Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]

Drosophila melanogaster ubiquitin specific protease 16/45,


LOCUS       NM_167037               4117 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant D (Usp16-45), mRNA.
ACCESSION   NM_167037
VERSION     NM_167037.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4117)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4117)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4117)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4117)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4117)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4117)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4117)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4117)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4117)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4117)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4117)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4117)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4117)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4117)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4117)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4117)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4117)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4117)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4117)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4117)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4117)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4117)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4117)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_167037.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4117
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4117
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="Ubiquitin specific protease 16/45"
                     /map="4F10-4F10"
                     /db_xref="FLYBASE:FBgn0029763"
                     /db_xref="GeneID:31458"
     CDS             178..3558
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /EC_number="3.4.19.12"
                     /note="CG4165 gene product from transcript CG4165-RD;
                     CG4165-PD; Usp16-45-PD"
                     /codon_start=1
                     /product="ubiquitin specific protease 16/45, isoform D"
                     /protein_id="NP_726995.1"
                     /db_xref="FLYBASE:FBpp0070738"
                     /db_xref="GeneID:31458"
                     /db_xref="FLYBASE:FBgn0029763"
                     /translation="MVKKRQADSRDHDCSTDSGNEDLHHRKGLGSPGQSDGATPTTAS
                     CQHIKKAVDAARLRRLLKSTGLLYECSQCQKLGKTAGSAAGAGASEGAVGPGGNPVTF
                     EFDNTLWLCLKCGSQLCGRARHKHALEHYQTPHSDSHALAMNTRSFDIWCYECDMKIC
                     SNLRKNLLECVELVKKLAQKPPTSTVTPSTPTISYIEEKLKAALEHLTPIVPMTGGSF
                     DDSSSRGSLAAAGGGGGVGSSRNRQVAIPMPPPEPSSGLSTSDSLTSVPGMAKRIDQY
                     SATTNGNTGNKRLLTLETPRIENERLPRVRGLTNLGNTCFFNAVMQCLAQTPFLLSVL
                     KELSEPGEEFILPGGTFTIKDKGDIELPMIKGTLSSWGGLTAALANALEELQAGGSVF
                     TPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVRNEDLKRYQRVILQNLGYKDQDV
                     NSVSEEMRQKCKIYGNQAGDRILRPEQVFRGFLVSTLTCQDCHNVSSRHEYFLDMSLP
                     VAVEKPQPPQRRKPSPELSLTSSSSSVTPSTGQPTINTKFTDGSVNFTASSPSFFLHA
