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Drosophila melanogaster ubiquitin specific protease 16/45,


LOCUS       NM_167036               4093 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant E (Usp16-45), mRNA.
ACCESSION   NM_167036
VERSION     NM_167036.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4093)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4093)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4093)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4093)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4093)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4093)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4093)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4093)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4093)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4093)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4093)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4093)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4093)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4093)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4093)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4093)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4093)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4093)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4093)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4093)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4093)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4093)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4093)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_167036.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4093
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4093
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="Ubiquitin specific protease 16/45"
                     /map="4F10-4F10"
                     /db_xref="FLYBASE:FBgn0029763"
                     /db_xref="GeneID:31458"
     CDS             154..3534
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /EC_number="3.4.19.12"
                     /note="CG4165 gene product from transcript CG4165-RE;
                     CG4165-PE; Usp16-45-PE"
                     /codon_start=1
                     /product="ubiquitin specific protease 16/45, isoform E"
                     /protein_id="NP_726994.1"
                     /db_xref="FLYBASE:FBpp0309403"
                     /db_xref="GeneID:31458"
                     /db_xref="FLYBASE:FBgn0029763"
                     /translation="MVKKRQADSRDHDCSTDSGNEDLHHRKGLGSPGQSDGATPTTAS
                     CQHIKKAVDAARLRRLLKSTGLLYECSQCQKLGKTAGSAAGAGASEGAVGPGGNPVTF
                     EFDNTLWLCLKCGSQLCGRARHKHALEHYQTPHSDSHALAMNTRSFDIWCYECDMKIC
                     SNLRKNLLECVELVKKLAQKPPTSTVTPSTPTISYIEEKLKAALEHLTPIVPMTGGSF
                     DDSSSRGSLAAAGGGGGVGSSRNRQVAIPMPPPEPSSGLSTSDSLTSVPGMAKRIDQY
                     SATTNGNTGNKRLLTLETPRIENERLPRVRGLTNLGNTCFFNAVMQCLAQTPFLLSVL
                     KELSEPGEEFILPGGTFTIKDKGDIELPMIKGTLSSWGGLTAALANALEELQAGGSVF
                     TPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVRNEDLKRYQRVILQNLGYKDQDV
                     NSVSEEMRQKCKIYGNQAGDRILRPEQVFRGFLVSTLTCQDCHNVSSRHEYFLDMSLP
                     VAVEKPQPPQRRKPSPELSLTSSSSSVTPSTGQPTINTKFTDGSVNFTASSPSFFLHA
