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Drosophila melanogaster DNA replication helicase/nuclease 2 (Dna2),


LOCUS       NM_167214               3683 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant B, mRNA.
ACCESSION   NM_167214
VERSION     NM_167214.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3683)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3683)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3683)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3683)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3683)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3683)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3683)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3683)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3683)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3683)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3683)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3683)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3683)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3683)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3683)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3683)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3683)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3683)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3683)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3683)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3683)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3683)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3683)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_167214.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3683
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3683
                     /gene="Dna2"
                     /locus_tag="Dmel_CG2990"
                     /gene_synonym="CG2990; DmDNA2; Dmel\CG2990; DNA2;
                     l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107;
                     mus109"
                     /note="DNA replication helicase/nuclease 2"
                     /map="9A4-9A4"
                     /db_xref="FLYBASE:FBgn0288690"
                     /db_xref="GeneID:31934"
     CDS             91..3393
                     /gene="Dna2"
                     /locus_tag="Dmel_CG2990"
                     /gene_synonym="CG2990; DmDNA2; Dmel\CG2990; DNA2;
                     l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107;
                     mus109"
                     /EC_number="5.6.2.3"
                     /note="CG2990 gene product from transcript CG2990-RB;
                     CG2990-PB; Dna2-PB; mutagen-sensitive 109; DNA helicase"
                     /codon_start=1
                     /product="DNA replication helicase/nuclease 2, isoform B"
                     /protein_id="NP_727386.1"
                     /db_xref="FLYBASE:FBpp0071350"
                     /db_xref="GeneID:31934"
                     /db_xref="FLYBASE:FBgn0288690"
                     /translation="MATKRVLTPNILENDNTDVTSSNPQKKFKEQLDFSSDEVENIDW
                     GDNDDFDLALIAAMDSISNHRLELTKWQRCEVVRLEQLPNRKGLKVHVKRISGGDPET
                     ADCQLLPPWNCMPMQVGDTVSLLGKWDPSAGCYVVDKEQGYCVSHPDFLISGTTVTGS
                     LFCKRKSVLQERFRGLDSGNSVMVIGTLVHELLQKVLRQKLFDKKHIQSALQEMLASS
                     SLAHLLYASNLIQVEMEDHLMKFIDPIVSFVAQYVKGEPPSVLLPEVYRGQIHEICDI
                     EENLWVPQLGLKGKVDVSVKVKNQRQREEIIPLELKTGRASFSMEHKGQLLLYQLMHS
                     AQGRDTQSGLLLYLKEGLLREVASGRNEQRDLLMLRNDLAYWLTREVAIPASKEDPLE
                     QLPLPEPVYHHSACGNCAYNTICSSFAQKDSSLQLSDSHPLKKLMPQLLEHLSEADHA
                     YVQHWCGLLALEEQHNRQSSHVRSFWTKDPAEREKEGIAIRHLKLVKGQEVILEEGRY
                     RQTLELGEEADPSRDLSLSGFDLGEYVVISSTSRLAVAAGFIVSIEARRLDLRLERDL
                     SQRYSEETFIIDKHDSQSFATFNFTNLGMLLSEGERFQELRDIIVAKKPPEQHKVLPK
                     IILTKGAPILLNLNKVQQNAALRALTTSSHLLIKGLPGTGKTQTLVALVRLLHLLGKS
