Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]
LOCUS NM_166846 5842 bp mRNA linear INV 26-DEC-2023 ACCESSION NM_166846 VERSION NM_166846.5 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 5842) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 5842) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 5842) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 5842) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 5842) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 5842) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 5842) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 5842) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 5842) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 5842) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 5842) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 5842) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 5842) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 5842) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 5842) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 5842) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 5842) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 5842) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 5842) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 5842) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 5842) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 5842) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 5842) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_166846.4. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..5842 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..5842 /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="silver" /map="1B5-1B7" /db_xref="FLYBASE:FBgn0004648" /db_xref="GeneID:30998" CDS 495..4808 /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /EC_number="3.4.17.-" /note="CG4122 gene product from transcript CG4122-RH; CG4122-PH; svr-PH; carboxypeptidase E; pointed; DmSilver; chlorotic; carboxypeptidase D; silver; dwarp" /codon_start=1 /product="silver, isoform H" /protein_id="NP_726675.3" /db_xref="FLYBASE:FBpp0288455" /db_xref="GeneID:30998" /db_xref="FLYBASE:FBgn0004648" /translation="MLFFCLALIIGCAVGEYSEVRVIQEEDNFLESPHYLKNEEIGDL FSQLAKDYPDLAQTYTIGKSLEDRPIYALALSAPTGESKNGDLLRPMVKLVANIQGDE AVGRQMVLYMAEYLATHYDGDPKVQALLNLTEIHFLPTCNPDGFAKAKEGNCESLPNY VGRGNAANIDLNRDFPDRLEQSHVHQLRAQSRQPETAALVNWIVSKPFVLSANFHGGA VVASYPYDNSLAHNECCEESLTPDDRVFKQLAHTYSDNHPIMRKGNNCNDSFSGGITN GAHWYELSGGMQDFNYAFSNCFELTIELSCCKYPAASTLPQEWQRNKASLLQLLRQAH IGIKGLVTDASGFPIADANVYVAGLEEKPMRTSKRGEYWRLLTPGLYSVHASAFGYQT SAPQQVRVTNDNQEALRLDFKLAPVETNFDGNFRKVKVERSEPPQKLKKQFNGFLTPT KYEHHNFTAMESYLRAISSSYPSLTRLYSIGKSVQGRDLWVLEIFATPGSHVPGVPEF KYVANMHGNEVVGKELLLILTKYMLERYGNDDRITKLVNGTRMHFLYSMNPDGYEISI EGDRTGGVGRANAHGIDLNRNFPDQYGTDRFNKVTEPEVAAVMNWTLSLPFVLSANLH GGSLVANYPFDDNENDFNDPFMRLRNSSINGRKPNPTEDNALFKHLAGIYSNAHPTMY