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Drosophila melanogaster LIM domain kinase 1 (LIMK1), transcript


LOCUS       NM_167327               4814 bp    mRNA    linear   INV 26-DEC-2023
            variant D, mRNA.
ACCESSION   NM_167327
VERSION     NM_167327.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4814)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4814)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4814)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4814)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4814)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4814)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4814)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4814)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4814)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4814)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4814)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4814)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4814)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4814)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4814)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4814)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4814)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4814)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4814)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4814)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4814)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4814)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4814)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Dec 17, 2009 this sequence version replaced NM_167327.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4814
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4814
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="LIM domain kinase 1"
                     /map="11B2-11B2"
                     /db_xref="FLYBASE:FBgn0283712"
                     /db_xref="GeneID:32207"
     CDS             102..3260
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /EC_number="2.7.11.1"
                     /note="CG1848 gene product from transcript CG1848-RD;
                     CG1848-PD; LIMK1-PD; LIM kinase 1; LIM-kinase 1;
                     LIM-DOMAIN KINASE; LIM domain protein kinase; agnostic;
                     LIM-kinase1; Lim kinase; LIM Kinase1; im kinase"
                     /codon_start=1
                     /product="LIM domain kinase 1, isoform D"
                     /protein_id="NP_727622.1"
                     /db_xref="FLYBASE:FBpp0073494"
                     /db_xref="GeneID:32207"
                     /db_xref="FLYBASE:FBgn0283712"
                     /translation="MSFWLHFVLKKILPWLKSTKIDVNLTNLHIGDRILEVNGTPVSD
                     SSVEQIDKLIRSNEKMLQLTVEHDPVQVCRSCSQADIQRAMSASTLILPLSTSASSVE
                     VGRERLYKTPGEQGTKARKLRQATNASTTIPPAAGATAMTQLKEKERCSSLSKLLDEQ
                     HQAQQHSAHPQLYDLSRTQSCRVVQKPQRIFRATDLVIGEKLGEGFFGKVFKVTHRQS
                     GEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGG
                     CLKELIHDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVA
                     DFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPY
                     WMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQEFREKFCA
                     QCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQRLADDLAADRVPPERLLHEIETFQEW
                     YASSEDALSPTSQRSLNNLDELVKSAVDSEISPVEKEKENMVIKPQDIPKSPHLGKDF
                     SPSGERLRDSMRARRRQRFLGAQEERRNLTPDTESKERALKKALKKCRPFGERGYLVD
                     LRAGAELQLEDVRDLNTYSDVDSSCDTSLNYHDVNNLPAAQEDENTVKPGKEELLEES
                     TNKPSNQESQHHRLAIDDMRTRLNQCRSKFEHLEEASRRNFNQSQHSMKNFFKTPPVA
                     LKMFQRLEHEAAALNGGNNCPPPPPRTQRINQTPIFGRKNPPVAIVGQKLQHAESLED
