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Drosophila melanogaster Spt6, transcript variant A (Spt6), mRNA.


LOCUS       NM_143705               6166 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_143705
VERSION     NM_143705.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6166)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6166)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6166)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6166)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6166)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6166)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6166)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6166)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6166)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6166)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6166)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6166)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6166)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6166)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6166)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6166)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6166)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6166)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6166)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6166)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6166)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6166)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6166)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_143705.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6166
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6166
                     /gene="Spt6"
                     /locus_tag="Dmel_CG12225"
                     /gene_synonym="CG12225; Dmel\CG12225; dspt6; dSpt6; Dspt6;
                     l(1)G0063; spt 6; spt6; SPT6"
                     /map="5E4-5E4"
                     /db_xref="FLYBASE:FBgn0028982"
                     /db_xref="GeneID:44000"
     CDS             111..5606
                     /gene="Spt6"
                     /locus_tag="Dmel_CG12225"
                     /gene_synonym="CG12225; Dmel\CG12225; dspt6; dSpt6; Dspt6;
                     l(1)G0063; spt 6; spt6; SPT6"
                     /note="CG12225 gene product from transcript CG12225-RA;
                     CG12225-PA; Spt6-PA"
                     /codon_start=1
                     /product="Spt6, isoform A"
                     /protein_id="NP_651962.2"
                     /db_xref="FLYBASE:FBpp0070861"
                     /db_xref="GeneID:44000"
                     /db_xref="FLYBASE:FBgn0028982"
                     /translation="MAEFLDSEAEESEEEEELDVNERKRLKKLKAAVSDSSEEEEDDE
                     ERLREELKDLIDDNPIEEDDGSGYDSDGVGSGKKRKKHEDDDLDDRLEDDDYDLIEEN
                     LGVKVERRKRFKRLRRIHDNESDGEEQHVDEGLVREQIAEQLFDENDESIGHRSERSH
                     READDYDDVDTESDADDFIVDDNGRPIAEKKKKRRPIFTDASLQEGQDIFGVDFDYDD
                     FSKYEEDDYEDDSEGDEYDEDLGVGDDTRVKKKKALKKKVVKKTIFDIYEPSELKRGH
                     FTDMDNEIRKTDIPERMQLREVPVTPVPEGSDELDLEAEWIYKYAFCKHTVSEQEKPE
                     SREKMRKPPTTVNKIKQTLEFIRNQQLEVPFIAFYRKEYVKPELNIDDLWKVYYYDGI