                     HEAASLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNGNDSGNGNELAESVDQDDAS
                     LASLGAGDGQANDGLEQTNGQTEDSTTSSVTTSEHSDADVEDNLVEDTAAPSTNNVPS
                     STASLTAPSKTYMDSNGNAQPPGEKRDDTPEHMDKDSLEEDENDSGIATSPAPTATNS
                     STSTSATGNNNSVAGSGLSGSSGALEDPLAPASLVTAGLSEKGASVIRQVSVGAEQGA
                     SNGTEDADGEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQSYSDWSTTIAPRYQCEDG
                     ECSVQSCLNNFTAVELMTGQNKVGCDSCTQRINGSDPKAKSVNTNATKQLLVSSPPAV
                     LILHLKRFQLGPRCIFRKLTRPVSYPNLLDIAAFCGSKVKNLPNIDRKQKKLLYALYG
                     VVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQLKKLEELLAKE
                     KAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLEEAAN
                     VRAPPGKWYYVSDSRVQEVSEDTALKAQAYLLFYERIY"
     misc_feature    499..654
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="Zn-finger in ubiquitin-hydrolases and other
                     protein; Region: zf-UBP; pfam02148"
                     /db_xref="CDD:460464"
     misc_feature    <1096..3147
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="Ubiquitin C-terminal hydrolase [Posttranslational
                     modification, protein turnover, chaperones]; Region:
                     UBP12; COG5560"
                     /db_xref="CDD:227847"
     misc_feature    1096..>1713
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    <2722..3546
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19K; cd02667"
                     /db_xref="CDD:239132"
ORIGIN      
        1 aagcaacggt cacacttggt cacgtcgttc acgttttcta tttacgcata aacgaataaa
       61 aagcgcctaa aagtgctata aaacatatat gttgtgtgct catgtgctac acatatcgca
      121 gcgagtaaat ttaagagcgc gcccacaagg aggccaaggc caagcagcta ccttgccatg
      181 gtaaagaagc gtcaggcgga cagtcgcgac cacgattgct caacggattc cggcaatgag
      241 gatctgcatc atcgaaaagg actcggctcg cccggtcagt cggatggcgc cacccccacc
      301 accgccagct gccagcacat caagaaggcg gtggacgcgg cccgactaag gcgtctactg
      361 aagtccacgg gtctactcta cgagtgcagc caatgtcaga agctgggcaa gacagcgggc
      421 agcgctgcgg gagcgggagc gagtgaagga gctgtcggtc ctggcggaaa tccggtcacc
      481 ttcgaatttg acaacaccct gtggctgtgc ctcaagtgcg gcagccagct gtgcgggagg
      541 gcacgccaca agcacgcctt agaacactac cagacacctc attcggactc acatgccctg
      601 gccatgaata cgcgctcctt cgacatctgg tgctatgagt gcgacatgaa gatctgctcc
      661 aatctgcgca aaaacctgct tgagtgcgtg gagctggtca agaaattggc ccagaagccg
      721 cccactagca cggttacgcc cagtacgcca acgattagct acatcgagga gaagcttaaa
      781 gccgcgctgg agcatctcac accaatagtg ccaatgactg gcggatcatt tgacgactcc
      841 agcagtagag ggtctctggc ggcggccggt ggcgggggcg gggtcggttc atctcgaaat
      901 aggcaggtgg ccataccgat gccaccacca gagcctagct ccggactttc gacctcagac
      961 tcgctgacca gtgtgccggg tatggcaaag agaattgacc agtactcggc caccaccaat
     1021 ggcaacactg ggaacaaacg actcctgacc ctagagacgc cgcgcatcga aaatgaacgc
     1081 ctgccccgcg tgcgaggatt gaccaacctg ggcaatacat gcttctttaa tgcggtgatg
     1141 cagtgcctcg cccagacgcc gttcctactt agcgtactga aagaactgtc ggagcccgga
     1201 gaagaattca tcttacctgg cggaacgttc accataaagg acaaaggtga cattgagctg
     1261 ccgatgatca agggtaccct gtcctcttgg ggtggactca cggccgcgtt agccaatgcc
     1321 cttgaggaac tgcaggctgg cggtagtgta tttacgccca gaaaactctt cgacaggctg
     1381 tgcgtaaagt gtcctcagtt tacgggcggc gatcagcatg atgctcacga actgctgcgc
