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Drosophila melanogaster tomosyn, transcript variant L (Tomosyn),


LOCUS       NM_167330               5062 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_167330
VERSION     NM_167330.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5062)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5062)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5062)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5062)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5062)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5062)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5062)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5062)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5062)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5062)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5062)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5062)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5062)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5062)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5062)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5062)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5062)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5062)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5062)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5062)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5062)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5062)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5062)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_167330.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5062
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5062
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /map="11B6-11B7"
                     /db_xref="FLYBASE:FBgn0030412"
                     /db_xref="GeneID:32217"
     CDS             761..4924
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="CG17762 gene product from transcript CG17762-RL;
                     CG17762-PL; Tomosyn-PL; tomosyn ortholog"
                     /codon_start=1
                     /product="tomosyn, isoform L"
                     /protein_id="NP_727630.3"
                     /db_xref="FLYBASE:FBpp0309353"
                     /db_xref="GeneID:32217"
                     /db_xref="FLYBASE:FBgn0030412"
                     /translation="MKKFTFKGVLDGFRQSVQPQATRQEQEIQEQLKADHFTLKKTFR
                     HGFPYSPTSFAFDPVQKLLAIGDKSGYIRILGRPGVDAHAKHEGESECAVLFAQFLVN
                     EGALVTVTADDTIHLWSIRQKTPRIVQSLKFQRERVTCIHLPVGSKWLYVGTEKGNIH
                     VVHIDTFALSGYIINWNKAIEVVRTSHPGAVIALCDNPLDANKLLIAFECGLLVLWDL
                     KAKCAELRWQAAEAVKSLAWHYEGKYFVSSHTDGSICSWPTKPQAKPQSQVCPHAKIN
                     KDGNAEKCKPIYKVDLKSSATGETFTIFSGGMPSEKGSKSNCITVMVGKATTVLEMEH
                     AVCDFITLCENPWPCETQEPYAIAVLLQYDLVLIDLLTPGFPCFESPYPMDLHESPVT
                     CCTYLTDCPSDLVPAFYSVGRTTTSKKSCFSEREWPISGGEWSPASCSYSEIVITGHQ
                     DGSLKFWDSGAGTLQILYKLKTAKMFEKPRSHVAHSHPESDNPLAVHLIFLCSESRRL
                     CVAGAMGQVMLFKFRKVESTSEVLVLEIPILYENFDDIYGTSPECDFLTGHQVQKAES
                     SDSDKTAECSLKVRNGAQRKPPGFQSQLVCLTTGPNRRNVQVTSLCISSSYGLMAYGT
                     EYGLVIIDIIQKICLLSVACPDLYGAHDPYSRTPKSPKRIENKEEQSRSPSSDQINGS
                     GVATAAPQQQQQQQQQLQQSQQQQQQQLQQQQQQQQQQQQQQQQQQQSLGGDPGDHAT
                     STSAGAATLAGSSIYGADDAGAGVASGGVGVGGISSAISGGFGGAAEPQQQQQVSQQL
                     HQLQQLQQQSQQQQQSFEASCDPWGGECGGGGAGGSGGGGGASGGGGASGAGAQQHQY
                     QHPHPYPHPHPYPHQTSVIQQQQSVTSYESLKKSKSQDKLDGTFSRSRSSSMSSIDMS
                     SSESVTCLAFIESYAKRNDILTLVPTLWIGTSFGSILTLFITMPERDVRKSQPVLITI
                     NGGPVVRLKGSITSMSFLDSYGSIIPYTFETWRDEKRDNKDRTPTKSSSRTSPTFTPT
                     TANTLSNTSVAGGASAGGGAGGGGGAGGGAASGGAAAGGPAGGGAGAGSAAGAAGGVG
                     SGVTSGGGMSSSSASSSGISGSVSTGLETLTDRQYIVIASEKQTKVFDVANQCCINRI
