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Drosophila melanogaster no circadian temperature entrainment


LOCUS       NM_167231               8362 bp    mRNA    linear   INV 26-DEC-2023
            (nocte), transcript variant B, mRNA.
ACCESSION   NM_167231
VERSION     NM_167231.5
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 8362)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8362)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8362)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 8362)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 8362)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 8362)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 8362)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 8362)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 8362)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 8362)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 8362)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 8362)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 8362)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 8362)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 8362)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 8362)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 8362)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 8362)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 8362)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 8362)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 8362)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 8362)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 8362)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_167231.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8362
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..8362
                     /gene="nocte"
                     /locus_tag="Dmel_CG17255"
                     /gene_synonym="CG17255; Dmel\CG17255"
                     /note="no circadian temperature entrainment"
                     /map="9C5-9D1"
                     /db_xref="FLYBASE:FBgn0261710"
                     /db_xref="GeneID:31976"
     CDS             798..7727
                     /gene="nocte"
                     /locus_tag="Dmel_CG17255"
                     /gene_synonym="CG17255; Dmel\CG17255"
                     /note="CG17255 gene product from transcript CG17255-RB;
                     CG17255-PB; nocte-PB"
                     /codon_start=1
                     /product="no circadian temperature entrainment, isoform B"
                     /protein_id="NP_727425.3"
                     /db_xref="FLYBASE:FBpp0071395"
                     /db_xref="GeneID:31976"
                     /db_xref="FLYBASE:FBgn0261710"
                     /translation="MSTLGGSRGERNAKPKFTALDINRMYKNSRGESSEPSAQKNQVP