LGQPCELFQNEFFPDGITNGAQWYSVTGGMQDWNYVRAGCLELTIEMGCDKFPKAAEL SRYWEDHREPLLQFIEQVHCGIHGFVHSTIGTPIAGAVVRLDGANHSTYSQVFGDYWK LALPGRHNLTVLGDNYAPLRMEVEVPDVHPFEMRMDITLMPDDPQHWASANDFRIIEN VVNTRYHTNPQVRARLAELENQNGQIASFGYADSEFGTIFNYLKMTSDIGEPEEHKYK LLVVSSLYDTTAPLGREILLNLIRHLVEGFKLQDTSVVELLKRSVIYFLPQTSKFQNV FDMYNSNTSICDPVLGDELAERILGPETDQAKDVFLQFLRSERFDLMLTFGAGNSDLN YPKGDSVLVKFAHRMQRTEFNYSPLQCPPSATRQLHRETTERLTNMMYRIYNLPVYTL GISCCRMPHQKKIASVWRKNIDKIKNFLALVKTGVSGLVQNDKGQPLREAYVRLLEHD RIINVTKNVARFQLMLPHGLYGLEVTAPNYESQMIKVDVEDGRVTELGIIRMHPFTLI RGVVLELPNNDNRATTSIAGVVLDESNHPVRNAKVSVVGQTQLRNFTGSMGQYRISAV PLGTITLKVEAPRHLEATRQMHLIQGGLATENVVFHLKVNEHVFGLPRFLFILCASVL IIVGVIVCVLCAQFWFYRRHRGDKPYYNFSLLPQRGKEQFGLEDDDGGDDGETELFRS PIKRGMTIQPYFDEEQLERILHTDDDDDDGPHMEPELDVADDSEDDIVMLHNNGNKRR H" misc_feature 597..1490 /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup; Region: M14_CPD_I; cd03868" /db_xref="CDD:349440" misc_feature order(789..791,798..800,981..983,1008..1013,1137..1142, 1158..1160,1170..1172,1323..1325,1335..1337,1341..1343, 1401..1403) /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="active site" /db_xref="CDD:349440" misc_feature 1500..1736 /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cd11308" /db_xref="CDD:200604" misc_feature 1854..2765 /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="Peptidase M14 carboxypeptidase subfamily N/E-like; Region: M14_CP_N-E_like; cd03858" /db_xref="CDD:349431" misc_feature order(2037..2039,2046..2048,2220..2222,2247..2252, 2364..2369,2385..2387,2397..2399,2598..2600,2610..2612, 2616..2618,2676..2678) /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="active site" /db_xref="CDD:349431" misc_feature 2775..3005 /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cd11308" /db_xref="CDD:200604" misc_feature 3858..4058 /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl21470" /db_xref="CDD:473874" misc_feature 4155..4391 /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620" /db_xref="CDD:433354" ORIGIN 1 catctgatcg cagccgagtg gcaacagtgg tcgctgctgc gttcgcgtac tttcgtgact 61 tcatttgcga ttttatttat attctccgtg ttgcgaataa aatgtatgta tcatggcagt 121 tgtttaagaa gcgaatatac gctgattcat cctaggctgg cgagaagatc attgcgaaaa 181 aagtgtacga aaagaaagtg caataactgc agctctattg tgcgcgcatc tgggtgtgcg 241 tagatctttg catcggtgtg tcggtgtttt tttacgtttg tgtgcgtggc gtgcccacat 301 ttgtggcaca agtttaaaaa ttggcactaa gaaagttcaa gaaagtggtt ctggggaaaa 361 tagttcattc attcagcatc cactttctgt tgaaagtggc gcgcctgcgt tttgtgtctt 421 aatcatcgca ttgctgcctg cctacgtgta cagaaactgc gagcgctccg ggagagtccc 481 cgagaatccc caaaatgttg tttttctgcc tagccttgat catcggctgc gcagtcggag 541 aatacagcga agtccgggtc atccaggaag aggacaactt cctggagagt cctcactacc 601 taaaaaacga ggaaatagga gatcttttca gccagctagc caaggattac cccgacttgg 661 cgcagaccta tacaataggc aaatccctgg aggatcgacc catctacgcc ctagccttaa 721 gtgcacctac cggggagtcc aagaatggag atctcctaag gccaatggtt aaactggtgg 781 ccaacataca aggcgatgaa gccgtgggtc gtcagatggt tctctatatg gccgaatacc 841 tggccaccca