     1441 cagctactgg agagcgtgcg gaacgaggac ctaaagcgct accagcgtgt aattctgcag
     1501 aacctcggct acaaggatca ggatgtaaat agtgtgtcag aggagatgcg acaaaagtgc
     1561 aagatctatg gcaatcaagc aggagaccga attctgcgcc cggaacaggt attccgtggc
     1621 tttcttgtgt caacgctcac ctgccaggat tgtcacaatg tttcctcgcg gcacgagtac
     1681 ttcctggaca tgtcgctgcc cgtggccgta gagaaacctc agccgccgca gcgccgaaag
     1741 ccaagtccgg agctcagtct tacgtccagc agctctagcg tcaccccgag cactggccag
     1801 ccgacgataa acaccaagtt tacggatggt agtgtcaact ttacagcctc atccccgtcc
     1861 ttcttcctgc acgcccatga ggcggcatcc ctgggcccat ccaagtcgca ggtgaaaaag
     1921 gagaaggagc gacagcgtaa ggcgaagcgg gcggccaaga agcgtcagaa gtctagcctt
     1981 aatctgaacg gaaatgatag cggaaatggc aatgaattgg ccgagtccgt agaccaggac
     2041 gatgcctcat tggcttccct gggtgccggc gacggccagg ccaatgatgg cctcgaacag
     2101 accaacggcc agaccgagga ttccaccacc tccagcgtga ctacttcgga gcactccgac
     2161 gccgatgttg aggacaatct ggtggaggat acagccgcgc cgtccactaa taatgtgccg
     2221 agcagtacgg catccttgac agctccctcc aagacctaca tggacagcaa tggcaatgcc
     2281 cagccgccgg gggagaagcg cgacgatacg ccggagcaca tggacaagga ttcgctcgaa
     2341 gaggacgaga atgactcggg aatcgccacc agtccagcac caactgctac caacagcagc
     2401 accagtacca gtgccacagg gaacaataac tctgttgccg gatcggggct gtccggttca
     2461 tcgggcgctc tggaggatcc cttggcgcca gccagcttgg tcactgccgg actctcagag
     2521 aagggcgcct cggtgatccg ccaggtctcg gtgggagctg agcagggcgc atccaatggc
     2581 acagaagacg cggatggcga agccaaggca atcgagcagc cagagaagac tcctagccaa
     2641 gctcaagcca tggctcaggc ccaggcccgt acgaagcgag tgcgcacgca aagctactcg
     2701 gactggagca ccacgatagc gccgcgctac cagtgcgagg atggagagtg ctccgtgcag
     2761 tcgtgcctca ataatttcac cgctgtcgag ctgatgacgg gacagaacaa ggtgggatgc
     2821 gatagctgca cgcagcgcat taacggcagt gatccgaagg ccaagtcggt gaacaccaat
     2881 gccacgaaac agctgctggt ctccagtccg ccagcggtgc tcatactaca cctgaagcgt
     2941 tttcagctgg gaccgcgctg catcttccgc aagctgacgc gcccggttag ctatcccaat
     3001 ctgctggaca ttgccgcctt ttgtgggtcc aaggtcaaga atctgccgaa catcgatcgc
     3061 aagcagaaga agctgttgta cgcgctatat ggcgtagtgg agcactcggg cggcatgtac
     3121 ggtggccact atacggcgta cgtgaaggtg cgtccaaagg tggcgccggg cgacaaacgc
     3181 tggaagttcc tgccgcatgg cagcaaggcg gaattggacc aggacgatga ccaactaaaa
     3241 aaactggagg agctgcttgc caaggagaag gcgcgcgagc agcacctgaa ggtgttggac
     3301 gacagcgatg actttagcaa ctccagcagc aactcgtcca cctccgacga gagccagacc
     3361 ccagccacgc cactggagga gcaacagacg cagcaggcgc agcagccgca gcagccgcag
     3421 cagctggagg aggctgccaa cgttcgtgcg ccgcctggca aatggtatta cgtgtccgac
     3481 tcgcgtgtcc aggaggtcag cgaggatacg gcgctgaagg cgcaggccta tctgcttttc
     3541 tacgaacgca tatactaggg attagctcga gctttaagcg gaactgagga tgcgaggcgt
     3601 atggaagaaa attttggaat cctatatttg atacagacag agtgccggag aaagagaagg
     3661 cagatactca cacatgccaa atgcatttgg tttctcccac tcaaaattaa ttgtacactt
     3721 tcgctatttt tattattatt attttttttt tttggaacaa gctttagtta gttaaatgat
     3781 gcaaaggagt agacacacgc actcatgtta aattgtagtt ctcaggaggt ttgctattat
     3841 gtcctcgatt taattgtact atttttttag tcattaacaa aaagacactg aagagaaaat
     3901 tatgttttat tagctgtaag ttcttttgtt accaaaattg cccattatga cagaaagtta
     3961 cttaaacata ctcgagttgg gggttaaaaa aatggatcga aaggaaaaga cagaccgcag
     4021 aatggatagc taaaaacgga taagcacaaa tgaaatggag gcggttaacc aagagagaaa
     4081 ctatttgcag atgttcataa gttataataa cgaatac