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Drosophila melanogaster chronophage, transcript variant I (Cph),


LOCUS       NM_167121               6934 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_167121
VERSION     NM_167121.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6934)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6934)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6934)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6934)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6934)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6934)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6934)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6934)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6934)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6934)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6934)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6934)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6934)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6934)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6934)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6934)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6934)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6934)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6934)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6934)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6934)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6934)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6934)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_167121.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6934
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6934
                     /gene="Cph"
                     /locus_tag="Dmel_CG9650"
                     /gene_synonym="Bcl11; CG9650; cph; Dmel\CG9650"
                     /note="Chronophage"
                     /map="6F10-7A5"
                     /db_xref="FLYBASE:FBgn0029939"
                     /db_xref="GeneID:31660"
     CDS             1281..4904
                     /gene="Cph"
                     /locus_tag="Dmel_CG9650"
                     /gene_synonym="Bcl11; CG9650; cph; Dmel\CG9650"
                     /note="CG9650 gene product from transcript CG9650-RI;
                     CG9650-PI; Cph-PI; chronophage"
                     /codon_start=1
                     /product="chronophage, isoform I"
                     /protein_id="NP_727173.2"
                     /db_xref="FLYBASE:FBpp0301059"
                     /db_xref="GeneID:31660"
                     /db_xref="FLYBASE:FBgn0029939"
                     /translation="MRIKMPAVRIAQDSDSTENDAVATQDILTCGACQKAFALSDIVK
                     FIQHKVLQCNKENYGQCATQNPQMDRDAEEGRPLSLVNRRPSISAPISGRKSAPASAA
                     AAVAAAAAAAAAAAAASSTASGSRIHTPPPSPADLLADGASSTPKRLVDENDNTTPKD
                     SETGATTLDSNAAPSSPAAIERQSSGDSSCEMEEQQDRQDKQSQPKQAKVKQEPYDEE
                     GVNHHQNQDDDDDEEMEERSLAKRPKMELVDAEANTVHTEPSNYTCSTCKTRYTSAWR
                     LIQHVQHSHGVKIYVESPGGGATLTVATPAALNNSALALAAAAAAASASGLASPQPAV
