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Drosophila melanogaster dunce (dnc), transcript variant B, mRNA.


LOCUS       NM_166960               4093 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_166960
VERSION     NM_166960.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4093)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4093)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4093)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4093)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4093)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4093)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4093)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4093)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4093)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4093)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4093)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4093)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4093)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4093)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4093)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4093)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4093)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4093)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4093)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4093)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4093)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4093)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4093)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_166960.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4093
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4093
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="dunce"
                     /map="3C9-3D1"
                     /db_xref="FLYBASE:FBgn0000479"
                     /db_xref="GeneID:31309"
     CDS             310..3939
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /EC_number="3.1.4.-"
                     /EC_number="3.1.4.17"
                     /EC_number="3.1.4.53"
                     /note="CG32498 gene product from transcript CG32498-RB;
                     CG32498-PB; dnc-PB; dunce phosphodiesterase"
                     /codon_start=1
                     /product="dunce, isoform B"
                     /protein_id="NP_726847.2"
                     /db_xref="FLYBASE:FBpp0070485"
                     /db_xref="GeneID:31309"
                     /db_xref="FLYBASE:FBgn0000479"
                     /translation="MMRLARFTQGFSFNKNVAKHRGSGSSNGTGNGSGTGNGQGLGGS
                     CSANGLAATGGVGGGGGSGSGGGGCGSGSGSGSGKRKSKARTKCFGGTVFRCCLPCRG
                     GGSAAPATSPPQTPAQTPDELKVIPEDCNLEKSAEQKRDLLERNNKEDDLLNRTVSGS
                     ELDLYGGAGGGTKKHSLADTIDTSVTTPISLKTLINDVDEELDQQLSAADIAAASLAS
                     GLVARRAEPETLSDASVSPTAVVQQQQQQQQQLQQPLLQSQPHFVPSSGNILSQVTLY
                     SGSNPSTNPCQSAVQNQGQNSNPNPNQNPNTNPNQNQQRCSCQPQTSPLPHIKEEEES
                     DQANFKHQTSLKEHQPLPPPITIATGYCGSCESVHHSSATSSSAGTVPPGGQQTQEYI
                     AGTSSTPSPRIKLKFRKPHKSCWSRIVLAPIGSAGGSSSATTVIGSNSNETLASSSTT
                     GGTATTTQNSSSVSVAAHHRLTSSSASALATSHPSNSQLLPTSKMQAEQGSIGDLQKY
                     HSRYLKNRRHTLANVRFDVENGQGARSPLEGGSPSAGLVLQNLPQRRESFLYRSDSDF
                     EMSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLT
                     NVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQT
                     HRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDN
                     PELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETP
                     RENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNF
                     MSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVD
                     HPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLR
                     KMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADL
                     SNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIV
                     HPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLE
                     ESDQENLAELEEGDESGGESTTTGTTGTTAASALSGAGGGGGGGGGMAPRTGGCQNQP
                     QHGGM"
     misc_feature    2116..2484
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="Phosphodiesterase 4 upstream conserved regions
                     (UCR); Region: PDE4_UCR; pfam18100"
                     /db_xref="CDD:465648"
     misc_feature    2917..3639
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="3'5'-cyclic nucleotide phosphodiesterase; Region:
                     PDEase_I; pfam00233"
                     /db_xref="CDD:459723"
ORIGIN      
        1 ttatttgcac gcatgtcgtc gaccaggacg aatcgtttgg cagagcgcgg ctgaaaaagg
       61 aatcgaaaac ggggctataa cggtaatagc ggcacacgcg tccaacggta aacacgcgtg
      121 ccaacgcgcc atctcgctcg cacgcgctaa tgccgcgatt taagttttgt tttatttttt