                     HEAASLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNGNDSGNGNELAESVDQDDAS
                     LASLGAGDGQANDGLEQTNGQTEDSTTSSVTTSEHSDADVEDNLVEDTAAPSTNNVPS
                     STASLTAPSKTYMDSNGNAQPPGEKRDDTPEHMDKDSLEEDENDSGIATSPAPTATNS
                     STSTSATGNNNSVAGSGLSGSSGALEDPLAPASLVTAGLSEKGASVIRQVSVGAEQGA
                     SNGTEDADGEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQSYSDWSTTIAPRYQCEDG
                     ECSVQSCLNNFTAVELMTGQNKVGCDSCTQRINGSDPKAKSVNTNATKQLLVSSPPAV
                     LILHLKRFQLGPRCIFRKLTRPVSYPNLLDIAAFCGSKVKNLPNIDRKQKKLLYALYG
                     VVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQLKKLEELLAKE
                     KAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLEEAAN
                     VRAPPGKWYYVSDSRVQEVSEDTALKAQAYLLFYERIY"
     misc_feature    475..630
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="Zn-finger in ubiquitin-hydrolases and other
                     protein; Region: zf-UBP; pfam02148"
                     /db_xref="CDD:460464"
     misc_feature    <1072..3123
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="Ubiquitin C-terminal hydrolase [Posttranslational
                     modification, protein turnover, chaperones]; Region:
                     UBP12; COG5560"
                     /db_xref="CDD:227847"
     misc_feature    1072..>1689
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    <2698..3522
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19K; cd02667"
                     /db_xref="CDD:239132"
ORIGIN      
        1 aacaaagcaa acaaagccaa tagggtcagt ctgtcggtgc gagttccaat cgaattcaat
       61 cccgttgcca gttatacaca tcgatagccg aatcggaaga gcagcagcag gagcgcgccc
      121 acaaggaggc caaggccaag cagctacctt gccatggtaa agaagcgtca ggcggacagt
      181 cgcgaccacg attgctcaac ggattccggc aatgaggatc tgcatcatcg aaaaggactc
      241 ggctcgcccg gtcagtcgga tggcgccacc cccaccaccg ccagctgcca gcacatcaag
      301 aaggcggtgg acgcggcccg actaaggcgt ctactgaagt ccacgggtct actctacgag
      361 tgcagccaat gtcagaagct gggcaagaca gcgggcagcg ctgcgggagc gggagcgagt
      421 gaaggagctg tcggtcctgg cggaaatccg gtcaccttcg aatttgacaa caccctgtgg
      481 ctgtgcctca agtgcggcag ccagctgtgc gggagggcac gccacaagca cgccttagaa
      541 cactaccaga cacctcattc ggactcacat gccctggcca tgaatacgcg ctccttcgac
      601 atctggtgct atgagtgcga catgaagatc tgctccaatc tgcgcaaaaa cctgcttgag
      661 tgcgtggagc tggtcaagaa attggcccag aagccgccca ctagcacggt tacgcccagt
      721 acgccaacga ttagctacat cgaggagaag cttaaagccg cgctggagca tctcacacca
      781 atagtgccaa tgactggcgg atcatttgac gactccagca gtagagggtc tctggcggcg
      841 gccggtggcg ggggcggggt cggttcatct cgaaataggc aggtggccat accgatgcca
      901 ccaccagagc ctagctccgg actttcgacc tcagactcgc tgaccagtgt gccgggtatg
      961 gcaaagagaa ttgaccagta ctcggccacc accaatggca acactgggaa caaacgactc
     1021 ctgaccctag agacgccgcg catcgaaaat gaacgcctgc cccgcgtgcg aggattgacc
     1081 aacctgggca atacatgctt ctttaatgcg gtgatgcagt gcctcgccca gacgccgttc
     1141 ctacttagcg tactgaaaga actgtcggag cccggagaag aattcatctt acctggcgga
     1201 acgttcacca taaaggacaa aggtgacatt gagctgccga tgatcaaggg taccctgtcc
     1261 tcttggggtg gactcacggc cgcgttagcc aatgcccttg aggaactgca ggctggcggt
     1321 agtgtattta cgcccagaaa actcttcgac aggctgtgcg taaagtgtcc tcagtttacg
     1381 ggcggcgatc agcatgatgc tcacgaactg ctgcgccagc tactggagag cgtgcggaac
