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Drosophila melanogaster heavyweight (hwt), transcript variant B,


LOCUS       NM_167324               6878 bp    mRNA    linear   INV 26-DEC-2023
            partial mRNA.
ACCESSION   NM_167324
VERSION     NM_167324.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6878)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6878)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6878)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6878)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6878)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6878)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6878)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6878)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6878)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6878)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6878)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6878)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6878)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6878)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6878)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6878)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6878)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6878)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6878)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6878)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6878)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6878)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6878)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_167324.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on the 5' end.
FEATURES             Location/Qualifiers
     source          1..6878
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            <1..6878
                     /gene="hwt"
                     /locus_tag="Dmel_CG43921"
                     /old_locus_tag="Dmel_CG11146"
                     /old_locus_tag="Dmel_CG15729"
                     /old_locus_tag="Dmel_CG32653"
                     /old_locus_tag="Dmel_CG42251"
                     /gene_synonym="43921; BcDNA:GH02424; CG11146; CG15729;
                     CG32653; CG42251; CG43921; Dmel\CG43921; lincRNA.981"
                     /note="heavyweight"
                     /map="11A12-11B1"
                     /db_xref="FLYBASE:FBgn0264542"
                     /db_xref="GeneID:32202"
     CDS             1..4533
                     /gene="hwt"
                     /locus_tag="Dmel_CG43921"
                     /old_locus_tag="Dmel_CG11146"
                     /old_locus_tag="Dmel_CG15729"
                     /old_locus_tag="Dmel_CG32653"
                     /old_locus_tag="Dmel_CG42251"
                     /gene_synonym="43921; BcDNA:GH02424; CG11146; CG15729;
                     CG32653; CG42251; CG43921; Dmel\CG43921; lincRNA.981"
                     /note="CG43921 gene product from transcript CG43921-RB;
                     CG43921-PB; hwt-PB"
                     /codon_start=1
                     /product="heavyweight, isoform B"
                     /protein_id="NP_727617.2"
                     /db_xref="FLYBASE:FBpp0305358"