                     LASSGVAKQLATPAPKRSKATATTKGGQSSNPPLFLPPSLNISVALNSNGNVTTTTNT
                     NSSCPPSASDWLPKKHKLTLPLPSAQQQRTSSNHRLPMCNNKGKTLKPLPSRTGSQGI
                     PASNCVSPTRSSRPGSPTKHLAQRHTAATAQRLTNAAATHQQQHQQQSSKTTRLNILS
                     PEKVHRLGARLTDQKQKMREEAAATASSVGGAGCAAGTAAGSLNGHRTIGSSGTPNSA
                     VGERRRRAAPSPPVRTHFNTRC"
     misc_feature    <171..308
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="canonical PDZ domain; Region: PDZ_canonical;
                     cl49608"
                     /db_xref="CDD:483948"
     misc_feature    705..1565
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     LIM domain kinase; Region: STKc_LIMK; cd14154"
                     /db_xref="CDD:271056"
     misc_feature    order(705..719,729..731,768..770,774..776,861..863,
                     909..920,930..932,936..938,1050..1052,1056..1058,
                     1062..1067,1071..1073,1104..1106,1113..1115,1266..1277)
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="active site"
                     /db_xref="CDD:271056"
     misc_feature    order(705..719,729..731,768..770,774..776,861..863,
                     909..920,930..932,1050..1052,1056..1058,1062..1067,
                     1071..1073,1104..1106)
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271056"
     misc_feature    order(717..719,930..932,936..938,1050..1052,1056..1058,
                     1062..1064,1113..1115,1266..1277)
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271056"
     misc_feature    order(1101..1133,1227..1277)
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271056"
ORIGIN      
        1 gttgcctttg cgtttaatgt acatatgtta tacaaaccaa gccgtcttct cactttttac
       61 acacaagtca caacattttt tttatatgaa tttaaagaag aatgtctttt tggttacatt
      121 ttgtactgaa aaaaatttta ccatggctca aatctacgaa aattgatgtg aatcttacaa
      181 atctgcatat tggagatagg atattggagg tgaacggcac accagttagt gattcgtccg
      241 tggaacagat cgacaaattg atacggagta atgagaagat gcttcagctg accgtggagc
      301 atgatccggt gcaagtgtgc cgctcctgca gccaagcgga catccagcgg gccatgtcag
      361 cgtccacgtt aatcctgccg ctcagcacat cggcctccag tgtcgaggtg ggcagggagc
      421 gtctgtacaa gacacccggc gaacagggca cgaaggccag gaaactgcga caagccacca
      481 atgcctctac gacaatacca ccggcagctg gagccaccgc aatgacgcaa ctaaaggaga
      541 aggagcgttg ttccagtctg tccaagttgc tggatgaaca gcatcaggca caacagcatt
      601 cggcgcatcc tcagctctat gatctgtcca ggacgcaatc ctgccgtgtc gtccaaaagc
      661 cacaacgaat ctttcgtgca actgatctgg ttataggaga gaagctaggc gagggcttct
      721 ttggcaaggt tttcaaggtg acccaccgtc agagcggcga ggtgatggtc ctcaaagaac
      781 tgcatcgtgc ggatgaggaa gcgcaaagga atttcatcaa ggaagtggcc gttctccgtt
      841 tgctggacca tcggcatgtg ctcaaattca ttggtgttct gtacaaggat aagaaactgc
      901 acatggtcac ggagtacgtg gccggtggtt gtctcaagga gctgatccac gatccagccc
      961 aagtactccc ttggccccag cgcgtccgct tggccaggga tattgcgtgc ggcatgagct
     1021 atctgcactc gatgaacatc atccatcgcg atttgaactc aatgaattgc ctggtccgtg
     1081 aagatcgctc ggtcatagtg gcggattttg gactagctcg cagtgtggat gcgccgcggc
     1141 tgccaagtgg caatatgacg ccaggcggct atggatcagg cgctaacagc gatgcgccca
     1201 tgtcaccgag tggaacacta aggcgcagca agagcaggca gcgaaggcaa cgttacacgg
     1261 tggtcgggaa tccctactgg atggcacccg agatgatgaa aggtctcaaa tacgacgaaa
     1321 aggtggatgt cttctccttt ggcattatgt tgtgtgagat cattggacgc gtggaagccg
     1381 atccggattt tatgcctcgc aattcggact tcagtctcaa tcagcaggag tttcgcgaga
     1441 agttctgcgc tcagtgtcca gagcctttcg ttaaagtggc cttcgtgtgc tgtgatctta
     1501 atcccgatat gcgtccgtgt ttcgaaactc tgcacgtttg gctgcagcgt ctcgccgatg
     1561 atctggccgc cgatcgtgtg ccgccagagc gtctgctgca cgagattgag acctttcagg
     1621 aatggtacgc cagctctgag gacgccttgt cacccacctc ccagcgcagc ttaaataatc
     1681 tcgatgagtt ggtcaagagt gcggtggatt cggaaatttc gccggtagaa aaagagaagg
