Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]

Drosophila melanogaster Calmodulin-binding protein related to a


LOCUS       NM_167164               6115 bp    mRNA    linear   INV 26-DEC-2023
            Rab3 GDP/GTP exchange protein (Crag), transcript variant B, mRNA.
ACCESSION   NM_167164
VERSION     NM_167164.4
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6115)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6115)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6115)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6115)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6115)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6115)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6115)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6115)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6115)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6115)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6115)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6115)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6115)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6115)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6115)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6115)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6115)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6115)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6115)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6115)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6115)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6115)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6115)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_167164.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6115
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6115
                     /gene="Crag"
                     /locus_tag="Dmel_CG12737"
                     /gene_synonym="CG12737; CJ; crag; CRAG; Dmel\CG12737"
                     /note="Calmodulin-binding protein related to a Rab3
                     GDP/GTP exchange protein"
                     /map="7F7-7F8"
                     /db_xref="FLYBASE:FBgn0025864"
                     /db_xref="GeneID:31800"
     CDS             578..5512
                     /gene="Crag"
                     /locus_tag="Dmel_CG12737"
                     /gene_synonym="CG12737; CJ; crag; CRAG; Dmel\CG12737"
                     /note="CG12737 gene product from transcript CG12737-RB;
                     CG12737-PB; Crag-PB; Calmodulin-binding protein related to
                     a Rab3 GDP-GTP exchange protein"
                     /codon_start=1
                     /product="Calmodulin-binding protein related to a Rab3
                     GDP/GTP exchange protein, isoform B"
                     /protein_id="NP_727281.2"
                     /db_xref="FLYBASE:FBpp0089320"
                     /db_xref="GeneID:31800"
                     /db_xref="FLYBASE:FBgn0025864"
                     /translation="MEEKRIADYFVVAGMPENPQLLQENSFNDSGRLRAATTIEPITD
                     IGVYFPLLGEEVPEGYEILSHTPTGLQANLNHGSVRTTDCYIYFRRGKDRPPLVDIGV
                     LYDGHERIMSDAEIVAETPGGRVANVNNSSAKTFLTYRRARADMPCNELVVTELCVIV
                     QSKGERAPHAFCLIYKTLNKGYVGSDVYLCYKKSMYRPKHISYKPEILLRYPTFDHTD
                     FPLNLCPSVPLFCLPMGASLEAWPHVNGTEKRKPISPVFSTFVLTVSDGTYKVYGSAL
                     TFYEDYDESKLSAEQKELLGWDEEFGAQHSLHMIKAICLLSHHPFGDTFDKWLKYLHR
                     MVLYDVNIPIPVERYITQLLDEVPFPAPSIHLQLSSESNDRILLTQPEDSPLPRSGAG
