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Drosophila melanogaster dunce (dnc), transcript variant S, mRNA.


LOCUS       NM_166959               9576 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_166959
VERSION     NM_166959.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 9576)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9576)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9576)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 9576)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 9576)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 9576)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 9576)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 9576)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 9576)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 9576)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 9576)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 9576)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 9576)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 9576)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 9576)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 9576)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 9576)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 9576)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 9576)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 9576)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 9576)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 9576)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 9576)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_166959.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9576
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..9576
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="dunce"
                     /map="3C9-3D1"
                     /db_xref="FLYBASE:FBgn0000479"
                     /db_xref="GeneID:31309"
     CDS             1353..4982
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /EC_number="3.1.4.-"
                     /EC_number="3.1.4.17"
                     /EC_number="3.1.4.53"
                     /note="CG32498 gene product from transcript CG32498-RS;
                     CG32498-PS; dnc-PS; dunce phosphodiesterase"
                     /codon_start=1
                     /product="dunce, isoform S"
                     /protein_id="NP_726846.1"
                     /db_xref="FLYBASE:FBpp0305507"
                     /db_xref="GeneID:31309"
                     /db_xref="FLYBASE:FBgn0000479"
                     /translation="MMRLARFTQGFSFNKNVAKHRGSGSSNGTGNGSGTGNGQGLGGS
                     CSANGLAATGGVGGGGGSGSGGGGCGSGSGSGSGKRKSKARTKCFGGTVFRCCLPCRG
                     GGSAAPATSPPQTPAQTPDELKVIPEDCNLEKSAEQKRDLLERNNKEDDLLNRTVSGS
                     ELDLYGGAGGGTKKHSLADTIDTSVTTPISLKTLINDVDEELDQQLSAADIAAASLAS
                     GLVARRAEPETLSDASVSPTAVVQQQQQQQQQLQQPLLQSQPHFVPSSGNILSQVTLY
                     SGSNPSTNPCQSAVQNQGQNSNPNPNQNPNTNPNQNQQRCSCQPQTSPLPHIKEEEES
                     DQANFKHQTSLKEHQPLPPPITIATGYCGSCESVHHSSATSSSAGTVPPGGQQTQEYI
                     AGTSSTPSPRIKLKFRKPHKSCWSRIVLAPIGSAGGSSSATTVIGSNSNETLASSSTT
                     GGTATTTQNSSSVSVAAHHRLTSSSASALATSHPSNSQLLPTSKMQAEQGSIGDLQKY
                     HSRYLKNRRHTLANVRFDVENGQGARSPLEGGSPSAGLVLQNLPQRRESFLYRSDSDF