ctacgatggg gacccgaagg tccaggcgct actaaatctc accgaaatcc 901 acttcctgcc cacctgtaac cccgatggat tcgccaaagc caaggaaggc aactgcgagt 961 cgctgcccaa ctatgtgggt cgtggcaatg cggccaacat cgatttgaat cgcgatttcc 1021 ccgatcgcct ggagcagagc catgtccacc agttgcgcgc ccagtctcgt cagccggaaa 1081 cagcagccct ggtaaattgg atcgttagca aaccgtttgt gctctccgcc aatttccatg 1141 gcggagctgt tgtggccagc tatccctatg acaactcctt ggctcacaat gagtgctgcg 1201 aggagagttt gactccggat gatcgggtct tcaagcagct ggcccacacc tattctgaca 1261 accatccgat tatgagaaag ggcaacaatt gcaacgatag cttctcggga ggtatcacca 1321 acggagccca ctggtatgag ttgtccggtg gaatgcagga ctttaactat gcgtttagca 1381 actgtttcga gctgaccatc gagttgtcgt gctgcaagta tccggcagca agcactttgc 1441 cccaggaatg gcagcggaac aaggcatccc tgctgcagct gctgcgccag gcacatatcg 1501 gcatcaaggg cctggtgacc gatgccagtg gctttccaat agccgatgcc aatgtctacg 1561 tggctggact agaggagaaa cccatgcgca cttccaaacg tggcgaatac tggaggcttt 1621 tgaccccggg actctatagc gtgcacgcct ccgcttttgg ttaccagacc agtgccccgc 1681 aacaggtccg ggtgaccaac gataaccagg aggccttgcg cctggacttt aagcttgcgc 1741 ccgtcgagac gaactttgat ggcaacttcc ggaaagtaaa ggtcgagcgc tctgagcctc 1801 cacagaagct caagaagcag ttcaatgggt tcttgacccc gactaaatac gaacaccaca 1861 actttacggc aatggagagc tatctgaggg cgattagcag cagctatcct tcccttacac 1921 gcctctacag catcggtaaa agcgtccagg gtcgtgatct ttgggtgctt gagatttttg 1981 ccacgccggg ttctcatgtc ccgggggttc cggagttcaa atatgtggca aacatgcatg 2041 gcaacgaggt ggtgggcaag gaattgcttc taatcctcac caaatatatg ctggaacgct 2101 atggcaatga tgacaggatt accaagctgg tgaatggcac ccgtatgcat tttttgtaca 2161 gcatgaaccc cgatgggtat gagatctcca tcgagggcga cagaaccggc ggagttggaa 2221 gagcgaatgc ccatggaatt gatttgaaca gaaacttccc cgatcaatat ggcacggacc 2281 ggttcaataa ggtgacagag ccagaggtgg ctgccgtcat gaactggaca ctgtcgctgc 2341 cgtttgtttt gtccgccaat ctccatgggg gctccttggt ggccaactac cccttcgacg 2401 ataacgaaaa tgattttaat gatccgttta tgagactccg caattctagt atcaatggcc 2461 gcaagccaaa tcccaccgag gataatgctc ttttcaaaca cctcgccggg atttattcaa 2521 acgcacaccc cactatgtac ctgggccagc catgtgagct cttccagaat gaattcttcc 2581 ctgatggcat tacgaatggt gctcaatggt atagtgttac tgggggaatg caggactgga 2641 actatgtgcg ggctggatgc ctggagctaa ccatcgaaat gggttgcgat aagtttccca 2701 aggccgccga gctttcgcga tactgggagg atcatcgcga gcctctgcta cagtttatcg 2761 agcaagtgca ttgcggcatt catggatttg tgcatagcac cattggtacg ccgattgcgg 2821 gagctgttgt tcgtttggat ggagccaatc attcgaccta cagtcaagtc ttcggtgact 2881 attggaagct agcgctgcct ggtcgacaca atctcactgt gttgggggac aactatgcgc 2941 cactacgaat ggaagttgaa gtacccgacg tccacccctt cgaaatgcga atggatatca 3001 ccctcatgcc agacgatccc cagcattggg catccgccaa tgactttagg attattgaaa 3061 acgtagtcaa cacaaggtat cacactaacc ctcaagttcg cgcacgcctg gcggagctgg 3121 agaaccaaaa tggacagatt gccagctttg gatatgccga ttctgaattt ggcacaatct 3181 tcaattacct caaaatgaca tctgatattg gcgagcccga ggaacacaag tacaagctgt 3241 tggtggtcag ttccctatac gatacaacgg ctcctctggg aagggaaatt ttgctcaacc 3301 tgatacgaca cttggtcgaa ggatttaagc tgcaggacac gtctgtagtc