                     RKHGMQILGKVPSARRPPANLPSLKAETHTSSNNNLLVSVEGATSGGAGAGGAAGSGA
                     AGTNTSHNNTTAHSGSSGTSGGAGSGGGGTASSSAGGHLSQQLTHSQHQHNNNVALGP
                     NAGKFVNSNNGSSNNNAGSSGSGNKNFKLINNSVGSSGGGGQGGSGGGGSSGVGGGSG
                     SGSGGHSVNSPKTWSAITTGHERGSGGQNYGRQQQQVVPHYQSPQFQYEFPTLDGTVG
                     SGAGGGSGAGVGSGSGAGKSHYQNQVHHAGHQNHHQHQQHHQQHQQHHHQQQQHHRDY
                     HHGHGRQYGHHSHRDYRDGSDDVGGGSADLGELSLRPQNDTAAWLQQQEKAAKVAAAA
                     AADQGLNLQGPGHHQMGGNGGAGGGSGGAVPLPILSLMPSFMRSGAPMPASGATAASI
                     LAGGSLDTSALPNAPYQNGILGARSASPAVVGSGSFRAATAIPKRPPTSSSPPQSGLG
                     IGGSPTPPQSQQQANGGAGGAGRKDKDYVVEPEVAQMQRPIIREEDLERLNAIAKDDS
                     WTKQDDIDFTKKLAFSDDESTPEEHQGQGKQHSSAQLQAQGSSSSTDQRKLSASTTSW
                     QRGKESTDRDQPSEGIQDQQQQLQQQQQQQEVRQQNGHRGSSGNVGAPVAGGIALDAS
                     VYERVKQRKEEEERREMERKQAAAKKLQELEMKMNSKKAAAAALAGAEGGVSSASVPL
                     SNEVPPTSAPLGNASEDEGGGQGGGGGLNRRPRGSISSLGSGVTPTGGAGGGGGGVSS
                     SSSAGGDYGQKNFLTHFQSNLPPRFQRQQQQQQQQLPRLEKSASASSAFDSNSRYLQK
                     GGVSGGGGGVSGGAQANAGQGRSISGGYVQRGASVGGSSGYGRNRHDSSSAREDQDLD
                     QQRFTRGQDYRQAQALPRSISENSHRKTSVSSAGDDVLGGSCSSWAEQTDAEQKVHHR
                     HREESFSSSHSHDSAVQIKILQRPARQPSLSEESSTQQKQLPASPQQQKTLTTDPMPT
                     QILRRSVDIDKSGDERAEDKSALESDDKAKSAGKVEEDKSGNKRVSPRSGAACGGRGG
                     RGYAGSSGGSSVGSGSSYRGQRNASDWGSSRGSGGAGGRRYYGSGGEQSEHSEDVDEE
                     CYSSGGGGAARRSPKESGNGAPNSGASANKAGFSPRGEPSRRGRGGLSSGGGASASCY
                     RRQPVGTGSAGGSGSGGSGRSYGRLGYEEYGKQQRTSESETDLDKTKQNQLALSAGLH
                     KPSKDDKDLPALGGEEKDKTAALAPAHNTALLAKDELQKDAAGRLPLPPGLAAPGSAV
                     GSVTATSSSVVVPGAADKKKIESCAVVGGEKVTGSKLPAIGEKTSLGAVGSGPSTSLL
                     LDAGAPVNTIIFENSTYKQQAAAASVVTKPGTLSVSSSGATMTVDSLSSALSQMSFGG
                     KATAAGSGDDSQDMKLGFSFGDDPTTPLKVVDNIDKTASQQQQQQQQQHSQQQQQQQQ
                     QQNNSTADLNMKIASVKKVWESATPMSDGPSPAQVQQQQQQQPQQQQQSQVQVAAQQQ
                     QQQVVGPQQAGDDGSGHMSAASFVAAVAASQHQQQHQQMPHYAVSAVHMQSHHHQQQQ
                     QQQQAAVAAAQAQHHQQQQAQAHHQHHALSSPGPVPGSHGHGYSHGSPFDAGSLEQQF
                     QQEDYPSPQQQQQAHQKTKQLQQQQHLGMSPPPSQQQQQQHSQQQQQAQHQQQQQQAH
                     QQQQQQQQPSFYQASPQFGVGGIPTIPSPPAVVYNSSQMPPPSQGGNLYAPFHSLDHS
                     SRSPAYSAAAAAHSYPNPYAAAAAAAAAAAAGGGPFNVNVNAYAMQTPHGGSLPPTAP
                     TPDMYSNLSSQFRLGGGPGPGPGPFGQPSSQQLSNPSNHAAVAIISSSSNSMMSSGAA
                     KPPQSQQTIGAIGSKSAGSGGGPGPGPGPYATTQTYMNLYAAPPPQHPGQGGPPPGAH
                     QLQSNSFYSNSAPGGPSGPQFYGGPPPQGNGGAQSYGLATAAGMYGGHQGGPPGSNGP
                     PGPPQSQHTMGTFNTPFMNSQLLTAASINQYRGGPTPGAAYLKGNQGQTHMQDSMGRQ