      181 gcaagtgttc gaatcaaaaa gcctaacaaa acacaaaacc cgaaacagtt ctcaagaaat
      241 acatagatct cggcttgata gaaaaaaaaa atgttttcgc gcaacagata gctcccaacc
      301 gaagtgggaa tgatgcgatt ggcgcgattt acgcagggtt tctcgtttaa caagaatgtg
      361 gccaagcatc gcggcagtgg cagtagcaac ggcaccggaa acggaagcgg gaccggaaac
      421 ggccagggat taggtggcag ctgcagtgcc aacggcctgg cagccactgg cggcgttgga
      481 gggggcggtg ggagtggcag cggcggcggt gggtgtggca gcgggagtgg cagtgggagt
      541 ggcaagcgga aatcaaaggc aagaacaaag tgcttcggtg gcacagtgtt tcggtgttgc
      601 ctcccttgtc gcgggggcgg ctccgcagcc cccgccacaa gtccgcccca aacaccagcc
      661 cagacgccgg acgagctcaa ggtcattccg gaggattgta atctggaaaa gtccgcggag
      721 caaaagcgcg acttactgga gcggaacaac aaggaggacg atctgctgaa ccgcaccgta
      781 tccggatctg agctggatct atacggcggc gccggcggcg gtacgaaaaa gcattcgctg
      841 gcagacacca tcgatacatc ggtgaccacc ccgatttccc taaagaccct gatcaacgac
      901 gtcgacgagg agctggacca gcaactgagt gcggcggata tagcggccgc cagtttggcc
      961 agcggtctgg ttgcccgccg agcggaacca gaaacactga gcgacgccag tgtctcaccc
     1021 accgcggtgg tgcagcagca gcagcagcag cagcagcagc tgcagcaacc actcttgcaa
     1081 tcacaaccac attttgtgcc cagcagcggc aatatcctta gccaggtcac cctgtacagc
     1141 ggcagcaatc cctcgacaaa tccctgccag agtgcagtgc agaatcaagg ccaaaactcc
     1201 aatcccaatc ccaatcagaa tccaaacaca aatccgaacc agaatcaaca gcgttgcagt
     1261 tgccagccgc agacttcccc attgccgcat atcaaagagg aggaggaatc cgatcaggcc
     1321 aactttaaac accagacgag cctgaaggag catcagcctc tcccgccacc gatcaccata
     1381 gccactggct actgcggcag ctgcgagagc gttcatcact catccgcaac ctcgtcttcg
     1441 gcgggcacag tacctccggg gggtcagcaa actcaggagt atattgccgg tacctcttcg
     1501 acgccctcgc cgcgcatcaa actaaagttc cgcaagccgc acaagtcctg ctggtcgcga
     1561 atcgtccttg cgcccattgg atcggcgggt ggctcctcat cggccaccac tgtcattggc
     1621 agcaattcga acgagacttt ggcctccagc agcaccaccg gcggcaccgc caccaccacc
     1681 cagaacagca gcagcgttag cgttgccgca caccaccggc taacctcgtc gtcggcctcc
     1741 gccctcgcca cctcgcaccc cagcaactcg cagctgctgc ccaccagcaa gatgcaggcg
     1801 gagcagggat ccatcggtga cctgcagaag taccatagtc ggtatctcaa gaatcgtcgc
     1861 catactctgg ccaatgttcg tttcgatgta gaaaatggcc agggcgctag atcaccgctc
     1921 gagggcggct cacccagcgc cggtttggta ctacagaatt tgccgcagcg tcgcgaatcg
     1981 tttctatatc gctccgattc ggactttgag atgtcaccca agtccatgtc ccgaaactca
     2041 agcatcgcta gcgaaaggtt taaagaacag gaagcctcta tactcgttga ccgatcccat
     2101 ggcgaggatc tcattgtgac gcctttcgcc caaattttag ccagcttacg ttcagtgcgc
     2161 aacaatttat taagtctgac aaatgttcca gcatcaaaca aatccaggcg gcccaaccaa
     2221 tcgtcgtcgg cctcgcgatc aggaaatcca ccaggagccc cgctatccca aggcgaggag
     2281 gcatacaccc gcctggccac cgacacaatc gaggagctgg actggtgcct cgaccagctg
     2341 gagaccatcc agacccatcg cagcgtctcc gacatggcgt cgcttaagtt caaacgcatg
     2401 ctcaacaagg agctgtcgca ctttagcgag tccagcagat cgggaaatca gatttccgaa
     2461 tatatatgtt ccacattttt ggacaagcaa caggagttcg acttgccatc gctgcgcgtg
     2521 gaggataatc ccgagctggt cgccgccaat gcagccgctg gtcaacagtc cgctggacag
     2581 tatgcacgct cccgatcgcc gcgcggtccg cccatgtcgc agatcagcgg cgtgaagaga
     2641 ccgctgtcgc atacgaatag ctttaccggc gaacgtttgc ccaccttcgg tgtggagaca
     2701 cccagggaga atgagctggg cacgctgctc ggcgaactgg acacctgggg tattcagata
     2761 ttcagcatcg gcgagttcag tgtcaatcga ccgctcacct gtgtggcata caccatattt
     2821 cagagtagag aattactgac cagtcttatg ataccaccga aaacttttct taactttatg
     2881 tctactctgg aggaccacta cgtcaaagac aatccgtttc acaattcgct gcatgccgcc
     2941 gatgtgacac aaagcactaa tgtgctactc aatacaccgg cgctggaggg cgtattcacg
     3001 ccgctcgaag tgggcggggc gctgttcgcc gcttgcatac acgatgttga tcatcccggc
     3061 ttaaccaatc agttcttggt taactcaagt tccgaactag cattaatgta caatgacgaa
     3121 tctgttttgg aaaatcatca tttagctgtt gcctttaaat tattacaaaa tcaaggatgt
     3181 gatatattct gtaatatgca aaagaaacaa cgccaaacat tgaggaaaat ggttattgat
     3241 attgtgctgt ccacggacat gtccaagcac atgagtctgc tggccgacct aaagacaatg
     3301 gtggaaacca aaaaggtggc cggctccgga gtactgctgc tggacaacta caccgatcgc
     3361 atacaggtgc ttgagaatct ggtgcactgc gccgatctga gcaatcccac caagccgctg
     3421 ccgctttaca agcgctgggt agccctgctc atggaggagt tcttcctgca gggcgataag
     3481 gaacgcgaat cgggcatgga cattagtccc atgtgcgatc gccataatgc caccattgag
     3541 aagtcgcagg tgggcttcat cgactacatc gtccacccgc tatgggagac ctgggcggac
     3601 ctggtgcatc cggatgccca ggatatactc gacacgcttg aagagaacag agactactac
     3661 cagagcatga taccgccttc gccgccgcca tcgggcgtcg atgagaatcc gcaggaggac
     3721 aggatacgct ttcaagtaac ccttgaggaa tccgatcagg agaacctcgc cgaactggag
     3781 gagggcgacg agagtggtgg cgagagcacc accacaggca caaccggaac caccgctgca
     3841 tccgcgctaa gcggagctgg tggcggtggc ggtggaggcg ggggaatggc acccagaacg
     3901 ggtggctgcc aaaaccaacc gcaacacggt ggaatgtgac ggagagtcgt gggaatttat
     3961 cgcaaattac aggaaaaggc tcacaacttt ttcctattac gttagtgact actattaaca
     4021 cagaaaaaac caaaacaaaa acctaaaacg aaaagcaaaa aaaaaaacaa agaaaaactc
     4081 ttggaaaaaa tgc