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Drosophila melanogaster pyruvate dehydrogenase E1 alpha subunit,


LOCUS       NM_167019               1992 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant B (Pdha), mRNA.
ACCESSION   NM_167019
VERSION     NM_167019.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 1992)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1992)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1992)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 1992)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 1992)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 1992)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 1992)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 1992)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 1992)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 1992)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 1992)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 1992)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 1992)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 1992)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 1992)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 1992)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 1992)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 1992)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 1992)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 1992)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 1992)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 1992)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 1992)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_167019.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1992
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..1992
                     /gene="Pdha"
                     /locus_tag="Dmel_CG7010"
                     /gene_synonym="CG 7010; CG7010; Dmel\CG7010; E1-PDH; l (1)
                     G0334; l(1)G0334; L(1)g0334; L(1)G0334; Pdh; PDH; PDH-E1;
                     pdha; PDHA1; PDHalpha; Pdha[KK101856]; PDHE1"
                     /note="Pyruvate dehydrogenase E1 alpha subunit"
                     /map="4C14-4C14"
                     /db_xref="FLYBASE:FBgn0028325"
                     /db_xref="GeneID:31406"
     CDS             653..1639
                     /gene="Pdha"
                     /locus_tag="Dmel_CG7010"
                     /gene_synonym="CG 7010; CG7010; Dmel\CG7010; E1-PDH; l (1)
                     G0334; l(1)G0334; L(1)g0334; L(1)G0334; Pdh; PDH; PDH-E1;
                     pdha; PDHA1; PDHalpha; Pdha[KK101856]; PDHE1"
                     /EC_number="1.2.4.-"
                     /EC_number="1.2.4.1"
                     /note="CG7010 gene product from transcript CG7010-RB;
                     CG7010-PB; Pdha-PB; l(1)G0334; PDH complex; pyruvate
                     dehydrogenase; lethal (1) G0334"
                     /codon_start=1
                     /product="pyruvate dehydrogenase E1 alpha subunit, isoform
                     B"
                     /protein_id="NP_726947.1"
                     /db_xref="FLYBASE:FBpp0070678"
                     /db_xref="GeneID:31406"
                     /db_xref="FLYBASE:FBgn0028325"
                     /translation="MQTIRRLETAAGNLYKEKIIRGFCHLYSGQEACAVGMKAAMRDV
                     DNIISAYRVHGWTYLMGVSPSGVLAELTGVQGGCARGKGGSMHMYAPNFYGGNGIVGA
                     QVPLGAGVGLACKYKGNGGMCLALYGDGAANQGQVFEAYNMAYLWKLPVIFVCENNNY
                     GMGTSSERASCNTDYYTRGDALPGIWVDGMDVLAVRSATEFAINYVNTHGPLVMETNT
                     YRYSGHSMSDPGTSYRTREEIQEVRQKRDPITSFKELCIELGLITTDEVKAIDLKVRK
                     EVDEATAFAKSDAELGVSHLWTDVYSNNLEPKLRGTIAYDIDHIQERKGVNH"
     misc_feature    653..1585
                     /gene="Pdha"
                     /locus_tag="Dmel_CG7010"
                     /gene_synonym="CG 7010; CG7010; Dmel\CG7010; E1-PDH; l (1)
                     G0334; l(1)G0334; L(1)g0334; L(1)G0334; Pdh; PDH; PDH-E1;
                     pdha; PDHA1; PDHalpha; Pdha[KK101856]; PDHE1"
                     /note="Thiamine pyrophosphate (TPP) enzyme family,
                     TPP-binding module; found in many key metabolic enzymes
                     which use TPP (also known as thiamine diphosphate) as a
                     cofactor. These enzymes include, among others, the E1
                     components of the pyruvate, the acetoin and...; Region:
                     TPP_enzymes; cl01629"
                     /db_xref="CDD:470272"
     misc_feature    order(713..715,869..871,944..949,1040..1042,1046..1057,