                     LKSPLSADMSLGLAKQVQSQPSPPHHKNYGAWDLQNQVLQQQQQQSQQQQQQQQRQVG
                     GGNGPSMNALGGRGSGAVGSGSGNGGGGGGGAGGSQVGGNGGGNGVGSVGQSGGGGQG
                     RYPTPIQRPNNYPQHPQQQQQQQQQQQQQREQAAAAAVAAQRAQNMRQVTGAGGGVAG
                     SAGGGGSQTPVGPAGGNGGPGGAGGGGGAGGAAGSGPGKPYYANNASGAAVAANRGEW
                     HAN"
     misc_feature    798..1286
                     /gene="nocte"
                     /locus_tag="Dmel_CG17255"
                     /gene_synonym="CG17255; Dmel\CG17255"
                     /note="BAT2 N-terminus; Region: BAT2_N; pfam07001"
                     /db_xref="CDD:462063"
ORIGIN      
        1 cacacaactc tggcaacgct tgccgtaaaa tggcaaaaaa ataatacata cgatttaaaa
       61 ctaatggaca attacgtatt acgtgaaaag aacgcaacgc aaataatcaa aacaaataag
      121 aaacgcaact cgtgtgcgtg tgtagtgtgt gtgcagagct aaaacctagc gaaggaaagg
      181 caaaaacccg tggaaaaagc gaattcaaac gggtttactc gaagcctcct cacccgatac
      241 cattttccac ctacacttgc aaaaaagcga cagcgcgcga gagggacggc gcgagtgagc
      301 ggagagtggg agagcgcagt gcaagtgagt gggagcgaga gcgctgacaa agccagcgca
      361 acatagcgaa aatcgcaacc aaatcgaaat cgaaattcaa ccaaatcgaa gattctggcg
      421 aacaaaggcg actaacaaca acaactgcag cagcggcacg tctcgtcttg gttgcgctct
      481 cttttgtttt cgtcccgtgt tttaacaagc ggcgaaacgg gcgctgagta agcgccagaa
      541 agagtgcaaa aaaaaggcga aggaaagaaa gaagccaagg agcaacgaac tgtgtttgcg
      601 gtgtgtgctc tgcgtgcgaa aggcccacca gaaagactga aacaaggagc ttcggcccaa
      661 aagcgatccc agctccttaa actcattctc gtcaagaacc acagccacat cctagcccat
      721 cctccagcgc agcgggaaga cgaggagcgc ggcggtggcg agaaggaagc taacgctaat
      781 gaggatctat tggcagcatg agtacactgg ggggaagtag gggagagcga aatgccaagc
      841 ccaaattcac agcgttagat ataaatcgca tgtacaagaa tagccgcggc gagtcaagtg
      901 aaccatctgc acaaaagaat caagtgccac gtaaacatgg aatgcaaatc ttgggcaaag
      961 tgccgtccgc taggcgacca ccagccaatt tgccatccct gaaggccgag acccacacca
     1021 gcagcaacaa caatctctta gtctcagtcg aaggagccac atctggtggg gcgggcgcag
     1081 gcggagcagc gggatctggc gcggcaggaa ccaacactag ccacaacaac accactgccc
     1141 acagcggaag ttcaggaacg agcggcggag cgggatcagg cggcggagga actgcgtctt
     1201 catctgctgg tggccatcta tcccagcagc tgactcacag ccagcatcag cacaataata
     1261 acgtcgctct cggccctaac gccggaaagt ttgtcaacag caacaacggc agcagcaaca
     1321 acaacgccgg cagctcaggc agcggcaaca agaacttcaa attaatcaac aactccgtgg
     1381 gcagttccgg cggaggcgga caaggagggt cgggcggcgg cggatcgtca ggagtaggag
     1441 gtggatcagg gtcaggatcg ggcggacact cagtcaactc acccaagaca tggtctgcaa
     1501 ttaccacagg acacgagcgg ggctcgggcg gtcagaacta tggacgccag caacagcagg
     1561 tggtccccca ttatcagagt ccacagttcc agtacgaatt tcccacgctg gacggcacag
     1621 ttggcagcgg cgccggcgga ggatcgggag cgggtgtggg ttcaggatct ggagcgggca