                     SPNPAVTSSAKRSSPLGAAGSTILSTSVSSTCSNSLVNTSGGSISNTSSIGSPQQQQL
                     QLQQQQAQQQQQRVQQQQRENLASAMAAGMRHHPLLPPPEAMHANPFQLLRMPLPPAL
                     AQAGNVVPTVAPLFGRPSPADHYRMEQLVSEQFRHHGFNLAAAAAAAQAQFNANGQVV
                     GGVVSGSGEPRPPSSSSSGSQRGSVPPAALPPPSLSSQQQQQQQQAVQQQQQQGAQQQ
                     LQSAQQQQQSQQQSQQQQQITPGLVGGAGGSLKLEPQQMDFYSQRLRQLAGTTSPGAG
                     STVNSSSPSPRQKQSPHFASPSPSQQQQQQLATIPRPHSLTPPEKLGDASSENGSLGL
                     ILASTPRSASTPPSKTGDVSLQEPIAHCYSCSYCDKKFRFENNLIIHQRTHTGEKPYK
                     CTACDFECSHIQKLMKHMRVHRSPADDQDNQDNQDDGSNADSLETNEADNDEDPNPDE
                     SEEELGDGDNDPDGDGDLDGEDEDEDELEECEDMDYKAEDLSVSNRIDGKSQSPKTTS
                     SGATSLVGELMDKFGLSNIAQYSEAYKQALQESGRKEAAAAAAAAAAAADNNNRGGAG
                     APLSDKLNGLPVAALRLRDEFAKNCNMFQQPQDGGAPSQVPLFNPFPNPFELSKRMKM
                     DGGDWWGMSQALHRNEALFENLKLKPLGLGGANSLIQGPLLKKESRQRNDTCEFCGKV
                     FKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGKDVYRCRFCDMP
                     FSVPSTLEKHMRKCVVNQGKAAAAANAVAAAQAAQAAAQHIQAAAQQAQAVQAQAVQA
                     QAAQQSQQQQQQLSPMGVVGYPPQFVSGHNLSLPGSVSGDNDSNASSSMTGVHPISLK
                     EEA"
     misc_feature    3411..3479
                     /gene="Cph"
                     /locus_tag="Dmel_CG9650"
                     /gene_synonym="Bcl11; CG9650; cph; Dmel\CG9650"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    3417..3479
                     /gene="Cph"
                     /locus_tag="Dmel_CG9650"
                     /gene_synonym="Bcl11; CG9650; cph; Dmel\CG9650"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3453..3530
                     /gene="Cph"
                     /locus_tag="Dmel_CG9650"
                     /gene_synonym="Bcl11; CG9650; cph; Dmel\CG9650"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    3501..3563
                     /gene="Cph"
                     /locus_tag="Dmel_CG9650"
                     /gene_synonym="Bcl11; CG9650; cph; Dmel\CG9650"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    4347..4412
                     /gene="Cph"
                     /locus_tag="Dmel_CG9650"
                     /gene_synonym="Bcl11; CG9650; cph; Dmel\CG9650"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    4350..4412
                     /gene="Cph"
                     /locus_tag="Dmel_CG9650"
                     /gene_synonym="Bcl11; CG9650; cph; Dmel\CG9650"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(4365..4367,4371..4373,4377..4379,4383..4388,
                     4395..4400,4407..4409,4449..4451,4455..4457,4467..4472,
                     4479..4484,4491..4493,4539..4541,4545..4547,4551..4553,
                     4557..4562,4569..4574)
                     /gene="Cph"
                     /locus_tag="Dmel_CG9650"
                     /gene_synonym="Bcl11; CG9650; cph; Dmel\CG9650"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    4386..4463
                     /gene="Cph"
                     /locus_tag="Dmel_CG9650"
