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Drosophila melanogaster frizzled 4 (fz4), transcript variant B,


LOCUS       NM_167119               3674 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_167119
VERSION     NM_167119.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3674)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3674)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3674)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3674)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3674)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3674)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3674)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3674)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3674)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3674)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3674)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3674)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3674)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3674)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3674)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3674)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3674)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3674)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3674)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3674)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3674)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3674)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3674)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_167119.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3674
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3674
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="frizzled 4"
                     /map="6F5-6F5"
                     /db_xref="FLYBASE:FBgn0027342"
                     /db_xref="GeneID:31659"
     CDS             448..2565
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="CG4626 gene product from transcript CG4626-RB;
                     CG4626-PB; fz4-PB; Frizzled4; frizzled 4"
                     /codon_start=1
                     /product="frizzled 4, isoform B"
                     /protein_id="NP_727170.2"
                     /db_xref="FLYBASE:FBpp0070976"
                     /db_xref="GeneID:31659"
                     /db_xref="FLYBASE:FBgn0027342"
                     /translation="MKPTCILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFR
                     QCETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAA
                     YVPMCTPKAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMC
                     MEGPGELHQPQQEQDLYGLPGQGIPGGLGGKLPMDCSGLAKSHLYVRLPRSGRCAPLC
                     EADILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIW
                     CHNMVTLGWAVRFMVGRTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAA
                     CAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFV
                     AWGLPAFQTSAVIVARFVDADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLIS
                     GYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFA
                     NIDVWLGSGDTNTPLWPFLLRAFMELMLGICCFAWVLGPSISTLYKRQVSNGKMVKHT
                     SAGAATGHLDGHSSSRGSHAACNSTVVSYHSVRTSMASVPLPPSPYKLKTSPGTGSIS
                     LNQMSNYSLGRSVHHQQRHSPHHHHHQQQQHHQFHPHHNHQHHSTSSHRLYYPPGSYA
                     SQKYSQHGSYYPHLQQYGNETLL"
     misc_feature    574..954
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="Cysteine-rich Wnt-binding domain of the frizzled 4
                     (Fz4) receptor; Region: CRD_FZ4; cd07448"
                     /db_xref="CDD:143557"
     misc_feature    order(604..606,610..618,622..630)
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="putative Wnt binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:143557"
     misc_feature    1111..2118
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="class F frizzled/smoothened family, member of the
                     7-transmembrane G protein-coupled receptor superfamily;
                     Region: 7tmF_Frizzled_SMO; cd13951"
                     /db_xref="CDD:320089"
     misc_feature    order(1114..1116,1141..1143,1300..1302,1684..1686,
                     1699..1701,1705..1707,1732..1734,1975..1977,1984..1989,
                     2008..2010,2023..2025,2032..2037)
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:320089"
     misc_feature    1138..1215
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320089"
     misc_feature    1249..1314
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320089"
     misc_feature    1408..1488
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320089"
     misc_feature    1609..1659
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320089"
     misc_feature    1723..1812