                     WCQLNERKRKLKVLFEKMRQFQLDTLCADTDQPVPDDVRLILDSDFERLADVQSMEEL
                     KDVHMYFLLNYSHELPRMQAEQRRKAIQERREAKARRQAAAAENGDDAAEAIVVPEPE
                     DDDDPELIDYQLKQASNSSPYAVFRKAGICGFAKHFGLTPEQYAENLRDNYQRNEITQ
                     ESIGPTELAKQYLSPRFMTTDEVIHAAKYVVARQLAQEPLLRKTMREVYFDRARINIR
                     PTKNGMVLIDENSPVYSMKYVAKKPVSDLFGDQFIKLMMAEEEKLLEITFLEEFEGNA
                     CANGTPGDYVEESKALYQLDQFAKHVQEWNKLRAECVQLALQKWVIPDLIKELRSTLH
                     EEAQQFVLRSCTGKLYKWLKVAPYKPQLPPDFGYEEWSTLRGIRVLGLAYDPDHSVAA
                     FCAVTTVEGDISDYLRLPNILKRKNSYNLEEKAQKLADLRKLSDFIKMKKPHIVVIGA
                     ESRDAQNIQADIKEILHELETSEQFPPIEVEIIDNELAKIYANSKKGESDFKEYPPLL
                     KQAASLARKMQDPLVEYSQLCDADDEILCLRYHPLQERVPREQLLEQLSLQFINRTSE
                     VGLDINLMVQNSRTINLLQYICGLGPRKGQALLKLLKQSNQRLENRTQLVTVCHLGPR
                     VFINCSGFIKIDTSSLGDSTEAYVEVLDGSRVHPETYEWARKMAIDAMEYDDEETNPA
                     GALEEILESPERLKDLDLDAFAVELERQGFGSKSITLYDIRNELSCLYKDYRTPYTKP
                     SAEELFDMLTKETPDSFYVGKCVTAMVTGFTYRRPQGDQLDSANPVRLDSNESWQCPF
                     CHKDDFPELSEVWNHFDANACPGQPSGVRVRLENGLPGFIHIKNLSDRQVRNPEERVR
                     VSQMIHVRIIKIDIDRFSVECSSRTADLKDVNNEWRPRRDNYYDYVTEEQDNRKVSDA
                     KARALKRKIYARRVIAHPSFFNKSYAEVVAMLAEADQGEVALRPSSKSKDHLTATWKV
                     ADDIFQHIDVREEGKENDFSLGRSLWIGTEEFEDLDEIIARHIMPMALAARELIQYKY
                     YKPNMVTGDENERDVMEKLLREEKANDPKKIHYFFTASRAMPGKFLLSYLPKTKVRHE
                     YVTVMPEGYRFRGQIFDTVNSLLRWFKEHWLDPTATPASASASNLTPLHLMRPPPTIS
                     SSSQTSLGPQAPYSVTGSVTGGTPRSGISSAVGGGGSSAYSITQSITGYGTSGSSAPG
                     AGVSSSHYGSSSTPSFGAINTPYTPSGQTPFMTPYTPHASQTPRYGHNVPSPSSQSSS
                     SQRHHYGSSSGTGSTPRYHDMGGGGGGGVGGGGGSNAYSMQPHHQQRAKENLDWQLAN
                     DAWARRRPQQHQSHQSYHAQQQHHHSQQQPHMGMSMNMGITMSLGRGTGGGGGGGYGS
                     TPVNDYSTGGGHNRGMSSKASVRSTPRTNASPHSMNLGDATPLYDEN"
     misc_feature    1032..1340
                     /gene="Spt6"
                     /locus_tag="Dmel_CG12225"
                     /gene_synonym="CG12225; Dmel\CG12225; dspt6; dSpt6; Dspt6;
                     l(1)G0063; spt 6; spt6; SPT6"
                     /note="Helix-turn-helix DNA-binding domain of SPT6;
                     Region: HTH_44; pfam14641"
                     /db_xref="CDD:464230"
     misc_feature    1803..3944
                     /gene="Spt6"
                     /locus_tag="Dmel_CG12225"
                     /gene_synonym="CG12225; Dmel\CG12225; dspt6; dSpt6; Dspt6;
                     l(1)G0063; spt 6; spt6; SPT6"
                     /note="Transcriptional accessory protein Tex/SPT6
                     [Transcription]; Region: Tex; COG2183"
                     /db_xref="CDD:441786"
     misc_feature    2451..2915
                     /gene="Spt6"
                     /locus_tag="Dmel_CG12225"
                     /gene_synonym="CG12225; Dmel\CG12225; dspt6; dSpt6; Dspt6;
                     l(1)G0063; spt 6; spt6; SPT6"
                     /note="Crossover junction endodeoxyribonuclease RuvC and
                     similar proteins; Region: RuvC-like; cl21482"
                     /db_xref="CDD:473878"
     misc_feature    2925..3236
                     /gene="Spt6"
                     /locus_tag="Dmel_CG12225"
