590,5594..5599,5651..5653,5666..5674,5681..5683,
                     5720..5728,5735..5743,5747..5755,5759..5770,5813..5815,
                     5825..5827,5927..5929,5936..5941)
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Ras interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238087"
ORIGIN      
        1 cacattgttt gggaagcatt ttagcagcac tgcgcgacgg tcaccgcatt ttgttgttgt
       61 gttgcgcgtt taaaattgta ttgttatttt ttatattttc ttttttttgg accgaatgag
      121 agccggccaa aagtgcagtg cgagtgcgat tgaatttaag tgaatacaaa gtgcggatcg
      181 caacacaact ttataaatat atgtacatat atgtgtagtt agagcgagac ggggcgaaat
      241 atcaaataaa aatactgtac tgtgtgtgtg agcaaatact aatactactc aagcggagaa
      301 cgatgaaaat gtgcgtgtga gaggaaaaga gaatttagtg ttttttatat tatttactgg
      361 cctgcggcta tgagcaaaaa gaaccgaata tcattgcgga aaaaggagaa tgaaaattgc
      421 caagagggaa atctgtgaat cctggcggaa acacacggcc tcatcatgaa tatactgcag
      481 aaaatcgagg ccaaccagat agatagccca ctgcgggggc ggtgcgccaa cgagatggat
      541 ggatggatgg atgatgaaaa atcaaagaaa agagcgccaa attgcacttg aaaagtgaaa
      601 gaaattgcac tgagagtggc aggccaaaag tgttagctta tcgcttatcg gcgattgaat
      661 caatcagccg aagcctgttg aaatttcaag ttcagaaatg caaaagtgac tgtgcggcga
      721 atggaaagct attggggaaa attgcggaaa tcgcacttga aatataagta aagcaaaaga
      781 caagtggctt tggagttgat taccttcaat ttaccacaat cgggcaggca gtaagaaacg
      841 gaaattaggg cttgatggct tttaaacatt aaagaaaata atatacggaa atcactatgg
      901 ccaattgaag tgatctctaa gctggcatac ttgtatttca gtcaaacaaa gagtgtccag
      961 aacaattctt gcggttgcca caggaagctt gaatcggtaa tcgcttgaat tgcctatcgg
     1021 actatcgaac gaattgcaaa agtgaacgaa catgatgaga aagcaattga aatctacttc
     1081 ctgctggcag agcacatcgg atatagcttt tatcagtgct taaaactttt tccgaaaaca
     1141 ctgaaacaac cgaaaactga aagtgaaata atcaatgtaa aacatgccga aacagaaaaa
     1201 tgaattgatg ttgtaatcgc gacggcaatc gcttaaatca acaatcttat acgaaaacga
     1261 tgttgctgct atcgcttatc gctatttgga gaaatcagtt aggccaacgt gtgtgtcttt
     1321 tggccaagca tatttaagcc acaacaaatt gttgttatgc gtgttgctgt cgctgttgct
     1381 gctgttgtta ttgctgctgc tgctgctgct gtcattatgc aacattatgc cgcagtttga
     1441 tgaatctttt ttgagcgact gtgcgctcgc cgaccgctgg catttctatt cgtacacggt
     1501 caagcaattg ccgccacatc cgagtccgaa accgaatcgg aatcggaatc cgtatcccag
     1561 cggtgccagc cacgatgacc atcagcacca actccatcat catcatcatc aacagcacca
     1621 tcacaatcat catcgtcttt ggaagactca gcggcagtcg tggtcgccgc gcgacaccaa
     1681 caacaatcat agcctcacaa gcaacaactg caactgcaac agcagtaaca cctgcaacag
     1741 catcagtgcc accggcaaca cgttgcatag catcaaattc cacagacgtc gcaaatacaa
     1801 aaagctggca cgattggcgc tatcaacgcc agcgattcca ctgcagatgg atgtggatgt
     1861 cgatgtgaat gtgaccgtgg atagggagtt cgatatggag atggacacac ctgtgccgct
     1921 caagaatgcg gtgtgccacg gcagcatcag ttctccatcc acgcccggca cctgttccag
     1981 tggcatcgga gtgggcggtg gcggctgcag cagcagcagc aacaatagca tcaacagcgg
     2041 cagctactcc accgcctgca ctccgccacc acccacgcat cagcatcact cgcagcacca
     2101 gcagctgcag ggcacgccgg gaggatctag tcgggtaggg ggagcaggag caggcggagg
     2161 tggtggtgta ccaccggcac cacccagtgc cggatcctcg ggccacaaga acagtctcaa
     2221 gggcaccaag ctagcgcgcc gggcgcgttc ctttaaggac gacctcatcg agaagatttc
     2281 cctgatgcga accaccaaca atacactggg tcgctcccac tcgccgcaca gtccgcgcac