gagttgctta 3361 aacgaagtgt tatctacttc ctgccgcaga ctagcaagtt ccaaaatgtc tttgacatgt 3421 acaacagcaa cacctccatt tgcgacccag tcctggggga tgagttagca gagcgcattc 3481 ttggcccgga gacagaccag gccaaggacg tattcctgca atttttgcgt agcgaacgct 3541 ttgatttgat gcttaccttt ggagcaggca actccgactt gaactatccg aaaggggact 3601 cggtgctagt gaagtttgcc cacagaatgc agcgaacgga gttcaactac tcgcccctgc 3661 agtgccctcc atcggccacg agacagctcc accgggagac caccgagaga ttgaccaata 3721 tgatgtaccg catatacaat ttgcccgttt acaccttggg catttcctgc tgccgcatgc 3781 cgcaccaaaa gaaaatcgct tccgtttggc gcaaaaacat cgataagatt aagaactttt 3841 tggctctagt gaaaaccgga gtaagtggct tggtgcagaa cgataaagga caaccattga 3901 gggaggccta tgtccgattg ttggagcacg atagaatcat taatgttacc aagaatgtgg 3961 cgagattcca gttgatgctg ccccatggtc tttatggctt ggaggtaact gctcccaact 4021 acgagtcgca aatgattaag gtggacgtag aagatggtcg agtcacggaa ttgggcatta 4081 tacgcatgca tccattcacg ttgattcgtg gcgttgtcct ggagctgcca aataacgata 4141 acagagccac cactagcatt gcaggagtgg tgctggatga gagcaaccac ccagtgcgga 4201 acgccaaggt ctcggtggtg gggcagactc aattgagaaa ctttacaggc agcatgggac 4261 agtatcgtat atcggcggta cccttaggca ccatcactct aaaagtagag gcaccgcggc 4321 atctggaggc cacccgacaa atgcacctga ttcagggcgg cttggccaca gagaacgtgg 4381 tctttcacct aaaagttaac gagcatgtct ttggattgcc tcgctttttg ttcattttgt 4441 gcgccagcgt tctgatcatt gttggtgtca tcgtctgtgt gctatgtgcc cagttttggt 4501 tctatcgacg ccatcggggg gataagcctt attataactt ctcactgctg ccgcagaggg 4561 gtaaggagca gtttggcctt gaggacgatg atgggggtga tgatggggaa acggagctct 4621 ttcgatctcc catcaaacgc ggcatgacca tacagccgta ctttgatgag gagcagctgg 4681 agcggatcct gcacacggat gacgatgacg acgacggacc gcacatggag ccagaacttg 4741 atgtggctga cgatagcgaa gacgacatag tgatgttgca taacaacggg aacaagagac 4801 ggcactagat gttctgatag atgttcccaa tcaaacacaa tctcgagtga cacaaccacc 4861 agggatcacc taatccccga tcgactttaa ccacacacaa cataactgtg attcaaaacg 4921 ttttcaagag aaaccaacgc tctccttttt tgttattttt gtgtaatatc tacccttaaa 4981 aggtgaaaca ctttattttt gagttttagt gttactgagc ttgcacctag aatgcatcac 5041 aatcgtcagc tttaaataga aaatcctact acccactcgg caaatctctc gttcatgacc 5101 gtttatatag agatatacat ttttatgttc agccaaaaga actgtatgcg taaatgtaac 5161 ttaaactaaa gactgagagc ctcataattc tagcaaaaaa aaaaccataa caatttgtga 5221 aaaaatatta aatctaatct agctaaaaag aaaccgaaaa tcacagccaa caacagcaga 5281 agattgagtt tgttttaatg aaaaaattaa ctaacaatga atcaaaaaca atgtcaatat 5341 taaattatac taatttatta agcattgtct tcagaaagct aaattactta gcagctcatt 5401 atacagaaaa ttgattctta aagattaatt ttaagcttac tgttttacaa tttattaaac 5461 catatttagt agcttttatc ggaaattgaa tggttactcc catgaactct aaccctctgt 5521 atgctgaaat caggctttct aaaaatgatt ttaaatgctg gaaaaaaatg tgcaagatca 5581 taacaaaaac agttaacagc ttttgtaata ttttgaatat gcccaacata taaaattcaa 5641 acgtaaaatc aaatcgattt acataaacaa tgaatacata taaaagtgta ctgcacgatt 5701 ttatctaaat agagcacaaa aagacaaagc ggtagaaaat aacttgaaag taaaataata 5761 tatatatcat atacatatat atatatcata tacatatcct aatatatggc aatttaaact 5821 aagtaagcaa ctgaatctaa at