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Drosophila melanogaster dunce (dnc), transcript variant R, mRNA.


LOCUS       NM_166966               7521 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_166966
VERSION     NM_166966.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 7521)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7521)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7521)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 7521)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 7521)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 7521)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 7521)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 7521)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 7521)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 7521)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 7521)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 7521)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 7521)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 7521)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 7521)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 7521)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 7521)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 7521)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 7521)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 7521)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 7521)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 7521)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 7521)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_166966.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7521
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..7521
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="dunce"
                     /map="3C9-3D1"
                     /db_xref="FLYBASE:FBgn0000479"
                     /db_xref="GeneID:31309"
     CDS             816..2927
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /EC_number="3.1.4.-"
                     /EC_number="3.1.4.17"
                     /EC_number="3.1.4.53"
                     /note="CG32498 gene product from transcript CG32498-RR;
                     CG32498-PR; dnc-PR; dunce phosphodiesterase"
                     /codon_start=1
                     /product="dunce, isoform R"
                     /protein_id="NP_726854.2"
                     /db_xref="FLYBASE:FBpp0305506"
                     /db_xref="GeneID:31309"
                     /db_xref="FLYBASE:FBgn0000479"
                     /translation="MVCSFCCCCYNFRNSPSSFDVENGQGARSPLEGGSPSAGLVLQN
                     LPQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQ
                     ILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDT
                     IEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFL
                     DKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHT
                     NSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSR
                     ELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTP
                     LEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQG
                     CDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNY
                     TDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRH
                     NATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPSGV
                     DENPQEDRIRFQVTLEESDQENLAELEEGDESGGESTTTGTTGTTAASALSGAGGGGG
                     GGGGMAPRTGGCQNQPQHGGM"
     misc_feature    1104..1472
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="Phosphodiesterase 4 upstream conserved regions
                     (UCR); Region: PDE4_UCR; pfam18100"
                     /db_xref="CDD:465648"
     misc_feature    1905..2627
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="3'5'-cyclic nucleotide phosphodiesterase; Region:
                     PDEase_I; pfam00233"
                     /db_xref="CDD:459723"
ORIGIN      
        1 tctaattcta aaatcaagtt ttaaataaaa attcgcccaa tataacagag tatcgaaaat
       61 cgctcaatct cttacaaaaa aaaaataaac aaactttcgt aaagttctag aatgccgccg
      121 ccgcgacgtc gacgcagtgc gtgattgtgt gcgtgcgcct agtactcatg tgtgtcgtgt
      181 gagcttctga actggcgacc aaaactgacg acgccgtcgc tgcctctgcc tcagccgcag
      241 tcgccgcctc cgcagcagca gcagcagcag caacaactac aacaacaaca acaacagcca
      301 ccagggcagc aacaaccaca ccagttacaa cagccccaac accaacagcg ataacaacaa
      361 catatagatc gcggaatctg ctgaaagcca ccgccaaagt gaagaagaag aaaaagtgga
      421 agcaaatctc cttcgtcgac gaccagcaac gcttgaagca agcagcgacg tcggcggagc
      481 gcaaacgctc caccagcagc gccccgcccg ccctcgagag caacgtaccg ccgcggttgg
      541 ggcgctttct gcggcaaaag agcagcgaaa ctaacagcgc tgcaacgtca gcagcagcgg
      601 cggcagtgca aacggaagcg gaaacaggac gccggaaatc gtcggcggca tcgataatcg
      661 cagcggcagc gggcgctgct ggtttgcaca acaataacag cagcagctgc gcagcgaccg
      721 ccagcgagga gcaaaactcg agcggtacgc tcaccggcag cagcggcaat acttccacgt
      781 cgacgtggtg cggcagcatc aacttcctgg tgtatatggt gtgctcgttt tgctgctgtt
      841 gctacaactt tcgcaattcg ccgtctagtt tcgatgtaga aaatggccag ggcgctagat
      901 caccgctcga gggcggctca cccagcgccg gtttggtact acagaatttg ccgcagcgtc
      961 gcgaatcgtt tctatatcgc tccgattcgg actttgagat gtcacccaag tccatgtccc
     1021 gaaactcaag catcgctagc gaaaggttta aagaacagga agcctctata ctcgttgacc
     1081 gatcccatgg cgaggatctc attgtgacgc ctttcgccca aattttagcc agcttacgtt
     1141 cagtgcgcaa caatttatta agtctgacaa atgttccagc atcaaacaaa tccaggcggc
     1201 ccaaccaatc gtcgtcggcc tcgcgatcag gaaatccacc aggagccccg ctatcccaag
     1261 gcgaggaggc atacacccgc ctggccaccg acacaatcga ggagctggac tggtgcctcg
     1321 accagctgga gaccatccag acccatcgca gcgtctccga catggcgtcg cttaagttca
     1381 aacgcatgct caacaaggag ctgtcgcact ttagcgagtc cagcagatcg ggaaatcaga
     1441 tttccgaata tatatgttcc acatttttgg acaagcaaca ggagttcgac ttgccatcgc
     1501 tgcgcgtgga ggataatccc gagctggtcg ccgccaatgc agccgctggt caacagtccg
     1561 ctggacagta tgcacgctcc cgatcgccgc gcggtccgcc catgtcgcag atcagcggcg
     1621 tgaagagacc gctgtcgcat acgaatagct ttaccggcga acgtttgccc accttcggtg
     1681 tggagacacc cagggagaat gagctgggca cgctgctcgg cgaactggac acctggggta
     1741 ttcagatatt cagcatcggc gagttcagtg tcaatcgacc gctcacctgt gtggcataca
     1801 ccatatttca gagtagagaa ttactgacca gtcttatgat accaccgaaa acttttctta
     1861 actttatgtc tactctggag gaccactacg tcaaagacaa tccgtttcac aattcgctgc
     1921 atgccgccga tgtgacacaa agcactaatg tgctactcaa tacaccggcg ctggagggcg
     1981 tattcacgcc gctcgaagtg ggcggggcgc tgttcgccgc ttgcatacac gatgttgatc
     2041 atcccggctt aaccaatcag ttcttggtta actcaagttc cgaactagca ttaatgtaca
     2101 atgacgaatc tgttttggaa aatcatcatt tagctgttgc ctttaaatta ttacaaaatc