                     FHILLQNLGTDNCLHVLLLALTEQKILIHSLRPATLTAVAEAIVSLLFPFKWQCPYIP
                     LCPLGLAEVLHAPLPYLIGVDSRFFDLYEPPTDVTCIDLDTNNISLCESQRHLSPKLL
                     PKRAARLLRQTLTELENAKPISYDSTNSLDRDIRKRKRELVLEQRIQEAFLLFMASIL
                     RGYRDFLVPISKAPSVGATDPSALFQLKAFLRSRDKSHQKFFELMMKTQMFIRFIEER
                     SFVSDGDHGLSFFDECAEKVGNYDETPAQLHLVDWDTGQNSERTKYIFPPDSVTPAGS
                     QPGGGGGGLAYNYENFTLQPELLQSTKKTALSKFLQLQLNASLSPGSPIARRTKHEIK
                     LSQKMASRCQQHPEAWSKYLLATCYSLYFLILPSMVLDPRHAGKEPEILRAAYDVLVR
                     ASRLKITCDEFCYRIMMQLCGIHNLPVLAVRLHYLMKRSGVQANALTYGFYNRCVLES
                     QWPQDSTTISQIRWNRIKNVVLGAAQFRKAGKQRAASKVNKSLSASQDQNLSTLETVD
                     GQSRTSLASSSGDGGGHGLLDFAAFDRLRNKLGSIVRQTVTGGNNETMGDAVNNTGLL
                     IPGELSAPNTPTYGGDTEILAKALQQQQPRKQIMSIGGGDDDDEDEDEDEYTAGSPST
                     PQKQLEAGADDLEYAGGGDYEADEEDEDEVDEHVAAQRARQRVQSPTKISPRTPVTQN
                     DPLGALNEEESAASATPTQETQQEQQHSQSQIDSSIYSDKPILFRGQRSATFDESTQI
                     GKSMHRSETMPVASSGVTNSLANIGSSLKFTFGPSLTGKKSNELIQGSLSSIKSAANS
                     LTKKFDEIKGVISANSTPTKTNNGHHPHGLHHGHHHPHHHHHHHSQHGNAEQEEHDAA
                     VHEEGKLRRVSSDLDPWGRLSESRKSSYNNLVPLGENSSTGALHMHAFPAVPDNLYSL
                     TSENAADRDCDVLIQLTTCSQCHNCSVLVYDEEIMSGWTAEDSNLNTTCHACNKLTVP
                     FLSVQIERQVEESEQSDPLQDGKEQIANGNSHKTSLTVPYLNPLVLRKELENILTQEG
                     DIALIKPEFVDEHPIIYWNLLWLMERIESKTHLPELCLPVPSDKEHIDPLSKVKTVHI
                     QCLWDNLSLHTEASGPPMYLLYRETQPTSPLIKALLTDQAQLNKNVIQQIISAIRCND
                     FATPLKRLANERHKLKSNGVERSHSFYRDILFLALTAIGRSNVDLATFHREYAAVFDK
                     LTERECNMYYRNQDLPPSASTIFCRAYFRPLLLP"
     misc_feature    1142..1414
                     /gene="Crag"
                     /locus_tag="Dmel_CG12737"
                     /gene_synonym="CG12737; CJ; crag; CRAG; Dmel\CG12737"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; Region: uDENN;
                     smart00800"
                     /db_xref="CDD:214824"
     misc_feature    1499..2053
                     /gene="Crag"
                     /locus_tag="Dmel_CG12737"
                     /gene_synonym="CG12737; CJ; crag; CRAG; Dmel\CG12737"
                     /note="DENN (AEX-3) domain; Region: DENN; pfam02141"
                     /db_xref="CDD:460461"
     misc_feature    2228..2449
                     /gene="Crag"
                     /locus_tag="Dmel_CG12737"
                     /gene_synonym="CG12737; CJ; crag; CRAG; Dmel\CG12737"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; Region: dDENN;
                     smart00801"
                     /db_xref="CDD:129037"
     misc_feature    2999..3088
                     /gene="Crag"
                     /locus_tag="Dmel_CG12737"
                     /gene_synonym="CG12737; CJ; crag; CRAG; Dmel\CG12737"
                     /note="PPR repeat [structural motif]; Region: PPR repeat"
                     /db_xref="CDD:276811"
ORIGIN      
        1 aagctagtct tatctggcaa cgctgaaaat ggcctgaagc aaaggccaaa tagttattaa
       61 taatagtaaa tccgataata atagtcgcgt gtttcgtatt gcatgttaat tatatagttc
      121 gccaagcagc gcatacaggc gattggcaca ttccgccagt cacaccgagc cgcgcacacg
      181 gctggcaggc cagttaaatg aacattattc cttacttttc tgtccactgc actccacacg
      241 tatttgcgta gcttttaaag tagctaaatt cgtggatttc aacgcacttg gcgcgtctta
      301 gtcaaagtgg cccagttaag cagtccaatt ggaaaactgt gaaaatgatg taaaggaaaa
      361 ctctcaagta gtccaactgt gtgtgcgtgt gtgtgtgtgt gcgtgcggtg agtgttggtg
      421 tgtggaaatt aacgtagtgt gaagaagaaa agcgaaggaa aagcgacaat tgcagtccaa
