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LOCUS NM_167359 1014 bp mRNA linear INV 26-DEC-2023 (Prx2), mRNA. ACCESSION NM_167359 VERSION NM_167359.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 1014) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 1014) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 1014) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 1014) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 1014) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 1014) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 1014) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 1014) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 1014) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 1014) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 1014) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 1014) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 1014) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 1014) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 1014) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 1014) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 1014) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 1014) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 1014) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 1014) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 1014) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 1014) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 1014) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_167359.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..1014 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..1014 /gene="Prx2" /locus_tag="Dmel_CG1633" /gene_synonym="1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1; dPRDX2; dPrx I; dPrx1; dPrx2; Dpx-4783; DPx-4783; DPx4783; Jafrac; JAFRAC 1; jafrac1; Jafrac1; jf1; PRDX1; PRDX1/2/4; PRDX1_DROME; Prx; Prx4783; SSP5111; T20; TPX-1" /note="Peroxiredoxin 2" /map="11E11-11E11" /db_xref="FLYBASE:FBgn0040309" /db_xref="GeneID:53578" CDS 142..726 /gene="Prx2" /locus_tag="Dmel_CG1633" /gene_synonym="1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1; dPRDX2; dPrx I; dPrx1; dPrx2; Dpx-4783; DPx-4783; DPx4783; Jafrac; JAFRAC 1; jafrac1; Jafrac1; jf1; PRDX1; PRDX1/2/4; PRDX1_DROME; Prx; Prx4783; SSP5111; T20; TPX-1" /EC_number="1.-.-.-" /EC_number="1.11.1.24" /note="CG1633 gene product from transcript CG1633-RB; CG1633-PB; Prx2-PB; jafrac1; peroxiredoxin I; peroxidase; peroxiredoxin 4783; peroxiredoxin 1; thioredoxin peroxidase 1; Jafrac-1" /codon_start=1 /product="peroxiredoxin 2, isoform B" /protein_id="NP_727689.1" /db_xref="FLYBASE:FBpp0073594" /db_xref="GeneID:53578" /db_xref="FLYBASE:FBgn0040309" /translation="MPQLQKPAPAFAGTAVVNGVFKDIKLSDYKGKYLVLFFYPLDFT FVCPTEIIAFSESAAEFRKINCEVIGCSTDSQFTHLAWINTPRKQGGLGSMDIPLLAD KSMKVARDYGVLDEETGIPFRGLFIIDDKQNLRQITVNDLPVGRSVEETLRLVQAFQY TDKYGEVCPANWKPGQKTMVADPTKSKEYFETTS" misc_feature 151..666 /gene="Prx2" /locus_tag="Dmel_CG1633" /gene_synonym="1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1; dPRDX2; dPrx I; dPrx1; dPrx2; Dpx-4783; DPx-4783; DPx4783; Jafrac; JAFRAC 1; jafrac1; Jafrac1; jf1; PRDX1; PRDX1/2/4; PRDX1_DROME; Prx; Prx4783; SSP5111; T20; TPX-1" /note="Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015" /db_xref="CDD:239313" misc_feature order(151..153,274..279,286..288,475..477,505..507, 544..552,556..564,574..579,598..600,643..654) /gene="Prx2" /locus_tag="Dmel_CG1633" /gene_synonym="1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1; dPRDX2; dPrx I; dPrx1; dPrx2; Dpx-4783; DPx-4783; DPx4783; Jafrac; JAFRAC 1; jafrac1; Jafrac1; jf1; PRDX1; PRDX1/2/4; PRDX1_DROME; Prx; Prx4783; SSP5111; T20; TPX-1" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:239313" misc_feature order(268..270,370..375,448..450,454..456,490..492) /gene="Prx2" /locus_tag="Dmel_CG1633" /gene_synonym="1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1; dPRDX2; dPrx I; dPrx1; dPrx2; Dpx-4783; DPx-4783; DPx4783; Jafrac; JAFRAC 1; jafrac1; Jafrac1; jf1; PRDX1; PRDX1/2/4; PRDX1_DROME; Prx; Prx4783; SSP5111; T20; TPX-1" /note="decamer (pentamer of dimers) interface [polypeptide binding]; other site" /db_xref="CDD:239313" misc_feature order(271..273,280..282,508..510) /gene="Prx2" /locus_tag="Dmel_CG1633" /gene_synonym="1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1; dPRDX2; dPrx I; dPrx1; dPrx2; Dpx-4783; DPx-4783; DPx4783; Jafrac; JAFRAC 1; jafrac1; Jafrac1; jf1; PRDX1; PRDX1/2/4; PRDX1_DROME; Prx; Prx4783; SSP5111; T20; TPX-1" /note="catalytic triad [active]" /db_xref="CDD:239313" misc_feature order(280..282,643..645) /gene="Prx2" /locus_tag="Dmel_CG1633" /gene_synonym="1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1; dPRDX2; dPrx I; dPrx1; dPrx2; Dpx-4783; DPx-4783; DPx4783; Jafrac; JAFRAC 1; jafrac1; Jafrac1; jf1; PRDX1; PRDX1/2/4; PRDX1_DROME; Prx; Prx4783; SSP5111; T20; TPX-1" /note="peroxidatic and resolving cysteines [active]" /db_xref="CDD:239313" ORIGIN 1 aatccattcg cgaatttcaa ctcgtgccga aaggtttgtt tgtgcgaaag ctgaagctgc 61 gagagaacga acaagaggaa gcccacgcgg aagtcaagca attaccgaga attactaaga 121 gaaaaaatat aactgtttaa aatgccccag ctacagaagc ccgctcccgc attcgccggc 181 accgccgtcg tcaacggtgt tttcaaggac atcaagttga gcgactacaa gggcaaatac 241 ctggtgcttt tcttctaccc gctggacttc accttcgtgt gccccaccga gatcattgcg 301 ttctcggaga gcgccgccga gttccgcaag atcaattgcg aggtgatcgg ttgctccacg 361 gacagccagt tcacccactt ggcctggatc aacacgccaa ggaagcaggg tggtctgggc 421 agcatggaca ttccactgct ggctgacaag tcgatgaagg tggcccgcga ctatggagtg 481 ctcgatgagg agactggcat ccccttccgc ggcctgttca tcatcgatga caagcagaac 541 ttgcgccaga tcaccgtcaa cgatctgccc gtaggtcgca gtgtggagga gaccctgcgt 601 ctcgtccagg ccttccagta caccgacaag tacggcgagg tctgccccgc caactggaag 661 cccggccaga agaccatggt ggccgatccc accaagtcca aggagtactt cgagaccacc 721 tcctaaagag gctatctgtt cgctgaacgg ggccgctcct ggcgagtggg agtggattcg 781 aatcgcaaac cccccgttca actaaaacca atacatatac tacattatat atcctacaca 841 ttaaccctag agcgtagaag aagaagaaac tgtgaggcat ctttccctgc aacagcgcca 901 cccaaaaata agatgataaa cacctgcaga cgctaagcgg aaagtgatta ttttttacgt 961 atattttgtg tgcttttttt tttttgtaat tcaccacaat aaacgattgt acgg