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Drosophila melanogaster histone deacetylase 4, transcript variant B


LOCUS       NM_167356               5182 bp    mRNA    linear   INV 26-DEC-2023
            (HDAC4), mRNA.
ACCESSION   NM_167356
VERSION     NM_167356.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5182)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5182)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5182)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5182)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5182)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5182)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5182)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5182)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5182)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5182)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5182)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5182)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5182)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5182)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5182)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5182)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5182)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5182)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5182)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5182)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5182)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5182)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5182)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On May 8, 2012 this sequence version replaced NM_167356.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5182
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5182
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Histone deacetylase 4"
                     /map="11E8-11E9"
                     /db_xref="FLYBASE:FBgn0041210"
                     /db_xref="GeneID:32278"
     CDS             410..3955
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /EC_number="3.5.1.98"
                     /note="CG1770 gene product from transcript CG1770-RB;
                     CG1770-PB; HDAC4-PB; histone deacetylase 4"
                     /codon_start=1
                     /product="histone deacetylase 4, isoform B"
                     /protein_id="NP_727682.1"
                     /db_xref="FLYBASE:FBpp0073629"
                     /db_xref="GeneID:32278"
                     /db_xref="FLYBASE:FBgn0041210"
                     /translation="MELEHKLQLEHKYQFAVNSHGAFQELRNESMVTAAAAAVAQEQH
                     RQQLHQQQQQHQQQQQQQQHQQQQQQQQARGRDGMKLKQNCSANASPEVKQILNCFIL
                     SRKSQAAASNGTTTTSPYRNRGVVKSSSGESLPAGTVTSAHPYKIPQPPPSLLKYESD
                     FPLRKTASEPNLLKIRLKQSVIERKARIGGPAGARRHERLLQAAQRRQQKNSVLTNCN
                     STPDSGPNSPPSAAALAVGVVGSRGSPTSAPIQEENEEGSQYQPGQRSSINDLPLFSS
                     PSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGCGQP
                     GYYNPLGMAFVGRQPAPLAMIPATGIAPQQPSPVVRSASATSTSSSQASLVGDVAPPQ
                     AHAASTILPSSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHGHGS
                     HAHPHPHAHGHGHGHGHGIYAGHQHNVPITDAQVAQVHLHKQGHRPLGRTQSAPLPLG
                     HPMLTGAVQLNVVQTHYENSEAERQAYEHQVVNQKVRQTVLTRSGAAAAAAAAAGVSV
                     VREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTSTIATSTSQNLPEALAAAAAAAAYRA
                     PHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELAKSLMRPLSRTLSSPLVP
                     LGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMSTLYASQLRNHQPS
                     ASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRL
