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Drosophila melanogaster adenosine deaminase acting on RNA,


LOCUS       NM_166903               6645 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant B (Adar), mRNA.
ACCESSION   NM_166903
VERSION     NM_166903.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6645)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6645)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6645)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6645)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6645)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6645)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6645)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6645)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6645)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6645)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6645)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6645)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6645)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6645)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6645)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6645)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6645)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6645)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6645)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6645)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6645)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6645)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6645)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_166903.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6645
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6645
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /note="Adenosine deaminase acting on RNA"
                     /map="2B9-2B9"
                     /db_xref="FLYBASE:FBgn0026086"
                     /db_xref="GeneID:31130"
     CDS             448..2334
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /EC_number="3.5.4.37"
                     /EC_number="3.5.4.4"
                     /note="CG12598 gene product from transcript CG12598-RB;
                     CG12598-PB; Adar-PB; hypoxia, anoxia, sensitive 2;
                     adenosine deaminase acting on rna; hypnos-2; adenosine
                     deaminases acting on RNA"
                     /codon_start=1
                     /product="adenosine deaminase acting on RNA, isoform B"
                     /protein_id="NP_726761.2"
                     /db_xref="FLYBASE:FBpp0070287"
                     /db_xref="GeneID:31130"
                     /db_xref="FLYBASE:FBgn0026086"
                     /translation="MTLCRYSEPVSAPSDINMNGYNRKLPQKRGYEMPKYSDPKKKMC
                     KERIPQPKNTVAMLNELRHGLIYKLESQTGPVHAPLFTISVEVDGQKYLGQGRSKKVA
                     RIEAAATALRSFIQFKDGAVLSPLKPAGNLDFTSDEHLENDVSKSAITVDGQKKVPDK
                     GPVMLLYELFNDVNFECINIDGAQNNCRFKMTVTINEKKFDGTGPSKKTAKNAAAKAA
                     LASLCNISYSPMVVPQKNVPLPIDDKSSSMELPQIHADTIGRLVLEKFMEVIKGQEAY
                     SRRKVLAGIVMTENMNFCEAKVISVSTGTKCVSGEHMSVNGAVLNDSHAEIVSRRCLL
                     KYLYAQLDLQCNQATAYQSIFVRNTDGQYPYKLKSGVHFHLYINTAPCGDARIFSPHE
