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Drosophila melanogaster suppressor of rudimentary (su(r)), mRNA.


LOCUS       NM_167182               3399 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_167182
VERSION     NM_167182.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3399)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3399)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3399)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3399)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3399)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3399)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3399)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3399)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3399)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3399)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3399)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3399)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3399)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3399)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3399)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3399)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3399)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3399)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3399)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3399)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3399)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3399)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3399)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_167182.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3399
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3399
                     /gene="su(r)"
                     /locus_tag="Dmel_CG2194"
                     /gene_synonym="CG2194; Dmel\CG2194; Dreg-3; pyd1; Pyd1;
                     Reg-3; Su(r)"
                     /note="suppressor of rudimentary"
                     /map="8D1-8D1"
                     /db_xref="FLYBASE:FBgn0086450"
                     /db_xref="GeneID:31858"
     CDS             221..3316
                     /gene="su(r)"
                     /locus_tag="Dmel_CG2194"
                     /gene_synonym="CG2194; Dmel\CG2194; Dreg-3; pyd1; Pyd1;
                     Reg-3; Su(r)"
                     /EC_number="1.-.-.-"
                     /EC_number="1.3.-.-"
                     /EC_number="1.3.1.2"
                     /note="CG2194 gene product from transcript CG2194-RC;
                     CG2194-PC; su(r)-PC; dihydropyrimidine dehydrogenase;
                     rhythmically expressed gene 3; drosophila rhythmically
                     expressed gene 3"
                     /codon_start=1
                     /product="suppressor of rudimentary"
                     /protein_id="NP_727320.1"
                     /db_xref="FLYBASE:FBpp0071273"
                     /db_xref="GeneID:31858"
                     /db_xref="FLYBASE:FBgn0086450"
                     /translation="MSPPQLLSKDSPDIEDLLSLNPRVKTQCSVVPTKQTKENKKHWK
                     RNADHAAPPCTTLANDFSDIKHTTLSERGALEEAARCLKCADAPCQKSCPTQLDIKSF
                     ITSIANKNFYGAAKAIFSDNPLGLTCGMVCPTSDLCVGGCNLQASEAGPINIGGLQQF
                     ATEVFKKMGVRQRRTPQAEANPLSQKIALVGGGPASLSCATFLARLGYRDVTIYERRS
                     YLGGLSAAEIPQYRLPIDAVNFEIDLVRDLGVRIETGRSLGTKDLTIQGLLSTGHDAV
                     FVGIGLPEPKLNPIFAGLQPSNGFYTSKNFLPLVSDGSKPGLCACKAAAGLPKLHGNV
                     IVLGAGDTAFDCATSALRCGARRVFVVFRKGSSGIRAVPEEVELARDERCELLPYLSP
                     RKVIVKDGLITAMEFCRTEQNENDEWVEDEEQTQRLKANFVISAFGSGLEDQDVKAAL
                     APLQFRGELPVVDRVTMQSSVKQVFLGGDLAGVANTTVESVNDGKVAAWSIHCQLQGL
                     PLDTPAALPLFYTDIDAVDISVEMCGIRFENPFGLASAPPTTSTAMIRRAFEQGWGFV
                     VTKTFGLDKDLVTNVSPRIVRGTTSGYKYGPQQGCFLNIELISEKRAEYWLKSIGELK
                     RDFPEKIVIASIMCSFNEEDWTELAIKAEQSGADALELNLSCPHGMGERGMGLACGQD
                     PELVEQISRWVRKAVKLPFFIKLTPNITDIVSIAAAAKRGGADGGSAINTVQGLMGLK
                     ADSTAWPAIGKEQRTTYGGVSGNATRPMALKAISDIANRVPGFPILGIGGIDSGEVAL
