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Drosophila melanogaster dunce (dnc), transcript variant T, mRNA.


LOCUS       NM_166963               8691 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_166963
VERSION     NM_166963.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 8691)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8691)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8691)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 8691)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 8691)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 8691)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 8691)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 8691)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 8691)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 8691)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 8691)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 8691)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 8691)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 8691)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 8691)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 8691)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 8691)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 8691)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 8691)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 8691)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 8691)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 8691)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 8691)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_166963.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8691
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..8691
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="dunce"
                     /map="3C9-3D1"
                     /db_xref="FLYBASE:FBgn0000479"
                     /db_xref="GeneID:31309"
     CDS             1950..4097
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /EC_number="3.1.4.-"
                     /EC_number="3.1.4.17"
                     /EC_number="3.1.4.53"
                     /note="CG32498 gene product from transcript CG32498-RT;
                     CG32498-PT; dnc-PT; dunce phosphodiesterase"
                     /codon_start=1
                     /product="dunce, isoform T"
                     /protein_id="NP_726851.3"
                     /db_xref="FLYBASE:FBpp0305508"
                     /db_xref="GeneID:31309"
                     /db_xref="FLYBASE:FBgn0000479"
                     /translation="MQAEQGSIGDLQKYHSRYLKNRRHTLANVRFDVENGQGARSPLE
                     GGSPSAGLVLQNLPQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRS
                     HGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQ
                     GEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSG
                     NQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMS
                     QISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRP
                     LTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVL
                     LNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHH
                     LAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKK
                     VAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERE
                     SGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQ
                     SMIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDESGGESTTTGTTGTTA
                     ASALSGAGGGGGGGGGMAPRTGGCQNQPQHGGM"
     misc_feature    2274..2642
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="Phosphodiesterase 4 upstream conserved regions
