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Drosophila melanogaster dunce (dnc), transcript variant D, mRNA.


LOCUS       NM_166964               3828 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_166964
VERSION     NM_166964.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3828)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3828)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3828)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3828)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3828)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3828)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3828)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3828)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3828)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3828)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3828)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3828)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3828)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3828)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3828)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3828)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3828)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3828)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3828)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3828)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3828)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3828)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3828)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Dec 17, 2009 this sequence version replaced NM_166964.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3828
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3828
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="dunce"
                     /map="3C9-3D1"
                     /db_xref="FLYBASE:FBgn0000479"
                     /db_xref="GeneID:31309"
     CDS             468..3674
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /EC_number="3.1.4.-"
                     /EC_number="3.1.4.17"
                     /EC_number="3.1.4.53"
                     /note="CG32498 gene product from transcript CG32498-RD;
                     CG32498-PD; dnc-PD; dunce phosphodiesterase"
                     /codon_start=1
                     /product="dunce, isoform D"
                     /protein_id="NP_726852.2"
                     /db_xref="FLYBASE:FBpp0070491"
                     /db_xref="GeneID:31309"
                     /db_xref="FLYBASE:FBgn0000479"
                     /translation="MSQESNGGPAAGGGAAAAPPPPPQYIITTPSEVDPDEVRSMADL
                     ELGSPEKQVQVQSQKFSSTSSTTKVATHSFSMSSSAGTTGQQSKQDSAQQIQQLQQLQ
                     QLQQLQQQQQQQQSQRIISSSTRSQSLQSSTIVGEATTITSGAAQILSASAAASLAQQ
                     LKAQSSTSIITSSEQRTSTSTSSSSSTRYIASGSSNLAGGNSNSASSASSKTRFQSFL
                     QQPEGAHGFLTAHQKHVRQFVRSTSAHSEAAAGVAGARAEKCIRSASTQIDDASVAGV
                     VESAGNLTDSSATGGSMQLSMSKLGLQQSSSILISKSAETIEMKSSSAGMRTQLTLSG
                     GFLAPPGNRKITILSPIHAPPGLHDMLKRAQGRSPLSPRISFPGSDSDLFGFDVENGQ
                     GARSPLEGGSPSAGLVLQNLPQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEA
                     SILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKRPNQSSSASRSGNPPG
                     APLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSE
                     SSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPR
                     GPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEF
                     SVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQ
                     STNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESV
                     LENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTM
                     VETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQG
                     DKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEEN
                     RDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDESGGESTTTGT
                     TGTTAASALSGAGGGGGGGGGMAPRTGGCQNQPQHGGM"
     misc_feature    1857..2219
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="Phosphodiesterase 4 upstream conserved regions
                     (UCR); Region: PDE4_UCR; pfam18100"
                     /db_xref="CDD:465648"
     misc_feature    2652..3374
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="3'5'-cyclic nucleotide phosphodiesterase; Region:
                     PDEase_I; pfam00233"
                     /db_xref="CDD:459723"
ORIGIN      
        1 caacaacagc acagcggcag tagcaacaac gcagtaacag aagcagtagc agcagcaaca
       61 gcagcagcaa cagcaacagc aacatcactg tggcaaccgc aacagcacag cagcagcaac