                     EMSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLT
                     NVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQT
                     HRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDN
                     PELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETP
                     RENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNF
                     MSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVD
                     HPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLR
                     KMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADL
                     SNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIV
                     HPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLE
                     ESDQENLAELEEGDESGGESTTTGTTGTTAASALSGAGGGGGGGGGMAPRTGGCQNQP
                     QHGGM"
     misc_feature    3159..3527
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="Phosphodiesterase 4 upstream conserved regions
                     (UCR); Region: PDE4_UCR; pfam18100"
                     /db_xref="CDD:465648"
     misc_feature    3960..4682
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="3'5'-cyclic nucleotide phosphodiesterase; Region:
                     PDEase_I; pfam00233"
                     /db_xref="CDD:459723"
ORIGIN      
        1 ttatttgcac gcatgtcgtc gaccaggacg aatcgtttgg cagagcgcgg ctgaaaaagg
       61 aatcgaaaac ggggctataa cggtaatagc ggcacacgcg tccaacggta aacacgcgtg
      121 ccaacgcgcc atctcgctcg cacgcgctaa tgccgcgatt taagttttgt tttatttttt
      181 gcaagtgttc gaatcaaaaa gcctaacaaa acacaaaacc cgaaacagtt ctcaagaaat
      241 acatagtctg cggttgataa agactttgat tgaaaattaa agcgtgcgct aaaaaataat
      301 tcggattcga taataaaaga aaaaaaaaaa aaaaattctt tgacttcatt gcaaggaaga
      361 tccgaagttt tgttaatttt aatttttttt tcggttactg tgctaatcag aaattacaaa
      421 ttagaaattc gaaaatcgaa atttttcggc gttaggccag cggaagctga taaacaacag
      481 agaagcggcg gcatctggaa aataataaaa ctcgaaggtt tgaggtgagt tccctatttg
      541 agtgtgaaaa tcgagtgaaa gagcggcggc tgcgcaccac ttatcgcggg cttttcgcac
      601 aagggggttt ttctcgtcga caaaaaaaaa aaaaaaaaca aaaaactgtc aaatgagcaa
      661 agaggcggaa aagagacgaa acaacaacaa atgcagcgga acaagaaaaa ataagaaagc
      721 aaatagaaaa cgacaacaaa aaagctggcc aaacaacaac aaatgtaacg cggaaaaggc
      781 agttttcttt ggccgcagca gcagcagcat gcgggaaaat catccgcaag ccgcagaata
      841 aatatgattt aataaataac taaacgcagt tagcaataac catgagcaat atctattaaa
      901 tccatttaaa taaatcgcta tatttttgtt aaaacaacac ttttttttcg agtgcccaaa
      961 gtgtgtgtgc ataaatattt ttaagaaaag ccacaagctg tgcagcaaaa aaatttttaa
     1021 cattaggtgt gccaaaaaat ttaaatgaaa aacccaacaa gctcggcaaa caaatgtata
     1081 aagtgtttga aaaccaaaga tgaaacactt cggcgggcaa ctaaatgaat aatagtgtcg
     1141 tggtaaatta atacatatac gtggattaaa tcaaggaaaa tcgaaatttt cctgcccaaa
     1201 tgaatatgca aaccaaaata aacaacaaaa taacataggc ggcattctgc agagagcaag
     1261 aagcagagca gaatccgagg agacaaaaga tctcggcttg atagaaaaaa aaaatgtttt
     1321 cgcgcaacag atagctccca accgaagtgg gaatgatgcg attggcgcga tttacgcagg
     1381 gtttctcgtt taacaagaat gtggccaagc atcgcggcag tggcagtagc aacggcaccg
     1441 gaaacggaag cgggaccgga aacggccagg gattaggtgg cagctgcagt gccaacggcc
     1501 tggcagccac tggcggcgtt ggagggggcg gtgggagtgg cagcggcggc ggtgggtgtg