                     QLSEMDFAVKAETITMKDGSCLATYLSNGHLMVHSLPSLKLLLDTDFLPLMELSFQTK
                     CKQGIVDPMLSIWGQQIIVHEDTTQISKIFCFSHKGHGLYMASPTEIQKFTISSEFCQ
                     FILEMMGELYTVHEMPEQPKEGFFKGLFGGGAKLLDREELFGEQSGKPNRSVARHIPG
                     PNLEQLGQRASTAASEISRAHQLAMERGEKLNLLEERAERMANTAQDFSGTAHQLMLK
                     YKDKKWYQL"
     misc_feature    <881..1531
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    1043..1159
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1172..1312
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1334..1438
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1562..1888
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="LLGL2; Region: LLGL; pfam08366"
                     /db_xref="CDD:462446"
     misc_feature    4718..4900
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="SNARE domain of STXBP5, STXBP6 and related
                     proteins; Region: R-SNARE_STXBP5_6; cd15873"
                     /db_xref="CDD:277226"
     misc_feature    order(4727..4729,4736..4741,4745..4747,4757..4762,
                     4766..4774,4778..4783,4787..4792,4799..4804,4808..4825,
                     4829..4846,4850..4867,4871..4879,4883..4888,4895..4897)
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="heterotetramer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:277226"
     misc_feature    4799..4801
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="zero layer; other site"
                     /db_xref="CDD:277226"
ORIGIN      
        1 cagtcgacaa ctgaccagcc aagcactagc atatttccta ttggcccctt gcaacaaaaa
       61 gccccgaaaa tatattgaaa atttcacaaa aatggtagaa gccaaaactg tgaaaaacta
      121 aagcgaacgt cttgaagcca ttaaaaaagc gcgcctattc agtgaatgtg tgtgtgtgcg
      181 tgagaattga tgtgtaaaaa gaacagtgta ttgaaatatc aataaactat cgatgatcct
      241 ttgaaaatta agaaaaaaaa tttaattttt tttttgtatg ttcaagtgaa gaagctgcag
      301 gaggagcata agatgaagat gtagctaaca tcaaatattt cgaccactgt taacctagtt
      361 tcacatctca aaaataaaac caaacaacaa ggacgaactc agaccagcac tggctcctct
      421 gtcttcaatt acgcacagct ctaccagtat ctagagaata acgagtaaag gctaccaagg
      481 actcgaggga agagaatcgc ctggggcaga ggaagaagcc aatccccata cttttcggtt
      541 ctcctcggac cagaatcatc acctccccca tcccgacccc ggcactacct tcccgctgaa
      601 ccacatacac tctgtccact atccactatt cgacaccacc acactctgtg catccaacta
      661 tttggccaac cattaatcct tgggcgagac cagagcagcc ccatcgcata actgtggata
      721 gcagagcagc cggagcacga ggacgactca tgttacaaaa atgaaaaagt tcacattcaa
      781 aggagttcta gatggatttc gacaaagcgt tcagccccaa gccacacgac aggagcagga
      841 gattcaggag caactcaagg ccgatcactt tacgttaaag aaaacctttc gccatggctt
      901 tccatactcg cccacatcct tcgccttcga tccagtacaa aagctactag cgattggcga
      961 caaatcgggc tacattcgca ttttgggacg acctggcgtc gatgcccatg ccaaacacga
     1021 gggcgaatcc gagtgcgccg tgctctttgc ccagttcctg gtcaacgagg gcgcattggt
     1081 caccgtcacc gccgatgaca ccattcactt gtggagcatt cgccaaaaga caccgcgcat
     1141 tgtgcagagt ctgaagtttc agagggagcg cgtgacttgc atacacctgc ctgtgggcag
     1201 caaatggctg tacgtgggca ccgagaaggg aaacatacac gttgttcaca tagatacatt
     1261 tgcacttagt ggttatatta ttaactggaa taaagcaatt gaagtggtta gaactagtca
     1321 tccaggtgct gtgattgcgt tatgtgataa tccattggat gcaaacaagt tgcttattgc
     1381 atttgagtgc gggctgcttg tgctgtggga tctgaaggcg aaatgcgctg agctgcgatg
     1441 gcaggcggcc gaggccgtca agtccctggc ctggcactac gagggcaaat attttgtgtc
     1501 ctcgcacacg gatggctcca tttgctcctg gcccacgaag ccgcaggcta agccgcagtc
     1561 gcaggtctgt ccgcatgcta aaatcaacaa ggatggcaat gcggagaaat gcaagccgat
     1621 atataaagtt gacttgaagt ccagcgcaac tggggaaacc ttcacaattt tctcgggcgg
     1681 catgccctcg gagaagggct ccaagtccaa ctgcatcacg gtgatggtgg gcaaggccac
     1741 cacggtgctg gagatggagc acgccgtttg cgatttcata acactctgcg agaatccctg
     1801 gccctgcgag acccaggagc cgtatgctat tgccgtgctg ttgcaatacg acttagtatt
     1861 aatagactta ttaacacccg gttttccatg ttttgaatcg ccttatccaa tggacttaca