                     VLITAQTHSAVDNLIMRLLPFGLPMMRLGSGSRIHKQLEEISEERLTKDCKTVEELEK
                     ALGQPSIVGVTCLGCGHPLFQRRQFDYCIVDEATQVLQPTVLRPLIHCSKFVLVGDPE
                     QLPPIVRSKEARQRGADETLFQRLDSEKATAVLSLQYRMNKTITRLANELTYGGDLKC
                     ASDEVSGARFEVELLNEAPRWVQRALTTHLEQAVTLINTGDCLERCQEFVYASQRLVD
                     TCSSIEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLLKSGYEASRIGVIA
                     PYRAQVELFKKLASKLDTDLECNTVDQFQGRDKNLIIYSCSKTGGDFSDMERSREAEI
                     LEDQRRLTVAITRAKNKLILLGDIKCLEQYGPFRQLFKHIPDRCRLKLEEGRMEFGWQ
                     RIQEDLVGLMDT"
     misc_feature    547..1224
                     /gene="Dna2"
                     /locus_tag="Dmel_CG2990"
                     /gene_synonym="CG2990; DmDNA2; Dmel\CG2990; DNA2;
                     l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107;
                     mus109"
                     /note="Nuclease domain of the nuclease/helicase DNA2 and
                     related nucleases; Region: DNA2_N-like; cd22318"
                     /db_xref="CDD:411722"
     misc_feature    order(547..555,634..639,646..651,658..660,952..960,
                     964..966,1018..1020,1024..1032,1075..1077)
                     /gene="Dna2"
                     /locus_tag="Dmel_CG2990"
                     /gene_synonym="CG2990; DmDNA2; Dmel\CG2990; DNA2;
                     l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107;
                     mus109"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411722"
     misc_feature    1996..2598
                     /gene="Dna2"
                     /locus_tag="Dmel_CG2990"
                     /gene_synonym="CG2990; DmDNA2; Dmel\CG2990; DNA2;
                     l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107;
                     mus109"
                     /note="DEXXQ-box helicase domain of DNA2; Region:
                     DEXXQc_DNA2; cd18041"
                     /db_xref="CDD:350799"
     misc_feature    order(1996..2004,2011..2013,2080..2091,2185..2187,
                     2593..2598)
                     /gene="Dna2"
                     /locus_tag="Dmel_CG2990"
                     /gene_synonym="CG2990; DmDNA2; Dmel\CG2990; DNA2;
                     l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107;
                     mus109"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350799"
     misc_feature    order(2152..2160,2341..2343,2347..2349,2497..2499)
                     /gene="Dna2"
                     /locus_tag="Dmel_CG2990"
                     /gene_synonym="CG2990; DmDNA2; Dmel\CG2990; DNA2;
                     l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107;
                     mus109"
                     /note="nucleic acid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350799"
     misc_feature    2533..3255
                     /gene="Dna2"
                     /locus_tag="Dmel_CG2990"
                     /gene_synonym="CG2990; DmDNA2; Dmel\CG2990; DNA2;
                     l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107;
                     mus109"
                     /note="AAA domain; Region: AAA_12; pfam13087"
                     /db_xref="CDD:463780"
ORIGIN      
        1 aaacagtcac tctgttcccg ccaaatcatt tgtacgcata actgaaataa agtaaataat
       61 ttgatttaac aataacaaat agccccttcg atggccacca aacgcgtgct gacgcctaat
      121 attttggaga atgataacac tgacgtgacg tcatccaatc cacaaaagaa attcaaagag
      181 caactggatt tttcgtcaga cgaagtggag aacattgatt ggggtgacaa tgatgacttc
      241 gatttggcgc tgattgcagc tatggattct atatccaatc atcgattgga gctcaccaag
      301 tggcagcgtt gcgaagtggt gcggctggag cagctcccca atagaaaagg ccttaaagtg
      361 catgttaaga ggatttctgg cggggatccg gagacagctg attgccaact gctaccgccg
      421 tggaattgca tgccaatgca agttggagac actgtctccc tgttgggcaa gtgggatccg
      481 tctgcaggat gctatgtggt cgataaggag cagggctact gcgtgtccca tccggatttc
