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Drosophila melanogaster wings apart-like (wapl), transcript variant


LOCUS       NM_166931               5067 bp    mRNA    linear   INV 26-DEC-2023
            B, mRNA.
ACCESSION   NM_166931
VERSION     NM_166931.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5067)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5067)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5067)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5067)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5067)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5067)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5067)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5067)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5067)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5067)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5067)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5067)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5067)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5067)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5067)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5067)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5067)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5067)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5067)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5067)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5067)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5067)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5067)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_166931.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5067
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5067
                     /gene="wapl"
                     /locus_tag="Dmel_CG3707"
                     /gene_synonym="C204; CG3707; Dmel\CG3707; EG:87B1.2;
                     l(1)2Dd; l(1)2Df; l(1)C204; l(1)N2; l(1)N5[72]; l74; N2;
                     pasc; RNA D; RNAD; wap; Wapl; WAPL"
                     /note="wings apart-like"
                     /map="2D4-2D5"
                     /db_xref="FLYBASE:FBgn0004655"
                     /db_xref="GeneID:31187"
     CDS             1019..4297
                     /gene="wapl"
                     /locus_tag="Dmel_CG3707"
                     /gene_synonym="C204; CG3707; Dmel\CG3707; EG:87B1.2;
                     l(1)2Dd; l(1)2Df; l(1)C204; l(1)N2; l(1)N5[72]; l74; N2;
                     pasc; RNA D; RNAD; wap; Wapl; WAPL"
                     /note="CG3707 gene product from transcript CG3707-RB;
                     CG3707-PB; wapl-PB; parallel sister chromatids protein;
                     wings-apart-like"
                     /codon_start=1
                     /product="wings apart-like, isoform B"
                     /protein_id="NP_726796.2"
                     /db_xref="FLYBASE:FBpp0070414"
                     /db_xref="GeneID:31187"
                     /db_xref="FLYBASE:FBgn0004655"
                     /translation="MMMTIDGAGTGAASAVPETPLQEDILAVLRGEVPRLNGNTDPEP
                     TEEEDQQQQPKRATRGRGRKANNNVDVTPPATETRTRGRAKGADATTAAISPPTGKRN
                     TRGTRGSRKAEQEVDMEVDETAMTTVPANEEQLEQATLPPRRGRNAAARANNNNLASV
                     NNNINKIAANLSAKAEASRLAEGGVAGGAARSYGRKRKNQQVTQVLQQEPVPEEQETP
                     DAEEEQPTPAKIPHTDHREHSPDHDPDPDPDELSNNSNNSSLQHDGSSSSPPPRDFKF
                     KDKFKRTLTLDTQGAANAGAGGAAAAAPPESSGEQRGAVKLVISKKKGSIFKSRALVP
                     SDQAEQATVAKRHLYKHSWDAALEANGGGTNSDASNASASGVGVAGAKDHLHHLAAGK
                     SDGDFGDSPSSNNNGSSSACSSASTLRGDSPALGKISRLAGKQGVPATSTSSDAFDLD
                     LEPIAGELDLERSAAGASAGGTGATTGGGGATGGGGPVRVDRKTKDYYPVVRNVKTAH
                     QIQEIGEYQEMDDDVEYILDALQPHNPPATRCLSALQLAAKCMMPAFRMHVRAHGVVT
