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Drosophila melanogaster alpha-Mannosidase class I a (alpha-Man-Ia),


LOCUS       NM_167224               4102 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant I, mRNA.
ACCESSION   NM_167224
VERSION     NM_167224.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4102)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4102)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4102)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4102)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4102)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4102)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4102)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4102)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4102)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4102)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4102)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4102)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4102)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4102)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4102)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4102)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4102)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4102)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4102)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4102)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4102)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4102)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4102)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Dec 17, 2009 this sequence version replaced NM_167224.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4102
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4102
                     /gene="alpha-Man-Ia"
                     /locus_tag="Dmel_CG42275"
                     /old_locus_tag="Dmel_CG32682"
                     /old_locus_tag="Dmel_CG32684"
                     /gene_synonym="a-Man-Ia; alpha-Man-1; alpha-Man-I;
                     alpha-Man-l; alpha-Man-la; alphaMan1a; CG17809; CG18799;
                     CG32682; CG32684; CG42275; DM-GI; dManI; dMas-1;
                     Dmel\CG42275; MA12; Man'ase; MAN-1; ManI; mas-1; mas1"
                     /note="alpha-Mannosidase class I a"
                     /map="9B5-9B7"
                     /db_xref="FLYBASE:FBgn0259170"
                     /db_xref="GeneID:31957"
     CDS             547..2601
                     /gene="alpha-Man-Ia"
                     /locus_tag="Dmel_CG42275"
                     /old_locus_tag="Dmel_CG32682"
                     /old_locus_tag="Dmel_CG32684"
                     /gene_synonym="a-Man-Ia; alpha-Man-1; alpha-Man-I;
                     alpha-Man-l; alpha-Man-la; alphaMan1a; CG17809; CG18799;
                     CG32682; CG32684; CG42275; DM-GI; dManI; dMas-1;
                     Dmel\CG42275; MA12; Man'ase; MAN-1; ManI; mas-1; mas1"
                     /EC_number="3.2.1.113"
                     /note="CG42275 gene product from transcript CG42275-RI;
                     CG42275-PI; alpha-Man-Ia-PI; alpha mannosidase I;
                     alpha-D-mannosidase; alpha 1,2 mannosidase; mannosidase 1;
                     alpha-1,2-mannosidase I; alpha1,2-,mannosidase;
                     alpha-mannosidase"
                     /codon_start=1
                     /product="alpha-Mannosidase class I a, isoform I"
                     /protein_id="NP_727408.2"
