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Drosophila melanogaster echinus (ec), transcript variant A, mRNA.


LOCUS       NM_166992               6759 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_166992
VERSION     NM_166992.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6759)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6759)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6759)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6759)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6759)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6759)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6759)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6759)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6759)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6759)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6759)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6759)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6759)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6759)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6759)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6759)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6759)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6759)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6759)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6759)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6759)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6759)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6759)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_166992.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6759
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6759
                     /gene="ec"
                     /locus_tag="Dmel_CG2904"
                     /gene_synonym="CG2904; Dmel\CG2904; Ec; EG:EG0002.3;
                     Q1W9Q0"
                     /note="echinus"
                     /map="3F2-3F3"
                     /db_xref="FLYBASE:FBgn0000542"
                     /db_xref="GeneID:31339"
     CDS             585..5723
                     /gene="ec"
                     /locus_tag="Dmel_CG2904"
                     /gene_synonym="CG2904; Dmel\CG2904; Ec; EG:EG0002.3;
                     Q1W9Q0"
                     /note="CG2904 gene product from transcript CG2904-RA;
                     CG2904-PA; ec-PA"
                     /codon_start=1
                     /product="echinus, isoform A"
                     /protein_id="NP_726893.2"
                     /db_xref="FLYBASE:FBpp0100019"
                     /db_xref="GeneID:31339"
                     /db_xref="FLYBASE:FBgn0000542"
                     /translation="MDTAAIKTSLPHAPLAGQQQPQQAQTTTAMAVAPTTITNAQTSA
                     INAKNNIGAFFQTCKVLWHLDAFRRSFRGLNQHVCGGQDCIFCALKELFQQLQTSSEP
                     ALCPEPLRRALASGPLAGRRFPLGCLGDAAECFELLLHRVHSHISPDDGDSCESSACI
                     AHRRFAMRVIEQSVCKCGANSEQLPFTQMVHYVSASALTSQKSLALQSHQQLSFGQLL
                     RAAGNMGDIRDCPNTCGAKIGICRALLNRPEVVSIGIVWDSERPAADQVHAVLKAVGT
                     SLRLGDVFHQVSEPRWAQQTQHELVGIVSYYGKHYTTFFFHTKLKVWVYFDDANVKEV
                     GPSWEGVVDKCSRGRYQPLLLLYAVPQQPTVGNGVGIGHVDVAMPASAPSIAGSVVRR
                     AVTPSPEKPSLGNTRRAITPTPLRTPPNDYQNLSVIQKNIFPSNLAMGTDETDAYISR
                     KTVEHVLSAQYQNLSVIQDKIGGGNGVGVGQQSVDKDGGFLSRKPIEAVLSAQLARRQ
                     HLQLQRSHSAESSSGHASSNGSSPPSDGLTMPEHLNQPRRRDSGNWSGDRNSASSASS
                     TTLDNPYLYMVAKRGVAAVPQSPTRHGLPYDPGYDSFSLSSTDSYPPKHALNPQLAKI