                     /gene_synonym="Bcl11; CG9650; cph; Dmel\CG9650"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    4434..4496
                     /gene="Cph"
                     /locus_tag="Dmel_CG9650"
                     /gene_synonym="Bcl11; CG9650; cph; Dmel\CG9650"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    4524..4580
                     /gene="Cph"
                     /locus_tag="Dmel_CG9650"
                     /gene_synonym="Bcl11; CG9650; cph; Dmel\CG9650"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
ORIGIN      
        1 tgaattatct gcagtcgctc gcaggacatc gtcgcgttcg gacatgttcg cctaagaagc
       61 tcgcgtctgg agttggcact ctcttctcaa cactcacaca cacacacaca ccatactcca
      121 ctctctctcc ctctctcgct gagctgtggc gctctcttct tccgccgctc gcaagctttc
      181 gtctcgcttg caacgcgttc gctcgtgttc gttcgcgctc gccagtgtgg gctgtgcggc
      241 gtgcttcagc ttgtgcctgt ctgtgtgtgt gctttgtcgc actctggttg ttgttgcccg
      301 ctggacaaaa gctgccgcgc tgctgcagcg aagtcgccga gagcagaggc agcgaagacg
      361 cgctcgccgc taaaacctcg caagtagtcg cgtacttccg ccgttaccgt tagcaccaca
      421 cacaaaacgg agctgctaac cgctagacta cattacgccg ccaaaacata caaaacaaaa
      481 gcaaccaaaa taaaacaccg cttttgccga tttaccgtta gccgtcgcgg tcatcgataa
      541 tacaactaac ttggcaacaa aaacaaatca taatacaaat aaaaaaccaa aacatatttt
      601 ggtatatact taacaaaatc aaaagtatac ctatacacac tttgtgcaat ttttttcaag
      661 tgtctccggc gtgtgttatc aacaaaaata aaatacgaaa tacaaaatcc aattggttaa
      721 acatacagcc tgcgaaaacc caattggttt tcccttcttt tctatacaaa tgaaaccgcg
      781 tgcgtttgtg acaacaacaa caaaactgcc aaacaaacaa aaaagccttt aaggaagaaa
      841 ttaaaagagt ccccgtgctt aaggttccta tgctacaatt taaatcaaag atcacaagag
      901 tcttaaaaga aataaaaacc aagtgacaag tgtacgaaga atacgttttt tttttttttg
      961 gaaaatggca gccctagaaa agccccgaaa aaccaagctg aagctgtctg attaggaaac
     1021 taaaagctag agattccaat tggtgaatgt gtgatttttt ttttttaaac caaaaaacga
     1081 ggtttgtgca atagaaataa ataaagagga gtaggcctag gaagaaaaga aacaataact
     1141 agaaaaactt tagaaacgta tgccaattgg aagttggcat cccagttgga attgggagat
     1201 cggcaggaca ttgcccttcg ctgggtttgt gtgcctgtgt ctgcgaagtt ttgaaacacc
     1261 ttcggaaact ggaaacaaaa atgagaatta aaatgcccgc ggttcgaatt gcacaagatt
     1321 ccgactccac agagaacgat gccgtggcca cacaggacat cctcacgtgc ggcgcctgcc
     1381 agaaggcgtt cgccctctcg gacattgtta agttcatcca gcacaaggtg ctgcagtgca
     1441 acaaggagaa ctatggccag tgcgccaccc agaatccgca gatggatcgc gacgcggagg
     1501 aaggtcgccc gctcagcctt gtcaaccgcc gcccctcgat ctccgccccc atatccggcc
     1561 gcaaatccgc tccagcgtca gcggcagcag ctgttgcagc agcagcagcg gcggcagcag
     1621 cagcggcggc ggccagcagt acggccagcg gatctaggat acacacacca ccaccgagtc
     1681 cggcggacct tttggccgac ggagccagca gcacacccaa acgcttagta gacgagaacg
     1741 acaataccac gcccaaggac agcgagacgg gcgccaccac cctcgattcg aatgccgccc
     1801 cctccagtcc agcggccatt gagcggcaat cctccggcga cagcagctgc gaaatggagg
     1861 agcagcagga tcggcaggat aagcagtcgc agccgaaaca ggcgaaggtc aagcaggaac
     1921 cctacgatga ggagggcgtc aaccatcatc aaaatcagga tgatgatgac gatgaggaga
     1981 tggaggagcg ctcgctggcc aagcggccca aaatggagct ggtcgatgcc gaggccaaca
