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Drosophila melanogaster knockdown (kdn), transcript variant B,


LOCUS       NM_167072               2636 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_167072
VERSION     NM_167072.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 2636)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2636)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2636)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 2636)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 2636)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 2636)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 2636)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 2636)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 2636)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 2636)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 2636)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 2636)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 2636)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 2636)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 2636)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 2636)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 2636)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 2636)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 2636)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 2636)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 2636)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 2636)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 2636)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_167072.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2636
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..2636
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /note="knockdown"
                     /map="5F2-5F4"
                     /db_xref="FLYBASE:FBgn0261955"
                     /db_xref="GeneID:31579"
     CDS             108..1676
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /EC_number="2.3.3.-"
                     /EC_number="2.3.3.1"
                     /note="CG3861 gene product from transcript CG3861-RB;
                     CG3861-PB; kdn-PB; citrate synthase; lethal (1) G0030"
                     /codon_start=1
                     /product="knockdown, isoform B"
                     /protein_id="NP_727091.1"
                     /db_xref="FLYBASE:FBpp0070871"
                     /db_xref="GeneID:31579"
                     /db_xref="FLYBASE:FBgn0261955"
                     /translation="MFVRRFGNGSLGHHFAFQRRYLAKNSMWDSKSIGTPSSFRMRSK
                     KDNVTGNLKEQQQSATPETLNMPDMQDAQKLPNVGAYVRMIAADGKSLRDVLAAKVPQ
                     EQERVKNFRKQHGATKMGETTIDMMYGGMRGIKALVTETSVLDADEGIRFRGLSIPEC
                     QKVLPAADGGTEPLPEGLFWLLLTGEVPTKSQVQQLSREWAERAALPQHVVTMLNNMP
                     TTLHPMSQFAAAVTALNHDSKFAKAYSDGVHKSKYWEYVYEDSMDLIAKLPVVAATIY
                     CNTYRGGKGSRSIDSSLDWSANFVKMLGYDNAPFTELMRLYLTIHSDHEGGNVSAHTV
                     HLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLRKLQKEAGNNPSEEQLKEYIW
                     KTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPEDETFQLVSKIYKVVPPILTET
                     GKVKNPWPNVDAHSGVLLQYYGMKEMNYYTVLFGVSRALGVLASLVWDRALGLPIERP
                     KSFSTDLLVKMVQK"
     misc_feature    381..1664
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /note="Saccharomyces cerevisiae (Sc) citrate synthases
                     Cit1-2_like. Citrate synthases (CS) catalyzes the
                     condensation of acetyl coenzyme A (AcCoA) with
                     oxaloacetate (OAA) to form citrate and coenzyme A (CoA),
                     the first step in the citric acid cycle (TCA or...;
                     Region: ScCit1-2_like; cd06105"
                     /db_xref="CDD:99858"
     misc_feature    order(495..500,507..527,780..782,792..794,801..803,
                     1077..1079,1092..1094,1101..1106,1113..1118,1125..1133,
                     1143..1145,1164..1169,1176..1184,1326..1328,1617..1643)
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:99858"
     misc_feature    order(501..503,1077..1079,1089..1091,1179..1190,
                     1194..1196,1203..1205,1305..1328,1335..1337,1350..1352,
                     1473..1475,1482..1484,1488..1490,1554..1556,1566..1568,
                     1617..1619,1626..1628)