     1561 gcagcgggag tggcagtggg agtggcaagc ggaaatcaaa ggcaagaaca aagtgcttcg
     1621 gtggcacagt gtttcggtgt tgcctccctt gtcgcggggg cggctccgca gcccccgcca
     1681 caagtccgcc ccaaacacca gcccagacgc cggacgagct caaggtcatt ccggaggatt
     1741 gtaatctgga aaagtccgcg gagcaaaagc gcgacttact ggagcggaac aacaaggagg
     1801 acgatctgct gaaccgcacc gtatccggat ctgagctgga tctatacggc ggcgccggcg
     1861 gcggtacgaa aaagcattcg ctggcagaca ccatcgatac atcggtgacc accccgattt
     1921 ccctaaagac cctgatcaac gacgtcgacg aggagctgga ccagcaactg agtgcggcgg
     1981 atatagcggc cgccagtttg gccagcggtc tggttgcccg ccgagcggaa ccagaaacac
     2041 tgagcgacgc cagtgtctca cccaccgcgg tggtgcagca gcagcagcag cagcagcagc
     2101 agctgcagca accactcttg caatcacaac cacattttgt gcccagcagc ggcaatatcc
     2161 ttagccaggt caccctgtac agcggcagca atccctcgac aaatccctgc cagagtgcag
     2221 tgcagaatca aggccaaaac tccaatccca atcccaatca gaatccaaac acaaatccga
     2281 accagaatca acagcgttgc agttgccagc cgcagacttc cccattgccg catatcaaag
     2341 aggaggagga atccgatcag gccaacttta aacaccagac gagcctgaag gagcatcagc
     2401 ctctcccgcc accgatcacc atagccactg gctactgcgg cagctgcgag agcgttcatc
     2461 actcatccgc aacctcgtct tcggcgggca cagtacctcc ggggggtcag caaactcagg
     2521 agtatattgc cggtacctct tcgacgccct cgccgcgcat caaactaaag ttccgcaagc
     2581 cgcacaagtc ctgctggtcg cgaatcgtcc ttgcgcccat tggatcggcg ggtggctcct
     2641 catcggccac cactgtcatt ggcagcaatt cgaacgagac tttggcctcc agcagcacca
     2701 ccggcggcac cgccaccacc acccagaaca gcagcagcgt tagcgttgcc gcacaccacc
     2761 ggctaacctc gtcgtcggcc tccgccctcg ccacctcgca ccccagcaac tcgcagctgc
     2821 tgcccaccag caagatgcag gcggagcagg gatccatcgg tgacctgcag aagtaccata
     2881 gtcggtatct caagaatcgt cgccatactc tggccaatgt tcgtttcgat gtagaaaatg
     2941 gccagggcgc tagatcaccg ctcgagggcg gctcacccag cgccggtttg gtactacaga
     3001 atttgccgca gcgtcgcgaa tcgtttctat atcgctccga ttcggacttt gagatgtcac
     3061 ccaagtccat gtcccgaaac tcaagcatcg ctagcgaaag gtttaaagaa caggaagcct
     3121 ctatactcgt tgaccgatcc catggcgagg atctcattgt gacgcctttc gcccaaattt
     3181 tagccagctt acgttcagtg cgcaacaatt tattaagtct gacaaatgtt ccagcatcaa
     3241 acaaatccag gcggcccaac caatcgtcgt cggcctcgcg atcaggaaat ccaccaggag
     3301 ccccgctatc ccaaggcgag gaggcataca cccgcctggc caccgacaca atcgaggagc
     3361 tggactggtg cctcgaccag ctggagacca tccagaccca tcgcagcgtc tccgacatgg
     3421 cgtcgcttaa gttcaaacgc atgctcaaca aggagctgtc gcactttagc gagtccagca
     3481 gatcgggaaa tcagatttcc gaatatatat gttccacatt tttggacaag caacaggagt
     3541 tcgacttgcc atcgctgcgc gtggaggata atcccgagct ggtcgccgcc aatgcagccg
     3601 ctggtcaaca gtccgctgga cagtatgcac gctcccgatc gccgcgcggt ccgcccatgt
     3661 cgcagatcag cggcgtgaag agaccgctgt cgcatacgaa tagctttacc ggcgaacgtt
     3721 tgcccacctt cggtgtggag acacccaggg agaatgagct gggcacgctg ctcggcgaac
     3781 tggacacctg gggtattcag atattcagca tcggcgagtt cagtgtcaat cgaccgctca
     3841 cctgtgtggc atacaccata tttcagagta gagaattact gaccagtctt atgataccac
     3901 cgaaaacttt tcttaacttt atgtctactc tggaggacca ctacgtcaaa gacaatccgt
     3961 ttcacaattc gctgcatgcc gccgatgtga cacaaagcac taatgtgcta ctcaatacac
     4021 cggcgctgga gggcgtattc acgccgctcg aagtgggcgg ggcgctgttc gccgcttgca
     4081 tacacgatgt tgatcatccc ggcttaacca atcagttctt ggttaactca agttccgaac
     4141 tagcattaat gtacaatgac gaatctgttt tggaaaatca tcatttagct gttgccttta
     4201 aattattaca aaatcaagga tgtgatatat tctgtaatat gcaaaagaaa caacgccaaa