     2041 cagtccacac agaacccagc aactatacgt gctccacgtg caaaacccgc tacacctccg
     2101 cctggcgcct catccagcac gtccagcact cgcacggcgt caagatctac gtggagagtc
     2161 ccggaggagg agccacattg acggtggcca cacccgctgc cctcaacaac agtgctctgg
     2221 ccttggccgc cgccgctgca gcagcatccg cttccggtct ggcgagtcca cagccagcgg
     2281 tcagtcccaa tcctgcagtt acatcgtcgg ccaagaggag cagtccgctg ggagcagcag
     2341 gttcgaccat tctgtccacc tccgttagct ccacctgctc caattcgctg gtgaacacca
     2401 gcggtggcag cattagcaac accagcagca ttggctcacc gcaacagcag cagttgcagc
     2461 tgcagcagca gcaggcacag cagcaacagc agcgcgtgca gcagcaacaa agagaaaatc
     2521 tggcttcggc catggccgct ggcatgcgtc atcatccact gttgccgccg ccagaggcta
     2581 tgcacgccaa tcccttccag ctgctgcgca tgccactgcc accagctttg gcccaggccg
     2641 gaaatgtagt tcctacggtg gcgccgctct ttggacgccc ctcgcccgcc gatcactacc
     2701 gcatggagca gttggtgagc gagcagttcc gccaccatgg tttcaacctg gccgccgccg
     2761 ctgccgccgc tcaggcgcag ttcaatgcca atggtcaggt ggtgggtggc gtggtctccg
     2821 gttcgggtga gccacgtcct ccatcgtcga gcagcagtgg cagccagagg ggatcggtgc
     2881 ccccggctgc cctgccacca ccatctctga gctcccagca gcagcagcaa cagcagcagg
     2941 cggtgcagca gcagcaacaa caaggcgccc agcagcaact ccagtccgca cagcagcaac
     3001 agcagtccca gcagcaatcg caacagcaac agcagataac acccggtctg gttggtggag
     3061 ctggtggctc cctaaaattg gaaccccagc agatggattt ttactcgcag cgattgcgtc
     3121 agcttgcggg cacaacaagc cctggagctg gcagcactgt taactcgagc tcgccgagtc
     3181 ctcgacagaa gcaatcgccg catttcgcga gcccctcgcc ctcgcagcag cagcaacagc
     3241 aactggccac aatcccgcga ccccattccc tcactcctcc cgagaagctg ggcgatgcca
     3301 gctctgaaaa tggcagcttg ggactaatct tggccagcac cccgcgttcc gcgagcacgc
     3361 caccctcgaa aacgggagat gtgtccttgc aggaaccaat tgcccactgc tactcctgca
     3421 gctactgcga caaaaagttc cgcttcgaga acaatctgat tatccaccag aggacccaca
     3481 ccggcgagaa gccgtacaag tgcactgcct gcgactttga gtgctcccac atccagaagc
     3541 tgatgaagca catgcgggtg caccgcagtc cggcggatga tcaggacaac caggataacc
     3601 aggacgatgg cagcaatgcc gattcgctag aaacgaatga ggccgacaac gacgaggatc
     3661 ccaatcccga cgagtcggag gaggagttgg gcgacgggga taacgatccc gatggcgatg
     3721 gtgacctcga tggcgaggat gaagacgagg atgagctgga agagtgtgag gacatggact
     3781 ataaggcaga ggaccttagt gttagcaatc gtatcgatgg caagagccag agtcccaaga
     3841 cgacgagttc aggagccact tcactggtcg gtgaattgat ggacaagttc ggtttgtcca
     3901 acattgccca gtacagtgag gcctacaagc aggcgctcca ggagtcggga cgcaaggagg
     3961 cagccgccgc cgccgcagca gctgctgcag cagccgacaa caataatcgc ggtggagcgg
     4021 gtgctccgtt gagcgacaag ctgaatggtc tgcctgtggc cgctctgcgt ttgcgggatg
     4081 agttcgccaa gaactgcaac atgttccagc agccgcagga tggcggtgct ccctcccaag
     4141 taccgctctt caatcccttc cccaatccct tcgagctaag caagcggatg aagatggacg
     4201 gcggagattg gtggggcatg tcgcaggctc tccaccggaa tgaggctctg ttcgaaaacc
     4261 tgaagctgaa gcctctgggc ctgggcggag ccaactcgct gatccagggt cctttgctca
     4321 agaaggagag tcgccagcgc aacgacactt gcgagttctg cggaaaggtg ttcaagaact
     4381 gctcgaatct gacagtgcac cgcagaagtc acaccggcga gaagccgtac aagtgcgaac
     4441 tgtgctccta cgcctgcgcc cagagctcca agctgacacg gcacatgaag acccacggac