                     RARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTW
                     NEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAI
                     AAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGP
                     TECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDA
                     ATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALL
                     GDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHD
                     ESETINAMAGLSMQSMHRTLSRDDSEEPMDQDETK"
     misc_feature    2654..3778
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Histone deacetylases, class IIa; Region:
                     HDAC_classIIa; cd11681"
                     /db_xref="CDD:212544"
     misc_feature    order(3095..3100,3122..3127,3212..3214,3218..3220,
                     3494..3496,3614..3616)
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="active site"
                     /db_xref="CDD:212544"
ORIGIN      
        1 agttgggcca gtcggccgag tgaaactgaa atgaaagcgc ctccctcatt tcccagcgaa
       61 tgccgaggcc aaagcaaacg cgccaaatac caaagaaaaa atacaaaata atcataaaaa
      121 aaataaatga aataaataaa taaaaaaatc acaaaaaata aagtgaaaaa ctttgaaaaa
      181 ccaaaacatt attcgaagtt agagaccaaa cacgcagttt tcggaaatcc aacaaagtgt
      241 atagtcaaat atcgaaagta aacagcacaa aaaaaacaac aaagaaatct atgtaaaaga
      301 aaccaaagtg gcaacagaaa ccaaagatta tttattgagt gaactcaaga agagccagga
      361 gctgcaaaag cagcggctta tcaactcgtt tcaggagcaa tcgaagcaaa tggaattgga
      421 gcataaactt caattggagc acaagtatca atttgcggtg aattcacatg gcgctttcca
      481 ggaattgcga aacgagagca tggtgacagc cgccgctgct gcggtggctc aggagcaaca
      541 tcgccaacag ttgcatcaac agcagcagca acatcagcag cagcagcagc agcagcaaca
      601 tcaacagcag cagcagcagc aacaggcacg cggcagggat ggcatgaaac tcaagcagaa
      661 ctgtagtgcc aatgccagtc ccgaggtcaa acagattctc aactgcttca tcctgagcag
      721 aaagtcccag gcggcggcat cgaatggcac aacgacaacg tcgccctaca ggaatcgcgg
      781 cgtggtgaag agctcctcgg gcgaatccct cccagctgga accgtgacca gtgcgcatcc
      841 gtacaaaata cctcagccgc caccctcact gctcaaatat gaatctgatt ttccgctgag
      901 gaagacagca tccgaaccga acctgctgaa gatccggctg aagcagagcg tcatcgagcg
      961 caaggcccgc atcggaggac cggcgggagc ccggcgccac gaacgactcc tccaggcggc
     1021 gcagcgtagg cagcaaaaga actcggttct cacaaactgc aacagtacac cggattctgg
     1081 acccaattca ccgccctcgg cagctgcgtt ggcggtgggc gtggtcggta gccgtggatc
     1141 accgacaagt gcacccattc aggaggaaaa cgaggagggc agccaatatc agccgggcca
     1201 gaggagcagc atcaacgatt tgccattgtt cagttcacca tcgctgccga atatttcgct
     1261 cgggcgaccg catttaccca actcggcgca ggcgcatgcc caggtgaatg cccaggttgc
     1321 tgcccaggct caggcacagg cccaggcaca ggcacaggcg catgccatgt tcgcggcact
     1381 ggctgccgcc cagggtggct gcggacagcc gggctactat aatccactgg gcatggcatt
     1441 cgttggccgg caaccagcac cgctggccat gattccggcc acggggatag caccgcagca
     1501 accgtcgccg gtggtgcgca gtgcatcggc cacttcgaca tcgtcgtcgc aggcctcgct
     1561 ggtgggcgat gtggcgccac cgcaggctca tgccgcctcc accattctgc cctcgtcatc
     1621 gtcctacatg cagcaactgg gcagtgtggc cggttcgggt gttaatctcc atgccgccgc
     1681 cgttgctgca gcggcagcag cagcagccgc cgccggttca ctgccaccga ccaatagcca
     1741 tggtcacgga cacggttccc acgcacatcc acatccacat gcccatggac acgggcatgg
     1801 ccatggccat ggtatctacg ctggccacca gcacaatgtg cccataacgg acgcccaggt
     1861 ggcgcaggtg catctgcaca aacagggcca tcggccgctg ggacgaacgc agtcggcacc
     1921 actgcccctt ggacatccga tgctaaccgg agctgtgcaa ctgaatgtgg tccaaacgca
     1981 ctacgagaat agtgaggcgg agcgccaggc gtacgagcac caggtggtga accagaaagt
     2041 ccgccagacc gtcctgactc gcagcggagc tgctgcagca gccgctgctg ccgccggcgt
     2101 gagcgtggtg cgtgaggcac agttgaagga ggaggatgac gactcggccg ccgaggtgat
     2161 ggacctcaca gataagaaaa aaccgccgaa gacggtgcta accagcacga tagccaccag