     4261 cattgaggaa aatggttatt gatattgtgc tgtccacgga catgtccaag cacatgagtc
     4321 tgctggccga cctaaagaca atggtggaaa ccaaaaaggt ggccggctcc ggagtactgc
     4381 tgctggacaa ctacaccgat cgcatacagg tgcttgagaa tctggtgcac tgcgccgatc
     4441 tgagcaatcc caccaagccg ctgccgcttt acaagcgctg ggtagccctg ctcatggagg
     4501 agttcttcct gcagggcgat aaggaacgcg aatcgggcat ggacattagt cccatgtgcg
     4561 atcgccataa tgccaccatt gagaagtcgc aggtgggctt catcgactac atcgtccacc
     4621 cgctatggga gacctgggcg gacctggtgc atccggatgc ccaggatata ctcgacacgc
     4681 ttgaagagaa cagagactac taccagagca tgataccgcc ttcgccgccg ccatcgggcg
     4741 tcgatgagaa tccgcaggag gacaggatac gctttcaagt aacccttgag gaatccgatc
     4801 aggagaacct cgccgaactg gaggagggcg acgagagtgg tggcgagagc accaccacag
     4861 gcacaaccgg aaccaccgct gcatccgcgc taagcggagc tggtggcggt ggcggtggag
     4921 gcgggggaat ggcacccaga acgggtggct gccaaaacca accgcaacac ggtggaatgt
     4981 gacggagagt cgtgggaatt tatcgcaaat tacaggaaaa ggctcacaac tttttcctat
     5041 tacgttagtg actactatta acacagaaaa aaccaaaaca aaaacctaaa acgaaaagca
     5101 aaaaaaaaaa caaagaaaaa ctcttggaaa aaatgcaaaa aaaaatccac aaaaaaaaaa
     5161 ccaaaaaacc caagtaagga aatattaaac caatgtttaa acgcatacaa aaatccaaac
     5221 agcaatagca aaactaacgt taaacctata aagtctagag aaaatcgaaa aaggaaatta
     5281 gaaatttact taatggaacc cgagattgat gttgaaaata cactgaaaaa gaaggaggag
     5341 gccgagctaa ctaagataaa atcgtacata ttgttaaaaa caaaacaaaa aaacatagac
     5401 acactaaatt caagacaaag caaagataat aagaaaaatt gataagttac aaaaaataag
     5461 acgataccga aaactcccgc cccaaaagcc taagaaatcc cagtaccccc cccccccctc
     5521 cactcccctt tatatatata tatatacaat ttttgttgca tgtgtaggta aatgattttt
     5581 gtcaaaattc atctgaagta gtacatccat cagaggcagc cccttagctg agtctcctct
     5641 tttaatccat tgactaaagt gaaatattta aaaaacagag aatcaggcga acgaaaagga
     5701 ataattaata tgacctagct tataagagaa gttattaagt ttttaaatgt tttgcatgcc
     5761 cgaacagatt tattttactt gattgattga taacgctaga tctaactgat aaacgataac
     5821 agcaacacat ggagtttttt ttttatataa tttagaccac agcgatagaa gcgaaagaaa
     5881 atcaaccatg taaagtttaa gaacccagtg aattaaacca aaattgaaag ccaaccgagt
     5941 tgaaaccaat ttaattctaa atctaaatct aaatccacaa cccaaaaccc aaaaccccaa
     6001 gcaacaaaaa agaaagaaag aaggaaaagt aaggaacagt ctacagccag actgtagttg
     6061 tatagtaata tatatgatat aaatattttt tttaaatatt atttgtaaat aatttaaatg
     6121 ttggactcga atttaaatca agcggctagc aaatgttgca gctaaactaa aatgaaaaca
     6181 aagccaaaaa acacacacat aaataggtaa actaagtgaa aaatgtggaa aaggaaaaac
     6241 tattgtacaa ttagctaaag aatttccatt tcaattttca atttgaattg caatttaatt
     6301 tgcttccaga aatgaatgaa aggagacaag aaaaagatag ggagataaac cgaaaattag
     6361 tttcaaacgc tgtcttcgca aatatttttc gctatatata tatatatata ttacttataa
     6421 cattatttta ctagttacta agctacttac tgagccacac aaatttaaaa cgaaagagac
     6481 aagacaccag gacaagaaag agaaggagct ttcatgaatt tagtgaacaa acataactgg
     6541 caatggccac acacacacac acaatttaca aagcgaacaa caccaaaaaa aataaataaa
     6601 aagactcttc aagcacaaaa aaaactgttt agttttcagt aaacagtaaa accaaagcaa
     6661 agcaaaataa cacacaagat ataatcccca aaaaagtcat tggctataat atgattactt
     6721 aacctaacct atacaatata tagatatata gatatatcct atatgcatat gtaaagtcac
     6781 gatactggcg ctggtgcgcg gatcgatcaa tgtggcaggc caaattctaa atgcgcataa
     6841 tttaactatt gtttacatta tgttttattg ttattaattt attaccaaaa acgaaaacat
