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Drosophila melanogaster hyperkinetic, transcript variant G (Hk),


LOCUS       NM_167222               7021 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_167222
VERSION     NM_167222.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 7021)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7021)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7021)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 7021)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 7021)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 7021)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 7021)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 7021)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 7021)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 7021)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 7021)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 7021)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 7021)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 7021)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 7021)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 7021)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 7021)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 7021)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 7021)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 7021)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 7021)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 7021)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 7021)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_167222.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7021
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..7021
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /old_locus_tag="Dmel_CG32688"
                     /old_locus_tag="Dmel_CG34319"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="Hyperkinetic"
                     /map="9B4-9B5"
                     /db_xref="FLYBASE:FBgn0263220"
                     /db_xref="GeneID:31955"
     CDS             1157..2335
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /old_locus_tag="Dmel_CG32688"
                     /old_locus_tag="Dmel_CG34319"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="CG43388 gene product from transcript CG43388-RG;
                     CG43388-PG; Hk-PG; kvbeta channel subunit; hyperk;
                     hyperkinetic"
                     /codon_start=1
                     /product="hyperkinetic, isoform G"
                     /protein_id="NP_727405.1"
                     /db_xref="FLYBASE:FBpp0300313"
                     /db_xref="GeneID:31955"
                     /db_xref="FLYBASE:FBgn0263220"
                     /translation="MCRAPIASLDCMEEFSGTGGHLDFGRSISLGSNPALPLRHGSTP
                     TPGLRYKNLGKSGLRISNVGLGTWPVFSPGVSDDQAEAILKLAIESGINLFDISEAHS
                     ETEIGKILQRAGWKRTAYVITTKVYWSTKSEERGLSRKHIIECVRASLQRLQLQYIDI
                     VIIHKADPMCPMEVVRAMSYVIQQGWAMYWGTARWSQVEIMEAYTNCRQFNCITPIVE
                     QSEYHMFCREKCELYLPEMYNKIGVGLMAWGPLSMALSDTQNGDKLFLPKGSFKTKSF
                     SWTEDEINRNAALSPQGSWGKDRIDEGRRHCDRLRDLAALAEKLGCSPTQLSIAWSLK