                     QFIHAGATVLQICSSVQNQDFTVIEDYCTALKALLYLKANPPPVDGPFWDGQSPPTPV
                     HQKGKPVVRLTGEGKATLGFFGPYQRQRDIKMAELRSQKGALWDAEQVKATPPASNGA
                     PNPAPRIKDVIGAALDKIGSYNKLDNKQQKVALIDDDMCINCGKCYMTCADSGYQAIE
                     FDKDTHIPHVNDDCTGCTLCVSVCPIIDCITMVPKKIPHVIKRGVEEKIFYTHALSQC
                     Q"
     misc_feature    383..1741
                     /gene="su(r)"
                     /locus_tag="Dmel_CG2194"
                     /gene_synonym="CG2194; Dmel\CG2194; Dreg-3; pyd1; Pyd1;
                     Reg-3; Su(r)"
                     /note="dihydropyrimidine dehydrogenase subunit A;
                     Provisional; Region: PRK11749; cl46914"
                     /db_xref="CDD:481254"
     misc_feature    1799..2707
                     /gene="su(r)"
                     /locus_tag="Dmel_CG2194"
                     /gene_synonym="CG2194; Dmel\CG2194; Dreg-3; pyd1; Pyd1;
                     Reg-3; Su(r)"
                     /note="Dihydropyrimidine dehydrogenase (DHPD) FMN-binding
                     domain. DHPD catalyzes the first step in pyrimidine
                     degradation: the NADPH-dependent reduction of uracil and
                     thymine to the corresponding 5,6-dihydropyrimidines. DHPD
                     contains two FAD, two FMN, and...; Region: DHPD_FMN;
                     cd02940"
                     /db_xref="CDD:239244"
     misc_feature    order(1859..1864,1874..1882,1886..1891,1952..1960,
                     1964..1981,2033..2035,2039..2041,2048..2056,2063..2065,
                     2072..2074,2084..2086,2345..2350,2420..2425,2486..2491,
                     2507..2509,2519..2521,2531..2533,2540..2545,2615..2617,
                     2624..2626,2663..2668,2672..2680)
                     /gene="su(r)"
                     /locus_tag="Dmel_CG2194"
                     /gene_synonym="CG2194; Dmel\CG2194; Dreg-3; pyd1; Pyd1;
                     Reg-3; Su(r)"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:239244"
     misc_feature    order(1925..1930,1973..1975,2030..2032,2036..2038,
                     2207..2209,2213..2218,2330..2332,2408..2416)
                     /gene="su(r)"
                     /locus_tag="Dmel_CG2194"
                     /gene_synonym="CG2194; Dmel\CG2194; Dreg-3; pyd1; Pyd1;
                     Reg-3; Su(r)"
                     /note="active site"
                     /db_xref="CDD:239244"
     misc_feature    order(1925..1927,1973..1975,2030..2032,2036..2038,
                     2207..2209,2330..2332,2411..2416)
                     /gene="su(r)"
                     /locus_tag="Dmel_CG2194"
                     /gene_synonym="CG2194; Dmel\CG2194; Dreg-3; pyd1; Pyd1;
                     Reg-3; Su(r)"
                     /note="FMN binding site [chemical binding]; other site"
                     /db_xref="CDD:239244"
     misc_feature    order(2030..2032,2036..2038,2207..2209,2213..2215,
                     2411..2416)
                     /gene="su(r)"
                     /locus_tag="Dmel_CG2194"
                     /gene_synonym="CG2194; Dmel\CG2194; Dreg-3; pyd1; Pyd1;
                     Reg-3; Su(r)"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:239244"
     misc_feature    <2879..3247
                     /gene="su(r)"
                     /locus_tag="Dmel_CG2194"
                     /gene_synonym="CG2194; Dmel\CG2194; Dreg-3; pyd1; Pyd1;
                     Reg-3; Su(r)"
                     /note="Ferredoxin [Energy production and conversion];
                     Region: NapF; COG1145"
                     /db_xref="CDD:440760"
     misc_feature    3056..3232
                     /gene="su(r)"
                     /locus_tag="Dmel_CG2194"
                     /gene_synonym="CG2194; Dmel\CG2194; Dreg-3; pyd1; Pyd1;
                     Reg-3; Su(r)"
                     /note="4Fe-4S dicluster domain; Region: Fer4_21;
                     pfam14697"
                     /db_xref="CDD:434137"
ORIGIN      
        1 gagcattttc aattgggcgt ttccagtgtg aagaccaatt cgaatttttc gtgttttttt
       61 ttttagtcgc caaaccgtcg ccagtcgatt ttcactccag ctagtgaata gctattatta
