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Drosophila melanogaster ubiquitin specific protease 16/45,


LOCUS       NM_167035               4066 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant B (Usp16-45), mRNA.
ACCESSION   NM_167035
VERSION     NM_167035.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4066)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4066)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4066)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4066)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4066)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4066)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4066)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4066)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4066)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4066)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4066)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4066)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4066)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4066)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4066)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4066)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4066)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4066)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4066)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4066)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4066)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4066)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4066)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_167035.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4066
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4066
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="Ubiquitin specific protease 16/45"
                     /map="4F10-4F10"
                     /db_xref="FLYBASE:FBgn0029763"
                     /db_xref="GeneID:31458"
     CDS             127..3507
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /EC_number="3.4.19.12"
                     /note="CG4165 gene product from transcript CG4165-RB;
                     CG4165-PB; Usp16-45-PB"
                     /codon_start=1
                     /product="ubiquitin specific protease 16/45, isoform B"
                     /protein_id="NP_726993.1"
                     /db_xref="FLYBASE:FBpp0070741"
                     /db_xref="GeneID:31458"
                     /db_xref="FLYBASE:FBgn0029763"
                     /translation="MVKKRQADSRDHDCSTDSGNEDLHHRKGLGSPGQSDGATPTTAS
                     CQHIKKAVDAARLRRLLKSTGLLYECSQCQKLGKTAGSAAGAGASEGAVGPGGNPVTF
                     EFDNTLWLCLKCGSQLCGRARHKHALEHYQTPHSDSHALAMNTRSFDIWCYECDMKIC
                     SNLRKNLLECVELVKKLAQKPPTSTVTPSTPTISYIEEKLKAALEHLTPIVPMTGGSF
                     DDSSSRGSLAAAGGGGGVGSSRNRQVAIPMPPPEPSSGLSTSDSLTSVPGMAKRIDQY
                     SATTNGNTGNKRLLTLETPRIENERLPRVRGLTNLGNTCFFNAVMQCLAQTPFLLSVL
                     KELSEPGEEFILPGGTFTIKDKGDIELPMIKGTLSSWGGLTAALANALEELQAGGSVF
                     TPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVRNEDLKRYQRVILQNLGYKDQDV
                     NSVSEEMRQKCKIYGNQAGDRILRPEQVFRGFLVSTLTCQDCHNVSSRHEYFLDMSLP
                     VAVEKPQPPQRRKPSPELSLTSSSSSVTPSTGQPTINTKFTDGSVNFTASSPSFFLHA