                     PEAAMGVVPNGGAMPHGHGNGQLALSGDCEKLCHEADQLLEKSRLVEESHDLETALVL
                     CNAAAGRARAAMDAPYSNPHTMTFARMKHNTCVMRARSLHRRILVEKGAETEAMPELK
                     HMREGSTSSVKHVRQNSKDRTLEKEQQQLQFQQIQQIQQIHQIQQQIPASIEIYATLP
                     KRKSPLKALASASACDDNAIEYEQEKQLATSPGKPERESRSLFGRKDKEKEKRSRSED
                     RNKLTREFSLTETLLVNAKDTLKKHKEDKDEKKEKDKSGKKQHKIRRKLLMGGLIRRK
                     NRSMPDLTEAVDDSTANAGITHHPHYPAQGVTTAGTLLGTSVDDSAVGLGKHGHGMSG
                     YISEGHFDYSGSGSASNSGAGSNPNPNLERSKLMRKSFHGSGRQLTMVPKVAPPPPMR
                     TSSTLTPQQQQQQQQQFHHEANLSNLSAMSSNTSISEDSCQTIITTCAQVHSEQSPLK
                     DLQMLVAQDELPLPPPMELPPYPSPPHSSCHSRQASEDFPPPPPPELDLEPLNQQLSQ
                     LQALEAASKQQRQQLESLEGTTSILAQLQQRQHLLKLRKEQANHPGAATTDATWLKEL
                     QAKQANDLRAMQRKLEASSPSSVRDLTHRFEQTSIRSYASQELLSQPGQSQQLGQLRT
                     QMNGLPNGNAKMDVDEVDAMPAVRNSLPAALSAHQLLPKPKYEMTQSQIAEEIREVEL
                     LNTMVQQTLNQNGAAALPKRVKKKSVSFCDQVILVATAGNEEDDDFIPNPILERVLRT
                     AQHPNEKVTAQMIQQQQQNMMRLQTEAQPRQQQVQQLQQPSPMLGRPAGATADMQRYV
                     QRMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQELYRQQQLHRTSMSGIASQ
                     QHLQQLDAQYTTMPRPLHHSQLGSYSVTLQKHQQLQQQQQQQQQQQAPQQLSLGYFSN
                     GSVATSEQVPLPSPYQRVPLPHGYQPAAAGPYYPLPNAQQHLQQQQLMAKPVQKKVSF
                     EPGTKGEADCLPPPPPPPQKNGLPETGSAGSGHPGAAPGASGAGGTTSAGITAIPTRV
                     YNNAIVKASAKAVECNLCRKRHVIAPAVYCTNCEYYLQMLNQRR"
     misc_feature    729..1595
                     /gene="ec"
                     /locus_tag="Dmel_CG2904"
                     /gene_synonym="CG2904; Dmel\CG2904; Ec; EG:EG0002.3;
                     Q1W9Q0"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    <5631..>5699
                     /gene="ec"
                     /locus_tag="Dmel_CG2904"
                     /gene_synonym="CG2904; Dmel\CG2904; Ec; EG:EG0002.3;
                     Q1W9Q0"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     superfamily; Region: C1; cl00040"
                     /db_xref="CDD:412127"
ORIGIN      
        1 tagtattgtt tgcgctctcg gcttcgtaag acgttcgctc agtagccgtc gcagcttcaa
       61 aaaaaaaaca tatttttttt ttggtttaac aacaaacaaa acattttttt caaaagaaac
      121 aaagcaatct ttttgtgaaa caaatgggaa aagaatacat ttcttttgca cattgtgctg
      181 tactgtttta taagaattaa tcgagggaaa tcaaagacga aacattttaa gagccaagct
      241 gctcttcaaa accgtctgtt tatatgtgcg tgtgtgtgtt tttgtgagcg tgacattaaa
      301 gccgaaagag ccacaacaac aacaaatgat agccaagctg tggaaaagtt aaaaacctta
      361 caaaaaaaaa ctagctaagt gaacgcaaac aggtgcgaaa agtacaaaaa acgtacgaga
      421 aggaaacgaa gaggttgccc aagaactcca aagggttgcg gcaacttccc ttgctggctt
      481 ctttttcatg tgtttcccat tttgcggaag tttgcgaaga gcccaaaaaa cacaaataca
      541 atgtgctaag aagttctcga gcaaaacagc gaagaacctt cgatatggat acggcggcca
      601 ttaaaacatc gctgccacat gccccactgg cggggcagca acaaccgcag caggcgcaga
      661 caacaacagc tatggcagta gcgccaacaa caataacaaa tgcccaaaca tcggcaatca
      721 atgccaaaaa caacattggc gcattctttc agacctgcaa ggtcttgtgg cacttggacg
      781 cctttcgacg atcgtttcgc ggcctaaatc agcacgtatg cggtggccaa gactgtatct
      841 tttgcgctct aaaggaactt ttccagcagc tgcagaccag ttctgagccc gccttgtgcc
      901 cggagccact gcgtcgggct ttggccagtg gtccattggc tggacggcga ttcccactcg
      961 gctgcttggg cgatgcagcc gaatgcttcg agctccttct ccaccgcgtc cactcgcaca
     1021 tttcgccgga tgacggcgac tcctgcgaat cctccgcctg cattgcccac cgaagattcg
     1081 ccatgcgcgt catcgagcag agcgtctgca agtgcggagc caattcggag cagctgccct