      541 ctcatttccg gcaccacagt caccggttcc ctgttttgca aacggaaatc tgttctgcag
      601 gaacgatttc gcggtctgga ctcgggaaac tctgttatgg tcattggcac tctggtgcac
      661 gaattgctgc aaaaggttct acgccagaag ctcttcgata aaaaacacat tcaatctgcc
      721 ctccaggaga tgctggccag ctcttctttg gctcatttac tctatgccag caatctcatc
      781 caggtggaaa tggaggatca tctgatgaaa ttcattgatc ccattgtcag ttttgtggcc
      841 caatatgtga agggtgaacc gccaagtgtt ttgctgcccg aagtctatag aggtcaaatc
      901 cacgagatat gcgatataga ggagaacctc tgggttccac aactgggact caagggtaag
      961 gtggatgtct ccgtaaaggt aaaaaatcaa cggcagaggg aggagatcat accactggaa
     1021 ctgaagaccg gccgagccag cttctccatg gaacacaagg gccaattgct gctctaccaa
     1081 ctgatgcact ctgcccaggg cagggatact caatcgggat tgcttctgta cctcaaagag
     1141 ggactcctac gagaagttgc tagcgggaga aacgaacaga gggatctcct tatgttaaga
     1201 aatgatctgg cctactggct aacacgtgaa gtagccattc cggctagcaa ggaggatcca
     1261 ctggagcaac tgccgctacc cgaacccgtt taccatcaca gcgcctgcgg caattgtgcc
     1321 tacaatacca tttgctccag tttcgcccag aaggattcaa gtttacagct aagcgactca
     1381 catcccctca agaaactcat gccacagcta ttggagcatc taagtgaggc agaccatgcc
     1441 tacgtgcagc attggtgtgg tttgctggct ctagaagagc aacacaatcg gcagtcctcg
     1501 catgtgaggt ctttttggac gaaggaccct gcggagagag aaaaagaagg catagccatt
     1561 cgacatttga agctagtgaa gggtcaagaa gtgatattag aagagggacg ctatcgccag
     1621 accttggagc tcggtgaaga ggcagatccc agtcgagatc tcagcctcag tgggttcgac
     1681 ttgggcgaat atgttgtaat cagttccaca tcccgtttgg ccgttgctgc tggttttatt
     1741 gtatctatag aagctcgtcg tttggatctt cggctggaga gggatcttag ccagcgttat
     1801 agcgaggaga cctttattat tgataagcac gattcgcagt cctttgccac ttttaacttt
     1861 accaatcttg gtatgctgct ctccgaggga gaacgcttcc aggagctgag agatattatt
     1921 gtggccaaga agccaccaga gcagcacaaa gttctgccca agatcatcct caccaaggga
     1981 gcacccattc tgctgaatct taacaaagtg caacaaaatg ctgctttgcg tgctttgaca
     2041 accagcagtc acctgttgat caagggactg cccggcactg gtaagaccca gacattggtt
     2101 gcccttgtca gactgctcca tcttctcgga aagagtgtgc ttattacagc acaaacgcat
     2161 tcggctgtgg acaatctgat catgcgtttg ctgcctttcg gattgcccat gatgagattg
     2221 ggctctgggt ctaggattca taagcagttg gaggaaatca gcgaagagag gttaacaaaa
     2281 gactgcaaaa cagtagagga attggagaag gctctagggc agccttccat tgtgggagtg
     2341 acctgtctgg gatgtggaca tccgctcttt cagcgtcgtc agttcgatta ttgcatcgtg
     2401 gatgaggcca cgcaggtgtt gcagcccacc gtgttgcgtc cattgattca ctgcagcaaa
     2461 tttgtccttg tgggagatcc agaacagttg ccgccgattg tcagatccaa agaagcccga
     2521 caaaggggag cggatgagac tttattccaa agattggact cggaaaaggc caccgccgtt
     2581 ttgagtttac agtaccgcat gaacaaaacc atcacccggc tggccaatga gctcacctat
     2641 ggaggagacc ttaagtgtgc atcggatgag gtgtccggcg cgaggtttga agtcgaactg
     2701 ttgaacgaag cacccagatg ggtgcagcgt gccttaacca ctcatttaga gcaggcagtc
     2761 acgctgataa atacagggga ttgcttagag cgttgccagg aattcgttta tgcatcccag
     2821 cgactggtgg atacctgctc atccatagag caaagcttta gcgaggacaa agatgagatt
     2881 aggaagctta cttccaaaaa gagagtatcc aaatacacaa actactgtga agcgggcata
     2941 gtgatgcact tgctcagata tttattaaaa tcgggctacg aagcctccag gattggcgtg
     3001 atagcaccat atcgcgctca agtagagcta ttcaaaaagc tcgcctccaa actggacacc
     3061 gacctggagt gcaacaccgt ggatcagttc caaggcaggg ataaaaatct catcatatac
     3121 agctgctcca aaacaggtgg tgatttctct gacatggaac gctcacggga ggcagagatc
     3181 ctggaggatc agcgccgtct cacagtggct attacccgtg ccaagaacaa gctcatccta
     3241 ctgggggaca ttaagtgcct ggagcaatac ggtcccttcc gtcagctttt taagcacatt
     3301 ccggacaggt gtcggctcaa gttggaagaa ggccgcatgg agttcggctg gcagcgcatc
     3361 caagaggatt tggttggtct aatggacacc taggtaattg ctatatttat tacttttttt
     3421 ttaattatta ttattattat ttacttggct tgttgaagaa attattctaa atgggattta
     3481 gtgagatatg cattattgta gcatttaatg tttacaatat atactgatta aattagattt
     3541 atttaataat ttgaaagtga gaagtttaac acattcttgc tactacaaat ttaagaataa
     3601 ttgtttattt ttgagaatct ttactcacta aatcctcact taagacccct caataaaatc
     3661 tttaacacat tgttattaac cgc