     2221 tacgtcccag aatctgcccg aagctttggc ggcggcggcg gcggcagccg cctaccgtgc
     2281 cccgcacaac gcgtccagta actccgcctc cgccacaaag tccggtatta agctgcggga
     2341 ccaggagtat ttgcaacagc agcgggagca actattgctc cttcagcagg aggaggaact
     2401 ggcgaagagc ctaatgcgtc cgctatcgcg aacgcttagc agtccgctgg tgccgctggg
     2461 gccacatggt cttagtcaga ttcccgacac tggacaacag ccggcaccga tagccacatc
     2521 ctcgtcggcc gatcatatac cgcccgttaa cctctcgctg ccgcatcgcc agcaccgcca
     2581 gctaatgagc acactatacg ccagccaatt gcgtaaccac cagccatcgg cgagtggttc
     2641 accgccgcac aaggtcacca ccggtttggc ctacgatccg cttatgctga agcattcgtg
     2701 tatttgcgga gacaatgccc agcatccgga gcacagtggt cgactgcaga gcgtgtgggc
     2761 acggttaaat gaaacggatc tggtgaagcg ttgcgatcgc ctgcgcgctc gcaaggcgac
     2821 acaggaggag ctgcagactg tgcacaccga agcgcatgcc atgctcttcg gttcgaatca
     2881 gtgccagctc agcaggccca agttggaaaa cacgttgtcg gccagctttg tgcgtttgtc
     2941 gtgcggcggc ttgggtgtgg atctggatac cacgtggaat gagcaccata cggcaaccgc
     3001 tgcacgaatg gcagccggtt gtgttatcga tttggcactg aagacggcca agggtgacct
     3061 gcggaatggc tttgccgttg tccggccgcc gggccatcat gcggaggcca atttggccat
     3121 gggcttttgt ttcttcaatt cgatagccat tgcggccaag ctgctgcgtc agcggatgcc
     3181 cgaggtgcgg cgcatcctga tcgtcgattg ggatgtgcat cacggcaatg gcacacagca
     3241 agcattctac caaagtcccg acattctata tctttccata catcgacacg atgacggtaa
     3301 cttctttccc ggcacaggtg gacccacaga gtgcggctcc ggtgctggtc tcggctttaa
     3361 cgtgaacatc tcatggtctg gggcacttaa tccgccactg ggcgacgccg agtatatcgc
     3421 tgcattccgt accgttgtga tgcccatcgc gcggagcttt aatccggaca ttgtgctggt
     3481 atcctccggc ttcgatgcgg ccaccggcca tccggcaccg ctgggtggct accatgtctc
     3541 tccggcctgc tttgggttca tgacccgcga actccttcag ttggccaacg gcaaagtggt
     3601 gctggccctc gagggcggct acgatctggc cgccatctgt gattccgccc aggagtgtgt
     3661 gcgggcgctg ctcggcgatc ccgctgctcc cattgccaag gccgagctgg agcgcccgcc
     3721 ttgccagaat gccatcaata cgctccagaa gacgatagcc atacagcaaa cgcattggcc
     3781 ctgcgtgagg atgctggagc acacggttgg cttgtctgcg ctggagacgc tcaaggtgga
     3841 gcacgacgag tccgagacga tcaacgccat ggctggcctc tcgatgcagt cgatgcacag
     3901 aactctatcc cgcgatgatt ccgaggagcc gatggatcag gatgaaacca aatagaaggc
     3961 gatgcagacg tatattgcgg aagaggaggc ggtgggcgtg gcgaggtttt tgtggacctg
     4021 gtagagtggg aatggcagga gggggcgtgg ccgcaagctg ctcaatgcac atttagttat
     4081 ttgttgtagt tgaattgatt gttgttgctg ttgttgttgt ggcgctcgct tgcaattgtt
     4141 gtcgttgtca ttgatcgtct atagccacat ctatctctct cactcgatcg attatagcat
     4201 cccaattccc cgccccgcca aaaaaaacaa aaagaagaga aacatcgaaa atatagggga
     4261 acatgtctaa aagaagcaga acagggccta aagttcaaaa tggtggctgt gcctccaaaa
     4321 gaagaaataa ttataataat tagaaaagaa tcctttcaaa aaaaaaggag attttatatg
     4381 aatatatata tatatgaata tatatgtagc ttaagctcag aatttagttg tagaagtcat
     4441 cgagattttt tttttttgtt ttaaggtgag agcagaggta ttttaacgca cacacaaaca
     4501 cacgcaactc aatgtatctt attattatta tttaagtaag tgtgtcaaaa ggatatagaa
     4561 ccactaacgt actggtgaac atcatcagta agctataaag ataatgttta aagaggtcgg
     4621 gtgcaagaag catgtgtttt tttttataag gtaaggttca acctcaaagt tcccaagtct
     4681 agaccccacc acgcccactt atccgccatc gcttacagag atcgagtggg gagttgatta
     4741 catgttatgt agaatgcttt agttgataat aagatatgag aaaaaaaaaa cttaacaact
     4801 aactagttgg atgaaaagcg aaaaaactga gaaatctttt tgtacaattt atagtttagt
     4861 gcaagtttca agtacaacat gctattattt aaagaattct atatatatac atatatatat
     4921 atatatatac aaaaaaaata tatattgtgc aataaatgtg agaaaatgaa aatcgccaca
     4981 caaaacagaa actaaaacga ataagagaaa atttgttgtt aaatgttgcc gagatcttat
     5041 atacgtatgt atacctaata actgttacaa taataaccct ttatatatat aactatataa
     5101 atgcacatgt gtattcacca tgtgtgtaac gataacgatg ttcaacaaat gtctgaaatg
     5161 aagtaaaact attattatat gt