     1141 tcacccagat ggtgcactac gtctctgcct cggctctgac ctcccagaaa agtctggcac
     1201 tgcagtccca tcagcaactg agttttggcc agcttttaag ggccgccggc aacatgggcg
     1261 acatacgcga ttgtccgaac acctgcggcg ccaagattgg aatttgtcgt gcgctgctta
     1321 accgaccaga agtggtgtcc attggcatcg tttgggactc tgagcgaccg gcggcggatc
     1381 aggttcatgc cgtcctaaag gcagtgggca ccagcctgcg tctgggtgac gtttttcacc
     1441 aggtcagcga gccacgatgg gcccagcaga cccagcacga gctggttggc atcgtttcct
     1501 actacggcaa acactacacc accttcttct tccacacgaa gctcaaggtg tgggtctact
     1561 tcgatgatgc gaacgttaag gaggtggggc ccagttggga gggcgtggtg gacaaatgca
     1621 gccggggaag atatcagcca ctcctgctgc tgtacgccgt tccccagcag cctacggtgg
     1681 gcaacggcgt aggtatcggt cacgtggatg tggccatgcc ggcgagtgct ccatcgatag
     1741 ctggctcagt ggttcgcagg gcagttacgc ccagtccgga gaagcccagc ttgggcaaca
     1801 caaggagggc catcaccccc actccgctga ggacaccacc caacgactat cagaacctga
     1861 gtgtgattca aaagaatatc tttccgagca atctggcaat gggtacggat gaaacggatg
     1921 cctacattag ccgcaagacg gttgaacatg tgctgagtgc ccagtaccag aatttgagcg
     1981 taatccagga caagattgga ggcggcaatg gagtcggtgt cggccaacag agtgtggata
     2041 aggatggagg ctttctgagc cgaaagccca ttgaggcagt gctgagtgcc caactggcgc
     2101 ggaggcagca cctccagctt caacgcagcc acagtgcgga gtcaagctcc ggccacgcct
     2161 cctccaacgg cagttctccg cccagcgatg gactgaccat gccggagcac ctgaatcagc
     2221 cacgtcgtcg cgactcgggc aattggtcag gcgatcgaaa cagcgctagt tcggccagtt
     2281 ccacgacgct ggataatccc tacctgtaca tggtggccaa gcggggtgtg gcagcagtgc
     2341 cacagagccc cacgcgacat ggtttgccat atgacccggg ctacgattcg ttttcgctaa
     2401 gctccacgga ctcatatccg ccgaagcatg cgctaaatcc acagctggct aaaatcccgg
     2461 aagcagccat gggcgtcgtt ccaaacggag gagcaatgcc ccatggacat ggcaacggac
     2521 agctggcctt gtctggggac tgcgagaagc tgtgccacga ggcggaccag ttgctggaaa
     2581 agtcccgact ggtggaggag tcacatgatc tggaaacagc cctggtgctc tgcaatgcgg
     2641 ctgctgggcg ggcacgagcc gctatggatg ccccgtatag caatccgcac acgatgacct
     2701 ttgcccggat gaagcacaat acttgcgtga tgcgggcccg tagtctgcac cggcggattc
     2761 tggtggagaa gggagctgaa acagaggcta tgcccgaact gaagcacatg cgcgaaggaa
     2821 gcacgagtag tgtgaagcat gtgcgccaga atagcaagga tcgcacgtta gagaaggagc
     2881 agcagcagct gcagttccag caaatacagc agatccagca gattcatcag atccagcagc
     2941 agatcccagc cagcatcgaa atatatgcca cgctcccgaa gcgcaagagt cctctgaagg
     3001 ccttggcctc tgcgtctgcg tgcgatgaca acgcaatcga gtacgagcag gagaagcaac
     3061 tggccaccag tccgggaaaa ccggagcgcg agagtcgctc gctgttcggg cgcaaggaca
     3121 aagagaagga gaagcggagt cgcagcgagg atcgcaacaa gctaacccgt gagttctcgc
     3181 tcaccgaaac gcttctagtg aatgccaagg atacgctgaa gaagcataag gaggacaagg
     3241 acgagaagaa ggagaaggac aagagcggca aaaagcagca caaaatcaga cgcaagctgt
     3301 taatgggcgg gctcattcgt cgcaagaatc gctccatgcc ggatctcaca gaggcggtgg
     3361 atgactcgac ggccaatgcc ggcataacgc accatccaca ttatcctgca cagggcgtaa
     3421 ctacggcggg cactctcttg ggtacctccg tagacgacag tgccgttgga ttgggcaaac
     3481 acggccacgg catgagcggc tacatctctg agggacactt cgactactcg ggttccgggt
     3541 cggcctcaaa ttcgggagcc ggcagcaatc caaatccgaa tctggagagg agcaagctga
     3601 tgcgcaagag cttccacggc agcggcaggc agttgacaat ggtaccgaaa gtggctccac
     3661 cgccgcccat gcgaaccagc tccactttga ccccacagca gcaacaacaa caacaacagc
     3721 aatttcacca tgaggccaac ttgtccaacc tctcggccat gagttcaaac acctcgatta
     3781 gcgaggattc ctgccagacg atcatcacca cttgcgcaca ggtgcactcg gagcagagtc
     3841 cactaaagga tctgcaaatg ctggtcgctc aggacgagct gccactgccg ccgccaatgg
     3901 aacttcctcc gtacccaagt ccaccgcact cctcctgcca ttcgcggcag gctagcgaag