                     HEAASLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNGNDSGNGNELAESVDQDDAS
                     LASLGAGDGQANDGLEQTNGQTEDSTTSSVTTSEHSDADVEDNLVEDTAAPSTNNVPS
                     STASLTAPSKTYMDSNGNAQPPGEKRDDTPEHMDKDSLEEDENDSGIATSPAPTATNS
                     STSTSATGNNNSVAGSGLSGSSGALEDPLAPASLVTAGLSEKGASVIRQVSVGAEQGA
                     SNGTEDADGEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQSYSDWSTTIAPRYQCEDG
                     ECSVQSCLNNFTAVELMTGQNKVGCDSCTQRINGSDPKAKSVNTNATKQLLVSSPPAV
                     LILHLKRFQLGPRCIFRKLTRPVSYPNLLDIAAFCGSKVKNLPNIDRKQKKLLYALYG
                     VVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQLKKLEELLAKE
                     KAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLEEAAN
                     VRAPPGKWYYVSDSRVQEVSEDTALKAQAYLLFYERIY"
     misc_feature    448..603
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="Zn-finger in ubiquitin-hydrolases and other
                     protein; Region: zf-UBP; pfam02148"
                     /db_xref="CDD:460464"
     misc_feature    <1045..3096
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="Ubiquitin C-terminal hydrolase [Posttranslational
                     modification, protein turnover, chaperones]; Region:
                     UBP12; COG5560"
                     /db_xref="CDD:227847"
     misc_feature    1045..>1662
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    <2671..3495
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19K; cd02667"
                     /db_xref="CDD:239132"
ORIGIN      
        1 gtgtgcgtgc gtatgggctt gattggttgg gtgcgtgtat gagttcgggg tcctttggat
       61 tttcgagaaa tcatcgcaaa aaggagcgcg cccacaagga ggccaaggcc aagcagctac
      121 cttgccatgg taaagaagcg tcaggcggac agtcgcgacc acgattgctc aacggattcc
      181 ggcaatgagg atctgcatca tcgaaaagga ctcggctcgc ccggtcagtc ggatggcgcc
      241 acccccacca ccgccagctg ccagcacatc aagaaggcgg tggacgcggc ccgactaagg
      301 cgtctactga agtccacggg tctactctac gagtgcagcc aatgtcagaa gctgggcaag
      361 acagcgggca gcgctgcggg agcgggagcg agtgaaggag ctgtcggtcc tggcggaaat
      421 ccggtcacct tcgaatttga caacaccctg tggctgtgcc tcaagtgcgg cagccagctg
      481 tgcgggaggg cacgccacaa gcacgcctta gaacactacc agacacctca ttcggactca
      541 catgccctgg ccatgaatac gcgctccttc gacatctggt gctatgagtg cgacatgaag
      601 atctgctcca atctgcgcaa aaacctgctt gagtgcgtgg agctggtcaa gaaattggcc
      661 cagaagccgc ccactagcac ggttacgccc agtacgccaa cgattagcta catcgaggag
      721 aagcttaaag ccgcgctgga gcatctcaca ccaatagtgc caatgactgg cggatcattt
      781 gacgactcca gcagtagagg gtctctggcg gcggccggtg gcgggggcgg ggtcggttca
      841 tctcgaaata ggcaggtggc cataccgatg ccaccaccag agcctagctc cggactttcg
      901 acctcagact cgctgaccag tgtgccgggt atggcaaaga gaattgacca gtactcggcc
      961 accaccaatg gcaacactgg gaacaaacga ctcctgaccc tagagacgcc gcgcatcgaa
     1021 aatgaacgcc tgccccgcgt gcgaggattg accaacctgg gcaatacatg cttctttaat
     1081 gcggtgatgc agtgcctcgc ccagacgccg ttcctactta gcgtactgaa agaactgtcg
     1141 gagcccggag aagaattcat cttacctggc ggaacgttca ccataaagga caaaggtgac
     1201 attgagctgc cgatgatcaa gggtaccctg tcctcttggg gtggactcac ggccgcgtta
     1261 gccaatgccc ttgaggaact gcaggctggc ggtagtgtat ttacgcccag aaaactcttc
     1321 gacaggctgt gcgtaaagtg tcctcagttt acgggcggcg atcagcatga tgctcacgaa