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320089"
     misc_feature    1888..1971
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320089"
     misc_feature    2002..2079
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320089"
ORIGIN      
        1 gacgcagagc catctctagc tcagagtgac cagtatgcgt tgaattttac cacgaaaaca
       61 aaataaaata tataaacgtt cgatgttaat accaattaga ttagaataca ttcgctaagg
      121 ctacaaactg actgcgccat tcgtttaagc acatcgaaac aaatacacta ttcgttcact
      181 gagatgtgtg aaagattcga tggtttgcta gatcgttttc gggttaatcc ctgaggaaaa
      241 acccgtttat cgacgtcgat cagcgggttg ggcggcgtgc ggtggagaaa ggggagtggt
      301 tggggctgaa gaacgagtgg gggaaggagg agaagcgata acaagaacga cgccgaaaaa
      361 aaagagagaa acggaaatcg gaacaccaag cgaagaaacg tatcgaattc gtattcttcg
      421 gaacgaaaga acaacaaatc agccgcaatg aagccaacct gcatattgtg tctcctggtg
      481 gtgatcctcc tgcatccgcg catctcaaaa tcctcaacga gcggcaaccc cagtgccagt
      541 tccagttcca gttctccgcc agaaatcccc gccttccggc aatgcgaaac cattcgcatt
      601 gagatgtgcc gcaagatcgg ctacaatgag acctccatgc caaatctggt gggtaacgaa
      661 atgcaaacgg acgtggagta cacactgcaa acctttgcac cactgatcga atacgactgc
      721 agttcccagt tgaagctgtt cctgtgcgcc gcctacgtgc ccatgtgcac gcccaaagct
      781 ccagtccatg ccatcggtcc gtgccggagt ctctgtgagt ccgtgcgaat acgttgtcat
      841 ccagttttgc agggattcgg atttccatgg ccaccggctc tcgactgcga taaatttccg
      901 cgagagaaca accacgagac gatgtgtatg gaaggtcccg gtgaattgca tcagccgcag
      961 caggagcagg atttgtatgg gctaccgggc caaggaatac ccggtggatt gggcggtaaa
     1021 ctgcccatgg attgctcggg actggccaaa tcgcatctgt acgtaaggct acccagatct
     1081 ggacgctgtg caccactctg cgaggcggac atactgttca caccggcgga gaagcatctg
     1141 gcagagatct gggtctccac atgggcctat gccgctttgg gtttggccct ggtagccacc
     1201 gtgtgtcttt tggccagcga tggcagtcgt ttggccagcg ccaagtggtc cagattgttg
     1261 tcgccgctga tttggtgcca caacatggtc accttgggct gggcagtgcg ctttatggtg
     1321 ggaagaacgg gaactgcgtg cggcacggat ccccaggcgc ccaatgaatc cctactcacc
     1381 gtggacggac tgtccaatgc ctcctgcgct agtgtcttcc ttatgcgcta ctattttgga
     1441 atggccgcct gcgcttggtg ggctgtgctc tgtttgggct ggcaccgcga cattcgtcgg
     1501 cacagtccgg actccaaggg ccatgtggtc attccctcga actttggagg cagtccggcg
     1561 aagaggaaca gtgccaagac ggctcagcag gatctaacgc aaaacaactt tgtgtgcttc
     1621 gtggcctggg gattgccggc ctttcaaacg tcagcagtga tcgttgcccg tttcgtggat
     1681 gctgacgagt tgcttggcgc ctgtttcgta ggcaatcagt cggataaggc gctacagata
     1741 ttggtggcta cgcccgtttt ttgctactgg atctttggct cgatgaatct gatctccggc
     1801 tatttggtac actgtcgcac caaggagatc ctgaggaata gcaatgcact cagcgtgcaa
     1861 cagcaactgc aacagctaag cgcacacagt agttccggca ttggcatatt ccttttcatc
     1921 tatggacttg catgtgccat gcttctgttg gctgtcattt acgagtttgc caacatcgat
     1981 gtctggctgg gatcgggtga taccaatacg ccactttggc catttttgtt gcgcgccttc
     2041 atggaactga tgctgggcat ttgctgtttt gcctgggtac ttggaccaag catttccact
     2101 ctctacaaga ggcaagtcag caatggcaaa atggtgaagc atacgtctgc cggagcagca
     2161 actggacacc tggacgggca tagtagctcg cgtggatcgc atgcggcttg caatagcacg
     2221 gtggtctcct accattcggt gcgaacttct atggccagtg ttccgttgcc gccaagtccg
     2281 tacaaactga agacttcgcc tggtaccggc tctatatcgc tgaatcagat gtccaactat
     2341 tcgctgggca ggagcgtgca tcaccagcag cgccattcgc cgcatcatca tcatcaccag
     2401 cagcagcagc atcatcagtt ccatccccac cacaatcacc agcatcactc cacatcctcg
     2461 catcggctgt attatccgcc aggtagctat gcctcgcaaa agtacagcca gcacggcagc
     2521 tactatcccc acttgcagca gtatggcaat gagacgctac tctagacgga attggattag
     2581 gtaccatttc agggcaggaa atgcttcctg cttccagtca atgttcctgc agcagctgct
     2641 gtgccaaagt caatcctcta ctataactta atgcggtttc gggtatcgaa agaggcaaag
     2701 caacttaaat gggtggggaa acggtccaat ttgtttgtca taaaacgatc gtgagataac
     2761 gatatcgtta tttcgatttt agttgctttg cctgtccata gaacacaatg gggtaaaccg
     2821 atctatgtac tgtgtatata accccggaaa tgtgctctta gtgctttagt ttgggccttt
     2881 atcgcgaggt cataggtcat ctacaatgta tttgtaattg ccctagatgg gcttcatatc
     2941 ctattttcct gtgtgtactt aatgttgctc ctaattagtt gccccttgcg ttgccttttt
     3001 accattttgg tgtaaccaaa ttcaataatc gctcttgcct tttagacatt aggacttaat
     3061 gtgtgtcgcc tttgcgtaca taacacatat atacatatat atatttagca tttttatata
     3121 aattcttttt ttttgagtta gagagagaga gaaacgcgca gcaaccaaat actgtgatac
     3181 gcatgttcat gtcttcaaaa acaaaaaaat aaaaatggga accagaaact aggtttccaa
     3241 ctttgctgtc ttctcccgat gccgaaacaa gtgtacttaa caatcgaaaa aaaaaaacgc
     3301 aattgcaatc gtagccgtaa tgcctaattg tattcagtgt gccattagct ttagggactt
     3361 aactgaaacg agtcaatatc atgaaattac cttaaaagag tccttttcca gcaacgaact
     3421 ttggcggaat tactgagggt tttccttcaa cttctgctga ttttcgcaca gaaaaagtcc
     3481 tacttctaaa tgtccaacta actagctaag aaactaacta acctttatac aattgcgggc
     3541 taatacgaat cgtatggagc ccgcgactaa cagtatatgt attgtattgt attgtatttt
     3601 atatgtgtat tttttttatt atcatatatg tatatgtata acttatttgc tagcgaataa
     3661 agtgtcgaaa agtt