                     /db_xref="GeneID:32202"
                     /db_xref="FLYBASE:FBgn0264542"
                     /translation="MFCRLCWIDFNAGEAMVECAGPCGSCFHRNCVDCVTGDVAHILA
                     TGGGYYSGLEWYCRTCRQLYRLQVYFEIAICDDYSLPVDFVKKRPSSFDPCLAEAIPA
                     NPEHWIAPSPQTEFLPFGEAQQALQLQPAAAAATAAATTSAAAAANATAAAPQLPPPL
                     PVPVATLPNQAATAAAAATAAILATHQQQQQQQHQHLSNNNNNGGSTHGQQHTHSNNN
                     NTLPVGAQQQQQQQHQQQRATLQHPPLPNSNIKQASVKLIEGYSDPKDTRNHKKVYHK
                     KAKKRSTTGHKRHQQQQQQQQPHQQQLQQQQQQTLPTPRSAQQQQQLQQKLQQRHSTY
                     NNNNGNSRKDKRNSQYNSDSSAPKSSDDEADIDEEVEQQPLPVPQAPVQSASQPAAGL
                     NSPDSISDDLVRPLPPQLQRSPRKLTVAPAEHNKRQPSPYYYSDLLKSRDKDKDKDKD
                     KDKDKDKDKDKDKDKDKERDKDREDFKLKCRQSTASEPPQQTQTQLGGYRKSSSLDVP
                     PAEEQPEAESHEEEDPRTGQDSQSTPKRYSFTEEGVHIIRCETPSTSTSEESDCSECL
                     KRREWHARALALVRKTCNVQPRNQNPTGSELQLQLQHCDAGEGELLKCCPPPPAPAEN
                     QSQVQPMPPHRLLGPAAVCGACITSAPASSLAGGRGSELGDDLEEEYFRPRSIFYVHP
                     HGVHECIECAQPAQPATVPAPTLSNPSLDIYGDDEDEVDGDEDEDEEDDSEDIMGSRR
                     RQIYETAFDCKIAKSDDDLDEVDRITNCSVLLQLSNGNGGDISKVTGSSKTRAECKRA
                     KNSKNQALQEQTGEAHVQVHHVEAELGKLQLSQVDQQNQNQNQSQNQQHGVSATGSGA
                     SASSTQQLPVRGYTPSPPSTAPLPMKFPGKHDRYLNMNSIRSAPNLPAANPAHPRLRD
                     LRLPIQSMRHQCGGSSNDNSLTDSAYVNPPSTNSNSNAASASASASVSATGSAAPRRP
                     RSFVLESGRVLELRRSAQGHQGGQSTHHHHHHHHHAPGSRRNRHGQSQGQTTGGGHNY
                     SSTESIATSSSGGSMESLRSSTSEGNRSTSSSESRHSSSLSSHSSESGSGGSGGSGGS
                     SVAYPLRPAPLLLHSKLHILSPISDKSSQEPASASASEQSQQPSQQLAPMASQEDDST
                     TSGAPAGNQVQVNASLKQPRSNRGAPNKALLQLADELLGSDSGISLHSREDGKPQALA
                     LQRLTLPKLQLIGAEGTTTSATASGAGGSSATGGSSGAGGSGSGSVVASGSTGIQQDL
                     RDLPFDMPKLRRRKTLQQEAACTSGSATSVDLGELPFDMPKLRRRLRANQAEINNLLM
                     HSTESSGISQASSSHSMRDDQKMSSKLDTALFRQNLTLNLNESRQATKQFGSLDLRGL
                     NSNKELNMNLSQGYVTAVDLIDVTIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRN
                     CESTKQDYSLSLKGAKGFMHMRIQRNETGQYILGQFSRPFETVPEMIRHFCLNRLPVR
                     GAEHMCLIEPVIAQLL"
     misc_feature    4..180
                     /gene="hwt"
                     /locus_tag="Dmel_CG43921"
                     /old_locus_tag="Dmel_CG11146"
                     /old_locus_tag="Dmel_CG15729"
                     /old_locus_tag="Dmel_CG32653"
                     /old_locus_tag="Dmel_CG42251"
                     /gene_synonym="43921; BcDNA:GH02424; CG11146; CG15729;
                     CG32653; CG42251; CG43921; Dmel\CG43921; lincRNA.981"
                     /note="PHD zinc finger; Region: PHD; smart00249"
                     /db_xref="CDD:214584"
     misc_feature    4222..4515
                     /gene="hwt"
                     /locus_tag="Dmel_CG43921"
                     /old_locus_tag="Dmel_CG11146"
                     /old_locus_tag="Dmel_CG15729"
                     /old_locus_tag="Dmel_CG32653"
                     /old_locus_tag="Dmel_CG42251"
                     /gene_synonym="43921; BcDNA:GH02424; CG11146; CG15729;
