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Drosophila melanogaster ER degradation enhancer, mannosidase


LOCUS       NM_166915               4251 bp    mRNA    linear   INV 26-DEC-2023
            alpha-like 1 (Edem1), transcript variant C, mRNA.
ACCESSION   NM_166915
VERSION     NM_166915.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4251)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4251)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4251)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4251)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4251)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4251)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4251)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4251)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4251)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4251)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4251)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4251)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4251)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4251)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4251)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4251)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4251)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4251)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4251)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4251)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4251)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4251)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4251)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 31, 2011 this sequence version replaced NM_166915.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4251
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4251
                     /gene="Edem1"
                     /locus_tag="Dmel_CG3810"
                     /gene_synonym="CG3810; dEDEM1; DM-pI; Dmel\CG3810; edem1;
                     EDEM1; EG.86E4.2; EG:86E4.2"
                     /note="ER degradation enhancer, mannosidase alpha-like 1"
                     /map="2B15-2B15"
                     /db_xref="FLYBASE:FBgn0023511"
                     /db_xref="GeneID:31154"
     CDS             677..3625
                     /gene="Edem1"
                     /locus_tag="Dmel_CG3810"
                     /gene_synonym="CG3810; dEDEM1; DM-pI; Dmel\CG3810; edem1;
                     EDEM1; EG.86E4.2; EG:86E4.2"
                     /EC_number="3.2.1.113"
                     /note="CG3810 gene product from transcript CG3810-RC;
                     CG3810-PC; Edem1-PC"
                     /codon_start=1
                     /product="ER degradation enhancer, mannosidase alpha-like
                     1, isoform C"
                     /protein_id="NP_726778.1"
                     /db_xref="FLYBASE:FBpp0070337"
                     /db_xref="GeneID:31154"
                     /db_xref="FLYBASE:FBgn0023511"
                     /translation="MQQKPRNNGYPGTLICAVLLVLLSTGVSGQKQYSKARKLELRED
                     VRRMFQHAYDGYLRHASNYDELRPLTCDGHDTWGSYSLTLIDALDTLATMGNFTEFRR
                     AARLLEEKMDFDRDINVSVFETNIRIVGGLLSAHLLSKRAGVELEPGWPCKGPLLRLA
                     EDVARRLLPAFVTNTGMPYGTVNLRYGVPKGETSITCTAGVGTFLIEFGTLSRLTGKT
                     IYEDVAMKAVHALWAYRSPIGLFGNHIDVQSGRWTALDSGIGAGVDSLFEYLVKASVL