      121 ttattttttt tcgctgtgct aatctaaaga ttctaataaa aaaaagtgtt cataaattag
      181 ctaataacgt tccttcgatc ggtgaaacag tgccagcaag atgagtccgc cccaactttt
      241 gagcaaggac tccccagata ttgaggacct gctgtcgcta aatccgcgag tgaagacgca
      301 gtgctccgtg gtgcccacca agcagacgaa ggagaacaag aagcactgga aacgcaatgc
      361 ggatcacgct gctccgccgt gcaccacgct ggccaacgac ttctcggaca tcaagcacac
      421 cacattgtcg gagcgcggag ctctagagga ggcggccagg tgcctcaaat gcgccgatgc
      481 tccgtgccaa aagtcctgtc ccacgcagct ggacatcaag agcttcatta cgagcattgc
      541 gaataagaat ttctatggcg ccgccaaggc gatcttctcc gacaatccgc tgggtctgac
      601 ctgcggcatg gtctgtccca ccagcgatct ctgcgtgggc ggttgcaatc tgcaggcctc
      661 cgaggcggga ccgattaaca ttggtggcct ccagcagttc gccaccgagg tgttcaagaa
      721 gatgggcgtg cggcagcgga ggacaccgca ggcggaggcc aatccgctgt cgcaaaagat
      781 cgccctcgtg ggcggcggac cggcatcgct gtcgtgcgcc accttcctgg cccgtctggg
      841 ctatcgggat gtgaccatct acgagcggag aagctatctg ggtggcctga gtgccgctga
      901 aattccccag tatcgtctgc ccatcgatgc ggttaacttt gagatcgatt tggttcgcga
      961 tctgggcgta cgcatcgaaa cgggtcgctc gctgggcacc aaggatttga ccatccaggg
     1021 actcctgtcc accggccatg atgccgtctt tgtgggcatt ggcctgccgg aaccgaagct
     1081 gaatcccatt ttcgctggcc ttcagcccag caatggtttc tacacctcga aaaacttcct
     1141 gcccttggtg tcggatggct cgaaaccggg tttgtgcgcc tgcaaggcag cggccggttt
     1201 acccaagctc catggcaatg tcatcgtttt gggtgccggt gatacggcct tcgattgcgc
     1261 cacttcggcg ctgagatgtg gtgctaggcg tgtgttcgtc gtcttccgca aaggatcctc
     1321 cggcattcgt gctgtgcccg aagaggtgga gctggcgcgt gacgaacgct gtgagctgtt
     1381 gccgtacctg agtccacgca aagtgatcgt caaggatggc ctgatcacag ccatggaatt
     1441 ctgtcgcacg gagcagaacg aaaacgatga atgggtggag gatgaggagc agacgcagcg
     1501 cttgaaggcg aactttgtga tctccgcctt tgggtccggc ctggaggatc aggatgtcaa
     1561 ggcggcacta gcgccgttgc aattccgcgg cgaattgccc gtggtggaca gggtgacgat
     1621 gcagagcagt gtgaaacagg tgttcctcgg cggcgatctc gctggagtgg ccaacaccac
     1681 ggtggagtcg gtcaatgatg gcaaggtggc cgcctggagc attcattgtc aactgcaggg
     1741 cctgccactg gacacgccgg ctgcactgcc gctcttctat acggacatcg atgccgtgga
     1801 catatcggtg gagatgtgcg gcatccggtt cgagaatccc tttggcctgg cctccgcacc
     1861 gcccaccacc agcacggcca tgatacgtcg cgccttcgag cagggctggg gctttgtggt
     1921 gaccaagacg ttcggtctgg acaaggatct ggtcacgaat gtctcgccgc gcatcgtcag
     1981 gggcaccacg tcgggctaca agtatggacc gcagcagggc tgtttcctga acatcgaact
     2041 aatctcggag aagcgggccg agtactggct gaaatcgatt ggagaactga agcgtgactt
     2101 ccccgagaag atcgtgatag ccagcattat gtgcagcttc aacgaggaag actggacgga
     2161 gttggccatt aaggcggagc agtcgggtgc cgatgccctc gagctgaatc tatcgtgtcc
     2221 acatggcatg ggcgagcgag gtatgggctt ggcctgtggc caggatcccg agttggtgga
     2281 gcagatctct cgctgggtgc gaaaggcggt caagctgccc ttcttcatca agctaacgcc
     2341 aaacattacg gatatcgttt ccattgcggc ggccgcaaag cggggaggag ccgatggcgg
     2401 atcggccatc aacaccgttc agggactgat gggcctcaag gcggactcca ccgcctggcc
     2461 ggcgattggc aaggagcagc gcaccactta cggcggcgtc tccggcaatg ccactcgtcc
     2521 gatggctctg aaggccatct ctgatattgc caaccgtgtg ccgggattcc ccattctcgg
     2581 tatcggtggc atcgattccg gtgaggttgc gctgcagttt attcatgcgg gcgccactgt
     2641 tctgcagatc tgctcctccg tacagaacca ggacttcacc gtcatcgagg actattgcac
     2701 ggcactgaag gcactgctct acctgaaggc gaatccgcca ccagtcgatg gtcccttctg
     2761 ggatggccag tcaccaccca cgccggtcca tcagaagggc aagcccgttg tccgtttgac
     2821 cggcgagggc aaagccacgc tgggtttctt tggtccctac cagcggcagc gcgacatcaa
     2881 gatggccgag ctgcgaagtc agaagggagc tctttgggat gccgagcagg tgaaggccac
     2941 tcctccggcg tccaatggag cacccaatcc ggcaccaaga atcaaggatg tgatcggagc
     3001 agcgctagac aagatcgggt catacaacaa gctggataac aaacaacaga aggtggcgct
     3061 catcgatgat gacatgtgca taaactgcgg aaagtgctat atgacctgcg ccgattccgg
     3121 ctaccaggcc atcgaattcg acaaggacac ccacattccg cacgtgaacg acgattgcac
     3181 gggctgcaca ctctgcgtct ccgtttgtcc catcatcgac tgcatcacca tggtgcccaa
     3241 gaagattccg cacgtgatca agcgaggagt cgaggagaag atcttctaca cccacgctct
     3301 cagccagtgc cagtaaaagt ccctagttct acgcgaaata ccgatagtaa attccaatct
     3361 atgtaattca attaaataca aaacatgttt caaaagcag