                     1064..1066,1076..1078,1088..1090,1133..1144,1184..1186,
                     1334..1336,1346..1348)
                     /gene="Pdha"
                     /locus_tag="Dmel_CG7010"
                     /gene_synonym="CG 7010; CG7010; Dmel\CG7010; E1-PDH; l (1)
                     G0334; l(1)G0334; L(1)g0334; L(1)G0334; Pdh; PDH; PDH-E1;
                     pdha; PDHA1; PDHalpha; Pdha[KK101856]; PDHE1"
                     /note="tetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238958"
     misc_feature    order(803..808,944..946,950..952,1034..1045,1124..1126,
                     1130..1132,1322..1324)
                     /gene="Pdha"
                     /locus_tag="Dmel_CG7010"
                     /gene_synonym="CG 7010; CG7010; Dmel\CG7010; E1-PDH; l (1)
                     G0334; l(1)G0334; L(1)g0334; L(1)G0334; Pdh; PDH; PDH-E1;
                     pdha; PDHA1; PDHalpha; Pdha[KK101856]; PDHE1"
                     /note="TPP-binding site [chemical binding]; other site"
                     /db_xref="CDD:238958"
     misc_feature    order(929..931,935..937,941..943,956..958,965..970,
                     977..982,986..991,998..1000,1055..1060,1076..1081,
                     1088..1090)
                     /gene="Pdha"
                     /locus_tag="Dmel_CG7010"
                     /gene_synonym="CG 7010; CG7010; Dmel\CG7010; E1-PDH; l (1)
                     G0334; l(1)G0334; L(1)g0334; L(1)G0334; Pdh; PDH; PDH-E1;
                     pdha; PDHA1; PDHalpha; Pdha[KK101856]; PDHE1"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238958"
     misc_feature    order(1307..1327,1331..1363,1388..1396)
                     /gene="Pdha"
                     /locus_tag="Dmel_CG7010"
                     /gene_synonym="CG 7010; CG7010; Dmel\CG7010; E1-PDH; l (1)
                     G0334; l(1)G0334; L(1)g0334; L(1)G0334; Pdh; PDH; PDH-E1;
                     pdha; PDHA1; PDHalpha; Pdha[KK101856]; PDHE1"
                     /note="phosphorylation loop region [posttranslational
                     modification]"
                     /db_xref="CDD:238958"
ORIGIN      
        1 caaacggttg ttatagttgt gcaatatagt agttgataaa ctaatctcgc tacctttttt
       61 tccgattgtt taacttacaa cgacgcgcgg cggtgcgact gagacaccag atatatagcg
      121 tgcgattcta gatccggaca atccgcatat agaaagcccc cattcacatc caatttctgt
      181 cagtcgaacg agaataacac agcgaaaatg ttgcgtactc tgtcacgcgt tagcgaattg
      241 cccattattg ttaagcaact gcaaaaagta cgtaatccca atcccgcttt gcacccacta
      301 acatttctaa ttgttgtcac taaaaatgca attgaacaaa tccattcgat aatgaaaaca
      361 ctaaaagcgt tgccataaca acaacaacaa caacatcatc atcagcggat gtcggatact
      421 tagcaacaac aacaacaaca gcagcatcga tatcatcagg aatgggagat attcatcgtc
      481 gtttttcggt ttattccaga atgcagccca agcaggtgtt tcgaaaacca acaattatgc
      541 cacggaggcc accgttcaag tgaatcggcc cttcaagctg caccgcctgg acgaaggacc
      601 cgccacggaa gtgaagctga ccaaggatca ggccctcaag tactacacac agatgcagac
      661 gatccgtcgg ttggagacgg ccgccggtaa tctgtacaag gagaagatca ttcgcggctt
      721 ctgtcatctg tattccggcc aggaggcatg cgccgttggc atgaaggcgg cgatgcggga
      781 tgtggacaac atcatctcgg cgtaccgtgt ccacggatgg acctacctga tgggcgtctc
      841 acccagcggc gtactggctg agctcaccgg tgtccagggt ggctgtgccc gcggcaaggg
      901 tggctccatg cacatgtacg caccgaactt ctacggaggc aatggcatcg tgggtgctca
      961 agttcctttg ggtgccggcg ttggcttggc ctgcaagtac aagggcaatg gcggcatgtg
     1021 cctggccctc tacggtgatg gtgccgccaa tcaaggacag gtgttcgagg cttacaacat
     1081 ggcctacctg tggaaactgc ctgtgatctt tgtctgcgag aacaacaact acggaatggg
     1141 caccagttct gagcgtgctt cctgcaacac tgattactat acccgcggcg acgctctgcc
     1201 cggaatctgg gtggacggca tggatgtgct ggccgtgcgc agcgccaccg agttcgccat
     1261 caactatgtg aacactcacg gacctttggt gatggagacg aacacgtacc gatactctgg
     1321 acactccatg tccgatccgg gcacatcgta ccgcacacgc gaggagatcc aggaggtgcg
     1381 ccagaagcgt gatcccatca cctccttcaa ggagctgtgc atcgagctgg gtctgattac
     1441 caccgatgaa gttaaggcca tcgatctgaa ggtacgcaag gaggtcgacg aggccaccgc
     1501 cttcgccaag tccgatgccg agctgggcgt gagccacctc tggacggacg tgtactccaa
     1561 caatctggag cccaagctgc gcggcaccat cgcctacgat attgatcaca tccaggagcg
     1621 caagggcgtc aatcactaag tcatcgggcc aacgaatctg attcgggaac tcacaagaac
     1681 cttaaacgaa acaagaaaac cgaacagcaa acacaaatca ctgacagaca gacaagaaga
     1741 cacaataact cagaaacttg gacacaagcg aaatctctag atcataagcc gaaagttgaa
     1801 cgatgagaac cccgtagaac ggaacggatc cgaagagacc cacaaaaagc ttagctaatc
     1861 ggagcactcc aaccacacat cgtagcgcac cacataactc tggggtactg cattggatat
     1921 tatattgcga acgtgttcaa taaggataaa gcgaggtgta aattgttgaa aatataaaaa
     1981 tctagaaaaa tt