     2341 caagcacggc acaaaggcac cgcccaccac cgaggaggtg ctacggtcca cccaaaccct
     2401 ggagacgcac gtcaaggaca tttcgaatgc cctgaagcac ttccgggatg ttatactcaa
     2461 gaagaagctg gaggtgttgc cgggcaacgg aacggtcatt ctggaaacca tagccagcat
     2521 gtactccgtg atccaaacct ataccctgaa tgaaaacagt gccatcatga gcagcgccac
     2581 gctgcaggtt taccagagcc tgggcaagct catcaagctc tgcgacgagg tgatgctctc
     2641 cgaggacagc ggcgagtgcg cctccctgag caacgagaat gtgcgggaag tcattgatct
     2701 tctcgaggat gctgtgcgga atctcgttac gctggcgcag ggcaagctga aggagcagga
     2761 tcagtgcgcc tttcgctaca gtggatctgg cttgggcggc attggagcgg cggcggagat
     2821 catgggtgcg gtcaccgcct cgccgggagc gagtgttccc ggtactggag tcatgcgcgt
     2881 ttcggccgcc gaatcagctg cccagcgtac ttcgttgccg gacatagcgc tcacgcccaa
     2941 ggagcgcgac atactggagc agcacaatgt gaacccgatg cgcggctccc acagcaccga
     3001 aagtatcctg cgcgacacga gtccaccgcc gaagccaccg ctacccaata gggccagtaa
     3061 tccgccgccg ttgccaccaa agcgacgcag ccagccgagc gcatcagctg gtacagtggg
     3121 cgtaggctgc tcatcgtcga catccacctc caatcaggcc agtccactgc cctacgccca
     3181 gtcccataat attagtctga actcggacct ggactgcagt tccaatatct cgctgctgaa
     3241 ttatggcgtg gatcgcctat ccgtgcgttc acggtcaccg gatgagaata gtcagtgctc
     3301 ctttgactcg gcgttgaatc actcacgcga ggaggaggac cagcaacagc aacatcagca
     3361 tctgaggtca tttccaaagt tggctgcgat gatggacgaa gacatggaca agatggtcag
     3421 ctacagtttc gtgtcgatgc gtgagtttcg cacttccaca cagacgacgg actacagtgt
     3481 ccagtcctcc acgaagtcgt ccagcagcaa ttcggagatt gcgttcagca tcagtgagtc
     3541 gacggcggtc ggcagcagta gcgagtacca gcagattagc cagttggtgt cgcacagcca
     3601 gcgtcatata tcctcgagca gtagcagctg caccaccacg accaccagca gcagcacaac
     3661 caccggctat ggcagcagcg aagtggagca gctgcagcag cagcagcagc agcagacgac
     3721 gacgacgccg gccgatctgg cgcccgcctt gccgccaaag agcatccaac ggagcagcct
     3781 aacccgccac gactcgcccg gagttggcga tgagctggac gaggtgcagt cctcctccgg
     3841 ctgggccagc catcggagca gccagtcgga ggtggccgag ctgcgtcagc tgtcgccgct
     3901 ccatcacctc aatcaccatc cgcatactgc gtccgccggt caactgcagc agtggcactc
     3961 caagcaccac agcctgatcg agggaccccg cctccagctg gcggggagtg gcagctgcag
     4021 tgcgttcgat cagcgacact tggatcagga gccaccgccg ctgccaataa aaaagaagca
     4081 cattctggcg tacatggaaa tctgttcggc gtccacgcga tccattgagc agcatcgtca
     4141 cacaatgcac gcctgcaaca taagtcgcaa catctcgcac agccagacca tgaacattat
     4201 gcccatgagc aaggaactgt cgccggagct cgagatgcca cctgccctgc cgccaaagaa
     4261 ctacaagcag cgcaaggcga caagcatggt agcatcaccc acgctgcagc ccgtcattgt
     4321 gaccacgcca ccgccgagtc cgaagccgac gctgggcgag aatgggtcga cgggcaggcc
     4381 ggacagccgg atggccaccg tatgcgagga gctgaacgat gcagtggcca gcgaggatgc
     4441 gatgccggag ccccgttcgc ccgtgctgga cagcaatgag aatgtgagcg ccgtcgatga
     4501 tggacagact ttctactgtc actcacatca gttgcccgcc gccgaaatgg agatgagcga
     4561 ggatgcgagc agtgccgaca accagccaat aaccacgccc caagtgctcg aggagcagga
     4621 ggagccaacg gcggagtccc gaccactggt cgctgtgcac gagtcggtta agccagcgaa
     4681 cgtcgacgag gatgaggagg cggagcgagc ggatatgctg atcaacatgc tggaagaggt
     4741 caacatcaca cggtacctga tactcaagaa gagagaggag gacgggcccg aggtgaaggg
     4801 cggctacatc gatgccctca tcgtgcacgc cagccgtgtc caaaaggtcg ccgacaatgc
     4861 attctgcgag gccttcatca ccacctttcg caccttcatc cagccgatcg acgtgatcga
     4921 gaagctgacc catcgctaca catacttctt ctgtcaagtg caggacaaca agcagaaggc