      481 ggcgaacagc aaaagcaact gaaggttgcc cacgccccct tcgtccccgc gcccccttgg
      541 aggacaacta acgggagtgc aaggaaacgg cgccgccatg gaggaaaagc gcatcgccga
      601 ctactttgtg gtggccggaa tgccggagaa tccgcagctg ctgcaggaga acagcttcaa
      661 tgactcggga agattgagag cggccaccac catcgaaccg atcacggaca tcggcgtcta
      721 tttcccgctg ctgggcgagg aggtgcccga gggatacgag atcctctcgc acacgcccac
      781 gggtctacag gcgaacctca atcacggatc ggtccgcacc accgactgct acatctactt
      841 ccggcgtggc aaggatcgcc cgccgctggt ggacatagga gtcctgtacg atggccacga
      901 gcggatcatg tcggatgcgg aaatcgttgc ggagacgcct ggcggcaggg tggccaatgt
      961 gaacaactcg tccgcgaaga cgttcctcac gtaccgacgc gcccgagcgg acatgccctg
     1021 caacgagctg gtggtcaccg aactgtgcgt cattgtccag agcaagggtg agcgggctcc
     1081 gcacgccttt tgcctaatct acaagaccct gaacaagggc tatgttggca gcgacgtcta
     1141 cctgtgctac aagaagtcca tgtaccggcc taagcacatc agctacaagc cggagatcct
     1201 gctgcgctac cccaccttcg accacaccga cttcccgctg aatctgtgcc cgagcgtgcc
     1261 gctcttctgc ctgccaatgg gcgcctccct ggaggcctgg ccacacgtca acggcacgga
     1321 gaagcggaaa cccatcagtc cggtgttcag cacttttgtg ctcaccgtga gcgatggcac
     1381 ctacaaggtt tacggatcgg cgttaacttt ctacgaggat tacgatgagt caaagttgtc
     1441 ggctgagcag aaggagctgc tcggttggga cgaggagttc ggcgcccagc actcgctgca
     1501 catgatcaag gctatatgtc tgctgtcgca tcatcccttt ggcgacacct tcgacaaatg
     1561 gctgaagtac cttcatcgaa tggttctgta tgacgttaat atacccattc ccgtggagcg
     1621 ctacatcacc cagctgctgg acgaagtacc gtttccggcg cccagcattc acctgcagct
     1681 gtccagcgag tccaacgatc gcatactgct cacacagccg gaagattccc cgctgccgcg
     1741 aagtggcgcc ggtttccaca tactgctcca gaacctgggc accgacaact gtctgcatgt
     1801 gctgctgctg gccctcaccg aacagaagat actcatccac tcactcagac ctgccacgtt
     1861 gactgctgtg gccgaagcca ttgtctccct gctgtttccg ttcaagtggc agtgtccgta
     1921 catcccactt tgtccgctgg gcttggcgga ggtgctccat gccccattgc cttatctcat
     1981 tggcgtggac tcgcgcttct tcgatttgta cgagccgccc acggatgtca cctgcatcga
     2041 tttggacacc aacaacatta gcctatgtga gtcgcagcgt cacttgtcac ccaagctgct
     2101 gccgaaacgg gcagcccgcc tacttcgcca gacgctcacc gaactggaga atgccaagcc
     2161 cattagctat gactccacaa acagtttgga tcgcgatatt cgaaagcgga aacgagaact
     2221 ggtgctggag cagcgcatcc aggaggcctt tctgctcttc atggccagca ttctgcgcgg
     2281 ctacagagac tttctggtgc ccatatccaa ggcaccatcg gtgggagcca ccgatccaag
     2341 tgccctcttc cagctgaagg cttttttgcg atcgcgtgat aagtcgcacc agaagttctt
     2401 cgagctgatg atgaagaccc agatgttcat ccgtttcatt gaggagcgtt cctttgtctc
     2461 cgatggcgat catggtctca gcttcttcga cgagtgtgcg gagaaggtgg gcaactacga
     2521 tgaaacgccc gcccagctgc atttggtgga ctgggacacg gggcagaaca gcgagcgcac
     2581 caagtacatc tttccgccgg acagcgtaac tccggcggga tctcagcctg gcggcggagg
     2641 aggaggatta gcctacaact acgagaactt tacgctgcaa ccggaactgt tgcagagcac
     2701 gaagaagacg gctttatcga aatttctgca gctgcagctg aacgcttccc tctcgccagg
     2761 atcacccatt gcccggcgaa ccaaacacga gattaagctg tcccagaaga tggccagccg
     2821 ttgtcagcag catccggagg cgtggtccaa atacttgttg gccacctgtt actcgctgta
     2881 cttcctcatc ctgccatcca tggtcttgga tccgcggcac gccggcaagg agccagagat
     2941 actgcgcgcc gcctacgatg tcctcgtgcg agccagtcgt ctaaagatca cctgtgacga
     3001 gttctgctac aggatcatga tgcagctatg cggtattcac aatctgcctg tgctggccgt
     3061 ccgtctgcac tacctgatga aacgctctgg cgtgcaggcc aatgcgctca cctatggctt
     3121 ctacaaccgc tgcgtccttg agtcgcagtg gccccaggac agtaccacga tcagccagat
     3181 ccgctggaat cgcattaaga acgtggtgtt gggagcggcg cagttccgca aggctggcaa
     3241 acaaagggcc gcctccaagg tgaacaagtc gctcagtgcg tcccaggacc agaacctcag
