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Drosophila melanogaster dunce (dnc), transcript variant C, mRNA.


LOCUS       NM_166962               3792 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_166962
VERSION     NM_166962.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3792)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3792)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3792)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3792)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3792)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3792)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3792)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3792)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3792)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3792)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3792)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3792)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3792)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3792)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3792)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3792)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3792)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3792)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3792)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3792)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3792)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3792)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3792)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Dec 17, 2009 this sequence version replaced NM_166962.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3792
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3792
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="dunce"
                     /map="3C9-3D1"
                     /db_xref="FLYBASE:FBgn0000479"
                     /db_xref="GeneID:31309"
     CDS             465..3638
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /EC_number="3.1.4.-"
                     /EC_number="3.1.4.17"
                     /EC_number="3.1.4.53"
                     /note="CG32498 gene product from transcript CG32498-RC;
                     CG32498-PC; dnc-PC; dunce phosphodiesterase"
                     /codon_start=1
                     /product="dunce, isoform C"
                     /protein_id="NP_726850.1"
                     /db_xref="FLYBASE:FBpp0070488"
                     /db_xref="GeneID:31309"
                     /db_xref="FLYBASE:FBgn0000479"
                     /translation="MSQESNGGPAAGGGAAAAPPPPPQYIITTPSEVDPDEVRSMADL
                     ELGSPEKQVQVQSQKFSSTSSTTKVATHSFSMSSSAGTTGQQSKQDSAQQIQQLQQLQ
                     QLQQLQQQQQQQQSQRIISSSTRSQSLQSSTIVGEATTITSGAAQILSASAAASLAQQ
                     LKAQSSTSIITSSEQRTSTSTSSSSSTRYIASGSSNLAGGNSNSASSASSKTRFQSFL
                     QQPEGAHGFLTAHQKHVRQFVRSTSAHSEAAAGVAGARAEKCIRSASTQIDDASVAGV
                     VESAGNLTDSSATGGSMQLSMSKLGLQQSSSILISKSAETIEMKSSSAGMRTQLTLSG
                     GFLAPPGNRKITILSPIHAPPGLHDMLKRAQGRSPLSPRISFPGSDSDLFGFDVENGQ
                     GARSPLEGGSPSAGLVLQNLPQRRESFLYRSDSDFEMSPKSMSRNSSIASESHGEDLI
                     VTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYT
                     RLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEY
                     ICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVK
                     RPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAY
                     TIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPAL
                     EGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFK
                     LLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGV
                     LLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDIS
                     PMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPS
                     PPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDESGGESTTTGTTGTTAASALSG
                     AGGGGGGGGGMAPRTGGCQNQPQHGGM"
     misc_feature    1815..2183
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="Phosphodiesterase 4 upstream conserved regions
                     (UCR); Region: PDE4_UCR; pfam18100"
                     /db_xref="CDD:465648"
     misc_feature    2616..3338
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="3'5'-cyclic nucleotide phosphodiesterase; Region:
                     PDEase_I; pfam00233"
                     /db_xref="CDD:459723"
ORIGIN      
        1 caacaacagc acagcggcag tagcaacaac gcagtaacag aagcagtagc agcagcaaca