                     (UCR); Region: PDE4_UCR; pfam18100"
                     /db_xref="CDD:465648"
     misc_feature    3075..3797
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="3'5'-cyclic nucleotide phosphodiesterase; Region:
                     PDEase_I; pfam00233"
                     /db_xref="CDD:459723"
ORIGIN      
        1 ttatttgcac gcatgtcgtc gaccaggacg aatcgtttgg cagagcgcgg ctgaaaaagg
       61 aatcgaaaac ggggctataa cggtaatagc ggcacacgcg tccaacggta aacacgcgtg
      121 ccaacgcgcc atctcgctcg cacgcgctaa tgccgcgatt taagttttgt tttatttttt
      181 gcaagtgttc gaatcaaaaa gcctaacaaa acacaaaacc cgaaacagtt ctcaagaaat
      241 acatagtctg cggttgataa agactttgat tgaaaattaa agcgtgcgct aaaaaataat
      301 tcggattcga taataaaaga aaaaaaaaaa aaaaattctt tgacttcatt gcaaggaaga
      361 tccgaagttt tgttaatttt aatttttttt tcggttactg tgctaatcag aaattacaaa
      421 ttagaaattc gaaaatcgaa atttttcggc gttaggccag cggaagctga taaacaacag
      481 agaagcggcg gcatctggaa aataataaaa ctcgaaggtt tgagcatcgc ggcagtggca
      541 gtagcaacgg caccggaaac ggaagcggga ccggaaacgg ccagggatta ggtggcagct
      601 gcagtgccaa cggcctggca gccactggcg gcgttggagg gggcggtggg agtggcagcg
      661 gcggcggtgg gtgtggcagc gggagtggca gtgggagtgg caagcggaaa tcaaaggcaa
      721 gaacaaagtg cttcggtggc acagtgtttc ggtgttgcct cccttgtcgc gggggcggct
      781 ccgcagcccc cgccacaagt ccgccccaaa caccagccca gacgccggac gagctcaagg
      841 tcattccgga ggattgtaat ctggaaaagt ccgcggagca aaagcgcgac ttactggagc
      901 ggaacaacaa ggaggacgat ctgctgaacc gcaccgtatc cggatctgag ctggatctat
      961 acggcggcgc cggcggcggt acgaaaaagc attcgctggc agacaccatc gatacatcgg
     1021 tgaccacccc gatttcccta aagaccctga tcaacgacgt cgacgaggag ctggaccagc
     1081 aactgagtgc ggcggatata gcggccgcca gtttggccag cggtctggtt gcccgccgag
     1141 cggaaccaga aacactgagc gacgccagtg tctcacccac cgcggtggtg cagcagcagc
     1201 agcagcagca gcagcagctg cagcaaccac tcttgcaatc acaaccacat tttgtgccca
     1261 gcagcggcaa tatccttagc caggtcaccc tgtacagcgg cagcaatccc tcgacaaatc
     1321 cctgccagag tgcagtgcag aatcaaggcc aaaactccaa tcccaatccc aatcagaatc
     1381 caaacacaaa tccgaaccag aatcaacagc gttgcagttg ccagccgcag acttccccat
     1441 tgccgcatat caaagaggag gaggaatccg atcaggccaa ctttaaacac cagacgagcc
     1501 tgaaggagca tcagcctctc ccgccaccga tcaccatagc cactggctac tgcggcagct
     1561 gcgagagcgt tcatcactca tccgcaacct cgtcttcggc gggcacagta cctccggggg
     1621 gtcagcaaac tcaggagtat attgccggta cctcttcgac gccctcgccg cgcatcaaac
     1681 taaagttccg caagccgcac aagtcctgct ggtcgcgaat cgtccttgcg cccattggat
     1741 cggcgggtgg ctcctcatcg gccaccactg tcattggcag caattcgaac gagactttgg
     1801 cctccagcag caccaccggc ggcaccgcca ccaccaccca gaacagcagc agcgttagcg
     1861 ttgccgcaca ccaccggcta acctcgtcgt cggcctccgc cctcgccacc tcgcacccca
     1921 gcaactcgca gctgctgccc accagcaaga tgcaggcgga gcagggatcc atcggtgacc
     1981 tgcagaagta ccatagtcgg tatctcaaga atcgtcgcca tactctggcc aatgttcgtt
     2041 tcgatgtaga aaatggccag ggcgctagat caccgctcga gggcggctca cccagcgccg
     2101 gtttggtact acagaatttg ccgcagcgtc gcgaatcgtt tctatatcgc tccgattcgg
     2161 actttgagat gtcacccaag tccatgtccc gaaactcaag catcgctagc gaaaggttta
     2221 aagaacagga agcctctata ctcgttgacc gatcccatgg cgaggatctc attgtgacgc
     2281 ctttcgccca aattttagcc agcttacgtt cagtgcgcaa caatttatta agtctgacaa
     2341 atgttccagc atcaaacaaa tccaggcggc ccaaccaatc gtcgtcggcc tcgcgatcag
     2401 gaaatccacc aggagccccg ctatcccaag gcgaggaggc atacacccgc ctggccaccg
     2461 acacaatcga ggagctggac tggtgcctcg accagctgga gaccatccag acccatcgca
     2521 gcgtctccga catggcgtcg cttaagttca aacgcatgct caacaaggag ctgtcgcact
     2581 ttagcgagtc cagcagatcg ggaaatcaga tttccgaata tatatgttcc acatttttgg
     2641 acaagcaaca ggagttcgac ttgccatcgc tgcgcgtgga ggataatccc gagctggtcg
     2701 ccgccaatgc agccgctggt caacagtccg ctggacagta tgcacgctcc cgatcgccgc