     1381 ctgctgcgcc agctactgga gagcgtgcgg aacgaggacc taaagcgcta ccagcgtgta
     1441 attctgcaga acctcggcta caaggatcag gatgtaaata gtgtgtcaga ggagatgcga
     1501 caaaagtgca agatctatgg caatcaagca ggagaccgaa ttctgcgccc ggaacaggta
     1561 ttccgtggct ttcttgtgtc aacgctcacc tgccaggatt gtcacaatgt ttcctcgcgg
     1621 cacgagtact tcctggacat gtcgctgccc gtggccgtag agaaacctca gccgccgcag
     1681 cgccgaaagc caagtccgga gctcagtctt acgtccagca gctctagcgt caccccgagc
     1741 actggccagc cgacgataaa caccaagttt acggatggta gtgtcaactt tacagcctca
     1801 tccccgtcct tcttcctgca cgcccatgag gcggcatccc tgggcccatc caagtcgcag
     1861 gtgaaaaagg agaaggagcg acagcgtaag gcgaagcggg cggccaagaa gcgtcagaag
     1921 tctagcctta atctgaacgg aaatgatagc ggaaatggca atgaattggc cgagtccgta
     1981 gaccaggacg atgcctcatt ggcttccctg ggtgccggcg acggccaggc caatgatggc
     2041 ctcgaacaga ccaacggcca gaccgaggat tccaccacct ccagcgtgac tacttcggag
     2101 cactccgacg ccgatgttga ggacaatctg gtggaggata cagccgcgcc gtccactaat
     2161 aatgtgccga gcagtacggc atccttgaca gctccctcca agacctacat ggacagcaat
     2221 ggcaatgccc agccgccggg ggagaagcgc gacgatacgc cggagcacat ggacaaggat
     2281 tcgctcgaag aggacgagaa tgactcggga atcgccacca gtccagcacc aactgctacc
     2341 aacagcagca ccagtaccag tgccacaggg aacaataact ctgttgccgg atcggggctg
     2401 tccggttcat cgggcgctct ggaggatccc ttggcgccag ccagcttggt cactgccgga
     2461 ctctcagaga agggcgcctc ggtgatccgc caggtctcgg tgggagctga gcagggcgca
     2521 tccaatggca cagaagacgc ggatggcgaa gccaaggcaa tcgagcagcc agagaagact
     2581 cctagccaag ctcaagccat ggctcaggcc caggcccgta cgaagcgagt gcgcacgcaa
     2641 agctactcgg actggagcac cacgatagcg ccgcgctacc agtgcgagga tggagagtgc
     2701 tccgtgcagt cgtgcctcaa taatttcacc gctgtcgagc tgatgacggg acagaacaag
     2761 gtgggatgcg atagctgcac gcagcgcatt aacggcagtg atccgaaggc caagtcggtg
     2821 aacaccaatg ccacgaaaca gctgctggtc tccagtccgc cagcggtgct catactacac
     2881 ctgaagcgtt ttcagctggg accgcgctgc atcttccgca agctgacgcg cccggttagc
     2941 tatcccaatc tgctggacat tgccgccttt tgtgggtcca aggtcaagaa tctgccgaac
     3001 atcgatcgca agcagaagaa gctgttgtac gcgctatatg gcgtagtgga gcactcgggc
     3061 ggcatgtacg gtggccacta tacggcgtac gtgaaggtgc gtccaaaggt ggcgccgggc
     3121 gacaaacgct ggaagttcct gccgcatggc agcaaggcgg aattggacca ggacgatgac
     3181 caactaaaaa aactggagga gctgcttgcc aaggagaagg cgcgcgagca gcacctgaag
     3241 gtgttggacg acagcgatga ctttagcaac tccagcagca actcgtccac ctccgacgag
     3301 agccagaccc cagccacgcc actggaggag caacagacgc agcaggcgca gcagccgcag
     3361 cagccgcagc agctggagga ggctgccaac gttcgtgcgc cgcctggcaa atggtattac
     3421 gtgtccgact cgcgtgtcca ggaggtcagc gaggatacgg cgctgaaggc gcaggcctat
     3481 ctgcttttct acgaacgcat atactaggga ttagctcgag ctttaagcgg aactgaggat
     3541 gcgaggcgta tggaagaaaa ttttggaatc ctatatttga tacagacaga gtgccggaga
     3601 aagagaaggc agatactcac acatgccaaa tgcatttggt ttctcccact caaaattaat
     3661 tgtacacttt cgctattttt attattatta tttttttttt ttggaacaag ctttagttag
     3721 ttaaatgatg caaaggagta gacacacgca ctcatgttaa attgtagttc tcaggaggtt
     3781 tgctattatg tcctcgattt aattgtacta tttttttagt cattaacaaa aagacactga
     3841 agagaaaatt atgttttatt agctgtaagt tcttttgtta ccaaaattgc ccattatgac
     3901 agaaagttac ttaaacatac tcgagttggg ggttaaaaaa atggatcgaa aggaaaagac
     3961 agaccgcaga atggatagct aaaaacggat aagcacaaat gaaatggagg cggttaacca
     4021 agagagaaac tatttgcaga tgttcataag ttataataac gaatac