                     CG32653; CG42251; CG43921; Dmel\CG43921; lincRNA.981"
                     /note="Src homology 2 domain found in SH2
                     domain-containing adapter proteins B, D, E, and F (SHB,
                     SHD, SHE, SHF); Region: SH2_SHB_SHD_SHE_SHF_like; cd09945"
                     /db_xref="CDD:198198"
     misc_feature    order(4249..4251,4303..4305,4366..4368,4372..4374)
                     /gene="hwt"
                     /locus_tag="Dmel_CG43921"
                     /gene_synonym="43921; BcDNA:GH02424; CG11146; CG15729;
                     CG32653; CG42251; CG43921; Dmel\CG43921; lincRNA.981"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198198"
     misc_feature    order(4369..4371,4456..4458)
                     /gene="hwt"
                     /locus_tag="Dmel_CG43921"
                     /gene_synonym="43921; BcDNA:GH02424; CG11146; CG15729;
                     CG32653; CG42251; CG43921; Dmel\CG43921; lincRNA.981"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198198"
ORIGIN      
        1 atgttctgtc gtctctgctg gattgatttt aatgccggcg aggcaatggt ggagtgcgcg
       61 ggtccctgtg gtagttgctt ccaccgcaat tgtgtcgatt gtgtcaccgg ggatgtggcg
      121 cacatcctgg ccaccggcgg tggttactat tccggtctgg aatggtattg ccgcacttgt
      181 cgtcaacttt atcgcctgca agtgtacttc gagattgcca tctgtgatga ttacagcctg
      241 cccgtagact ttgttaaaaa acgaccgtcc agctttgatc cgtgcctggc ggaggcgata
      301 ccagcgaatc ccgagcattg gatagcaccc agtccgcaaa ccgagtttct gccatttggt
      361 gaagcccaac aagcgttgca gctacaacca gcagcagcag cagcaacagc agcagcaaca
      421 acatctgcag cagcagcggc aaacgcaaca gcagcagctc ctcaactacc gccaccgctg
      481 cccgttcccg tggcaacatt gcccaatcag gcggcgacgg cagcagcagc agcaacagct
      541 gcgattttgg ccactcacca gcaacagcag cagcagcagc atcagcattt gagcaacaac
      601 aacaacaacg gcggcagcac acacggccaa cagcatacgc acagcaacaa taacaacaca
      661 ttgccagtag gggcacagca gcagcaacag cagcagcatc aacaacaacg tgcaacattg
      721 caacatccac cgctgcccaa cagcaacatc aagcaggcat cggtgaaatt aatcgaagga
      781 tattcagatc caaaggatac gcgcaatcac aaaaaggtct atcacaaaaa ggccaagaaa
      841 cgctcgacta ctggccacaa gcggcatcag caacagcagc agcaacagca gccgcatcag
      901 cagcaattgc agcagcagca acagcaaacg ttgccaacgc ctagaagtgc gcagcagcaa
      961 cagcaactgc agcaaaagtt acagcagcgg cattccacct acaacaacaa caacggcaac
     1021 tcaagaaagg ataaacgcaa cagtcaatac aattcagact cctcggctcc gaaatcctcc
     1081 gacgacgagg cggacatcga cgaagaggtt gagcagcaac cgctgcccgt gccacaagca
     1141 cctgtccaga gtgcttcaca accagcggcc ggactcaact cgccggattc catatccgat
     1201 gacctggtgc gtccgcttcc accgcaactg cagcgcagtc cgcgcaaact gaccgtcgct
     1261 ccggcggagc acaacaagcg ccagccctcg ccctactact actccgatct gctcaagagt
     1321 cgtgacaagg acaaggataa agacaaggac aaggacaaag acaaggacaa ggataaagac
     1381 aaggacaagg acaaggacaa ggaacgggac aaggacaggg aggactttaa gctcaagtgt
     1441 cgccagtcga cggccagtga accgccgcag caaacccaga cacagttggg tggctaccgg
     1501 aagagctcca gcttggatgt gccgccggcg gaggagcagc cggaagcaga gagtcacgaa
     1561 gaggaggatc cccggacggg acaggactct caatccacgc ccaagcgtta cagtttcacc
     1621 gaggagggtg tacacatcat tcgctgcgag acgcccagca ccagtacttc cgaggaatcc
     1681 gattgcagtg agtgcctcaa gcgacgcgag tggcacgctc gtgccttagc cttagtccgc