                     NDTGVDKHPNRKARGQLRTKIESGEGTIPVKSSDGIQTWDGVLQGQRLLTMSCSDKIA
                     RWNIVGIQGSLLSSIIEPVYLHSIVLGSLLHPEHMYRAVCGRIEKSIQGLPPPYHLNK
                     PRLALVTSAEPRNQAKAPNFGINWTIGDTELEVVNSLTGRTIGGQVSRITKQAFFVKY
                     GFLMANLPGILVRKVTTDYGQTKANVKDYQIAKLELFSAFKREDLGSWLKKPIEQDEF
                     GLAE"
     misc_feature    601..789
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /note="first double-stranded RNA binding motif of STRBP,
                     ILF3, RED1, RED2 and similar proteins; Region:
                     DSRM_STRBP_RED-like_rpt1; cd19865"
                     /db_xref="CDD:380694"
     misc_feature    order(601..603,610..615,622..627,631..633,673..678,
                     682..684,688..690,739..747,754..756)
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380694"
     misc_feature    925..>1065
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /note="double-stranded RNA binding motif (DSRM)
                     superfamily; Region: DSRM_SF; cl00054"
                     /db_xref="CDD:444671"
     misc_feature    1204..2319
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /note="tRNA-specific and double-stranded RNA adenosine
                     deaminase (RNA-specific editase); Region: ADEAMc;
                     smart00552"
                     /db_xref="CDD:214718"
ORIGIN      
        1 tattgtgata actgctcaca tcgctagatt ccgagcaaca aaaaagcgac gaagggtcat
       61 tgttattttt tctaatgcaa tgtaatgcag caaatgtgca gatttgaaca agtgtaacgc
      121 gatttatgtt taatccgcat cgaggaacca aatcgaagta aacgcgcggc cagagaaaag
      181 agcagcaccg caccgaagat aaaacaaaca agcattgatt tgtttgtccg gccatgtcag
      241 tgtgtgtgtc acaagggctt gcaagtgtgt gcgtgtgtcc gtgcgtgtac gtgggtgctt
      301 ttttttttct cccgagtgcc gccaagtgaa atatgcaatt gcacgccact gcagttgcag
      361 ccacacaaat cctatcctaa tcgacgaaac agcgaagcga ggaggctaga atcggctgcc
      421 caacgaagag agcagaaccg ttaacaaatg acactctgcc gatacagcga accggtgagt
      481 gcaccatccg atatcaacat gaatggctat aaccgaaaat tgccacaaaa acgtggctat
      541 gagatgccaa aatactctga tccaaaaaag aaaatgtgca aggagcgcat tccccagccg
      601 aagaacacgg tggccatgct gaatgagcta agacatggac tgatttacaa attggagtca
      661 cagactggtc cggtacacgc acctctattc acgatatccg tggaggtcga tggacagaaa
      721 tacttgggcc agggccgtag taaaaaagtt gcacgcatcg aagcagcagc aactgcactg
      781 cgcagcttta tacagtttaa ggatggagca gttctgtcgc ctctgaagcc ggcgggcaac
      841 ttggacttta ccagcgatga acatcttgaa aatgatgtca gcaaaagtgc tattactgtt
      901 gacggtcaga agaaggttcc agataagggt cctgtcatgc tcctctacga attatttaat
      961 gacgttaatt tcgaatgcat taatattgac ggcgcccaga acaattgtcg cttcaaaatg
     1021 accgtcacaa tcaacgaaaa gaagttcgat ggaacaggtc cttccaaaaa gacggcgaaa
     1081 aatgcggcag ctaaggcggc acttgcttcg ttatgcaata tttcctacag tccaatggtg
     1141 gtgccacaga agaacgtacc cctgccaatc gacgacaagt cgtcatcgat ggagttgcct
     1201 cagatacacg cggatacgat tggtcggttg gtcttagaaa agttcatgga agtaatcaag
     1261 ggccaggagg cttactcgcg tcgaaaggta ttagcgggca ttgtaatgac tgaaaacatg
     1321 aatttttgtg aagccaaagt tatttcagtt tcgacgggca ccaagtgtgt cagcggtgag
     1381 catatgagtg tgaacggagc tgtcctaaat gattcccatg ctgaaatagt ctccaggcgt
     1441 tgtcttctca aatatttata tgcacagctg gaccttcagt gcaatcaggc cacagcatat