                     /db_xref="FLYBASE:FBpp0288908"
                     /db_xref="GeneID:31957"
                     /db_xref="FLYBASE:FBgn0259170"
                     /translation="MCSRKCFRMPTLVICGVVLTIILVCITGITLTNSINISNIVKLR
                     EKVASDSAAANGGHQAAQTRAALVEQQYSTLQQHHLSRSDLNYIQAATHPKNLQRQLQ
                     QQQQQQLQQQQPNKIVIEIGLSNDSGPSSAPASSTLGSSSTGPRILQAAEALMEGNVD
                     SISLPAAAPLTAATTSSAKSLENSQGSDTPHSHANTTNADITMGIADHNPGGIQFERR
                     AHVKQMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYDLGATIVDGLDTLYIMGL
                     EKEYREGRDWIERKFSLDNISAELSVFETNIRFVGGMLTLYAFTGDPLYKEKAQHVAD
                     KLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPL
                     YRERVQTIRQVLKEIEKPKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQS
                     GQTDEEAREMFDEAMLAILDKMVRTSPGGLTYVSDLKFDRLEHKMDHLACFSGGLFAL
                     GAATRQNDYTDKYMEVGKGITNTCHESYIRAPTQLGPEAFRFSEAVEARALRSQEKYY
                     ILRPETFESYFVLWRLTHDQKYRDWGWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDD
                     VQQSFFLAETLKYLYLLFSDDSVLPLDEWVFNTEAHPLPIKGANAYYRQAPVTLPVSN
                     AS"
     misc_feature    1192..2538
                     /gene="alpha-Man-Ia"
                     /locus_tag="Dmel_CG42275"
                     /old_locus_tag="Dmel_CG32682"
                     /old_locus_tag="Dmel_CG32684"
                     /gene_synonym="a-Man-Ia; alpha-Man-1; alpha-Man-I;
                     alpha-Man-l; alpha-Man-la; alphaMan1a; CG17809; CG18799;
                     CG32682; CG32684; CG42275; DM-GI; dManI; dMas-1;
                     Dmel\CG42275; MA12; Man'ase; MAN-1; ManI; mas-1; mas1"
                     /note="Cyclases involved in the biosynthesis of
                     lantibiotics, and similar proteins; Region: LanC_like;
                     cl04955"
                     /db_xref="CDD:471159"
ORIGIN      
        1 cgagcagttc gaaatgcgca ctgaaaggcg cgacgatcgc taaattaagc aaagacaaat
       61 gaaaataaag taaagaaaac aatatttagt gtggcgctct cgcgagttgg caacagccca
      121 aaaaccagat taccaatatt tgttgaaaat ctcgtgagtt ggacacaaat aaaaattgga
      181 agaaatcgtt tttaaatata attgctaaag aaaataaaag aaaattatac gacaccttgc
      241 cagttgctaa ttaaactaca taatatggta gaacaataac aaaaataaaa aaaaacagta
      301 aacggactga aatgaaaata gtgatacaaa ccaaaacaaa tcaataataa atcaaaaata
      361 cataatacat ttcgcaaata attccaacga agactatata aatctaatgc gaatatcaat
      421 tgccttggac aacaaatgat taaaatccaa ttgcttgaaa gcctacactt tgcttaactc
      481 actgggcgat tgatttccat cgcctgcatg cgtttctggc cgtaatcccc ctccaccaag
      541 gtgaccatgt gcagccggaa atgcttccgc atgcccaccc tggtcatctg cggcgtcgta
      601 ctgaccatta tcctggtctg catcacgggc atcacgctga cgaacagcat caacatatcg
      661 aatatcgtga agctgcgcga gaaggtggcc agcgattcgg cggcggccaa tgggggtcac
      721 caggcggccc agacgcgggc ggctctcgtt gagcagcagt actccacgct gcagcagcat
      781 catctttccc gcagcgatct caactatatt caggcggcga cacatccgaa gaatctacag
      841 cgccaactgc agcagcagca gcagcaacag ttgcaacagc agcaaccgaa taagattgtc
      901 atcgaaattg gtctgagcaa tgacagcgga ccaagcagtg cgcccgcaag cagtacactt
      961 ggttcaagca gtaccggtcc gcgtattctt caggcggccg aggctttgat ggagggtaat
     1021 gtggattcga tttcattgcc agcagcagcg ccgctaacag cagctactac aagttcagct
     1081 aaaagcttag aaaacagcca agggagcgat acgccgcata gccatgcaaa tactaccaat
     1141 gcagatatta caatgggcat cgccgatcac aatccagggg gcattcagtt cgagcgacgc
     1201 gcccacgtta aacagatgat ggaacatgcg tggcacaatt acaaattgta tgcgtggggc