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /note="active site"
                     /db_xref="CDD:99858"
     misc_feature    order(501..503,1179..1187,1194..1196,1203..1205,
                     1305..1328,1335..1337,1473..1475,1482..1484,1488..1490,
                     1617..1619)
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /note="coenzyme A binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:99858"
     misc_feature    order(501..503,1077..1079,1089..1091,1182..1187,
                     1305..1310,1314..1328,1350..1352,1482..1484,1566..1568)
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /note="citrylCoA binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:99858"
     misc_feature    order(1077..1079,1089..1091,1185..1190,1323..1328,
                     1350..1352,1488..1490,1554..1556,1566..1568,1626..1628)
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /note="oxalacetate/citrate binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:99858"
     misc_feature    order(1185..1187,1323..1325,1488..1490)
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:99858"
ORIGIN      
        1 aataaatttt tgtatcctac atcactagct ttcacattcc caaaaacaag agaaaaagcg
       61 aactagaaac ttcgaaatat cgtatatatt tacagctaaa agtagtaatg ttcgtacgcc
      121 gtttcggaaa tggctctttg ggccatcatt ttgcctttca acgacgttat ttggctaaaa
      181 attctatgtg ggactcgaag tccattggga ctccaagttc attccgaatg cgttccaaaa
      241 aggataacgt gactggcaat ctcaaggagc agcaacaatc ggcgactccg gaaaccttga
      301 acatgcctga tatgcaggat gcccaaaaac tgccaaatgt gggagcctat gttcgcatga
      361 tcgccgccga tggcaagagc ctgcgcgacg tgctggccgc caaggtgccc caggagcagg
      421 agcgcgtaaa gaacttccgc aagcagcatg gcgccaccaa gatgggcgag acgaccatcg
      481 acatgatgta cggcggcatg cgcggcatca aggccctggt caccgagacc tcggtgctgg
      541 atgctgacga gggtatccgc ttccgcggcc tctccattcc cgagtgccaa aaggttctgc
      601 cagccgccga tggcggcact gagcccctgc ccgagggtct cttctggctg ctgttgaccg
      661 gcgaggtgcc caccaagtcc caggtgcagc agctgtcccg cgaatgggcc gagcgcgccg
      721 ccctgcccca gcacgtggtc accatgttga acaacatgcc caccaccctg cacccgatgt
      781 cgcagtttgc tgccgccgtc actgcgctga atcacgacag caaattcgcc aaggcatact
      841 cggatggtgt gcacaagagc aagtactggg agtacgtcta cgaggacagc atggacctga
      901 tcgccaagct cccagtggtg gcggccacca tctactgcaa cacctatcgc ggcggcaagg
      961 gctcccgttc gattgactcc agcctggatt ggtcggcgaa ctttgtgaag atgctcggct
     1021 acgacaacgc ccccttcacc gagctgatgc gtctctatct gaccatccac agtgaccacg
     1081 agggtggcaa cgtgtctgcc cacaccgttc acttggtggg ctccgccctc agcgatccct
     1141 acctctcctt tgccgccggc ctgaacggtc tggctggtcc cctgcacggc ctggccaacc
     1201 aggaggtgct cgtgtggctg cgcaagctgc agaaggaggc cggcaacaac ccgtcggagg
     1261 agcagctcaa ggagtacatc tggaagaccc tcaagtccgg acaggtggtt cccggctacg
     1321 gacacgccgt gctccgcaag accgatcccc gctacacctg ccagcgtgag ttcgcgctga
     1381 agcacctgcc cgaggacgag acgttccagc tggtgtcgaa gatctacaag gtggtgccac
     1441 caattctgac cgagaccggc aaggtgaaga acccctggcc caatgtagat gcccattccg
     1501 gtgtgctgct gcagtactac ggcatgaagg agatgaacta ctacaccgtg ttgttcggcg
     1561 tttcccgtgc cctcggcgtg ctggcctccc tcgtctggga tcgcgccctc ggcctgccca
     1621 tcgagcgccc caagtcattc tccaccgatc tgctggtcaa aatggtccag aagtaagcaa
     1681 ctggagcagg aggagcggga ggagctggag ttcaaccttt tgtagccgga ggacgatgga
     1741 cgtaaaatgc agaagctgta gattgtaatt gacgagggaa gaggcagaaa gagagagata
     1801 gagagagaga gagaatcgat cggattggat taggatgaga tgggattgga ttggatggat
     1861 atcgatatga cgacgctgat attgagggag ttggagatgt gtagttgagg agaagagcaa
     1921 ccaaatacga accaatagga caaaaacgaa aaccagaaga aaactgcaac acactgcaac
     1981 tgcaaaacaa taagttggaa ataaggcaga aacatatttt tagtagtaaa ataattaacg
     2041 aagggcaacc gacaagcaac cacttaatta tttgtataag ctatatatat atataaatat
     2101 atatatatat atatatatat atatatacga ttgactatat atatagggac aggcagagag
     2161 agtaaaatgt ttgcgcctat tgtttatgtt cagcatttcc cccacccgaa accgcccacg
     2221 atacccactc tttattaagt ttgttatgtt tatattttgt tcatcttagc cgatcgatgg
     2281 actaaccacg acacgacctt aatgatttat cccccaaaaa gcccgcccga cccaccagca
     2341 cccaccccgc ctgaaaaacc taaaaaaaaa ttactaactt gataacattt tacttttaat
     2401 ttaactataa tttattatgc aaacaagata caaacaaaca agtgtaaaga aaccaacaaa
     2461 aacatttgaa aaaaactcaa taaaaaaaca gaacaataaa taatataatg catagagagt
     2521 agttattgtc aactccacca gtggaagctg caaacgcgtt cgttcatcgc cgtgcaagtg
     2581 tattcgagaa agcaaaaccc acaataaatc ttagcaaact tgaatcgcag atcgtt