     1501 cagtcgattt tcgtgaggaa tactgatggg caataccctt ataaactaaa atccggggta
     1561 catttccatt tgtatataaa tacagcacct tgtggggatg cacggatatt tagtcctcac
     1621 gaaaacgaca ctggtgttga taaacatcca aatagaaaag ctcgtggcca gctgcgcacc
     1681 aaaatcgagt ccggtgaggg gacgattcca gtgaaaagca gtgatggtat ccagacgtgg
     1741 gatggcgtat tgcagggcca acgcctgcta acaatgtcgt gctcggataa aattgcccgt
     1801 tggaacatcg tgggcatcca aggctcacta ttgtcttcca taattgaacc ggtgtacctg
     1861 cattcgattg tgctgggaag cctgttgcat ccggagcaca tgtaccgcgc agtttgcggc
     1921 cgaattgaga agtccattca aggcctgcca ccgccgtacc atctgaacaa gccgcgcctg
     1981 gcactagtca cttcggccga gccgcggaat caggccaagg ctcccaactt cgggatcaat
     2041 tggaccattg gggacaccga gctggaagtg gtgaactcgc taaccggtcg aaccattggc
     2101 ggccaggtgt ctcgcatcac aaagcaggcg tttttcgtta agtatggatt tctaatggca
     2161 aacttgcccg gtattttagt ccgcaaagta accactgact atgggcaaac caaagctaac
     2221 gttaaggact atcagatcgc aaagctagaa ttgttctctg cattcaagcg agaagacctt
     2281 ggcagctggc tgaagaaacc cattgaacaa gacgagttcg gtcttgccga atgactgcac
     2341 tcagcactat tatataattt taaaaaagac aacagcaacg gcaagcaatt aatagaatta
     2401 gacgacatag attttatgac aaattctgat atagaatgca aattatattg ggtgcaagca
     2461 catcgctatg atataccact tcatatgatt gacaacctgc caactttgcg tacccattgc
     2521 aatagcaagc acaaagatgc ttatgctcga aatataaaga acagctctag aatatttata
     2581 gaatagaatg tagtttttat gctggaactg agtaaaggag tattatggcg tttttttttg
     2641 aatcaattca tttttaaatt ggctaaagca atttctttat catttaagtt tgtgacttgt
     2701 tttgttattt gaatgaatgc gatgcgttgc gatgtcgtcg taaccacact gtcgaaactt
     2761 tcaagtgagt tgtgtctttc gttttccgta ttttatatgg taaatatggt aatatggaat
     2821 gttacgaaac agttaaaaga tatatataaa accaaaaacc aacaagtaca ctcaatgaat
     2881 aacaataatc caaacagaaa tctagaattc gttctcttat cgattaagca atgtattttg
     2941 ttaagtaatg ttatttgcaa cgacataata attataataa taataaagtc acgcttaata
     3001 taagcataag aacattttag gtgaatctgc gttaatttcg cgtacttttc ttcagatcag
     3061 atataaacct aagctttaat cgattttcaa tgaataaaac tgtgttcttg gttgaaaaac
     3121 attatatcta tgtaacaaca ttttatcaat taaattacgt agatttcttt gcatattagt
     3181 tgatacaaat cacatgcaag cgaaagcaga taagaataaa aatacatata ttagttacca
     3241 attttgtagc atgctgataa aggcatttga actacctaac taagtcttat catgaagctt
     3301 gtatcgctat ttcgtatatt gtagaaatac atactatatt agttgtggtt acttgtacat
     3361 cataatacct tctcttaaat ttacttccgc cctgagttct tccggttgtt cgttcaattt
     3421 gaaatgacaa ttgttaatgg tcaaatcaat aactactctt ccaacgtcga ttgacgtatt
     3481 ccaatttaaa acaaggcgat ttggctcctc ttttattgtg tacttgaaaa tgctacgacg
     3541 aatgatctag tcaaatgtgg taacctaata aagccatagt ctcctaccat tcagttatgt
     3601 gaaataaata ttacgtcgaa gttgcataga aaacgaaaat gaaaaggact gcatgacatt
     3661 agagcagcac agcatatttt gttgcagttg cagtttgtcc gaatcgtctt aatctcactc
     3721 acgacctcga aaaggtttga gtaccgactt cttgcgatat aatttttcat ttaaagccgt
     3781 aaaatttctt taagtactaa aattcaaccg cttaattcgt ccaatgccgt ttataattaa
     3841 caagctactt cgaagtttaa tttcctttga ctttctcaca gtccacttaa tgatactttt
     3901 agtagtaatt tacatgattg cttcgcaact tgtatccttc actaccgagt gaacctgatg
     3961 ggctgattgt gttttaaaaa tgaaaaagaa ttaattgtta actttttcag cacggcacga
     4021 agtaggcaat tgagttttaa gctattgaat ttggaagcgt agcttatggg aaatttgctg