      121 atcagcacgt gtgcgtgccc caaacagcag agagataaat acataaaacg ccgagaaatt
      181 caagagaaaa gcaagaaaaa agttaaggct aaaaagcaat taaaacaaat tgtgccgtaa
      241 gtcaagtcgg tgggcttaca gcccagtccc ccgcaaataa aagaaaaaat aaaaaaaaaa
      301 ataaaaaaaa aaatagaaag aaacaaagaa aactgtaaga aaaaaagaac agaaatacac
      361 gagtaaccac cgcaggatcc gcaggacaac gtacccaccg atcccaaaaa agaaacgcac
      421 gagacaaaac aaaaaaaaaa cgaaaaaaag tgaaataaaa ggaaaccatg tcccaggaga
      481 gtaatggtgg cccagcagca ggaggcggag cagcagcagc accaccacca ccaccacaat
      541 acataataac cacacccagc gaggtggatc ccgacgaagt gcgctccatg gccgacctag
      601 agctgggatc ccccgaaaag caggtgcagg tacagagtca aaagttctcc agcacgtcga
      661 gcaccaccaa ggtggccacc cactcatttt cgatgagcag tagtgccggc actactgggc
      721 agcaaagcaa acaggacagc gcccagcaaa tccaacagct tcagcagctc caacagctcc
      781 agcaactcca gcagcagcag cagcagcaac agtcccagag aatcatatcc agttcgacga
      841 gaagccagag cctgcagtcc agcacaattg tgggcgaggc cactacaatt acgagcggag
      901 ctgcccaaat cctaagcgcc tcggcggcgg cttcgctggc ccagcagctg aaggcccaaa
      961 gctccacctc gattatcaca agcagcgagc agaggacgag cacaagcacc agtagcagca
     1021 gcagcacccg ttacatagcc agcggctcga gcaacctggc cggtggcaat tcgaattcgg
     1081 ccagctcggc cagcagcaag actcgcttcc agagtttcct tcagcagccg gagggtgcgc
     1141 acggttttct gacggcccat cagaagcatg tgcgtcaatt tgtgcgctcc acatcggcac
     1201 attcggaggc ggcagccgga gtggctgggg cacgggcgga gaagtgcata cgcagcgctt
     1261 ccacacagat cgatgatgcc agtgtggccg gtgtggtgga gtcggctggt aacttgactg
     1321 acagctccgc cacgggagga tccatgcagc tgtcgatgag caaactgggc ctgcagcagt
     1381 catcgtccat attgatctcc aagtcggccg aaacgatcga gatgaagagc tcgtcggcgg
     1441 gcatgcgcac ccagttgaca ttgagcggtg gcttcttggc gccgccgggc aatcgaaaaa
     1501 taaccatttt gagtccaatt cacgcaccgc ccggtctgca tgatatgctc aagcgggccc
     1561 aaggacgatc gccgctatcg cccaggatca gctttcccgg cagcgattcg gacctctttg
     1621 gtttcgatgt agaaaatggc cagggcgcta gatcaccgct cgagggcggc tcacccagcg
     1681 ccggtttggt actacagaat ttgccgcagc gtcgcgaatc gtttctatat cgctccgatt
     1741 cggactttga gatgtcaccc aagtccatgt cccgaaactc aagcatcgct agcgaaaggt
     1801 ttaaagaaca ggaagcctct atactcgttg accgatccca tggcgaggat ctcattgtga
     1861 cgcctttcgc ccaaatttta gccagcttac gttcagtgcg caacaattta ttaagtctga
     1921 caaatgttcc agcatcaaac aagcggccca accaatcgtc gtcggcctcg cgatcaggaa
     1981 atccaccagg agccccgcta tcccaaggcg aggaggcata cacccgcctg gccaccgaca
     2041 caatcgagga gctggactgg tgcctcgacc agctggagac catccagacc catcgcagcg
     2101 tctccgacat ggcgtcgctt aagttcaaac gcatgctcaa caaggagctg tcgcacttta
     2161 gcgagtccag cagatcggga aatcagattt ccgaatatat atgttccaca tttttggaca
     2221 agcaacagga gttcgacttg ccatcgctgc gcgtggagga taatcccgag ctggtcgccg
     2281 ccaatgcagc cgctggtcaa cagtccgctg gacagtatgc acgctcccga tcgccgcgcg
     2341 gtccgcccat gtcgcagatc agcggcgtga agagaccgct gtcgcatacg aatagcttta
     2401 ccggcgaacg tttgcccacc ttcggtgtgg agacacccag ggagaatgag ctgggcacgc
     2461 tgctcggcga actggacacc tggggtattc agatattcag catcggcgag ttcagtgtca
     2521 atcgaccgct cacctgtgtg gcatacacca tatttcagag tagagaatta ctgaccagtc
     2581 ttatgatacc accgaaaact tttcttaact ttatgtctac tctggaggac cactacgtca
     2641 aagacaatcc gtttcacaat tcgctgcatg ccgccgatgt gacacaaagc actaatgtgc
     2701 tactcaatac accggcgctg gagggcgtat tcacgccgct cgaagtgggc ggggcgctgt
     2761 tcgccgcttg catacacgat gttgatcatc ccggcttaac caatcagttc ttggttaact
     2821 caagttccga actagcatta atgtacaatg acgaatctgt tttggaaaat catcatttag
     2881 ctgttgcctt taaattatta caaaatcaag gatgtgatat attctgtaat atgcaaaaga
     2941 aacaacgcca aacattgagg aaaatggtta ttgatattgt gctgtccacg gacatgtcca
     3001 agcacatgag tctgctggcc gacctaaaga caatggtgga aaccaaaaag gtggccggct
     3061 ccggagtact gctgctggac aactacaccg atcgcataca ggtgcttgag aatctggtgc
     3121 actgcgccga tctgagcaat cccaccaagc cgctgccgct ttacaagcgc tgggtagccc
     3181 tgctcatgga ggagttcttc ctgcagggcg ataaggaacg cgaatcgggc atggacatta
     3241 gtcccatgtg cgatcgccat aatgccacca ttgagaagtc gcaggtgggc ttcatcgact
     3301 acatcgtcca cccgctatgg gagacctggg cggacctggt gcatccggat gcccaggata
     3361 tactcgacac gcttgaagag aacagagact actaccagag catgataccg ccttcgccgc
     3421 cgccatcggg cgtcgatgag aatccgcagg aggacaggat acgctttcaa gtaacccttg
     3481 aggaatccga tcaggagaac ctcgccgaac tggaggaggg cgacgagagt ggtggcgaga
     3541 gcaccaccac aggcacaacc ggaaccaccg ctgcatccgc gctaagcgga gctggtggcg
     3601 gtggcggtgg aggcggggga atggcaccca gaacgggtgg ctgccaaaac caaccgcaac
     3661 acggtggaat gtgacggaga gtcgtgggaa tttatcgcaa attacaggaa aaggctcaca
     3721 actttttcct attacgttag tgactactat taacacagaa aaaaccaaaa caaaaaccta
     3781 aaacgaaaag caaaaaaaaa aacaaagaaa aactcttgga aaaaatgc