                     LNRPELLELFHEARAAIDKYMRKEDWYVWVGMNKGRVTLPVFQSLEAFWPGILSIIGD
                     TEPALRTISRYIGVWKKYGFLPEFYNIAAGEASPNREVYPLRPELIESAMYLYRATGN
                     EYLLEFGEHMLETLEFSAKTKCGYATIRNVVTHEKENRMESFFLAETSKYLYLLFDEE
                     NFLHNDGSGGELLSTEDDVCVVQAGAYIFNTEAHPMDMSALHCCHAHNEDIYTSLDLQ
                     RFSPRAILERSKKRQVAVQEQWVPQCHPENNEFFNKEDESVQAQDSEKEQEREQSGTS
                     TTMAVDIEVFDEFQQPAGDLLVSNFEQIREERELNESLHRNVVARNQLTVSDLDEFFA
                     QRRESFASASEALNYVKTFMGNYTMDVAFIRGLQLYDTNMSSVLGTGAQKEYESRMRT
                     LWQLYELQQQYVANIRVIQGLGLLTFPADGDRIPSHLTEVLDSLDKSAHLEHMDLQDL
                     ETRVSNTSSPQLAHIREVILKARNAYAIAMVNTSAMQEFAIRIYLSGTSEAGVRIHPL
                     LEDGELSEEARKRPLKLAEERALFSYARRIVDFRKRMAETVDRLQTLMQDIPPPKRKE
                     ATTDSQAADASTVYTQTKAQMAAPAQQPEPSQEEKQSTQIQKGKLAENGSGLGEEESG
                     CVWSQLVQTILRKTTVQRVKFDEAVLQENTRKALEKYARKELPHHLFACHRPEYIEGF
                     AYRDFYPEAL"
     misc_feature    818..2134
                     /gene="Edem1"
                     /locus_tag="Dmel_CG3810"
                     /gene_synonym="CG3810; dEDEM1; DM-pI; Dmel\CG3810; edem1;
                     EDEM1; EG.86E4.2; EG:86E4.2"
                     /note="Glycosyl hydrolase family 47; Region:
                     Glyco_hydro_47; pfam01532"
                     /db_xref="CDD:460241"
ORIGIN      
        1 cgacagccct gaccaaaaaa tttaatattt ttctttaatt gtttataaat atgcaaacaa
       61 ctgggtggaa acacgatttc cagatcccaa atggcacacg cttatatcta cggtcaacgg
      121 gatggtttca atgtggtttc tggtcagcca gaggcaatcc cgcatgtata gacccacaat
      181 gttgttactt ttcgcccaac ggacaattaa gcatacgcga ttgcatttaa acgatcgcct
      241 tacgcggagt acaaaaggca cacgggccgt gatgcagtta ctccgcgagg ttatagtcga
      301 ccctctttct gagttttttt tacgcggaga atgattcaaa accgaaacac atcgctgccc
      361 atcgccagaa ctgcaattcg cagtcggaag cgtaacaaag gctgcggatt tcttggtcag
      421 ctcatccgga ggatgtccgg gtgtgaaacg ggtgcagagg gcagttactt accataggcg
      481 ctctataaaa aaacactcac cgaacggaat tagtagggca ttcggcggtc gatgccaccg
      541 ccgaatcagc ccttgttgtg attttgcgtc aacgtagccg catttgactt ccacacatcc
      601 cacatccacg ctggctatgg aacactgacc atgcccataa ttgaattagc ggccctgatt
      661 gattgactgt cccacgatgc agcaaaaacc ccgaaacaac ggctatccgg gcaccctcat
      721 ctgcgcggtc ctcctcgtcc tgctgtccac cggtgtcagc ggccagaagc agtattccaa
      781 ggcaagaaag ttggaactga gggaggatgt gcggcgcatg ttccagcacg cctacgatgg
      841 ttacctgcgc cacgcctcca actacgatga actgcgtccg ctgacctgcg atggccacga
      901 cacctggggc agctactcct tgacactgat cgacgctctg gacacgctgg ccaccatggg
      961 caacttcacg gaattccgcc gcgcggcaag actgctcgag gagaagatgg attttgacag
     1021 ggacatcaac gtgtccgtgt tcgagacaaa catccgcatc gtgggcgggc tgctgtccgc
     1081 gcatctgctc tccaagcgtg ctggcgtaga gctagagcca ggatggccct gcaagggacc
     1141 tctgctgcga ctggcggagg atgtggcccg acgattattg ccagccttcg tcacgaacac
     1201 gggtatgcct tatggcacgg tgaacctgcg ctatggcgtg cccaagggcg agacctctat
     1261 aacctgtacg gcgggcgtgg ggacattcct catcgaattt ggtaccctta gccggttgac
     1321 cgggaaaacc atctacgagg atgttgctat gaaggcggta catgctctat gggcatatcg
     1381 ctcgcccatt ggactttttg gcaatcacat cgacgtgcag agcggtcgtt ggaccgccct
     1441 cgactctggt atcggagcag gagtggattc cctttttgaa tacctagtta aggcatctgt
     1501 cctgctcaat cgcccagaac tcttggagtt attccatgag gctcgcgcgg ccattgataa