     1681 agagccatta ccagaatcag gtgcaccatg ccggccacca aaaccatcac cagcatcagc
     1741 agcaccacca gcagcatcaa cagcaccacc accagcagca acagcaccat cgggactacc
     1801 accatggcca cgggcgccag tatggacacc actcgcatcg cgactacaga gatggcagcg
     1861 acgacgtcgg cggcgggtcc gcggatctgg gcgagctcag ccttcggcca cagaacgaca
     1921 cggccgcctg gttgcagcag caggagaagg cggccaaggt ggcagcagct gcggcagcgg
     1981 accagggcct caacctacag ggcccgggcc accatcagat gggcggtaat ggcggagcag
     2041 gaggagggtc gggcggagct gtgcccctgc ccatactatc gctgatgccc tcgttcatgc
     2101 gtagcggagc tccgatgccc gccagtggag cgacagcggc cagcatcttg gccggcggat
     2161 cgttggacac ttctgcgttg cccaacgctc cctaccagaa cggaatcctg ggtgctcggt
     2221 ctgcctcgcc agctgtggtg ggcagtggaa gcttcagggc ggccactgcc attcccaagc
     2281 gaccaccgac ctcctcgtcg cccccacaat ctggcctagg cattggagga tcacccactc
     2341 ccccacaatc ccagcagcag gccaacggag gcgctggcgg agccgggcgc aaggataagg
     2401 actacgtggt ggagccggag gtggcccaaa tgcagcgtcc tatcatacgc gaagaggact
     2461 tggagcgcct caacgccatc gccaaggacg atagctggac caagcaggac gacattgact
     2521 tcacgaagaa actagcattc tcggacgatg agtccactcc ggaagagcac caaggccagg
     2581 gcaagcagca cagctccgcc caactgcagg cgcaaggatc ctcctcctca accgatcaac
     2641 gaaagctgtc cgcttccaca accagttggc agcgcggcaa ggagagcacc gatcgcgacc
     2701 agccatcgga aggcattcag gatcagcagc agcagcttca gcagcaacag cagcagcaag
     2761 aggttcgcca acagaatggc caccgcggta gctctggcaa cgttggagca ccagtggccg
     2821 gtggaattgc cttggatgcc agcgtgtacg agcgagtaaa gcagcgcaag gaggaggaag
     2881 agcgtcgcga gatggaacgc aagcaggcgg ctgctaagaa gttgcaagaa ctggaaatga
     2941 agatgaatag caaaaaggca gcggctgcgg ctctggctgg agccgagggc ggcgtgtcct
     3001 ctgcctcagt cccgttgagc aatgaggtgc cacccacgtc cgcaccgcta ggcaatgcca
     3061 gcgaagatga gggcggaggc caaggcggcg gcggagggtt gaatcgtcga ccccggggaa
     3121 gcatctctag cttgggaagc ggcgtaacac ccacgggagg agctggcggc ggcggcggag
     3181 gagtttcgtc atcctcgtca gcaggcggcg actatggtca aaagaacttc cttacccatt
     3241 tccaatcaaa tttaccacca cgtttccagc gccagcaaca gcaacaacag cagcagctgc
     3301 cgcgcttgga gaagagcgcc tcggcaagca gtgcattcga tagcaattcc cgctacctcc
     3361 agaagggagg agtaagcgga ggaggcggtg gtgtaagtgg aggagcgcaa gccaatgctg
     3421 gccagggtcg cagcatctcc ggcggttatg tgcagcgtgg tgcaagtgtc ggaggaagca
     3481 gcggatacgg acgaaatcgt cacgacagca gcagtgctcg ggaggatcag gatctggatc
     3541 agcagcgttt cacccgtggc caggactatc ggcaggcaca agctctgccg cgcagcatat
     3601 ctgagaactc gcaccgtaag accagcgtct catcggctgg cgacgatgtg ctgggtggct
     3661 cgtgctcctc atgggcggag caaacggatg ccgagcagaa ggtgcaccat cggcaccgcg
     3721 aggagagctt ctcctcgtcg cacagccatg actcggcagt gcaaataaag atcctgcaac
     3781 gcccggcccg acagccgagc ctcagtgagg agtcctcgac ccagcagaaa cagctgcccg
     3841 cctcgccgca gcagcaaaag acgctgacga cagatcccat gcctacccag attctgcgac