     4501 ggaccggcaa ggatgtgtac cgctgccgct tctgcgacat gcccttcagc gtgccctcga
     4561 ctctggagaa gcacatgcgc aagtgcgttg tcaaccaggg caaggcggcg gcggctgcaa
     4621 atgcggtggc cgccgctcag gcggcacagg ctgcagcgca gcacatccag gccgctgccc
     4681 agcaggctca ggcggtacaa gctcaggcgg tacaggccca ggcggcgcag cagtcgcaac
     4741 agcagcagca acaactgtcg cccatgggcg tcgttggcta tccgccgcag ttcgtcagcg
     4801 gtcacaatct ctcactgccg ggcagcgtga gcggcgacaa tgactcgaat gcctcctcca
     4861 gcatgaccgg cgtccatccc atatcgctta aggaggaggc atgacttttc agtggttttc
     4921 ccgtgccgct ggcgccacca ccgccactgc aacagcatca gccgcatctg cagcagccgc
     4981 agcagcaaca gaccagtcgc agtcgcatca tgtcgcgcat cttctaaagg tgttaaaacg
     5041 atttagaaag caaaaaatat accaagcccc ctgtaaatat gacttttttg aaaaaagccc
     5101 ccatccagct ccttccaggc gacgaaaaaa aaacgaccag aggcatttaa taccaaagca
     5161 ataaccgtta tgtaatataa ttttaaagat tcgaaccttt tttttgtaac gaaaacaaaa
     5221 ccacaccaca tttttttcca acattttttt ttcgtgcttg taatttatat atatagtata
     5281 taaatatacg taaatgtaat aatataatca attagtgagt acttgtgtgg acacacattt
     5341 tccagtgtat tttctaggac taagtaagaa aatgagaaag gatttgtata aaatgaaaaa
     5401 gaaacctact aaacctaaac gtaaaaaaaa aaatatgcaa aaattctgct cccagcgagc
     5461 cacaaaaata agcaaaatta tactctaaac ttaaaggcat tactatatga atattaccga
     5521 tatgggcgag cgaatgaatg aatatttttt tcatcgatgt acatttttta gtaaatctag
     5581 acccctagca ctaaagacga acacttgtaa aaatcctaaa tctaattcta atcatgatta
     5641 tcgtatatgt attcgtttta ttcgagttcc ccttgatttt atttcctttc ctctccttac
     5701 cttttttttt gcatagatat aattctatta ttaaatgtaa tttaaacgaa aaaacgaaaa
     5761 ataatcaaat ttttttacat acataaataa atataaatgt aaaacacaaa ttttttttaa
     5821 acaattttag tctaagctga caaggaaaat catgcataaa ttttgaagca gcagcaaatt
     5881 gaaaaaagat gaagatgcaa atttgtacgt aaaacttcaa gtgaattata agaaatagaa
     5941 gaaagcaatt aacgagaaaa taccgaaaca acaacaaaca aacaaacaaa acgacaacaa
     6001 ctagatttag aagactgaag aactgagaac gaaaattgtt ttcttgctaa caaaaaaaaa
     6061 gacagaatta aagtaaaaga cgaaagagag ctggaaaacg gacaatgaaa aggcggaaaa
     6121 aaaggacacg ataaagtgca ttttttttat aaattgtttt ttgctgttga ttttcgttat
     6181 ttgattgaaa ctaaaaaaaa attgagatcc aaaattttga ttaatattta attgtttgtt
     6241 tttgtagtaa aaatacattt ttgtgagcaa aattcaaagg cgcaacatta gtttaaacct
     6301 tgttttgttt cgagtcccct aaaatcccac ctggaaatcc ccctactaaa gcagttatat
     6361 tttcccaaat tgccttatta ccggcgattt ccacagttta tatcgacgaa gtttaccgtg
     6421 cataatttat cgaattcgac atgtactaaa tttaagaatg aggttttaat gcattgtgtt
     6481 taacatatat agaacatata tataaatcga aaactgaata aacaaaaatc catgaaaatt
     6541 aaaaaaaaaa aacacacgag ttatgattta tttggcaaca tttttggttt caatactgat
     6601 ttcttccacg agaagcagag gagcataggc gaacggaaac cggaacgaaa cgaagcaaac
     6661 taaaactatc attaaatctt agaaaattaa atgtagctat aaaaaagaaa cctttatact
     6721 aaaaaaaatt aaaccaagac attgtctcat ttggccgaga gcaatagcaa ggagcgaatt
     6781 aaaggaaaaa caaaacggaa aaaaaaaaac aaaaatattt ttcaaatgtg tgtaattttt
     6841 tgaaagtaac aataacgaga atacgaaaag gaaaacaaaa acacaaattt aaaaattaat
     6901 aattaaatga tagttgtctg tgttacgaaa atac