     1741 agaatatggt gattaagccc caggatatac cgaaatctcc gcatctcggc aaggatttct
     1801 cgcccagcgg cgagagactg cgtgacagta tgcgggccag gcgtcgccaa cgtttcttgg
     1861 gcgcccagga ggagcgtcgt aatctcacgc ccgacacgga gtccaaggaa agggctttga
     1921 agaaggcgct gaagaaatgt cgtccgtttg gcgaaagagg ttacctggtg gatctgcgtg
     1981 ccggtgccga attgcagcta gaggatgtca gggatttgaa cacctattcc gatgtggact
     2041 ccagttgcga tactagccta aattaccatg atgtaaataa tctgccagca gcgcaagagg
     2101 atgagaatac agtgaaaccg ggcaaggaag aactgttgga ggagagcaca aataaaccca
     2161 gcaaccagga gtcacaacac catcgtctgg ccatcgatga tatgcgcacc cgcctgaatc
     2221 agtgccgcag caaattcgag catttggagg aggctagtcg gcggaacttc aaccagtcgc
     2281 agcactccat gaagaacttt ttcaaaaccc caccggtggc ccttaagatg tttcagcgcc
     2341 tggagcacga ggctgcagcc ctgaatggtg gcaacaattg cccaccgcca ccaccacgta
     2401 cgcagcgcat caatcagacg cccattttcg gtcgaaagaa tccgccagtg gcaatcgtcg
     2461 ggcaaaaact acagcatgct gagtccctag aggacctggc ctccagcgga gttgccaaac
     2521 agctggccac accagcaccc aaacgcagca aagccacagc aacgaccaaa ggcggccaga
     2581 gcagcaatcc gccacttttc ctgccgccta gccttaacat aagtgtcgca ttaaatagca
     2641 atggaaatgt gaccacaacg accaatacca atagtagttg tccaccatcc gcatcagact
     2701 ggctgccgaa gaagcacaag ctaactttgc cacttccgtc ggcccaacag cagcgaacga
     2761 gcagcaatca tcgcctgcca atgtgcaata acaaagggaa gacactgaag ccactgccaa
     2821 gtcgcacggg cagtcaaggc attcccgcaa gcaattgcgt ctcgccgacg aggagcagca
     2881 ggcccggatc acccaccaag catctggccc agaggcacac agccgccacg gcgcagcgac
     2941 tgacaaatgc ggccgccact caccagcagc agcatcagca acaatcctcg aagacgacgc
     3001 gcctgaatat cctgagtccg gaaaaggtgc atcgcctggg cgctcgactc accgatcaga
     3061 agcagaaaat gcgcgaggag gccgcagcga cggcctcgtc cgtcggagga gccggttgtg
     3121 cggcaggaac agcggctgga agcttaaatg gtcatcggac catcggatcc tccggcacac
     3181 cgaattcggc ggtcggtgaa cggaggaggc gagcagctcc atcgccgcca gttcgcacgc
     3241 atttcaatac gcgctgctag ctagacgaag tagccatact ctctattaac gattgtcaag
     3301 tgttgtgcgc agtttgttgt ggttccactc aggaagctgt tgtaagcagc ttaatgttct
     3361 acaaacaaac tgtcgtaatt agcgtaaatc tttgaaggat ataactgttg taacttctat
     3421 aaccaaccat tcgccatttg tatcgtacgg aattaaattt ccacgacatg tagaggcact
     3481 ttttttttta aatacataat gacttttaaa gtgtaatgta acattaagaa ccagtgaact
     3541 gtgccgctgt tataaacgca actgttatac gcacataaca agatcaacat tccgacgaaa
     3601 gtgtttattt tttttttgat tccaacattt gattttaagt ttcaactgaa cgaaggttaa
     3661 gtgcctgata ggaatgaaaa accaataagt tgcaatattt acacggattg tataaaccaa
     3721 gcgaataatt atagtatgta agattacagg gtaacaactg tctcgactaa cctaaaaaaa
     3781 aaaactgaac tagaagcaaa gctaagcaaa tacttgttta acccactatt gtctgacata
     3841 aagttatatt gcgaaagaga tagcgaaaga cggataaaga gagaaggaag aaacttgtgc
     3901 catgatgttg atgcgaaaaa cgaacgaatc tgaagaatcc tcgagagagg gagatcccac
     3961 ccgcaaaaaa aagacaaaag gaacgaaaag aactttaact agaaaaattg tggtttaaat
     4021 attttttgat aaacagcgta tataaatgta tttgtatatc tattccataa ttatatagat
     4081 aaacgtattc catgttagtg cttaaatcta atttattatt tatcgattct cgacccattc
     4141 accccgtccc ctcattccaa gaacaataat taacaatgct aagaaacaaa cttttttgta
     4201 ttgacgagaa taagtctaac tcctataact aaatatataa gaatgttttt gctcaaaggc
     4261 aattttagtt gtaattgata cgaacagaca tacaaacaca cacacacgct aactgttata
     4321 caaatgaaac gcacacgctc aagcctaata ctgttatact gtgtacttta tatagccatt
     4381 atatacctaa acctatatac atataggatc gaaacgcttg caattaactg cttacataag
     4441 acatttgagt cgggcccttg ttatacggac gtatgccagt agaacagtgg ccgcgccgaa
     4501 ccgatctagc atttaactat ctatatacaa caaatatgtg cgatattttt tatatgcagc
     4561 taatttaatg tgttgtattt tgaccccaca ccaccttgta actacgttta tacgcctgct
     4621 tttcgaaaat tgagtaacgc ttatagaatt ttcgattcaa ttctttatgc cttttaacag
     4681 ttgaacatat ataatcagta tagcaacatt ttctacccac ttgtaaataa gtttataact
     4741 aatgcagttt ttgttgccta cttattcggg agtcgaaagg tctgtaatta caaataaagc
     4801 ttgtgtataa acgt