     3961 atttcccgcc gccaccaccg ccggaactgg atctggagcc actcaaccag caactgagcc
     4021 agctgcaggc actggaggcg gccagtaagc agcagcgcca gcaactcgag tccctcgagg
     4081 gcaccaccag cattttggcc cagctgcagc agcgccagca cctgctcaag ctgagaaagg
     4141 agcaggccaa tcacccggga gcagccacca cggatgccac ctggctgaag gagctgcagg
     4201 cgaaacaggc aaacgatttg agagccatgc aacgtaagct ggaggcctcg tcgccatcaa
     4261 gtgtcaggga cttgactcat cgtttcgagc aaacctccat tcgatcctac gcctcgcagg
     4321 agctattgtc ccagccggga cagagtcagc agctggggca gctgcgcacc cagatgaatg
     4381 ggctgccaaa cggcaatgca aaaatggatg tagatgaggt ggacgctatg ccagcggtga
     4441 gaaactctct gcccgccgca ctcagcgccc accaattgct gcccaagcct aagtacgaaa
     4501 tgacccaatc gcagattgca gaggagattc gcgaagtgga gttgctgaac acgatggtac
     4561 agcagacact gaatcagaac ggagctgccg cactacctaa gcgggtaaag aaaaagagcg
     4621 tctccttttg cgaccaggtg atcctggttg ccacagccgg aaacgaggag gacgatgact
     4681 ttatacccaa tcccatactg gagcgggtcc tgcggactgc ccagcatccc aacgaaaaag
     4741 tcactgctca aatgatccag cagcagcagc agaacatgat gcgattgcaa acagaagcgc
     4801 agccgcggca acagcaggtg cagcagctgc aacaaccatc acccatgttg ggcagaccag
     4861 caggagccac agcagatatg cagcgatacg tccagaggat gcagcaacaa cagcagcagc
     4921 agcaacaaca gcagcagcaa caacagcagc agcagcaaca acagcagcaa caacagcagc
     4981 agcaacagca gcagcagcag caacaccagg agttgtaccg ccagcagcag ctacatcgca
     5041 ctagtatgag cggcatagcc agccagcaac acttgcagca attggatgca cagtacacca
     5101 ccatgccgcg tcccttgcat cattcacagc ttggtagcta ctctgtgacc ttgcagaaac
     5161 accagcaact tcagcagcaa cagcaacagc agcaacagca gcaggccccg cagcagctca
     5221 gcttgggcta ctttagcaat ggcagtgttg cgacttcaga gcaagtcccg ctgccttcgc
     5281 cctaccagcg ggtgcccctg ccacatggat accagcctgc agcagcagga ccctactacc
     5341 cgctacccaa tgcccagcaa catctgcagc agcaacagct gatggctaag cccgtgcaga
     5401 aaaaggtgag ctttgagcca ggaactaaag gcgaagccga ttgcttgccc ccaccaccgc
     5461 cgccgccgca aaagaacggc ttgcccgaga cgggatctgc aggatcagga caccctggag
     5521 cagcacccgg ggcaagtgga gcgggcggca ccacatcggc cggcatcacc gccattccca
     5581 cccgcgtcta caacaatgcc attgtaaagg cttcggccaa agccgttgag tgcaatttgt
     5641 gccgcaagcg gcatgtgatc gcaccggcgg tatattgcac caactgcgag tactacctgc
     5701 agatgctgaa ccagcgcaga tgatgatgat tcgacactcg accatcgacc atctctagtg
     5761 caactttcta gccgtacatg gaacccgtta atctcaagca ttaaaatgct gccacgtcgc
     5821 caataaggag ccgccaagga tgtacatagc atgcttacaa atacatagat aggtgtaagg
     5881 atataaagtg gtgccagcta acaggcgaat tgcatggacc cggactcaag gatcaggcgg
     5941 aatgcggaaa cggaggggaa acacagtcct tctatggttc tacatgagaa gttcccgctg
     6001 tgacacataa cccacccact aacccaccca tcaccaccca catcaatgcc aatgttccca
     6061 agcacacgca cacaagcata ttgtacacgc ccattcatac ctacacatat acttgcccag
     6121 gaatcgtgct aaagcttagc gatgcagcgg caccaccgaa tgggattgca gtgaagtcca
     6181 gccgctgcaa cgcttacgaa ctgcacagtg ccacccgtcg ccccattgga catcgatcgc
     6241 ttgactaact ccacattttt taaacaccca aagcctgacc agtcgtccgc ctccataaac
     6301 cacattagtg ctttttgttt cgacatcgaa ttttatttac atttttttac ctaagctaac
     6361 taaatacgat ttatttctct gtgtgagacg ccagcagttt gaaacttggt cgttgagctt
     6421 ccttgtgcgt gctgttgtcc aacgacactc gcacttccat tttttttaca tatttttttt
     6481 ttgtataatt tttaatttta ctctaaatca gttaaggcat ttatttttgt attgtcgtac
     6541 ttaattatgt taagaatatt ttttgtgtct tgcatttaaa cgaatacgtg tatttttagt
     6601 gttaatatag ctcttacata taacataaat tttttacgat tttattttgc tataacatta
     6661 ttaaaagata ctttgcagca tatgaacaac gaaataagag atgtcgagca tccacaagaa
     6721 tgggaagaaa gtaatatttc taaataaatg catagaaac