       61 gcagcagcaa cagcaacagc aacatcactg tggcaaccgc aacagcacag cagcagcaac
      121 atcagcacgt gtgcgtgccc caaacagaga gataaataca taaaacgccg agaaattcaa
      181 gagaaaagca agaaaaaagt taaggctaaa aagcaattaa aacaaattgt gccgtaagtc
      241 aagtcggtgg gcttacagcc cagtcccccg caaataaaag aaaaaataaa aaaaaaaata
      301 aaaaaaaaaa tagaaagaaa caaagaaaac tgtaagaaaa aaagaacaga aatacacgag
      361 taaccaccgc aggatccgca ggacaacgta cccaccgatc ccaaaaaaga aacgcacgag
      421 acaaaacaaa aaaaaaacga aaaaaagtga aataaaagga aaccatgtcc caggagagta
      481 atggtggccc agcagcagga ggcggagcag cagcagcacc accaccacca ccacaataca
      541 taataaccac acccagcgag gtggatcccg acgaagtgcg ctccatggcc gacctagagc
      601 tgggatcccc cgaaaagcag gtgcaggtac agagtcaaaa gttctccagc acgtcgagca
      661 ccaccaaggt ggccacccac tcattttcga tgagcagtag tgccggcact actgggcagc
      721 aaagcaaaca ggacagcgcc cagcaaatcc aacagcttca gcagctccaa cagctccagc
      781 aactccagca gcagcagcag cagcaacagt cccagagaat catatccagt tcgacgagaa
      841 gccagagcct gcagtccagc acaattgtgg gcgaggccac tacaattacg agcggagctg
      901 cccaaatcct aagcgcctcg gcggcggctt cgctggccca gcagctgaag gcccaaagct
      961 ccacctcgat tatcacaagc agcgagcaga ggacgagcac aagcaccagt agcagcagca
     1021 gcacccgtta catagccagc ggctcgagca acctggccgg tggcaattcg aattcggcca
     1081 gctcggccag cagcaagact cgcttccaga gtttccttca gcagccggag ggtgcgcacg
     1141 gttttctgac ggcccatcag aagcatgtgc gtcaatttgt gcgctccaca tcggcacatt
     1201 cggaggcggc agccggagtg gctggggcac gggcggagaa gtgcatacgc agcgcttcca
     1261 cacagatcga tgatgccagt gtggccggtg tggtggagtc ggctggtaac ttgactgaca
     1321 gctccgccac gggaggatcc atgcagctgt cgatgagcaa actgggcctg cagcagtcat
     1381 cgtccatatt gatctccaag tcggccgaaa cgatcgagat gaagagctcg tcggcgggca
     1441 tgcgcaccca gttgacattg agcggtggct tcttggcgcc gccgggcaat cgaaaaataa
     1501 ccattttgag tccaattcac gcaccgcccg gtctgcatga tatgctcaag cgggcccaag
     1561 gacgatcgcc gctatcgccc aggatcagct ttcccggcag cgattcggac ctctttggtt
     1621 tcgatgtaga aaatggccag ggcgctagat caccgctcga gggcggctca cccagcgccg
     1681 gtttggtact acagaatttg ccgcagcgtc gcgaatcgtt tctatatcgc tccgattcgg
     1741 actttgagat gtcacccaag tccatgtccc gaaactcaag catcgctagc gaaagccatg
     1801 gcgaggatct cattgtgacg cctttcgccc aaattttagc cagcttacgt tcagtgcgca
     1861 acaatttatt aagtctgaca aatgttccag catcaaacaa atccaggcgg cccaaccaat
     1921 cgtcgtcggc ctcgcgatca ggaaatccac caggagcccc gctatcccaa ggcgaggagg
     1981 catacacccg cctggccacc gacacaatcg aggagctgga ctggtgcctc gaccagctgg
     2041 agaccatcca gacccatcgc agcgtctccg acatggcgtc gcttaagttc aaacgcatgc
     2101 tcaacaagga gctgtcgcac tttagcgagt ccagcagatc gggaaatcag atttccgaat
     2161 atatatgttc cacatttttg gacaagcaac aggagttcga cttgccatcg ctgcgcgtgg
     2221 aggataatcc cgagctggtc gccgccaatg cagccgctgg tcaacagtcc gctggacagt
     2281 atgcacgctc ccgatcgccg cgcggtccgc ccatgtcgca gatcagcggc gtgaagagac
     2341 cgctgtcgca tacgaatagc tttaccggcg aacgtttgcc caccttcggt gtggagacac
     2401 ccagggagaa tgagctgggc acgctgctcg gcgaactgga cacctggggt attcagatat
     2461 tcagcatcgg cgagttcagt gtcaatcgac cgctcacctg tgtggcatac accatatttc
     2521 agagtagaga attactgacc agtcttatga taccaccgaa aacttttctt aactttatgt
     2581 ctactctgga ggaccactac gtcaaagaca atccgtttca caattcgctg catgccgccg
     2641 atgtgacaca aagcactaat gtgctactca atacaccggc gctggagggc gtattcacgc
     2701 cgctcgaagt gggcggggcg ctgttcgccg cttgcataca cgatgttgat catcccggct
     2761 taaccaatca gttcttggtt aactcaagtt ccgaactagc attaatgtac aatgacgaat
     2821 ctgttttgga aaatcatcat ttagctgttg cctttaaatt attacaaaat caaggatgtg
     2881 atatattctg taatatgcaa aagaaacaac gccaaacatt gaggaaaatg gttattgata
     2941 ttgtgctgtc cacggacatg tccaagcaca tgagtctgct ggccgaccta aagacaatgg
     3001 tggaaaccaa aaaggtggcc ggctccggag tactgctgct ggacaactac accgatcgca
     3061 tacaggtgct tgagaatctg gtgcactgcg ccgatctgag caatcccacc aagccgctgc
     3121 cgctttacaa gcgctgggta gccctgctca tggaggagtt cttcctgcag ggcgataagg
     3181 aacgcgaatc gggcatggac attagtccca tgtgcgatcg ccataatgcc accattgaga
     3241 agtcgcaggt gggcttcatc gactacatcg tccacccgct atgggagacc tgggcggacc
     3301 tggtgcatcc ggatgcccag gatatactcg acacgcttga agagaacaga gactactacc
     3361 agagcatgat accgccttcg ccgccgccat cgggcgtcga tgagaatccg caggaggaca
     3421 ggatacgctt tcaagtaacc cttgaggaat ccgatcagga gaacctcgcc gaactggagg
     3481 agggcgacga gagtggtggc gagagcacca ccacaggcac aaccggaacc accgctgcat
     3541 ccgcgctaag cggagctggt ggcggtggcg gtggaggcgg gggaatggca cccagaacgg
     3601 gtggctgcca aaaccaaccg caacacggtg gaatgtgacg gagagtcgtg ggaatttatc
     3661 gcaaattaca ggaaaaggct cacaactttt tcctattacg ttagtgacta ctattaacac
     3721 agaaaaaacc aaaacaaaaa cctaaaacga aaagcaaaaa aaaaaacaaa gaaaaactct
     3781 tggaaaaaat gc