     1921 cgaatcacct gttacatgtt gcacatattt aaccgattgc ccatcggatt tggttcctgc
     1981 tttctattca gttggtcgca caacgacaag taaaaagagc tgcttctcgg agcgcgaatg
     2041 gccgatatcc ggtggcgagt ggtcgccggc gtcgtgcagc tattcggaga tcgtgatcac
     2101 cggacaccag gacggcagcc tcaagttctg ggattccggt gccggcacac tgcagatcct
     2161 ctataagctg aagacagcca agatgttcga gaagccgcgc tcccacgtcg cccactcgca
     2221 tccggaaagc gacaatccgc tggcggtgca cctaatcttc ctttgctcgg aatcgcgacg
     2281 cctgtgtgtg gccggcgcca tgggacaggt gatgctcttc aagttccgca aagtggagtc
     2341 cacgtcggag gtactggtgc tggagatacc catactctat gagaattttg atgacattta
     2401 tgggacaagt cccgagtgcg attttctaac gggccatcaa gtgcagaagg ctgagtcgag
     2461 tgattcggat aagacggccg agtgttcgct aaaggtgcgc aatggggcgc aacgcaagcc
     2521 gccgggcttc cagtcgcagc tggtctgcct caccaccgga ccaaatcgcc ggaacgtgca
     2581 ggtcacctcg ctgtgcatca gctccagtta tggcctaatg gcttatggta ccgaatatgg
     2641 acttgtcata attgatataa tccaaaaaat ttgcctattg agtgttgcat gccccgatct
     2701 gtatggcgca catgatcctt actcgcgaac accaaaaagt ccaaaacgta ttgaaaacaa
     2761 agaggagcaa agccgatcgc ccagctcaga tcagatcaac ggcagcggag ttgcaactgc
     2821 agcaccgcag cagcaacagc agcagcagca acagttgcag caatcacagc aacaacagca
     2881 gcagcagcta cagcagcaac agcagcagca gcaacaacaa cagcagcagc agcaacaaca
     2941 acaacaatcg ttaggtggtg atcctggtga tcatgcaaca tcgacgtcag cgggagcagc
     3001 aacattggcg ggatcctcca tttacggtgc agatgatgca ggtgcgggtg ttgctagtgg
     3061 cggtgttggt gttggtggta ttagcagtgc gattagcggt ggatttggtg gtgcggctga
     3121 gccgcaacag cagcaacagg tgtcgcaaca gttgcatcaa ttacagcaac tacagcagca
     3181 atcgcagcag cagcagcaat cgtttgaggc gtcttgtgat ccatggggcg gcgagtgcgg
     3241 cggtggtggt gctggcggca gcggcggcgg cggtggtgca agcggtggtg gtggtgctag
     3301 cggtgcaggt gcgcaacaac atcaatatca gcatccgcat ccgtatccgc atccgcatcc
     3361 gtatccgcat caaacatccg ttatacagca acagcagtca gtgacatcgt acgaatccct
     3421 aaaaaagtcc aaatcacaag ataaattgga tggaactttc tcaagatcca gatcatcgtc
     3481 aatgtccagc attgatatgt cttcctctga atctgttacc tgtttagctt ttatcgagag
     3541 ttatgcaaaa cgaaatgata ttttgacact tgttcctact ttgtggattg gaactagttt
     3601 cggttcgata ctgacattgt tcatcaccat gcccgagcga gatgtgcgca aatctcagcc
     3661 agtattgata acaataaatg gtggccccgt ggtacgactc aaaggatcca taacttccat
     3721 gtctttttta gactcatacg gttcgatcat accctatacg tttgagacct ggcgtgacga
     3781 gaagagggac aacaaagatc gcacaccaac aaagagcagc agccgcacca gtcccacatt
     3841 cacaccgaca actgccaata cattatcaaa cacttcggtc gcgggtggtg cgtccgcagg
     3901 cggaggagct ggcggcggtg gtggtgccgg cggtggtgcg gccagcggtg gcgcagccgc
     3961 aggagggcca gccggcggtg gtgccggagc aggatcggcg gctggagcgg ccggcggcgt
     4021 tggaagcggt gtaaccagcg gcggggggat gagcagcagc agcgccagca gcagcggcat
     4081 cagcggaagt gtgagcaccg gcctggaaac tctcaccgat cgacaataca tcgttatcgc
     4141 aagcgagaag caaacaaaag tcttcgatgt cgccaaccag tgctgcatca accgcataca
     4201 attatcggaa atggattttg cagtcaaggc agaaactatc acgatgaaag atggctcttg
     4261 cttagcaacc tatctttcga atggccatct aatggtacat agtcttccta gtctaaaact
     4321 gttattggat actgatttct taccacttat ggaactaagt tttcaaacaa aatgtaaaca
     4381 gggaattgtg gatccaatgc tttcgatatg gggtcaacag atcattgttc atgaagatac
     4441 aactcaaata tcaaaaatat tttgctttag tcataaaggt catggattgt acatggcatc
     4501 gcccaccgaa attcaaaaat tcacgatatc atcggaattt tgtcaattta ttttggagat
     4561 gatgggtgaa ctatatacgg tacacgaaat gcccgaacag ccgaaggagg gtttcttcaa
     4621 gggtctattt ggtggtggcg ccaaactcct ggatcgcgag gagctatttg gcgagcagag
     4681 cgggaaaccg aatcgatcgg tggcacggca catacccggc cccaatttgg agcagctcgg
     4741 ccagagggct tccaccgccg catcggagat cagccgggcg caccagctgg ccatggagcg
     4801 cggcgagaag ctaaatttgc tggaggagcg cgccgagcgc atggccaaca ctgctcaaga
     4861 tttcagcggc actgcgcatc aattaatgct taaatataaa gacaagaagt ggtatcagtt
     4921 gtaaaatatc tattttagga gccaattcta ccacagttat tgtaatattg cttttataac
     4981 actttctact acattacgag taaagtacac ttatttaatt tctgttttca agtcgtcacg
     5041 ttatttacaa aaaccgaaaa cc