     4081 atgctgaata caaatataat aggaaaacca tcagggcttt ttaaatgtga aattatattt
     4141 taagtggaga ggacattatt tataattttc aatagtggta ttcttcaaat tacgtcgata
     4201 gcaaaaattt aattatagat ttcctttaag ttcaaagtga tacatgtaca ccattttttt
     4261 tcctgcgcat gctaaaaata tattggcata ttatttgtga aaaagaaaaa aaaacttgcg
     4321 agtttttctc cattacttga ttaaataata atatgacgat ataattgact taagtaatat
     4381 ttgcaaaaat accgcgtatg atggataaac caaagttgat cttatataaa atactgtgat
     4441 actaaatttt actagtactt ccagcatagc tgcattttat ccattcttaa atattctatg
     4501 ataagcagca gcagataata atcaatgact atataggaaa acaaaaattt ttaaatggca
     4561 tgcaccatgc ttgtctacat tagattttca aataagaaat tttacaaact agattaatac
     4621 gtatggaatg gtgggtataa cattgggact cctcaaatat catttttaat tgcaaaataa
     4681 aacaataggc tctcgaatgc agcgtacaca ggaaaacttc agtcaactaa tttctattgc
     4741 gaaaagatac actaaattaa accctataaa acgtaggcta gtcgtcaagt cggtatattc
     4801 aagaaccagc taataaacgt tcaacacgta ttagaatacc tagctaagaa cacacaatga
     4861 taactatgag aattttttaa atatacttag ttggaagaag atcagacata tacaatagta
     4921 tgctagtcga gtcctctact cttgttatgg aatggtttta accattcacc tactaagttg
     4981 gtttgcctat cggttcgcat tcacattatt tcataatata attgaaacca gtttgggaat
     5041 aaatagaaat agacatagac atagtaaata tcacagtttg aaatggatat tgtacttgga
     5101 agttggaagt tggacttaca tgaataagta tacaaaacaa aaggttgctc aaattgcaaa
     5161 acacttggaa agtatttcta catcttccaa acaaaaagca gtcctcagaa acacacttag
     5221 atgctataga actataaaac atgccgggtt ttactatata tcccgctaaa ccagtgataa
     5281 gaagccgcgt tctagaccaa acccatatac caactaccat atagcatgaa gacactaatc
     5341 aagctgcata catatgtacg agctaaaggc agcaatccaa cacagattat attaccactt
     5401 gcaattgtat taatagttag aacatttgat gttttgggag ttcaaggact gtatgcaatc
     5461 aattatctaa gacacaacat gctaaacata ttgcagatcc ggcaggatgc caagattgaa
     5521 tctgttttac gtgctcctga gatcaagaat cattcattac tgacattctg ggctaaacgc
     5581 gttagaaaaa gagaccaaaa aaacaatcat aatttgggct tatctactag gcattgctta
     5641 cacatatttc actaagttta cgaaacggat attaaactac caaagaaata aacagtataa
     5701 tcgtggtaaa tttacattta cattacatcg agccaaaaac accttattac aaaacatcaa
     5761 atattttttg attccaccga aacttgcaat tttgatggaa aagtgggttt gggaatttag
     5821 caatgcggac atccaaatat agatggcttt tctttagttt acgaacaagc ccgtatttac
     5881 caggaaatca atatatgcat aacttaatat atagaaatac acacttatac gtaaaacttt
     5941 gttcttgaaa aagattagtg catatatcca aaagatttaa gcaaataata aacacttaat
     6001 atctaaatac acagaacaaa ctttaataag aactaggttt acacttccta cacttaaact
     6061 tcgcttgtcc acgtttcaag aaattcgctt ggataacgaa tcaataaaat tccaaaatag
     6121 taacagtcta gtctgcgaat tacaaattct atttgcaatt taagaaatat tcttttaaac
     6181 actaaaacac tgaatacttg caagaacgta gaaatcaatt gcatgcatcc aaaattgctc
     6241 gtttagttat aaaagaaatc cgtatgtacc aggaattctg tatatgcgtg gcttaataca
     6301 tataaaatac atacacactt atacgtaaag ctttgttcaa aacttgatca aaatttagtg
     6361 caaatagcca ggcgattcaa atggaataat agcgagcaag aaagagcatt gttaacagct
     6421 accataaaca tttaagtcgg caaaaaccaa tgtatcaata acttaaactt ttaaaataga
     6481 ttttacgatg gcctttttgt tttataatcg actgtcagcc aataaaatga tccccacgtc
     6541 attgaagacg aaacttaaac cctataagcc tatgaatatt tacacaatcg ttcggtctcc
     6601 aactaatgta aatgaaattt aataaattac caataatata tagag