                     KFFKALSDANKDLSLGLCTSAIMYILSQEGLNMDLDRDSLELMINLLEADGVGGSTET
                     GHPDRAGYDRNKQKVRELCEEIKAQGKGTHLNVDSLTVGTLAMETLLSLTSKRAGEWF
                     KEDLRKLGGLEHIIKTISDFCRPVIACDTEIDWQPTLLDNMQTVARCLRVLENVTQHN
                     ETNQRYMLTSGQGKAVETLCQLYRLCSRQIMLHPSDGGGSNKEHPGVAMRELLVPVLK
                     VLINLTHTFNEAQPSLGAELLGQRGDVVETSFRLLLLSANYIPDQCVFELSILVLTLL
                     INLCMHTVPNRAALMQAAAPAEYVADNPPAQGSVSALQALLEYFYKCEELARLVEKNT
                     DAFLESNEKGKKKQEEVEETVNNLVQRAGHHMEHTLKGSYAAILVGNLIADNELYESV
                     VRRQLRGNSFKEIIGVLEKYHTFMNLTSSLEAAFVAHMKSTKRIIDNFKKRDYIYEHS
                     DEHDNPLPLNLETTAQVLAVGADASHAATSSTTVGSGSAPSSTSATGTTRAPRVYKTY
                     SSHR"
     misc_feature    2525..3616
                     /gene="wapl"
                     /locus_tag="Dmel_CG3707"
                     /gene_synonym="C204; CG3707; Dmel\CG3707; EG:87B1.2;
                     l(1)2Dd; l(1)2Df; l(1)C204; l(1)N2; l(1)N5[72]; l74; N2;
                     pasc; RNA D; RNAD; wap; Wapl; WAPL"
                     /note="Wings apart-like protein regulation of
                     heterochromatin; Region: WAPL; pfam07814"
                     /db_xref="CDD:462278"
ORIGIN      
        1 ttttgttccg catttatctg tcggttcttg cccatttcgg ttcacttgga gtgctaatta
       61 ccgggaacgc gacatagttg tgcttatttt catttgccag atcagctagc caaaaggcac
      121 ttcgcggttg gtcagcacgg atagcgagga gccgccgagc agctcgcccg ctcaccagaa
      181 ccaactgaat caactttcgg tcacggagga ggagccagcg gagcggtccg gagacgaaac
      241 agttcctgca agtacgccaa aaatcacagt gaagccactg aggccgccca cagcagcaga
      301 ttccgtcgat ggatcatctg cggcagttgg aggagcatca gcaggcgatt ctttcgagga
      361 acgcaagtcc cagtcactag aacccaacga ggacgaggag gaggaagaag aggaggagga
      421 cgaggaggag gaaccgccgg agatcaacta ctgcacggta aagatatccc cggacaaacc
      481 gccgaaggag cggctcaaac tgatcatcaa gacggacgtg atccgcaacg ccatcgccaa
      541 agccgcagca gcagccgagt cccgcagtga aaagaagtcg aggagcaaaa agcacaagca
      601 caagcagctg cttgccgcgg gatctggtgc cgctccagct tctggagcca cccccgccga
      661 gatcaactcc gaattcaaga caccctcacc tcatttggct ctcagcgagg ccaatagtca
      721 acaagcacag catacaccat ctcatctaca tcaactgcac cagctgcatc cgcagcgagg
      781 ctccgcggtc atatcaccaa ccactcgatc cgatcacgac ttcgactcgc agtcctcggt
      841 gctgggcagc atctcctcga agggcaacag cacgccgcaa ctgttagcgc aggctgtgca
      901 ggaggatagt tgtgtgattc gcagcagggg atctagtgtg atcaccagtg atctagagac
      961 gagtcagcac tcctcgctgg tggctccccc ctcggacatt gagtcacgac tggagtccat
     1021 gatgatgacc atcgacggag cgggaacggg agcagcatct gcagtgccgg agacaccact
     1081 gcaggaggac atactggctg tgctgcgagg ggaagtgcca cggctaaatg gcaatacgga
     1141 cccggagcca accgaggagg aggatcaaca gcaacagccg aagagggcca cgcgtggcag
     1201 gggcagaaag gccaataaca atgtggatgt aaccccaccc gccacggaga ccagaacccg
     1261 aggtagggcc aaaggagcag atgcgaccac ggctgccata tcgccaccaa cgggcaaaag
     1321 aaacacgcgg ggcacccggg gctccagaaa ggccgagcag gaagtcgaca tggaagtgga
     1381 cgaaacggcg atgacgacgg tgccagcgaa cgaggaacag ctggaacagg ccacacttcc
     1441 accgaggaga ggtcgcaatg ctgctgcccg agccaataac aataatttgg caagcgttaa
     1501 caataacatt aataaaatag ccgccaattt gtcagccaag gccgaggcca gccgactagc
     1561 agaaggcgga gtcgcgggtg gagcggcacg aagctatggt cggaaacgaa agaaccagca
     1621 ggtaacgcag gtgctacagc aggagccagt gcccgaagag caggaaactc ctgatgctga
     1681 ggaggagcag cccacacccg ccaagattcc gcacacagat cacagggaac attcgccaga
     1741 ccatgatccg gatcctgatc cggatgaact gtcgaacaac tcaaacaact cctcgttgca
     1801 gcacgatggg tcctcctcct cgcccccacc ccgcgatttc aagtttaagg ataagtttaa
     1861 gcgaacattg acactggaca cacagggcgc ggcgaacgcc ggagcgggag gagcagcagc
     1921 ggcggcgcca cctgagtcct ctggcgaaca gcggggcgct gtcaagctgg tcatctcaaa
     1981 gaagaaaggc agcatcttca aaagccgcgc tctggtgcca tccgatcaag cggaacaggc