     6901 tattttttca gacctagtgc tataaatttc ttttttgtgt tgaagcgggc aggatccgcg
     6961 cataaaatag tgtttttttt ttttttgtaa ttacaaatat atataaagat acatacatat
     7021 atatatatat atataatatg atatgtgaat gaaatgtaat gaaatgaagt ggaaccttga
     7081 tggtctaaaa atatcattaa aagctgatgg agatggaaag ttgaagaaca agatacttta
     7141 tagcaattta agcagcattg taaatgtgcg cttcagaact actttttttt cgaaacttaa
     7201 tcgaccttca gcaaatacag caagatatat tacctacatt acaaacatat attattaatt
     7261 gaaccatagt tgcgacacaa aacaaaaatg acggcaagtc catggcaaac ttaagcaaaa
     7321 accaaaagct actttaacaa attgagtgaa ataaataaaa gaaagaaaac aaacaaaaaa
     7381 aaaaaaacac aaaaaaaaac catatgactt ttttctcctc tcacaaaata aaagcgaaaa
     7441 acagaaaaat aaactagtat tgtattgtat ttgtaacacg aattttcctg cgagtgaaca
     7501 ctttacgcag aaccataaag ccggaaactg aaaacctaca gagattccgc agcaatcgcg
     7561 gcactggtat gtgtgtatag ctaatagcta tactcattat gtaatttacc agagtattaa
     7621 tcgaacaatt taaatttaca tatatgcata tgcataccaa catactagga atactaggaa
     7681 tatatgcagt aacggacatt tgatgtatac tcgagttgaa acataaccct aaccaaatgt
     7741 tgtatgtgta tgtgtaattc gatgaactta aaagtccaaa gccatacgtg aaaataagaa
     7801 caagcaattt atagtgaaaa agtcgaaaag tatctaaatg taattgttag aaaatgccaa
     7861 gtaaatccga aagttaccac agagttaatg aggaggcatc atctatcttg tcatccaaga
     7921 aatccccaaa tcaatttttg actgaaattg aatcgtccta gtagaggcac tcgattcgta
     7981 ctccttcctt acccctaccg cccccccccc tcaccaactt cctttgcccc aactattgta
     8041 ctttatccaa tattttccta tcgacgtgcc gccaattata tcagtgtata taaactattt
     8101 gaaaatcacg catatatatg cacacataga gtttttgtag cgtcatatgt gtcattaagg
     8161 atgcccactt acatacatat atgaagggaa ataaataagc aagtaaatat acaatacaat
     8221 acatacatat atgtgtgtgt tgtgggtaac gagagatcag catttgtagc acaggttggc
     8281 caaatttatt gggaataacg agttgccgaa gttgccgaag aaaaaccaaa tgaaaactgt
     8341 ttgttgtgct gttagccgta aatgagaact tttttttgag ataacttaat acctatatat
     8401 ataaatatgt attacaatat atgtatctat aaatatataa aacaggcgac aaaccaaatt
     8461 aaaccaaata ccggaacaaa aaaaaaaaaa cgaaaaagaa gagagagaaa aaataataca
     8521 agcgatattg aaaatggcac gttttgtact ataatgaaat gagaaaacac caaagacgaa
     8581 tgcaaaacaa aaaaaaatgc aaacacataa caaaatatac aagaaatatt cttaacaaaa
     8641 agaaaaaaat accataaatt gtgcgctggc gacgacggtt gtttgaaaaa aagagaaagc
     8701 aaaaaacagg acatgccgct tgaagtgccg atcgtaagcg agtcctttcg attcgcaaat
     8761 cgtcggcatt tcaatcgatt gaagaatcgg gagatattat atacatatag aacacgtaac
     8821 gctggcgtta ctgggcaaac agttaggcat tttttttttt tcttttttgg aaatttatac
     8881 aattacatat acaaaaagag ctcaccccca caacaacaag gacaactgca gaagaagaac
     8941 aaaaaaaata cacacataca tggaaacact aacgcgtaca cggacagcga tttgccggaa
     9001 caaaattctg ggtatttcga accgagaaag ggaacggaaa cggaaacgga aacgaaaata
     9061 tagaacgcgg caagttattt aacactgaaa ctgatcgggt gtaactatag taccgaaatg
     9121 gggcttacac aggctgattc acccaaaata agtatacatg tattgtagta acgagcgctg
     9181 gcttttgtta ttaagttatg tatttgtttc gattatgttt tgcctctctc agaatatata
     9241 tatatatata tatatatata tatatatgta tattctatgt atatatatat attagttatg
     9301 tatgtgaaaa aagcgtaatc atttatgaaa ccaatgaaaa tctaacctga aaacaaagag
     9361 aaaaccccaa gtcaaataca caattgcatg caagagtaag taatattaat gaaatctaag
     9421 aacaaaggtc actcccgggc ttaaaaaaaa aaaaagaaga aaaaaaatgg gccgcatggc
     9481 aaatgataaa tggtaaaaca aaacaatgag caggtggcat tatgaacaga tttgaatgat
     9541 tacggaatac agactaaaaa tgaaaatgaa aaattt