     2161 aaggatgtga tatattctgt aatatgcaaa agaaacaacg ccaaacattg aggaaaatgg
     2221 ttattgatat tgtgctgtcc acggacatgt ccaagcacat gagtctgctg gccgacctaa
     2281 agacaatggt ggaaaccaaa aaggtggccg gctccggagt actgctgctg gacaactaca
     2341 ccgatcgcat acaggtgctt gagaatctgg tgcactgcgc cgatctgagc aatcccacca
     2401 agccgctgcc gctttacaag cgctgggtag ccctgctcat ggaggagttc ttcctgcagg
     2461 gcgataagga acgcgaatcg ggcatggaca ttagtcccat gtgcgatcgc cataatgcca
     2521 ccattgagaa gtcgcaggtg ggcttcatcg actacatcgt ccacccgcta tgggagacct
     2581 gggcggacct ggtgcatccg gatgcccagg atatactcga cacgcttgaa gagaacagag
     2641 actactacca gagcatgata ccgccttcgc cgccgccatc gggcgtcgat gagaatccgc
     2701 aggaggacag gatacgcttt caagtaaccc ttgaggaatc cgatcaggag aacctcgccg
     2761 aactggagga gggcgacgag agtggtggcg agagcaccac cacaggcaca accggaacca
     2821 ccgctgcatc cgcgctaagc ggagctggtg gcggtggcgg tggaggcggg ggaatggcac
     2881 ccagaacggg tggctgccaa aaccaaccgc aacacggtgg aatgtgacgg agagtcgtgg
     2941 gaatttatcg caaattacag gaaaaggctc acaacttttt cctattacgt tagtgactac
     3001 tattaacaca gaaaaaacca aaacaaaaac ctaaaacgaa aagcaaaaaa aaaaacaaag
     3061 aaaaactctt ggaaaaaatg caaaaaaaaa tccacaaaaa aaaaaccaaa aaacccaagt
     3121 aaggaaatat taaaccaatg tttaaacgca tacaaaaatc caaacagcaa tagcaaaact
     3181 aacgttaaac ctataaagtc tagagaaaat cgaaaaagga aattagaaat ttacttaatg
     3241 gaacccgaga ttgatgttga aaatacactg aaaaagaagg aggaggccga gctaactaag
     3301 ataaaatcgt acatattgtt aaaaacaaaa caaaaaaaca tagacacact aaattcaaga
     3361 caaagcaaag ataataagaa aaattgataa gttacaaaaa ataagacgat accgaaaact
     3421 cccgccccaa aagcctaaga aatcccagta cccccccccc ccctccactc ccctttatat
     3481 atatatatat acaatttttg ttgcatgtgt aggtaaatga tttttgtcaa aattcatctg
     3541 aagtagtaca tccatcagag gcagcccctt agctgagtct cctcttttaa tccattgact
     3601 aaagtgaaat atttaaaaaa cagagaatca ggcgaacgaa aaggaataat taatatgacc
     3661 tagcttataa gagaagttat taagttttta aatgttttgc atgcccgaac agatttattt
     3721 tacttgattg attgataacg ctagatctaa ctgataaacg ataacagcaa cacatggagt
     3781 ttttttttta tataatttag accacagcga tagaagcgaa agaaaatcaa ccatgtaaag
     3841 tttaagaacc cagtgaatta aaccaaaatt gaaagccaac cgagttgaaa ccaatttaat
     3901 tctaaatcta aatctaaatc cacaacccaa aacccaaaac cccaagcaac aaaaaagaaa
     3961 gaaagaagga aaagtaagga acagtctaca gccagactgt agttgtatag taatatatat
     4021 gatataaata ttttttttaa atattatttg taaataattt aaatgttgga ctcgaattta
     4081 aatcaagcgg ctagcaaatg ttgcagctaa actaaaatga aaacaaagcc aaaaaacaca
     4141 cacataaata ggtaaactaa gtgaaaaatg tggaaaagga aaaactattg tacaattagc
     4201 taaagaattt ccatttcaat tttcaatttg aattgcaatt taatttgctt ccagaaatga
     4261 atgaaaggag acaagaaaaa gatagggaga taaaccgaaa attagtttca aacgctgtct
     4321 tcgcaaatat ttttcgctat atatatatat atatattact tataacatta ttttactagt
     4381 tactaagcta cttactgagc cacacaaatt taaaacgaaa gagacaagac accaggacaa
     4441 gaaagagaag gagctttcat gaatttagtg aacaaacata actggcaatg gccacacaca
     4501 cacacacaat ttacaaagcg aacaacacca aaaaaaataa ataaaaagac tcttcaagca
     4561 caaaaaaaac tgtttagttt tcagtaaaca gtaaaaccaa agcaaagcaa aataacacac
     4621 aagatataat ccccaaaaaa gtcattggct ataatatgat tacttaacct aacctataca
     4681 atatatagat atatagatat atcctatatg catatgtaaa gtcacgatac tggcgctggt
     4741 gcgcggatcg atcaatgtgg caggccaaat tctaaatgcg cataatttaa ctattgttta
     4801 cattatgttt tattgttatt aatttattac caaaaacgaa aacattattt tttcagacct