     1561 gtacatgcgg aaggaggact ggtacgtgtg ggtaggcatg aacaaaggcc gcgtcaccct
     1621 tcccgtcttt cagtccctgg aggcgttttg gcccggcatc ctgagcatta ttggcgacac
     1681 ggagccggcc ttgcgcacca tatcacggta cattggggtc tggaagaagt acggctttct
     1741 gccagagttt tataacattg ctgctggaga ggcatcgccg aatcgggagg tgtaccccct
     1801 gcgaccggag ctaatcgagt cagctatgta tctctatcga gccacaggaa acgagtatct
     1861 tctggagttt ggtgagcaca tgctggagac cttggagttc agtgccaaaa ccaaatgcgg
     1921 atatgcaacg attcgcaatg ttgtcaccca cgaaaaggag aatcgcatgg agtcattctt
     1981 cctggcggaa acaagcaagt acctttatct gctgtttgac gaggaaaact tcctgcacaa
     2041 cgatgggtcc ggaggcgagc tgctgtcaac cgaggatgat gtatgcgtgg tacaggccgg
     2101 tgcgtacatc ttcaacacag aggctcatcc catggacatg tcagccctcc actgttgcca
     2161 cgcccacaac gaggacatct acacctctct ggatctacag cggtttagtc cacgggcgat
     2221 attagagagg agcaaaaagc ggcaggtagc tgttcaggaa cagtgggtgc cgcagtgtca
     2281 cccagagaac aacgagttct ttaataaaga ggatgagagt gtgcaggcgc aggactctga
     2341 aaaagagcag gaacgcgagc aatccggcac aagcactacc atggccgtag atattgaggt
     2401 gttcgacgaa tttcaacagc ccgccggcga tctgttagta agcaacttcg agcagatacg
     2461 cgaggagcgg gagctaaacg agagcctgca cagaaacgtg gtggcacgaa accagttgac
     2521 agtcagcgat ttggatgaat tctttgctca gcgacgggag agtttcgcaa gcgcctccga
     2581 ggctcttaac tatgtaaaga ccttcatggg caactatacc atggatgtag cctttatacg
     2641 gggcttgcaa ctgtacgata ctaatatgag tagtgtattg ggcacaggcg cccagaaaga
     2701 gtatgagtct cgaatgagga ccctttggca gctgtacgaa ctgcagcagc aatatgtggc
     2761 caacatccga gtgattcaag gattaggttt gctaaccttt ccggcggacg gtgaccggat
     2821 acctagccat ttgacagagg tgttggacag cctggataag tcggctcact tggagcatat
     2881 ggatctacaa gatctcgaaa caagagtgtc caatacctcc tcgccccagt tggctcatat
     2941 aagagaagtt attctaaaag cacgtaatgc ctatgccata gccatggtca atacttcggc
     3001 catgcaggaa tttgctatcc gaatctacct cagtggcact tcggaggccg gtgttcgcat
     3061 tcacccactt ttggaagacg gagaactaag tgaggaagca cgtaaaaggc cattaaagtt
     3121 ggcggaggag cgagccctct tcagctacgc ccgtcgaata gtggactttc ggaaacgaat
     3181 ggcggagaca gttgatcgat tgcagacgct catgcaggac attccgccac ccaaaaggaa
     3241 agaggccact accgactctc aggccgcaga tgcgtccaca gtctacactc aaaccaaagc
     3301 ccagatggcg gcgcctgcac agcagccgga gccgagccag gaagagaagc agtcgacaca
     3361 aattcaaaaa ggaaagcttg ccgaaaacgg ctccggattg ggtgaagagg agtccggctg
     3421 cgtgtggtcg cagttggtgc agaccatcct tcggaagacc acggtgcagc gggtcaaatt
     3481 tgacgaggcc gtgctccagg aaaatacgcg caaggcactg gagaagtacg cccgcaagga
     3541 gttaccccac catctgttcg cctgccaccg gccggagtac attgagggat tcgcctatcg
     3601 ggacttttat ccggaagcgc tgtaagctcg caatcacctc accgaccaac acgactgatc
     3661 tgtagataga tatcaaagtt cggcgtcgat gcgcgcatga caatgagcga ctcaattgca
     3721 gagcgaaaag gacagagcgc taagccaaag cggcaagcgc gaaagtacaa gatgaagaca
     3781 gcgcgagagg aggggaactt agataacgaa agagaaccat cacctctaac ggttttctga
     3841 tatgttgccg atcatgatat ttgcagtgct gtactttgta cttttctatc gtttaaattg
     3901 taagctatgt acatatatgt acgtacatat gtatgcaatt accaaaccat ttccaggaat
     3961 ttcaacttct tgtacaatca tgtttaccag cgatttttta aagctcagtt aagatatgat
     4021 aatagaactt ccaaaaatat gtatagctaa agaaccttaa gtggtcctac ttgtgccgac
     4081 aattaattta attagcatat gaacccgcaa ctcttgaggt tttctcaata ccttaccaag
     4141 gcttaaacaa atttatatct gtaataataa tggttcgagt gcttgtgtgc gtgtaaacta
     4201 tttgcgatga ctgttgttgg ctgtattgta attaaattga tttatttccg t