     2761 gcggtccgcc catgtcgcag atcagcggcg tgaagagacc gctgtcgcat acgaatagct
     2821 ttaccggcga acgtttgccc accttcggtg tggagacacc cagggagaat gagctgggca
     2881 cgctgctcgg cgaactggac acctggggta ttcagatatt cagcatcggc gagttcagtg
     2941 tcaatcgacc gctcacctgt gtggcataca ccatatttca gagtagagaa ttactgacca
     3001 gtcttatgat accaccgaaa acttttctta actttatgtc tactctggag gaccactacg
     3061 tcaaagacaa tccgtttcac aattcgctgc atgccgccga tgtgacacaa agcactaatg
     3121 tgctactcaa tacaccggcg ctggagggcg tattcacgcc gctcgaagtg ggcggggcgc
     3181 tgttcgccgc ttgcatacac gatgttgatc atcccggctt aaccaatcag ttcttggtta
     3241 actcaagttc cgaactagca ttaatgtaca atgacgaatc tgttttggaa aatcatcatt
     3301 tagctgttgc ctttaaatta ttacaaaatc aaggatgtga tatattctgt aatatgcaaa
     3361 agaaacaacg ccaaacattg aggaaaatgg ttattgatat tgtgctgtcc acggacatgt
     3421 ccaagcacat gagtctgctg gccgacctaa agacaatggt ggaaaccaaa aaggtggccg
     3481 gctccggagt actgctgctg gacaactaca ccgatcgcat acaggtgctt gagaatctgg
     3541 tgcactgcgc cgatctgagc aatcccacca agccgctgcc gctttacaag cgctgggtag
     3601 ccctgctcat ggaggagttc ttcctgcagg gcgataagga acgcgaatcg ggcatggaca
     3661 ttagtcccat gtgcgatcgc cataatgcca ccattgagaa gtcgcaggtg ggcttcatcg
     3721 actacatcgt ccacccgcta tgggagacct gggcggacct ggtgcatccg gatgcccagg
     3781 atatactcga cacgcttgaa gagaacagag actactacca gagcatgata ccgccttcgc
     3841 cgccgccatc gggcgtcgat gagaatccgc aggaggacag gatacgcttt caagtaaccc
     3901 ttgaggaatc cgatcaggag aacctcgccg aactggagga gggcgacgag agtggtggcg
     3961 agagcaccac cacaggcaca accggaacca ccgctgcatc cgcgctaagc ggagctggtg
     4021 gcggtggcgg tggaggcggg ggaatggcac ccagaacggg tggctgccaa aaccaaccgc
     4081 aacacggtgg aatgtgacgg agagtcgtgg gaatttatcg caaattacag gaaaaggctc
     4141 acaacttttt cctattacgt tagtgactac tattaacaca gaaaaaacca aaacaaaaac
     4201 ctaaaacgaa aagcaaaaaa aaaaacaaag aaaaactctt ggaaaaaatg caaaaaaaaa
     4261 tccacaaaaa aaaaaccaaa aaacccaagt aaggaaatat taaaccaatg tttaaacgca
     4321 tacaaaaatc caaacagcaa tagcaaaact aacgttaaac ctataaagtc tagagaaaat
     4381 cgaaaaagga aattagaaat ttacttaatg gaacccgaga ttgatgttga aaatacactg
     4441 aaaaagaagg aggaggccga gctaactaag ataaaatcgt acatattgtt aaaaacaaaa
     4501 caaaaaaaca tagacacact aaattcaaga caaagcaaag ataataagaa aaattgataa
     4561 gttacaaaaa ataagacgat accgaaaact cccgccccaa aagcctaaga aatcccagta
     4621 cccccccccc ccctccactc ccctttatat atatatatat acaatttttg ttgcatgtgt
     4681 aggtaaatga tttttgtcaa aattcatctg aagtagtaca tccatcagag gcagcccctt
     4741 agctgagtct cctcttttaa tccattgact aaagtgaaat atttaaaaaa cagagaatca
     4801 ggcgaacgaa aaggaataat taatatgacc tagcttataa gagaagttat taagttttta
     4861 aatgttttgc atgcccgaac agatttattt tacttgattg attgataacg ctagatctaa
     4921 ctgataaacg ataacagcaa cacatggagt ttttttttta tataatttag accacagcga
     4981 tagaagcgaa agaaaatcaa ccatgtaaag tttaagaacc cagtgaatta aaccaaaatt
     5041 gaaagccaac cgagttgaaa ccaatttaat tctaaatcta aatctaaatc cacaacccaa
     5101 aacccaaaac cccaagcaac aaaaaagaaa gaaagaagga aaagtaagga acagtctaca
     5161 gccagactgt agttgtatag taatatatat gatataaata ttttttttaa atattatttg
     5221 taaataattt aaatgttgga ctcgaattta aatcaagcgg ctagcaaatg ttgcagctaa
     5281 actaaaatga aaacaaagcc aaaaaacaca cacataaata ggtaaactaa gtgaaaaatg
     5341 tggaaaagga aaaactattg tacaattagc taaagaattt ccatttcaat tttcaatttg
     5401 aattgcaatt taatttgctt ccagaaatga atgaaaggag acaagaaaaa gatagggaga
     5461 taaaccgaaa attagtttca aacgctgtct tcgcaaatat ttttcgctat atatatatat
     5521 atatattact tataacatta ttttactagt tactaagcta cttactgagc cacacaaatt
     5581 taaaacgaaa gagacaagac accaggacaa gaaagagaag gagctttcat gaatttagtg
     5641 aacaaacata actggcaatg gccacacaca cacacacaat ttacaaagcg aacaacacca