     4861 agtgctataa atttcttttt tgtgttgaag cgggcaggat ccgcgcataa aatagtgttt
     4921 tttttttttt tgtaattaca aatatatata aagatacata catatatata tatatatata
     4981 atatgatatg tgaatgaaat gtaatgaaat gaagtggaac cttgatggtc taaaaatatc
     5041 attaaaagct gatggagatg gaaagttgaa gaacaagata ctttatagca atttaagcag
     5101 cattgtaaat gtgcgcttca gaactacttt tttttcgaaa cttaatcgac cttcagcaaa
     5161 tacagcaaga tatattacct acattacaaa catatattat taattgaacc atagttgcga
     5221 cacaaaacaa aaatgacggc aagtccatgg caaacttaag caaaaaccaa aagctacttt
     5281 aacaaattga gtgaaataaa taaaagaaag aaaacaaaca aaaaaaaaaa aacacaaaaa
     5341 aaaaccatat gacttttttc tcctctcaca aaataaaagc gaaaaacaga aaaataaact
     5401 agtattgtat tgtatttgta acacgaattt tcctgcgagt gaacacttta cgcagaacca
     5461 taaagccgga aactgaaaac ctacagagat tccgcagcaa tcgcggcact ggtatgtgtg
     5521 tatagctaat agctatactc attatgtaat ttaccagagt attaatcgaa caatttaaat
     5581 ttacatatat gcatatgcat accaacatac taggaatact aggaatatat gcagtaacgg
     5641 acatttgatg tatactcgag ttgaaacata accctaacca aatgttgtat gtgtatgtgt
     5701 aattcgatga acttaaaagt ccaaagccat acgtgaaaat aagaacaagc aatttatagt
     5761 gaaaaagtcg aaaagtatct aaatgtaatt gttagaaaat gccaagtaaa tccgaaagtt
     5821 accacagagt taatgaggag gcatcatcta tcttgtcatc caagaaatcc ccaaatcaat
     5881 ttttgactga aattgaatcg tcctagtaga ggcactcgat tcgtactcct tccttacccc
     5941 taccgccccc ccccctcacc aacttccttt gccccaacta ttgtacttta tccaatattt
     6001 tcctatcgac gtgccgccaa ttatatcagt gtatataaac tatttgaaaa tcacgcatat
     6061 atatgcacac atagagtttt tgtagcgtca tatgtgtcat taaggatgcc cacttacata
     6121 catatatgaa gggaaataaa taagcaagta aatatacaat acaatacata catatatgtg
     6181 tgtgttgtgg gtaacgagag atcagcattt gtagcacagg ttggccaaat ttattgggaa
     6241 taacgagttg ccgaagttgc cgaagaaaaa ccaaatgaaa actgtttgtt gtgctgttag
     6301 ccgtaaatga gaactttttt ttgagataac ttaataccta tatatataaa tatgtattac
     6361 aatatatgta tctataaata tataaaacag gcgacaaacc aaattaaacc aaataccgga
     6421 acaaaaaaaa aaaaacgaaa aagaagagag agaaaaaata atacaagcga tattgaaaat
     6481 ggcacgtttt gtactataat gaaatgagaa aacaccaaag acgaatgcaa aacaaaaaaa
     6541 aatgcaaaca cataacaaaa tatacaagaa atattcttaa caaaaagaaa aaaataccat
     6601 aaattgtgcg ctggcgacga cggttgtttg aaaaaaagag aaagcaaaaa acaggacatg
     6661 ccgcttgaag tgccgatcgt aagcgagtcc tttcgattcg caaatcgtcg gcatttcaat
     6721 cgattgaaga atcgggagat attatataca tatagaacac gtaacgctgg cgttactggg
     6781 caaacagtta ggcatttttt ttttttcttt tttggaaatt tatacaatta catatacaaa
     6841 aagagctcac ccccacaaca acaaggacaa ctgcagaaga agaacaaaaa aaatacacac
     6901 atacatggaa acactaacgc gtacacggac agcgatttgc cggaacaaaa ttctgggtat
     6961 ttcgaaccga gaaagggaac ggaaacggaa acggaaacga aaatatagaa cgcggcaagt
     7021 tatttaacac tgaaactgat cgggtgtaac tatagtaccg aaatggggct tacacaggct
     7081 gattcaccca aaataagtat acatgtattg tagtaacgag cgctggcttt tgttattaag
     7141 ttatgtattt gtttcgatta tgttttgcct ctctcagaat atatatatat atatatatat
     7201 atatatatat atgtatattc tatgtatata tatatattag ttatgtatgt gaaaaaagcg
     7261 taatcattta tgaaaccaat gaaaatctaa cctgaaaaca aagagaaaac cccaagtcaa
     7321 atacacaatt gcatgcaaga gtaagtaata ttaatgaaat ctaagaacaa aggtcactcc
     7381 cgggcttaaa aaaaaaaaaa gaagaaaaaa aatgggccgc atggcaaatg ataaatggta
     7441 aaacaaaaca atgagcaggt ggcattatga acagatttga atgattacgg aatacagact
     7501 aaaaatgaaa atgaaaaatt t