     4981 cgctaaggag acctttgcgc tgctggtccg agtcgtcaac gatctaacgt cgacggatct
     5041 aaccagccag ctgttgagcc tgctggtgga gttcgtctat cagttggttt gctctgggca
     5101 attgtacttg gccaagttgc tgcgcaacaa gttcgtggag aaggtgacgc tgtacaagga
     5161 gcccaaggtg tacggctttg ttggggagtt gggcggagcc ggtagtgtcg gcggagcagg
     5221 aatcgccggc agtggtggat gcagtggtac agctggtggt ggaaaccagc ctagtctgct
     5281 cgacctcaag tcgctggaga ttgccgaaca gatgacgctg ctggatgcgg agctgttcac
     5341 gaagatcgag atacccgaag tattactatt tgccaaagat cagtgcgagg agaagtcgcc
     5401 caacctaaac aagttcaccg agcacttcaa caagatgtcc tactgggcgc gctccaaaat
     5461 cctgcgcctg caggatgcca aggagcggga gaagcatgtg aacaagttta tcaaaatcat
     5521 gaagcatcta cgcaagatga acaactacaa ctcgtatctg gcgttgttgt cggccctcga
     5581 ttcgggtccc ataagaagat tggagtggca aaaaggcatc accgaggagg tgcgatcatt
     5641 ctgcgccctc atcgattcca gctccagttt tcgcgcctat cgacaggcgc tggccgaaac
     5701 taatccgccc tgcataccct acatcggcct aattctgcag gatctaacgt ttgtgcatgt
     5761 gggcaaccag gactacttgt ccaagggcgt cataaacttc tccaagcgct ggcagcagta
     5821 caacataatt gacaacatga aacgttttaa gaaatgtgcc tatccatttc gacgcaacga
     5881 gcgcattata cgcttctttg ataacttcaa ggactttatg ggcgaggagg agatgtggca
     5941 gatatcggag aagatcaagc cgcgtggacg ccgccccgtt aactattagt cttcaagcag
     6001 caacagcaaa acaccaatat tatatatgat aaagtatata caccgtatta attaaacagt
     6061 tcaaaacggt tgccacgtct aggaggagga tcagcatcgg gagcagccaa caactattct
     6121 aatgggtctg agcaataatg ttcgctattc tctgtctata tatatacaat tatacaagat
     6181 atttagctgt aattaccagc cgatgccgaa tcggaaatac atatacatac ttacttaaga
     6241 tgtagcgatt cagatacgga tacggataca tgtagccgcg tacaaataac gagccgatct
     6301 gtagtttaac tattaagctc tatgagtcat tgggtcgatg gacctaacct cagctaactc
     6361 cccaccaata ttcgaatccg aatccctgtc tgcgagtccc aaaaactttt tcccggactt
     6421 ttgccagcac tagaacacca aactaactaa ctaacttact taccaccaga gacaaccaat
     6481 caagaaatca gcaattttcg cttttgtttt gagatctctt ttttacacaa gaacacaacg
     6541 aattttgaaa gcaagctacg tgaacgtaga ggccaaccga caaactatat tcgacgatat
     6601 atgtagcgat atctcggact ataaatcgat gcaatccacg agcagaacac caagcgaacc
     6661 ctagcacaaa gcgcgttata tgcaattctc tctccaaaca accaatatta aatacccgtg
     6721 tgtgtgtatg tgtgttagaa gttattcaaa ttgaaattga actcaaaatc aaaatcagag
     6781 atttcagagt gcacgaaaca gaaaacagaa ggcggtatct atcgatcaaa tcaatcaatc
     6841 aatgaaatca atcaaaaatt cattttgcga ctcaattaat tgaagaaact tttaaagtta
     6901 caaaacaaaa caaaatacaa aaaatacaaa aaaaaaaaaa aaaacaaaaa aggcgaggaa
     6961 cctgtggaag agattaacta aattcaattt gcttttaaat gtacgactaa cattaaaaat
     7021 atttatgggc atgtaataat agttctaaat aacgctttga cttctccttt caattctgtg
     7081 aggaataaat ttattgatat tgcgtgtaaa aatattaatc atgagaagaa atctgaaagc
     7141 agagttaaaa ctgaatgaaa tcgacctcaa gttgttttta ctaagcaata ctctgtctcg
     7201 tctgagaata atgtcttctt atttagaaat gggaaacaga aaaaaaggct gcttacttga
     7261 agaatttaat tcccgatcac catagccatt ttaataaaca aaaagaaaag tcaatttttt
     7321 tttttaattt gtgttgagtg aattcgatct tctttttgct gctgcttccg ctgccgctgg
     7381 cgcatcaatt gtgtttacta agctaacgaa cctagggaca acaatttatt cttgtttttt
     7441 tttttcacct atttttaaat taaatatttt gtatatgtag agaaaatttt caattgtaaa
     7501 tgtatttgta tttaaatgtt atgtgtgtat tcataagaat gaaaatagct acc