                     HEPVQCLLLGATSAEQLHQSLQSLQLLPRLSSSVMLELERILENKPVRPPMISTLALR
                     "
     misc_feature    1298..2296
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /old_locus_tag="Dmel_CG32688"
                     /old_locus_tag="Dmel_CG34319"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="AKR6B family of aldo-keto reductase (AKR); Region:
                     AKR_AKR6B1; cd19142"
                     /db_xref="CDD:381368"
     misc_feature    order(1352..1360,1442..1444,1457..1459,1529..1531,
                     1646..1648,1733..1738,1811..1813,1898..1915,1925..1927,
                     1931..1933,2129..2131,2180..2194,2204..2206,2213..2218)
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="putative active site [active]"
                     /db_xref="CDD:381368"
     misc_feature    order(1442..1444,1457..1459,1529..1531,1646..1648)
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="catalytic tetrad [active]"
                     /db_xref="CDD:381368"
ORIGIN      
        1 ttcgtcctat tcgctgatag taaaccattg ggccagcggg tgaccatcgc cgtgttgctc
       61 ggtaaattcc ccaagcgccg aaatgaacca ctgacacgcc ctaggcgctt ctctatttgg
      121 ctaactggat atctggccat ctggcagtac cattggaacc atccatcccc agtcggaccc
      181 agcctcactc aattcaacgc acgtgcctgg tcatagactg gaaaaacagt tcaactggat
      241 aactggacaa ctgaaaaacc actgaggtcc ttccacaggc tcacgcacac aagcgcaagc
      301 aacaggactt gtttatcgac agcccctcgg ttgggcccca ctccaaactg gcccatcaat
      361 tttggttctc ctacccgcca ccgggcgctg gcggcggttc ctcaagaatc ataaaactaa
      421 ggaatcacgt ctaacaaata cgaattacaa gcgaaagaat acaaaaataa gaaaatacag
      481 aattaaatcg aaaacggaga tctctccctt tcagtctctc ctctctttct atctgcctat
      541 atgtctatct ctttcttaaa agacacactc agacacaccg cactcaccta acggtactaa
      601 taccattcca atcgtttcgg tacgcgtcgc gatcgcgtgt aatcaattgc caaattcgac
      661 aagaatcgtt actaaaatat aatcaaaatc aaattcgaca caacaagaac aacatcatca
      721 ccacaagtac aacatcagaa aaaaaacaca ttgagacagc aagaactcgc agaccgacga
      781 agagaagcaa cgcgatcgac agcgaaacga gcgcgaggcg aaaaaggaag agcaggacgc
      841 tatcaactac aaggagctcg atagtacgac atcatcatcc tccacacagc agaccttccc
      901 tggcagcgca gtcggggcgg gcagaggagc gtcagcagcg gtacctggaa gcgggacagc
      961 gatagcggtt gcagtagcag gagcgggagc gggacaatcg gcgacattgg cggggccgcc
     1021 ggcaacggcc gcagctgcca cagctgcgat cataccgatt ctgccgctcg gcgttgcaac
     1081 gctgcgcgat gattccaccg aatctgagca gtccgtgacc tgtgcgcaca accagctcga
     1141 tgcctaccac cgcatcatgt gccgggctcc cattgcgtca ctcgactgta tggaggagtt
     1201 cagtggtacg ggcggtcatc ttgatttcgg tcgttcgatc agtttgggct ccaatccggc
     1261 gctaccattg cgccatggat ccacaccaac gccgggactg cggtacaaga atctgggcaa
     1321 aagcgggttg cgtatctcga atgtgggatt gggtacctgg ccggtatttt cgccgggcgt
     1381 gagcgatgac caggcggagg caatccttaa gctggccatc gagagcggta tcaatctgtt
     1441 cgacatctcg gaggcgcact cggagacgga gatcggcaag atactgcagc gggcgggctg
     1501 gaagaggacc gcctatgtca tcaccacgaa ggtctactgg agcaccaagt cggaggaacg
     1561 tggtctctcc cggaaacaca tcatcgaatg tgttcgtgcc agtttgcagc gattgcagct
     1621 gcagtacatc gatatcgtca tcatccacaa ggcggatccc atgtgtccca tggaggtggt
     1681 gcgcgccatg agctacgtga tacagcaggg ctgggcaatg tattggggca ccgctcgatg
     1741 gagccaggtg gagatcatgg aggcctatac caactgccgc cagttcaact gcatcacgcc
