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LOCUS NM_176688 2045 bp mRNA linear INV 26-DEC-2023 (MAPk-Ak2), transcript variant D, mRNA. ACCESSION NM_176688 VERSION NM_176688.3 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 2045) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 2045) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 2045) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 2045) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 2045) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 2045) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 2045) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 2045) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 2045) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 2045) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 2045) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 2045) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 2045) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 2045) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 2045) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 2045) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 2045) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 2045) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 2045) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 2045) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 2045) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 2045) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 2045) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_176688.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..2045 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..2045 /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="MAP kinase activated protein-kinase-2" /map="5B8-5B8" /db_xref="FLYBASE:FBgn0013987" /db_xref="GeneID:44573" CDS 158..1237 /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /EC_number="2.7.11.17" /note="CG3086 gene product from transcript CG3086-RD; CG3086-PD; MAPk-Ak2-PD; MAP kinase-activated protein kinase 2; MAP kinase activated protein kinase-2" /codon_start=1 /product="MAP kinase activated protein-kinase-2, isoform D" /protein_id="NP_788861.1" /db_xref="FLYBASE:FBpp0070804" /db_xref="GeneID:44573" /db_xref="FLYBASE:FBgn0013987" /translation="MLSLQNQRQPKTTPLTDDYVTSNTVLGYGINGKVVQCTHRRTQQ NYALKVLLDSERARREVDLHWRVSGCRYIVNIIDVYENTFKDRKCLLVVMECMEGGEL FQRIQDKADGAFTEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLLYTTTQPNATLK LTDFGFAKETFTSYTLQTPCYTPYYVAPEVLGPEKYDKSCDIWSLGVVMYIIMCGFPP FYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPSKRLRIQDVI SNKWIAQYNAVPQTPLCTGRMLKEAEETWPEVQEEMTRSLATMRVDYDQMQIKALDKS NNPLLTKRRKKIEEMELYMANATRN" misc_feature 209..997 /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases; Region: STKc_MAPKAPK; cd14089" /db_xref="CDD:270991" misc_feature order(233..250,257..259,296..298,302..304,377..379, 437..448,458..460,464..466,578..583,587..589,593..598, 602..604,641..646,653..655,695..709,713..715) /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="active site" /db_xref="CDD:270991" misc_feature order(233..250,257..259,296..298,302..304,377..379, 437..448,596..598,602..604,641..646) /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:270991" misc_feature order(245..247,458..460,464..466,578..583,587..589, 593..595,653..655,695..709,713..715) /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270991" misc_feature order(641..673,683..709) /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="activation loop (A-loop); other site" /db_xref="CDD:270991" ORIGIN 1 cattcagtgt cgcctggtca caccgcgaag catttacaaa taaattccct ggtcgtgttg 61 ttcttttttt tcgttccgtt acatagcacg ctaaagtaaa tatccgaaag gtaaatacga 121 tcagctgaag agcagttaaa gatcagccga ttccagaatg ctttctctgc agaatcaacg 181 gcaaccgaag accaccccac tgacggacga ctacgtgacc tcgaacacgg ttctgggcta 241 cgggatcaac gggaaggtgg tgcagtgcac ccatcgccgc acccaacaga actatgccct 301 caaggtgctg ttggacagtg aaagggcgcg tcgcgaagtg gacctgcatt ggcgggtcag 361 cggatgccgg tacattgtga acatcattga tgtgtacgag aacacgttta aggacaggaa 421 gtgcctcctg gtggtcatgg agtgcatgga gggcggcgag ctcttccaga gaattcagga 481 caaggccgac ggtgccttta cggagcggga ggcggcccag ataatgcacg agatctgcgc 541 ggccgtagac tatctgcaca gtcgcgacat agcgcatcgc gatctcaagc cggagaactt 601 gctgtacacc accactcagc cgaatgcgac ccttaaattg acggactttg gcttcgccaa 661 ggagacattc accagttaca cgctgcagac gccctgctac actccctatt acgtggctcc 721 tgaggttctg ggcccggaga agtacgacaa gagctgcgac atctggtcgc tgggcgtggt 781 gatgtacatc attatgtgcg gattcccgcc gttctacagc aaccacggcc tagccatatc 841 gcccggcatg aaaaatcgca tccgcaccgg ccagtatgac tttcccgatc cggagtggac 901 gaatgtgagc caggcggcaa aggatctgat caagggcatg ctgaacgtgg accccagcaa 961 gcgtctgcgc atccaggacg tcattagcaa caagtggatt gcccagtaca atgctgttcc 1021 acagacaccg ctctgcacgg gtcgcatgct aaaggaggcc gaggaaacct ggccggaagt 1081 gcaggaggag atgacgcgct cactggccac catgcgcgta gactacgatc agatgcaaat 1141 caaggcgctg gacaagtcga acaacccgct gctgacgaag cgcaggaaaa agatcgagga 1201 gatggagtta tacatggcca atgcgacgcg caactagaca acgaggaatc cagagcgact 1261 aacacggcca acccgggagt gagatgagat gagatgagga gagatgggcg taggatgtag 1321 gatgggcgaa ccatcggttt aacacttaag cggataacaa tgttgtacaa tgctttacaa 1381 aaacgataaa tactactata ctacgacggc ggcaagatct gctattaact aatatactac 1441 gatgacagca acctttgcaa aacaactact ccatgttatt gttacgttac gttttcttat 1501 tcattttgtc ccattatcta tctatccatt tccagtcaag ggttcttagg gtattttgta 1561 gtctgaaaag tgctcttttg taaaagaaac tataaagcgt aatgcgcaaa taacgaactt 1621 aagtaaagcc aagtgcaagc ctagctagcc agccagccca gccgaatatt caaaatgtct 1681 cggtatcgcg tgaaagtgtt tcgtttttcg attccctttt tttttttaaa tattattttc 1741 caaaaacgtg tcatttgtaa ccgaaccgtt ttttacgtgt acgtgacttt gattataatt 1801 atatatatat atgtatatgt ataaccgtct gtgtatgtat ggcatatgtg tggagaaaca 1861 attatacagc cagttcacgt tagcattaat ctgcgcaaga ttcagtgttg tttataactt 1921 ttatttgctg attctgcaag cgatatacca ttttaccgta tagcatattt gtagtccata 1981 aacaacaaga tcatccccca aattaataaa aacaaatcaa gcttatttta ctatgattaa 2041 aacat