     2041 tacagtggcc aagcgacatc tgtacaagca cagttgggat gctgcgctag aagcgaatgg
     2101 cggtggaacc aacagcgatg ccagcaatgc ctcggcatct ggcgtgggcg tcgctggggc
     2161 gaaggatcat ctgcatcatt tagcggcggg caagtccgat ggtgatttcg gtgacagtcc
     2221 gtcgtcgaac aacaatggct cctccagtgc gtgcagcagc gcatccacgt tgcgcggcga
     2281 tagcccggcc ctcggaaaga tctcgcgact ggcgggaaaa cagggagtac ctgccacctc
     2341 cactagttcc gatgcctttg acctggattt ggaaccaatt gccggagagc ttgacctaga
     2401 gcgtagtgca gctggtgctt ccgctggtgg aacaggggca acgacaggcg gaggtggagc
     2461 gacgggcggt ggcggccccg ttcgggtcga ccgcaaaact aaggactact atccagtggt
     2521 gcgtaacgtt aagacggccc atcaaattca ggagatcggc gagtaccagg aaatggacga
     2581 cgacgtcgag tacatcctgg acgcacttca gccgcacaat cccccggcaa cacggtgtct
     2641 ctccgccctt cagctagccg ccaagtgtat gatgcccgcc ttccggatgc acgtgcgtgc
     2701 ccatggggtg gtcaccaaat ttttcaaggc attatccgac gccaacaagg acctcagcct
     2761 aggcctgtgc acctcggcca tcatgtacat tctttcccag gagggcctca acatggacct
     2821 ggatcgcgac tccttggagc tgatgatcaa ccttctggag gcggacggcg tgggtggcag
     2881 cacggagact gggcacccgg atagagcggg ctacgaccgc aacaagcaga aggtgcgcga
     2941 gttgtgcgag gagatcaagg cgcagggcaa gggaacgcat ctcaacgttg attctctgac
     3001 tgtgggcacg ctggcaatgg aaacgctgct atcgctaaca tccaagcgcg cgggcgagtg
     3061 gtttaaagag gatctgcgca agctgggtgg cctggagcac attatcaaga ccatctcgga
     3121 cttctgcaga ccggtgattg cctgcgacac ggagattgac tggcagccga cgctgctgga
     3181 taacatgcaa acggtggcgc gttgtctgcg agtcctcgaa aacgtgacgc agcacaatga
     3241 gacgaaccag cgctacatgc tcacctctgg ccagggaaaa gcagtggaga cgctttgcca
     3301 actgtaccgt ctttgcagcc gacaaataat gctgcatcct tcggatggtg gtggcagcaa
     3361 caaggagcat ccgggtgtgg ctatgcgcga gctgctggtg ccggtgctca aggtactgat
     3421 caacctgacg cacacgttca acgaggcgca gccatcgttg ggagccgagc tgctaggtca
     3481 aaggggcgat gtggtggaga cgagcttccg attgctgctg ctctcggcca actacattcc
     3541 cgaccaatgt gtctttgagc taagcatact ggttcttaca ctgctaatca atttgtgcat
     3601 gcatactgtg cccaaccggg ctgctctaat gcaagctgcc gctccggcag agtacgtagc
     3661 ggataatcca ccagcgcagg gatctgtgag tgcactgcaa gctctgcttg agtacttcta
     3721 caagtgcgag gagctggcta gattggtgga aaagaacacg gacgccttcc tcgagagcaa
     3781 cgagaaggga aagaagaaac aagaagaagt ggaggagaca gtcaacaatc ttgtgcaacg
     3841 agccggccac cacatggagc acacgctaaa gggaagttat gcggccatcc tggtgggaaa
     3901 tctgatagcg gacaacgagt tgtacgagtc ggtggtgcgc cgccagctgc gaggaaatag
     3961 ctttaaggag attattggag tgctggagaa gtaccacaca ttcatgaacc ttacatccag
     4021 cttggaggca gcctttgtgg cgcatatgaa gtccacgaag cgcatcatcg acaactttaa
     4081 gaagcgcgac tacatctacg agcactcgga tgagcacgac aaccccctgc ctctgaatct
     4141 ggaaacgacg gcgcaagtct tggccgtggg agcggacgcg tcgcatgctg ctacaagctc
     4201 gaccacggtc ggctctggct ccgcaccctc atccacatcg gccacaggaa cgacgagggc
     4261 gccgcgggtc tataaaacgt acagcagcca caggtaatcg gacctgggat ctgaatcgga
     4321 atcgaagagc catcgcaatt gtcgttaacc acaccgaaag cctgccacca aaataaaatt
     4381 ctgttgtttg tgattatgta atttgtttat gtgttgatat aacaatcact acatgtatgt
     4441 gtatagcctg taatgcacct agtttcagtc agctatatat atatagatat atatatatat
     4501 agaagtatat agctaagagc gataggatac aatgcgatct gtttttgcgt ttgtattaac
     4561 ccaaagtgat agcgaattcc tgagcatggt ctgcgtttta actaaagaaa atgattaaga
     4621 ttgacgaaac gaaagcgaca ccccgaacaa cacaaagatc caaatcccca ctaatatgag
     4681 tacgttatat agtcataagc aatattagca gctaaatgtc ggcttaccct cgaaagcaca
     4741 cacccatgta aatattcttt aatcagcgat tttatcggac gcgtcttagg tttatttcga
     4801 atgtgttttt tttttaccta ttcatacttt atatattaaa cctttttttt attgattgta
     4861 aaacaagcgc tcttagcaaa aacgctgcag cagaaagagc gagagcgata gacatgtgta
     4921 aagagagagt tagagaggaa aattctagat tagatgtggg aaataaagtt attttattgc
     4981 ctaaacgtaa gctaaagaaa ctctacttat aaaactaaca ctgataaata aatatatata
     5041 tgtatatgga tatatgtgta cgtttac