     5701 aaaaaaataa ataaaaagac tcttcaagca caaaaaaaac tgtttagttt tcagtaaaca
     5761 gtaaaaccaa agcaaagcaa aataacacac aagatataat ccccaaaaaa gtcattggct
     5821 ataatatgat tacttaacct aacctataca atatatagat atatagatat atcctatatg
     5881 catatgtaaa gtcacgatac tggcgctggt gcgcggatcg atcaatgtgg caggccaaat
     5941 tctaaatgcg cataatttaa ctattgttta cattatgttt tattgttatt aatttattac
     6001 caaaaacgaa aacattattt tttcagacct agtgctataa atttcttttt tgtgttgaag
     6061 cgggcaggat ccgcgcataa aatagtgttt tttttttttt tgtaattaca aatatatata
     6121 aagatacata catatatata tatatatata atatgatatg tgaatgaaat gtaatgaaat
     6181 gaagtggaac cttgatggtc taaaaatatc attaaaagct gatggagatg gaaagttgaa
     6241 gaacaagata ctttatagca atttaagcag cattgtaaat gtgcgcttca gaactacttt
     6301 tttttcgaaa cttaatcgac cttcagcaaa tacagcaaga tatattacct acattacaaa
     6361 catatattat taattgaacc atagttgcga cacaaaacaa aaatgacggc aagtccatgg
     6421 caaacttaag caaaaaccaa aagctacttt aacaaattga gtgaaataaa taaaagaaag
     6481 aaaacaaaca aaaaaaaaaa aacacaaaaa aaaaccatat gacttttttc tcctctcaca
     6541 aaataaaagc gaaaaacaga aaaataaact agtattgtat tgtatttgta acacgaattt
     6601 tcctgcgagt gaacacttta cgcagaacca taaagccgga aactgaaaac ctacagagat
     6661 tccgcagcaa tcgcggcact ggtatgtgtg tatagctaat agctatactc attatgtaat
     6721 ttaccagagt attaatcgaa caatttaaat ttacatatat gcatatgcat accaacatac
     6781 taggaatact aggaatatat gcagtaacgg acatttgatg tatactcgag ttgaaacata
     6841 accctaacca aatgttgtat gtgtatgtgt aattcgatga acttaaaagt ccaaagccat
     6901 acgtgaaaat aagaacaagc aatttatagt gaaaaagtcg aaaagtatct aaatgtaatt
     6961 gttagaaaat gccaagtaaa tccgaaagtt accacagagt taatgaggag gcatcatcta
     7021 tcttgtcatc caagaaatcc ccaaatcaat ttttgactga aattgaatcg tcctagtaga
     7081 ggcactcgat tcgtactcct tccttacccc taccgccccc ccccctcacc aacttccttt
     7141 gccccaacta ttgtacttta tccaatattt tcctatcgac gtgccgccaa ttatatcagt
     7201 gtatataaac tatttgaaaa tcacgcatat atatgcacac atagagtttt tgtagcgtca
     7261 tatgtgtcat taaggatgcc cacttacata catatatgaa gggaaataaa taagcaagta
     7321 aatatacaat acaatacata catatatgtg tgtgttgtgg gtaacgagag atcagcattt
     7381 gtagcacagg ttggccaaat ttattgggaa taacgagttg ccgaagttgc cgaagaaaaa
     7441 ccaaatgaaa actgtttgtt gtgctgttag ccgtaaatga gaactttttt ttgagataac
     7501 ttaataccta tatatataaa tatgtattac aatatatgta tctataaata tataaaacag
     7561 gcgacaaacc aaattaaacc aaataccgga acaaaaaaaa aaaaacgaaa aagaagagag
     7621 agaaaaaata atacaagcga tattgaaaat ggcacgtttt gtactataat gaaatgagaa
     7681 aacaccaaag acgaatgcaa aacaaaaaaa aatgcaaaca cataacaaaa tatacaagaa
     7741 atattcttaa caaaaagaaa aaaataccat aaattgtgcg ctggcgacga cggttgtttg
     7801 aaaaaaagag aaagcaaaaa acaggacatg ccgcttgaag tgccgatcgt aagcgagtcc
     7861 tttcgattcg caaatcgtcg gcatttcaat cgattgaaga atcgggagat attatataca
     7921 tatagaacac gtaacgctgg cgttactggg caaacagtta ggcatttttt ttttttcttt
     7981 tttggaaatt tatacaatta catatacaaa aagagctcac ccccacaaca acaaggacaa
     8041 ctgcagaaga agaacaaaaa aaatacacac atacatggaa acactaacgc gtacacggac
     8101 agcgatttgc cggaacaaaa ttctgggtat ttcgaaccga gaaagggaac ggaaacggaa
     8161 acggaaacga aaatatagaa cgcggcaagt tatttaacac tgaaactgat cgggtgtaac
     8221 tatagtaccg aaatggggct tacacaggct gattcaccca aaataagtat acatgtattg
     8281 tagtaacgag cgctggcttt tgttattaag ttatgtattt gtttcgatta tgttttgcct
     8341 ctctcagaat atatatatat atatatatat atatatatat atgtatattc tatgtatata
     8401 tatatattag ttatgtatgt gaaaaaagcg taatcattta tgaaaccaat gaaaatctaa
     8461 cctgaaaaca aagagaaaac cccaagtcaa atacacaatt gcatgcaaga gtaagtaata
     8521 ttaatgaaat ctaagaacaa aggtcactcc cgggcttaaa aaaaaaaaaa gaagaaaaaa
     8581 aatgggccgc atggcaaatg ataaatggta aaacaaaaca atgagcaggt ggcattatga
     8641 acagatttga atgattacgg aatacagact aaaaatgaaa atgaaaaatt t