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LOCUS NM_167040 1933 bp mRNA linear INV 26-DEC-2023 (RhoGAP5A), transcript variant A, mRNA. ACCESSION NM_167040 VERSION NM_167040.4 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 1933) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 1933) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 1933) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 1933) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 1933) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 1933) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 1933) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 1933) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 1933) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 1933) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 1933) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 1933) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 1933) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 1933) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 1933) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 1933) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 1933) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 1933) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 1933) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 1933) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 1933) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 1933) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 1933) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_167040.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..1933 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..1933 /gene="RhoGAP5A" /locus_tag="Dmel_CG3208" /gene_synonym="CG3208; Dmel\CG3208; RhoGAP" /note="Rho GTPase activating protein at 5A" /map="5A8-5A8" /db_xref="FLYBASE:FBgn0029778" /db_xref="GeneID:31473" CDS 130..1614 /gene="RhoGAP5A" /locus_tag="Dmel_CG3208" /gene_synonym="CG3208; Dmel\CG3208; RhoGAP" /note="CG3208 gene product from transcript CG3208-RA; CG3208-PA; RhoGAP5A-PA" /codon_start=1 /product="Rho GTPase activating protein at 5A, isoform A" /protein_id="NP_727007.1" /db_xref="FLYBASE:FBpp0070751" /db_xref="GeneID:31473" /db_xref="FLYBASE:FBgn0029778" /translation="MPRNTEAGAGNANTGGSGGVGGAPEPSSPVQKVWKPELYKLQLE APAPCPLRCQRTLPLPPAKSTAEAVEANNLAGRLYGSEYHGLMGHLEAEQLLANARDG SYFVRRSPQSDGYYTLSLRFNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVADGLI NFHMQLHASPIIQQINQQTKNCYQQSPYMTLNGRKLRALSNELGKAAAKESKESPAEE KEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACG FVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGM LQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLI TFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKM NEHNLATVFAPTLIATPQHMTNLTEEIFMLSSLITHCKTIFATS" misc_feature 352..627 /gene="RhoGAP5A" /locus_tag="Dmel_CG3208" /gene_synonym="CG3208; Dmel\CG3208; RhoGAP" /note="Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins; Region: SH2_a2chimerin_b2chimerin; cd10352" /db_xref="CDD:198215" misc_feature order(394..396,448..450,511..513,517..519) /gene="RhoGAP5A" /locus_tag="Dmel_CG3208" /gene_synonym="CG3208; Dmel\CG3208; RhoGAP" /note="phosphotyrosine binding pocket [polypeptide binding]; other site" /db_xref="CDD:198215" misc_feature order(514..516,589..591) /gene="RhoGAP5A" /locus_tag="Dmel_CG3208" /gene_synonym="CG3208; Dmel\CG3208; RhoGAP" /note="hydrophobic binding pocket [polypeptide binding]; other site" /db_xref="CDD:198215" misc_feature 850..1008 /gene="RhoGAP5A" /locus_tag="Dmel_CG3208" /gene_synonym="CG3208; Dmel\CG3208; RhoGAP" /note="protein kinase C conserved region 1 (C1 domain) found in the chimaerin family; Region: C1_CHN; cd20806" /db_xref="CDD:410356" misc_feature order(868..888,910..924,931..933) /gene="RhoGAP5A" /locus_tag="Dmel_CG3208" /gene_synonym="CG3208; Dmel\CG3208; RhoGAP" /note="putative DAG/PE binding site [chemical binding]; other site" /db_xref="CDD:410356" misc_feature 1033..1602 /gene="RhoGAP5A" /locus_tag="Dmel_CG3208" /gene_synonym="CG3208; Dmel\CG3208; RhoGAP" /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms...; Region: RhoGAP_chimaerin; cd04372" /db_xref="CDD:239837" misc_feature order(1150..1152,1270..1272,1282..1284,1489..1491, 1498..1503,1558..1560) /gene="RhoGAP5A" /locus_tag="Dmel_CG3208" /gene_synonym="CG3208; Dmel\CG3208; RhoGAP" /note="putative GTPase interaction site [polypeptide binding]; other site" /db_xref="CDD:239837" misc_feature 1150..1152 /gene="RhoGAP5A" /locus_tag="Dmel_CG3208" /gene_synonym="CG3208; Dmel\CG3208; RhoGAP" /note="catalytic residue [active]" /db_xref="CDD:239837" ORIGIN 1 tcgccagtct ggcagctctg ctcgctcgga caaaattatt tgtatacttt acttaattgg 61 ctgcattcct taattattcg ccgcctactt agtggctttt gaccaagtgg cctgctaatc 121 cgagggagga tgccccggaa cacggaggcg ggcgccggaa atgcgaatac cggtggatcc 181 ggcggagtag gcggtgcccc cgagcccagt tctccggttc agaaggtttg gaagccggaa 241 ttgtacaaac tgcagctgga ggcaccggct ccatgtccac tgcgctgcca gcgaacactg 301 ccccttccgc cggcgaaaag cacggctgag gccgtggagg ccaataactt ggcgggcagg 361 ctatacggct ccgagtacca tggcctgatg ggccacctgg aggcggagca gctgctggcc 421 aatgcccgcg acggcagcta ctttgtacgc cggagccccc aatccgatgg ctactacacg 481 cttagcctgc gcttcaacaa gcgacccaag cactacaagc tcctctataa gcccggcgtg 541 ggacactatc tgcgcggcca ggacaagcgc ttcgacacgg tgcacgacat ggtcgccgac 601 gggctgatca actttcacat gcagctccac gccagtccca tcatccagca gattaaccag 661 cagaccaaga actgctacca gcaaagccca tacatgacct taaatggccg gaaacttagg 721 gctctgtcca atgagctggg caaggccgcc gccaaggaat cgaaggaatc gccagccgag 781 gagaaggagc agaagcagga ggagccaccg cctccagccg tggatcccat gccgctggtc 841 tacgagaagc cgcatcactt caaggtgcac acgtttaagg ggctcaattg gtgcgagttc 901 tgcgccaact tcttgtgggg attcaccgcc cagggcgtca agtgtgaggc gtgcggcttt 961 gtggcgcaca gcaagtgctc cgaactggtg ccgcccaagt gtgtgccgga tctgaagcgc 1021 atacgcggcg tatttggcac ggatctgacc acgatggtgc agctggagcc ccaccaccag 1081 atacccttcg tggtgcgccg ctgcgtggag gaggtggagg cccggggcat gctgcaggag 1141 ggtatctatc gggtctccgg ctttgccgat gagatcgagg cactcaaact cgccctggat 1201 cgcgagggcg agaagacgga catgtcggag acggcgtatg gcaatgtgaa tgtgatcgcc 1261 ggcacactga agctctacct gcgcctactg cccgtgccgc tcatcacatt ccaggcgtat 1321 cccagcttta tggcagcagg acgcaccggc aagcaggccg agcagcgcca gctcatggcg 1381 gaggcagtgc gtcgcctgcc gcccgcccac cacagctgtc tgcagtacat gctggagcac 1441 ctgaagcggg tggcctccca ctacgccgtt aacaagatga acgagcacaa tctggccacc 1501 gtatttgcgc cgaccctgat tgccacgccc cagcacatga ccaacctgac ggaggagatc 1561 tttatgctct cctcgctcat cacccactgc aagactatat tcgccacatc ctgaggacga 1621 ggtcatcata ccatgctgcc cataccaagc caataactaa ctttatcatc aattagagga 1681 gcacggccaa gcgaatcgcg tctgtgccca cctgtctctt tcgaagcgaa tccttaactt 1741 ccaccaaaaa aaaaaacttt agcctaagat caaaatcgat gatttttata caaacattta 1801 tatgaaaaaa aaaacaaatc aaccagtaga aaaaaacgaa tttagcgatt tttcgaaata 1861 tttttgcgct aattaaatat gcgtcacaat aaaaaaaagg atatttatta tacatatata 1921 caaatacaaa ttc