     1741 aagacctgca acgttcagcc aaggaatcag aatcccactg gcagcgagct tcagctgcag
     1801 ttgcagcatt gcgacgccgg cgagggcgaa ctgcttaagt gctgtccacc gccaccggct
     1861 ccagcggaga accagtctca ggtccagccg atgccaccgc accgcctgct gggaccagca
     1921 gccgtgtgcg gagcctgcat cacatccgct cctgcctcct ccttggccgg cggacggggc
     1981 agcgagctcg gcgatgatct ggaagaggag tacttccggc cgcgcagcat cttctatgtg
     2041 catccacatg gcgtccacga gtgcatcgag tgcgcccagc cagcccagcc tgcgactgtt
     2101 ccagcgccaa cgctgagcaa tccatcgctc gatatctacg gcgacgacga ggacgaagtg
     2161 gacggtgacg aggacgagga cgaagaggac gactccgagg acatcatggg cagccggcgg
     2221 cggcagatct atgagacggc cttcgactgc aagatagcca agtcggatga cgatctagat
     2281 gaggtggatc gcattaccaa ttgctcggtc ttgctgcagt tgagtaatgg caacggtggt
     2341 gacatcagca aggtaaccgg ctcttcgaag acgcgggccg agtgcaagcg agccaaaaac
     2401 tccaaaaatc aggctctgca agagcaaacg ggcgaggccc atgtacaagt gcatcatgtg
     2461 gaggcggagc tgggcaagct gcagctgagt caagtggacc agcagaatca gaatcagaac
     2521 cagagccaaa accagcagca tggtgtgagt gctaccggta gtggagcaag tgcatccagc
     2581 acgcagcagc tgcccgtgcg gggatatacc ccatcgccgc catcgacggc tccgctgccg
     2641 atgaaatttc ccggcaaaca tgatcgctac ctgaacatga acagcatcag gagtgcaccc
     2701 aatctgcccg ccgccaatcc agcgcatccc cgtctccggg atctccgtct gcccatccag
     2761 tccatgcggc atcagtgcgg cggcagcagc aatgacaaca gtctcaccga cagcgcctac
     2821 gtgaatccgc cctcgaccaa ctcgaattcg aatgcggcat cggcttccgc ctcggcctcc
     2881 gtctcggcaa ccggatcagc agctccacgc cgaccgcgat cttttgtcct cgaatcgggc
     2941 cgggtgctag agctgcgacg cagtgcccag ggccatcagg gtggccagtc gacccaccat
     3001 caccatcatc atcatcatca tgcgccgggg agcagaagaa atcgccatgg ccaaagccag
     3061 gggcaaacga ccggtggtgg ccacaactac agcagcaccg agagcattgc cacctcgagc
     3121 agtggcggca gcatggaatc gctgcgttcc agcaccagcg agggcaatcg cagcacctcc
     3181 agctccgagt cgcggcactc cagttcgctg agctctcaca gctcggagag cggcagcggt
     3241 ggcagcggcg gtagcggagg ctccagtgtg gcctatcccc tgcgaccggc tcccctgctg
     3301 ctacactcca agctgcacat cctgagtccc atttccgaca agtcctcgca ggaaccggca
     3361 tcggccagtg cctcggagca atcacagcag ccgtcccagc agctggcgcc gatggcgtcg
     3421 caggaagacg attccacaac gagtggcgca ccagcaggga accaagtcca ggtgaatgcc
     3481 tccttgaagc agccgcgtag caatcggggt gcaccaaata aggccctgct ccagctggcc
     3541 gatgagctac tgggttcgga tagtgggata tcgctgcatt cccgggagga tggaaaaccg
     3601 caggccttag cgctacagcg tttaacgctg cccaagctac agttgattgg tgctgaagga
     3661 acaacaacgt cggcaacggc ctccggagca ggaggtagct cagcaacggg tggcagtagc
     3721 ggcgctggag gatcaggatc cggttcggta gttgccagcg gatcgactgg catacagcag
     3781 gatctgcgcg atttgccctt cgatatgccc aaactgaggc gacgcaagac gctgcaacag
     3841 gaggccgcct gcacatcggg cagtgccacg tccgtcgatc tcggcgagct gcccttcgac
     3901 atgcccaagt tgcgacgacg cctgagggcc aaccaggcgg agatcaataa cctgctgatg
     3961 cacagcaccg aatccagtgg catctcgcag gcttcctcca gtcattcgat gcgcgacgac
     4021 caaaagatgt ccagcaagtt ggatacggca ctttttcggc agaatctcac tctaaacctt
     4081 aatgaatcgc gacaggcgac caaacagttt ggcagcctgg atctgcgtgg tctcaatagc
     4141 aacaaggagc taaacatgaa tctcagccag ggatatgtca ctgctgtgga tctaatcgat
     4201 gtgacaattc cgctggagcg gcagggttgg taccatggtg ccataacgcg aattgaggcg
     4261 gagaccacac tgcgtccgct gtccgaggga tccttcctgg tgcgcaactg cgagtccacg