     3901 gcagcgtgga tatcgataag tccggtgatg agcgcgcgga ggacaagtct gcattggaat
     3961 ctgatgacaa ggcgaagtcg gctggcaagg tggaggagga caagagcggc aataagcggg
     4021 taagtcccag gagcggagct gcttgcggag gtcgaggtgg ccgtggttat gccggcagct
     4081 ctggtggatc atccgtcgga tcgggcagta gctaccgcgg ccagagaaat gccagcgatt
     4141 ggggaagcag tcgtggaagc ggcggcgccg gcggcaggcg ctactacggc agcggcggtg
     4201 agcaatcgga gcactccgag gatgtggacg aggagtgtta cagcagtgga ggaggcggag
     4261 ccgctcgtcg cagcccaaag gaatcgggca acggtgcgcc caattccggt gcgtcggcaa
     4321 acaaggcagg attctcgcca cgcggcgaac catctagacg tggtcgaggc ggcctctcta
     4381 gcggaggagg cgcctctgct tcttgttacc gtcgacagcc cgtgggcact ggatccgctg
     4441 gtggatctgg ttcgggcgga tcgggccgca gctatggcag acttggctac gaggaatatg
     4501 gcaagcaaca gcgaacttcc gagtcggaga cggacctaga caagaccaag cagaaccagc
     4561 tggcactcag cgccggcctg cacaaaccaa gcaaggatga caaggatttg cctgcgcttg
     4621 ggggcgagga gaaggacaag actgccgccc tggcgcctgc ccataacact gccctgctag
     4681 caaaggatga attacagaaa gatgcagcgg gtcgcctgcc gttgcctccc ggcctcgcag
     4741 cacctggctc tgcagtggga tccgttactg ccacatcctc atcggtcgta gttcccggtg
     4801 cagcggacaa gaagaagatt gaatcctgcg ccgttgtcgg cggtgagaag gtgacgggta
     4861 gcaagttgcc cgccattggg gaaaagactt cgctcggcgc cgttggctcg ggtccatcaa
     4921 ccagtcttct actggacgcc ggcgcacccg tcaacacgat tatatttgag aactccacgt
     4981 acaagcagca ggcagctgcc gcttccgtgg taaccaaacc cggaacgctc tcggtgtcaa
     5041 gcagtggcgc caccatgacc gtggacagcc tgtccagcgc actctcccaa atgagtttcg
     5101 gcggcaaggc gacggcggcg ggctctggcg atgattcgca ggatatgaaa ctaggattta
     5161 gcttcggtga cgatcccacc acacccctca aggttgtgga taacatcgat aaaacggcca
     5221 gtcagcagca gcaacagcag cagcaacaac actctcaaca gcaacaacaa cagcagcagc
     5281 agcaaaacaa ttcgacggcg gatcttaaca tgaagatagc cagcgtaaag aaggtttggg
     5341 agtcagccac gcccatgtcc gacggcccat cgccagcaca ggtgcagcag caacagcaac
     5401 agcagcccca acagcaacaa cagtcccagg tgcaggtggc ggcgcagcag caacaacagc
     5461 aggtggtggg accgcagcag gcaggtgacg acggcagtgg tcacatgagc gccgcctcct
     5521 ttgtggcagc cgtggccgcc tcacagcatc agcagcaaca ccagcaaatg ccgcactacg
     5581 cggtgtcggc ggtgcacatg cagagccacc accaccaaca gcagcagcaa cagcagcagg
     5641 cagcggtggc ggcagcgcag gcgcagcacc accagcagca acaggcacag gcgcaccacc
     5701 agcaccatgc actttcctcg ccgggcccgg tgcccggtag tcatggccat ggctacagtc
     5761 atggatcgcc gttcgacgct ggatcgttgg agcaacagtt ccagcaagag gattatccca
     5821 gtccacagca gcaacagcag gcgcaccaga agaccaagca gttgcagcag cagcagcatc
     5881 tgggcatgtc accgccgccc agccagcagc aacagcagca gcactcgcaa cagcagcagc
     5941 aagcacagca ccagcaacaa cagcagcagg cccatcagca gcagcaacag cagcagcagc
     6001 cttcattcta ccaggcgtca ccgcagttcg gcgttggagg cattcccact atccccagtc
     6061 cgccggccgt ggtgtacaac tcgtcgcaga tgccgccacc gtcgcagggg ggtaatctgt