     3301 caccctggaa acggtggacg gacagtcgcg caccagtttg gcttcctcct ccggcgatgg
     3361 cggtggccat ggactgctcg attttgccgc cttcgatcgg ctcaggaaca agttgggcag
     3421 cattgtgcgg cagacggtga cgggcggcaa taacgagaca atgggcgatg cggtcaacaa
     3481 cactgggttg ctcatacccg gcgaactcag cgccccgaat acgccgacct atggcggtga
     3541 caccgaaatc ctggccaagg cacttcagca acagcagcca cgcaaacaga tcatgagcat
     3601 tggcggcggc gatgacgatg atgaggatga ggacgaagat gaatacacgg ccggatcgcc
     3661 gagcacgccg caaaagcaac tggaagcggg cgccgatgac ctggaatacg ccggtggagg
     3721 agactacgag gcggacgagg aggacgaaga tgaagtcgac gagcatgtgg ccgcacagcg
     3781 ggcacgtcag cgagtgcaga gtccaaccaa aatctcgcca cgcacgcccg tgacccaaaa
     3841 cgatccactg ggtgctctca acgaggagga gtccgccgcc agtgccacgc ccacgcagga
     3901 gacgcagcag gagcagcagc actcacagtc gcagatcgac agcagcatat acagcgacaa
     3961 gccgatcctg ttccggggcc agaggagcgc cactttcgac gagtcgacgc agatcgggaa
     4021 gagtatgcac cgttcggaaa cgatgccggt ggccagcagc ggtgtgacca acagcctggc
     4081 caacatcgga tcctcgctga agttcacgtt cggtcccagc ttgacgggca agaagtcgaa
     4141 cgagttgatc cagggcagtc tgagcagcat caaatcggcg gccaattcgc tgaccaaaaa
     4201 gttcgacgag atcaaaggcg tgatatcggc caattcaacg ccgacgaaaa cgaacaatgg
     4261 acaccatccg catggcctgc atcatggtca ccatcatccg caccaccacc atcatcatca
     4321 ttcgcagcac ggcaatgcgg agcaggagga gcacgatgcc gccgtccacg aggagggcaa
     4381 gctgcgtcgc gtctcaagcg acctggatcc atggggcagg ctcagcgagt cgcgtaaatc
     4441 cagctacaat aacctcgtgc cgctcggcga gaacagctcc accggcgccc ttcacatgca
     4501 cgcctttccc gctgtgcccg acaacctcta tagtctaaca agcgagaacg ccgcggatcg
     4561 tgactgcgat gtgctgatcc agctgacgac ctgctcgcag tgccacaatt gctcggtgct
     4621 cgtctacgac gaggagatca tgagcggctg gacggcggag gactctaacc tgaacaccac
     4681 ctgccatgcc tgcaacaagc tcacggtgcc tttcctcagc gtacagatcg aacggcaggt
     4741 ggaggagtcg gaacagtcgg atccgctgca ggacggcaag gagcaaatag ccaacggcaa
     4801 tagccacaag accagcctga ccgtgccgta tctaaatccg ctggtgctgc gcaaggagct
     4861 ggagaacata ctcacgcagg agggcgacat tgcgctgata aaaccggaat ttgtcgatga
     4921 gcacccgatc atctattgga acttgctctg gctgatggag cgcatcgaga gcaagacgca
     4981 cctgcccgag ctctgtctgc ccgtgccgag cgacaaggag cacatcgatc cgctgagcaa
     5041 ggtgaagacg gtgcacatcc agtgcctgtg ggacaatctg agcctgcata cggaggccag
     5101 tggtccaccc atgtacttgc tgtacaggga gacccagccg acgagtccgc tcatcaaggc
     5161 gctgctcacc gatcaggcgc agctcaacaa gaatgtcatt cagcaaatca tttcggccat
     5221 ccggtgcaat gacttcgcca ctcctctcaa gcgcttggcc aatgagcgac acaagctgaa
     5281 gagcaacggc gtggagcgat cgcactcgtt ctatcgcgac atactcttcc tggccctgac
     5341 cgccatcggt aggtccaacg tggacctggc cacattccat cgcgagtatg cagccgtgtt
     5401 cgacaagctg acggagcggg agtgcaacat gtactatcgc aatcaggatc tgccgccctc
     5461 ggcatcgacg atcttctgtc gtgcttactt ccgcccgctt ctgctgccct gacgcagtgg
     5521 ctcccagctg gaggcaggag cagcttcaag cgatgccgaa gtggacacat gagtggagca
     5581 gccgaagcct aaaagacaag acgaccaaat aacttgataa caaaatggaa acgaagggag
     5641 agtttgacga caacgaaacg cttatcacac accttaggct gggtcgattt tatagatggg
     5701 acaagtatga attaatttta cttagatatc agagctctta tttacgttac ggaaaagaaa
     5761 aggacggtat tttggaacta ttcctagtag gctataaaaa tgtaattgtt ttaaacgaaa
     5821 aaaaaaaaat acttgattcg aagtgttctt aggttttcaa actaatagtt ttttcccaag
     5881 cgaggaagcc ttctgggcaa acttctttag aattgtcctc aatttacttg tacttgtaca
     5941 caagccagaa tatttaaatt cttaaacgaa ctttcctaag tgaaagcccc aacttgacat
     6001 gtgttgcatt gtgaaaacat gcaaatgatt ttgtaaatga cttgatctta acatttaagt
     6061 acttaacgat ttttcgctgt ttaaaactaa tcaaaaatat acacacacac acacg