     4321 aagcaggact attcgctatc cctcaagggc gccaagggct ttatgcacat gcgcatccag
     4381 cgcaacgaga ctggacagta catccttggc cagtttagtc gtcccttcga gacggtaccg
     4441 gagatgatcc ggcacttttg cctcaaccgg ctgccagtgc gcggtgccga gcacatgtgt
     4501 ctgatcgagc cggtcatcgc ccagctgctc tagagaggct ccaagaactc gaaggacacc
     4561 gggatgtggc caatcggagg ctttagaggc tccaggggat ggggaaccaa aacagaataa
     4621 catattaata gcgtgtagag aacgtagaaa cctatgtgaa cgatgtgtat gcactagtta
     4681 tatatgcgag ttagttgtaa aaggatgatg gcaatttttt catgtttttt tttttttgcc
     4741 tcgaactttg tatgtcggtc tactaaagta cacacacaca aacacaaaac tcactcacta
     4801 atacacgaac tagtttagcg tttaaagtac gtagcacatt cagacaatac cagcaaatta
     4861 caaaaaccaa acaacaaacg atatttatat agaaggcata tatacaagcg agacgatata
     4921 tacaaaagca tatagatacg gataacaaaa gcacttgacg acagttgcta aaaacgtagc
     4981 ggtacatgat gatcccaaat gcggacaaag atggtacaga ttttagatgt gtttacaccg
     5041 aaccgagcat cagattagga gcaactaatt gtagcattgg gcgccaaaag taaaaacaaa
     5101 aaaaactctt ccattggcta aagatttatg gtagaacaca tacaactcac ttctagcgat
     5161 tatatggtcg aaacttatgc aacttttcgc agcacacaca cacacacaca caaacactcg
     5221 cccactagca ccgcccagca tcgtccgatt attcagataa ttacgccatt atttataaat
     5281 cctaattcct ttggcgacgg atgctagtgg gcatcgctta aggcacgttt acactaagaa
     5341 aagttttagc aagcaactct aaaaatttgt tgattaattt tatgttacca aaacgaagaa
     5401 aaacgaacaa aaaatctaaa atatgtatat ctatatgtat gaaaactaac tttagcaaga
     5461 gcgatgtcac attttttttt ttggtcttag ctgtaggtca gaggtacgcg aaatagaacg
     5521 ctcaaagcgc ttttggttaa aggatcgaaa cgaataggat cagatcagat cggatcggat
     5581 cagaaggaat tggaggattg atcggatcgg atcggatcga atcgataggg atggttagaa
     5641 ggggcaagga tatagcaacg catatgaaat gtcagtttaa gtgttagttt ctaattgagc
     5701 gaacgaaggg cagactctat atatatatac ataaatatat atatatatat tgaatgctac
     5761 aaaatgatat atacttacta tttatatttc tatatataca tctatatata tatatatata
     5821 tatatacata tatatatata cgatattaaa gagcagtcaa tggttttttg gttccagttc
     5881 cgaaagagaa gcaagtgtca ggatgcagga tgctaattaa ctaattaact aattattgtt
     5941 tctggcagtt ttctgttcca ccttcgtacc gccgagcaat acaactgatt tccagtatcc
     6001 caaacccaaa gttatgttta tatgtgtgtg ccaaagtatt attctagtcg tatgtatgtg
     6061 aatcgaatct ccgtgtgaat atcagcgcgt tatatttttt tcgatatgtt gattgttgcc
     6121 taatttctaa tactcaagca atccgaagca gtgcaatata cgaatacgtt ttaaatatct
     6181 cggttatgta tctatgattt gactaattta gctctaagtt acaaacgccc tgatttgtcc
     6241 atagttaagc gtatcggttg atgataacaa tctccatttg gcgaaagctg caccagtttg
     6301 taaacggctt ttttgtaaat atacggaata taaatacaac acgacagata tgtacgatat
     6361 atacaagtcg atatgatttt agttgcaata cacaactttt aagctaagat ttgaacttca
     6421 catagaaaca gcaaatcaac acatacatta acgacgtaca taacaatgta ttttgaggct
     6481 tccgtagcag taacagaaaa aaccaatcaa ccaaacaaac taccaaacaa aaaaaaaaat
     6541 ccaaaccaaa attccaagat tatcgcagca ctcgggcacc gtttacacct gccaaccatg
     6601 aggtcgtagt gcaaattcgc tgagtgtcga tcgcttccgt ttttgttgtg tataaaaatt
     6661 gtacttttag gtctgcggac gatgatgaac aaccggctta ctctaaccga aacttgtact
     6721 ccaaactaga ggcgctctct atctacggca ccctaatatc tgattaattc aattagtaca
     6781 gagcgaatac gtaacaagaa cttaacaaac agaaaccgca acaacaacaa acgaaagaaa
     6841 cgaaatgtat tgaataaaaa taaatatgat aaatttcc