     1441 gaggacctaa agcgctacca gcgtgtaatt ctgcagaacc tcggctacaa ggatcaggat
     1501 gtaaatagtg tgtcagagga gatgcgacaa aagtgcaaga tctatggcaa tcaagcagga
     1561 gaccgaattc tgcgcccgga acaggtattc cgtggctttc ttgtgtcaac gctcacctgc
     1621 caggattgtc acaatgtttc ctcgcggcac gagtacttcc tggacatgtc gctgcccgtg
     1681 gccgtagaga aacctcagcc gccgcagcgc cgaaagccaa gtccggagct cagtcttacg
     1741 tccagcagct ctagcgtcac cccgagcact ggccagccga cgataaacac caagtttacg
     1801 gatggtagtg tcaactttac agcctcatcc ccgtccttct tcctgcacgc ccatgaggcg
     1861 gcatccctgg gcccatccaa gtcgcaggtg aaaaaggaga aggagcgaca gcgtaaggcg
     1921 aagcgggcgg ccaagaagcg tcagaagtct agccttaatc tgaacggaaa tgatagcgga
     1981 aatggcaatg aattggccga gtccgtagac caggacgatg cctcattggc ttccctgggt
     2041 gccggcgacg gccaggccaa tgatggcctc gaacagacca acggccagac cgaggattcc
     2101 accacctcca gcgtgactac ttcggagcac tccgacgccg atgttgagga caatctggtg
     2161 gaggatacag ccgcgccgtc cactaataat gtgccgagca gtacggcatc cttgacagct
     2221 ccctccaaga cctacatgga cagcaatggc aatgcccagc cgccggggga gaagcgcgac
     2281 gatacgccgg agcacatgga caaggattcg ctcgaagagg acgagaatga ctcgggaatc
     2341 gccaccagtc cagcaccaac tgctaccaac agcagcacca gtaccagtgc cacagggaac
     2401 aataactctg ttgccggatc ggggctgtcc ggttcatcgg gcgctctgga ggatcccttg
     2461 gcgccagcca gcttggtcac tgccggactc tcagagaagg gcgcctcggt gatccgccag
     2521 gtctcggtgg gagctgagca gggcgcatcc aatggcacag aagacgcgga tggcgaagcc
     2581 aaggcaatcg agcagccaga gaagactcct agccaagctc aagccatggc tcaggcccag
     2641 gcccgtacga agcgagtgcg cacgcaaagc tactcggact ggagcaccac gatagcgccg
     2701 cgctaccagt gcgaggatgg agagtgctcc gtgcagtcgt gcctcaataa tttcaccgct
     2761 gtcgagctga tgacgggaca gaacaaggtg ggatgcgata gctgcacgca gcgcattaac
     2821 ggcagtgatc cgaaggccaa gtcggtgaac accaatgcca cgaaacagct gctggtctcc
     2881 agtccgccag cggtgctcat actacacctg aagcgttttc agctgggacc gcgctgcatc
     2941 ttccgcaagc tgacgcgccc ggttagctat cccaatctgc tggacattgc cgccttttgt
     3001 gggtccaagg tcaagaatct gccgaacatc gatcgcaagc agaagaagct gttgtacgcg
     3061 ctatatggcg tagtggagca ctcgggcggc atgtacggtg gccactatac ggcgtacgtg
     3121 aaggtgcgtc caaaggtggc gccgggcgac aaacgctgga agttcctgcc gcatggcagc
     3181 aaggcggaat tggaccagga cgatgaccaa ctaaaaaaac tggaggagct gcttgccaag
     3241 gagaaggcgc gcgagcagca cctgaaggtg ttggacgaca gcgatgactt tagcaactcc
     3301 agcagcaact cgtccacctc cgacgagagc cagaccccag ccacgccact ggaggagcaa
     3361 cagacgcagc aggcgcagca gccgcagcag ccgcagcagc tggaggaggc tgccaacgtt
     3421 cgtgcgccgc ctggcaaatg gtattacgtg tccgactcgc gtgtccagga ggtcagcgag
     3481 gatacggcgc tgaaggcgca ggcctatctg cttttctacg aacgcatata ctagggatta
     3541 gctcgagctt taagcggaac tgaggatgcg aggcgtatgg aagaaaattt tggaatccta
     3601 tatttgatac agacagagtg ccggagaaag agaaggcaga tactcacaca tgccaaatgc
     3661 atttggtttc tcccactcaa aattaattgt acactttcgc tatttttatt attattattt
     3721 tttttttttg gaacaagctt tagttagtta aatgatgcaa aggagtagac acacgcactc
     3781 atgttaaatt gtagttctca ggaggtttgc tattatgtcc tcgatttaat tgtactattt
     3841 ttttagtcat taacaaaaag acactgaaga gaaaattatg ttttattagc tgtaagttct
     3901 tttgttacca aaattgccca ttatgacaga aagttactta aacatactcg agttgggggt
     3961 taaaaaaatg gatcgaaagg aaaagacaga ccgcagaatg gatagctaaa aacggataag
     4021 cacaaatgaa atggaggcgg ttaaccaaga gagaaactat ttgcagatgt tcataagtta
     4081 taataacgaa tac