     1261 aaaaacgagc tgcgtccgct ttcgcagcga ccccattcgg ccagtatttt tggatcatac
     1321 gatctgggtg ctacaatcgt cgacggtctg gataccctgt acattatggg actggagaag
     1381 gaatatcgcg agggtcgcga ttggatcgag cgaaaattct cactggacaa tatcagcgca
     1441 gagttgagtg ttttcgaaac gaacattcgt tttgttggcg gcatgctgac gctgtacgcc
     1501 tttacgggcg atccactgta caaggagaag gcccagcacg ttgccgacaa gctgctgccc
     1561 gccttccaaa caccaacggg tattccctac gcgctggtca acaccaagac cggtgtggcc
     1621 aagaactacg gctgggcatc cggcggcagt tctatcctat ccgaatttgg cacactgcat
     1681 ctggaatttg cctatctgag cgacattacc gggaatccac tgtatcggga acgagtccag
     1741 accattcgcc aagtgctcaa ggagatcgag aaaccaaagg gcctctatcc caacttcctt
     1801 aatcccaaga caggcaaatg ggggcaactt cacatgtcat tgggcgctct gggcgacagc
     1861 tactacgagt acttgctgaa ggcctggctg caatccggcc aaacggatga ggaagcccgc
     1921 gagatgttcg acgaggcaat gctggccatt ctggataaga tggtccgcac aagtcccggc
     1981 ggactgacat acgtctctga tctcaagttc gacaggctgg agcataagat ggaccatttg
     2041 gcttgcttct cgggtggcct cttcgctttg ggagcggcta cacgtcaaaa tgactatacg
     2101 gacaagtaca tggaggtggg caagggcatt acgaatacct gccacgagag ctacatcaga
     2161 gcacccactc agctgggacc cgaggccttt agattcagcg aagctgtgga ggcgcgagca
     2221 ctgagatcgc aggagaagta ctacattcta cggccagaga ctttcgagag ctactttgtg
     2281 ctgtggcgac tcacgcacga ccagaaatac cgcgactggg gctgggaggc ggtcctcgcc
     2341 ctggagaagc actgccgcac ggcgcacgga tattgtggcc tgcgcaacgt ctaccagcag
     2401 gagccgcaaa aggacgacgt tcagcaaagc ttcttcctcg ccgaaacgct taagtacctg
     2461 tacttgctgt tctcggacga ttcggtgctg ccgctggacg aatgggtgtt caacacggag
     2521 gcccatccgc tgccgatcaa gggtgcgaat gcgtactata gacaggcgcc cgtaacgctt
     2581 ccggtttcga acgcatcgta aacgggcgcc atgttgcgcc gctggctatt cggcctgtcc
     2641 ctagcaatgc accttactta gctcgcgata tttggatatc tacacatgtg tgtaccagat
     2701 cgtaacattt tttttttttt ttgttttgtt taagttatta gttagattac gtgaggatga
     2761 caactgcgta cgaaagatat tgtatgttta caatcaatcc aggcacacac acacacacac
     2821 tcgagaaact gtcaatgtaa catatttata aagcttgcac atatatagga acgtaaactt
     2881 aaacggatat atcgtagttt agttcttaac tgtttgcaca agtttctcca agtctctctt
     2941 cttgatttat cttatggaat taatagcaat ccaaatagtt gacagaggtg gatggtggga
     3001 agacctcaat ttccatttaa atgcgaatga cgtagacgta ggcaaaaact cttgatatta
     3061 attatgatat gatatataat atgatatacg tgtaaatgta aaactcaggt gttcttatta
     3121 tgattttcct tgcgctcaca caaggcactt tttcaactaa accagctacg taactatctc
     3181 tacaagcatt ctatacgcaa ttctcgatct gcgactatat ctctgtgtgg atttatggcc
     3241 acttggcggg catttcgtta gatctactct gctaatttcc aattcgaatc tttgaccact
     3301 ttattttgta tataatttct actgactttc ctcgcaaaat gaaggcagaa gaaaatcgaa
     3361 ttgatattta tacaaatata ttcttacaca atattgttta ctttgtagcc taaatattta
     3421 aatataaatc taatatagag tctagcttac tgtatgtgac gaaagaaatg taacgcaaat
     3481 taccttaaat cgagaacatc aagcgaaaag aacgcaaatg aatatatata aagtaaaata
     3541 aataaatata tatttgtatt taattaaatc aaataaaacg taggcaattg ttaaaataaa
     3601 ttaattatac gatggcacga gccgagcgaa tggtaattta atttttaaca actgtaaagg
     3661 ttttttataa taataatacc agcagtaatc atatttataa ttctatttgt tcacacatga
     3721 acacgaatat atttaaagac ttacaatttt gggctccgtt catatcttat gtaaatgaat
     3781 cgagagcgat aaattatatt taggattttg ttatctaagg cgacatgggt gcattgctca
     3841 aaaacatgta atttaagtgc acactacatg agtcagtcac ttgagatcgt tccccgcctc
     3901 ctaaaatagt cccttagtgg gagaccacag ataaggtcct cgccgctcaa gataggcaga
     3961 tgtgcccgag cgtgggacct cgataaggcg gggactattt acgtaggcct ctgcgtaggc
     4021 catttacttt aagatgcgat tctcatgtca cctatttaaa ccgaagatat ttccaaataa
     4081 aaccagtttc ttacaaaaac tc