     1801 cattgtggag cagtccgagt accatatgtt ctgtcgcgaa aagtgcgaac tctacctgcc
     1861 ggagatgtac aacaagatcg gagtgggcct catggcctgg ggtccactct cgatggccct
     1921 cagcgacacc cagaatgggg acaagctttt cctgcccaag ggctccttca agacgaagag
     1981 cttctcgtgg accgaggacg agatcaatcg taatgccgct ctgtcgccgc agggcagttg
     2041 gggtaaggac cggatcgatg aggggcgccg ccactgcgac cgtctccgcg accttgccgc
     2101 cctcgccgag aagctgggct gcagccccac ccagctgtcc atcgcctggt cgctgaaaca
     2161 tgagccagtg caatgcctgc tgctgggcgc cacatcggcg gagcagctgc accaaagtct
     2221 gcagtcgttg cagctgctgc cacgactctc atcgagcgtt atgctggagc tggaaaggat
     2281 attggaaaac aagccggtgc ggccgccgat gatctcgacc ttggcgctcc ggtgacaatc
     2341 agcgtgcccg caggggccgc tcagcctgag cggtggcgga ccctgcggcg ccgattcgcc
     2401 caagcacgag gatgaggcct tcatcgagga ggtggacgct gccaaggacg ctgccaagca
     2461 aggcttctgc ctcatccagt gacaaaagga gtccttagat aacgataata aatttttgaa
     2521 agtgattagc agtaaaacta gcctaagtag caataccatg acgacaacaa taagcaagca
     2581 ggagcagcaa cagcagcagc agcagcaaca acagcagcaa catctccagc ctcagcagta
     2641 tgtgcaacta cagcagcaac atttgatggc cagcggcagc accagcgatt cggcggcagc
     2701 tgttcccatt gcagctgaac tccagttcga ctccctgaat aacaataaca acaacaacaa
     2761 taataatacc aatggcagtc cggaacaggc actgcccacc agcgatgaac gccaaaaacg
     2821 tcgctccctg ctcaacttta agtccctgga ctttcatcta aagtccctgt acagtggcct
     2881 acggagtaac tcaggaacaa ctccacccag tcaaccgaat agctctgttc cggcggtgga
     2941 tcagccgcag cgtagaatgc cctatttgcg ggtggagagt gttgatcccg aggagccaag
     3001 aggatcagtt ctgcccggac attcgcccag ctttctgtca ccctacagtg gcgttggcgg
     3061 tggagccgga agcctgcagt tgccctcaaa cgatggaggc accatcagga gatcctcaac
     3121 atccgacatt gttaattgca gacggggagg gggagcaggg ggatcgggcg gaggagcagc
     3181 ctctgcccag gacagcagga ggccgagcac atcggatttg ctcagaaagg caagggaacg
     3241 aaagggcagt gaggccagga tgggcagaag tgtctcccac agtgggctaa ccaggggcgg
     3301 acccggcgga ggaggtggtg gcctgggcgg gagacgaacc agcatggcct tctaaaaaca
     3361 gaaataatag tgaaaaaaaa aaaaactatg gaaaaaaaaa cttaagcaat gaggtatggc
     3421 gaaaaaaaaa actgttgatc aaatctgaat cagaaatagg ctgacaaaat ggcgcttatg
     3481 aatttttatc tagtgaaaag aaaattaaaa aaaaaagaaa acaagaaaaa aataacaata
     3541 atagagcagc tattaaggaa cgactttttt tgtggatcta ttatcattat aattatatta
     3601 tatggttact acaattgcgc ctcgaaagaa ctaaagttag tagataaatt aaagcaagta
     3661 atgaacagaa acataacatt tcatctctct taaactctgt atctctctct ctctccccca
     3721 ctcccggcaa atttataata tatatatata tataaatata tatttaaaga acccccaact
     3781 tttatgacaa tattagaacc taactatcgt gtactatcgt taactatcgc ctggcaaaag
     3841 ctctaaaact aacctgcgtt ccaacccaaa aaaccaacaa tgattcaaga tcgatccatt
     3901 atatcaccgc actgtgagag ttcatatcaa gcgagaagga taatgtatgg aggataaacg
     3961 atgaaggata cccaaatatg tactatccta tgggatagtg tctttttcat taatcgattt
     4021 gtagacttaa cgagtgttaa acgattgtta acgattgact tgaggcgagg cgctgaataa
     4081 aatgatcgaa gcgaatagcg actaaagatt actacatata tacgaaacag caatggtgtg
     4141 ctcgttgtat gattaaattt tagctaaact aatgaacaaa taaatgagta taaataaaaa
     4201 ctcaaatgga aaacaaagaa acaattcaaa tcaaatctta ttaaatagac attactagca
     4261 ttatgtagtt aattaaataa caattcaagc gaaatttttt taaatcaaca aacgaaaaac
     4321 aaagcaaatg cctttcataa cagcaacaac aacaacaaca aatttatatt ttaaatatat
     4381 gcagtatata tatagatata cacaaacaca cacacataca tatgtgaaaa taacgaaagc