     6121 acgctccatt ccattcgctc gatcattcga gccgttcgcc cgcctactcg gcggcggcgg
     6181 ccgcccacag ctacccgaac ccttatgcgg cagcagcagc ggcggcggcg gcagcggccg
     6241 ctggcggagg tcccttcaat gtcaacgtga acgcatatgc gatgcagact ccgcacggcg
     6301 gcagcctacc gcccacagcg cccacaccgg acatgtactc gaacctctct tcgcagtttc
     6361 gattgggcgg tggtccgggt cccggacccg gtccctttgg ccagcccagc tcgcagcagt
     6421 taagcaatcc gagcaatcat gctgcggtgg ctataatttc gtcaagcagc aactccatga
     6481 tgtcgtcagg tgcggccaaa ccgccgcaga gccagcagac aatcggtgcc attggctcca
     6541 agtcggcagg tagcggtggc ggtccaggac caggacctgg tccctatgcc accacccaga
     6601 cgtatatgaa tctttatgcg gctccaccgc cgcaacatcc aggacaaggt ggaccaccgc
     6661 cgggtgccca tcagctgcag tcgaacagtt tctactcgaa ttcggcgcca ggcggtccga
     6721 gcggaccaca gttctacggt ggtccgccgc cgcagggcaa tggtggagcg cagagctatg
     6781 gactggccac cgcggccggc atgtatggcg gccatcaggg cggaccgccc ggctccaatg
     6841 ggccgccggg accgccgcag tcgcagcaca cgatgggcac gttcaacacg ccgttcatga
     6901 actcgcagct gctgacggcg gccagcatta atcagtaccg cggcggacca acgcctggag
     6961 cggcttatct caagggtaac cagggccaga cacacatgca agactcgatg ggtcgtcagc
     7021 tgaagagtcc gctgagcgct gacatgagcc tcggtctggc caagcaggtg cagtcgcagc
     7081 ccagtccacc gcatcacaag aactacggcg cgtgggatct gcagaaccag gtgcttcagc
     7141 agcagcagca gcaatctcag cagcaacagc agcagcaaca gcgccaggtc ggcggcggca
     7201 atggtccgag catgaacgcc ttgggcggtc gcggcagtgg agcggtgggc agcggcagcg
     7261 gcaacggcgg aggaggagga ggaggagctg gtgggtccca agtgggcggc aatggcggcg
     7321 gtaacggcgt tggcagcgtg ggccaaagtg gcggcggcgg ccagggacgc tatcccacgc
     7381 ccattcagcg gcccaacaac tatccgcagc atccgcaaca acagcagcaa caacagcagc
     7441 aacagcaaca gcagagagag caggcggcag ctgccgccgt ggcggctcag cgggcacaga
     7501 atatgcgaca ggtgaccggt gccggcggag gcgtggccgg aagtgcaggt ggcggtggta
     7561 gtcaaacacc agtgggaccg gccggcggca atggtggccc cggtggcgca ggaggaggcg
     7621 gtggagctgg cggtgcagca ggatcaggac ccggaaagcc ctactatgcg aataacgcta
     7681 gcggagcggc cgttgcggcc aatcgaggtg agtggcatgc gaactgagtg ccagatggtc
     7741 accacccatc gaccagccga tcccagccac ccaccataac aaacccggaa taactatgta
     7801 cgagtacgaa acagaaacac aatgatgcaa attgataacg aaggaggatg gccaagagaa
     7861 tgagcaacag ctggaggaat gtattgcatc caaaacgaga atatgaacgt aaacagagca
     7921 agtcaggagt aaaactatat atgtggaata taatcaagtt accgagcgag acacaggcat
     7981 ccgaataata agcccacaaa atatgtgaaa ggggcgatgc gagtagaata gtgctatagc
     8041 tgtttggggg aatccccgtc acaatcgcaa aatggcaact cagctaaatc accgtagcga
     8101 ggaggaaatt aatttaaatc gcaatttgaa agtaagaaaa aagttaagac gaaagttaag
     8161 aatcaacagg aaacgagtaa ggaataccta aatgcaagaa gaaatattta acaaaaatga
     8221 acagaataca acaccatgcc acaccacaac acacacacac acacacatgc atacatttac
     8281 atatacatac atacatacag aatagcagat tgtatttttt gtcaaacaaa tttacataat
     8341 aatatattac ttttatatac tt