     4441 gatgaaataa aacaaagcag caacaaattg ttattaatta attgtagtcc attatcccga
     4501 tggcccatat cccatatttc atataagtga acaaaacaaa aaaaaacacc aatatagcaa
     4561 tatgtaggat atacatatag aggagttccc gaataccatg tattttatca tcattatcga
     4621 gtacatatat aaagtctttc tcacatacgg actgtgattt catataaaag taaacgtaaa
     4681 agtaaacaat taattattat atctaaccta atgtaattaa atgctaagtt cattcgaaag
     4741 atcttacaga tacacacaca cacacacaca cacacacaca cacacacaca cattgccccc
     4801 aaaaacacgc atgtaatttg aggatctgtt taagaaagca gaagcataaa tagcaatttt
     4861 caaatcgaat ggcattatat actactgata ctctacaatt aattaaccaa atgcgattgc
     4921 cttaataaag aataatgaat taaaaacatt ggatctaatc agatcgtatc ggatcagatc
     4981 ggatataacc cagtcggggg gccggtttcc tcaaacttca gttccagatc ggaatacatt
     5041 atatatacac gcatccattc gcatatatat tccccgcact gttgcttgag aaatcgcccc
     5101 gcgcaaagaa atacaatata tgtatacata cataaattgg tttagctcca tcggatcact
     5161 cagaataaat atatatacat atatatatat atatatatag ggaatactta tatatacgag
     5221 agtaattgca ttttttagta agtagttaat ccgtcctcaa caaacggcca accaaaaaag
     5281 caacaagttt ttgcgatcgg gcgctgctca gttgataacc catagcaaaa tttccaaaat
     5341 attgaatatt taaattcaga caaattcgaa aatatttgaa actttaactt tagatcattt
     5401 tcgagctttt caattgcaga gcattgtaaa gattagagtt tgttatttgg aggttgtgat
     5461 attaattgaa aaattgctga aaaaatcaaa tacatatctg caaatgggcg aattatgtta
     5521 ctttgataca tttttatgtg ttgagctcac taaagttcaa actaagcgtt attgagcaat
     5581 atccttagca atattagcca ttaggttgag caattaactt gatttcttac tgcatattta
     5641 gttatatagc tacaagttaa ttatgtataa acataactag aatgtgtatt tcgctttgta
     5701 aggcttaaag agtagtttat acctttaaag cttctgctta atttaaattg aaagtcacta
     5761 tgctgaacgg gtaatcaatt aaaaaagcag cgcctgtcga tagatccaat catcaattgt
     5821 ggccaagccc cctaaaaagt aatacaaaca aaaaaaaaaa aaaacagcca cgtcgtgtga
     5881 accggaaagc aataattcaa aatgctgctg aaaaacagtt cgactaacaa attgatgtac
     5941 atatgatcac aagcaaagta aagaagaagc acatacacgc agttgcatta tgagattaat
     6001 tttagtctgt tgttatcgca attattatca cgattattat gattacgatt attattaaca
     6061 cgtagctagt taaatcgaat gagaatcagc aatttatctg cctaagcctg aaagtaacca
     6121 caattacact cacacccaca ctcattacac acacacacac gcacacacac actcccttac
     6181 aaatacactg acaaaaagat gaaaaaaaaa agcaactgct aatgcagcaa acaaaagcaa
     6241 aaatgtaacg gaaagtatta agaagcgggg aagtgtagcg tttaaatcta gaaaacaaaa
     6301 ttttacttta catcaaaaca gaaatattta taacaattgc aataactaac aaaatgagag
     6361 gcgataaaat ggaagcatat atataataat atatcttaaa attattttct tatcgaaact
     6421 ggcaataata aatattaata taaatttaaa caactaaata attaaactat acacgcgcga
     6481 gaactttgta agttaacttt gcatagatga cacattttgg atcgaattac actgaatgaa
     6541 aggctcgcac acacgccaag cgtttacaca cacacacaca caccaacaca cacactcgaa
     6601 gacagacagt cgcgcaggaa gttcgatcat catttaccgt taatgcacca gtgtacacac
     6661 acctacacac aagaaatcag ctttacttta gattttcgat aattaattgc agggttgtcg
     6721 cctagggttg cttagaaatc gatgggagaa tccaattcag acgcttgcat ataggcgtag
     6781 ataagaaaat atatatacaa agtacataca taaacaagca atatcgcaat agcgctcgta
     6841 ttatttcgct aagttactag aaaaccgaat aataataaaa cagacaaacc tctttgatta
     6901 ccgtacgtat aaaatgcaag aaatgcaatt tgagggcaaa ttgtttacac ttcactttta
     6961 aagccacatt taatactaat atttcgaaaa aagctaatta aaataggtta taacaataac
     7021 g