                     /gene_synonym="CG12225; Dmel\CG12225; dspt6; dSpt6; Dspt6;
                     l(1)G0063; spt 6; spt6; SPT6"
                     /note="Helix-hairpin-helix domain; Region: HHH_5; cl22429"
                     /db_xref="CDD:473956"
     misc_feature    4044..4676
                     /gene="Spt6"
                     /locus_tag="Dmel_CG12225"
                     /gene_synonym="CG12225; Dmel\CG12225; dspt6; dSpt6; Dspt6;
                     l(1)G0063; spt 6; spt6; SPT6"
                     /note="SH2 domain; Region: SH2_2; pfam14633"
                     /db_xref="CDD:464227"
ORIGIN      
        1 atgcgatgag aaataaagaa gaagagaaga ggaagaaacg ctcacaaact cttcgtttct
       61 ctgcattaat acgcacttta ttattaagtt aagctttatt ccattatatt atggccgaat
      121 ttctggactc cgaggccgag gaatcggagg aggaggaaga attggacgtc aacgagcgca
      181 agagactcaa gaaactgaag gcggccgtct ccgatagtag cgaagaagaa gaagacgacg
      241 aggaacggct gcgcgaagag ctcaaagatc tgatcgacga caatcccatc gaggaggacg
      301 atggcagtgg ttacgattcc gatggcgtcg gcagcggcaa gaagcgcaaa aagcacgagg
      361 acgacgatct ggacgatcga ctggaggacg acgactacga tcttatcgag gagaatctgg
      421 gcgtcaaagt cgagagacgg aagcggttca agcgtctgcg tcgcatccac gacaacgaaa
      481 gcgatggcga ggagcagcac gtggacgagg gtctggtgcg tgagcagatt gccgagcagt
      541 tgttcgacga gaacgatgag agcattggtc atcgcagcga gcgcagtcac agggaggcgg
      601 acgactacga cgacgtggat acggagtcgg acgcagatga cttcattgtg gacgataatg
      661 ggcgtcccat agccgagaag aagaagaaac ggcgccccat ctttacagac gcatcacttc
      721 aagagggtca ggacatcttt ggcgtagact tcgactatga cgacttctca aagtacgagg
      781 aagacgacta cgaagatgac tcggaaggag atgagtacga tgaggatctg ggcgtcggcg
      841 atgatacgcg cgtcaagaag aagaaagcgc tcaaaaagaa ggtggtcaag aagacaatct
      901 tcgacatata cgagcccagc gagctcaagc gtggtcattt caccgatatg gacaacgaga
      961 ttcgcaagac agacatccca gaaagaatgc agctgcgaga ggtgcccgta accccggtgc
     1021 ccgagggatc agacgagctg gacctcgagg ctgaatggat ctacaaatat gccttctgca
     1081 agcacactgt ttcggaacag gaaaagccgg agagccgcga gaaaatgcgc aaaccaccga
     1141 caaccgttaa caagattaag cagacgctag aatttatacg caaccagcag ttggaggtgc
     1201 cctttatagc cttctatcgc aaggagtatg tgaagccaga gcttaatatc gacgatctct
     1261 ggaaggttta ctactacgat gggatctggt gtcagctaaa cgagcgaaag cgcaagctaa
     1321 aggtgctttt cgaaaagatg cgtcagttcc agctggacac gctatgcgcc gacacagatc
     1381 aacccgtacc ggatgatgtt cgcctcatcc tggacagcga tttcgagcgc ctcgccgacg
     1441 tacagtcgat ggaggagcta aaggacgtgc acatgtactt tctgctgaac tattcgcatg
     1501 agctgccccg catgcaggcg gagcagcgac gaaaagctat acaggagcgt cgcgaggcca
     1561 aggcgcgtcg ccaggcagcc gccgctgaga acggtgatga tgcggccgag gcgatagttg
     1621 taccagagcc ggaagacgat gacgatcccg agctgatcga ttaccaacta aagcaggcgt
     1681 ccaacagcag tccctatgcg gtattccgca aggcgggcat ctgcggcttt gccaaacact
     1741 ttggtctcac gccggagcag tatgccgaaa atctgcgcga caattaccag cgcaatgaga
     1801 tcacccagga aagcatcggt cccacagagc tggccaagca atatttgtcg ccgcgcttca
     1861 tgaccacgga tgaggttatc catgccgcaa aatacgttgt ggcccgacag ctggcacaag
     1921 agcctctgct gcgcaagacc atgcgtgagg tgtatttcga cagagctagg attaacatac
     1981 ggcccaccaa gaatggcatg gtgctgatcg atgagaattc gccggtgtat tcgatgaagt
     2041 acgtggccaa gaagccggta agcgatctat ttggcgatca attcataaag ctaatgatgg
     2101 ccgaggagga gaagctgctg gagataacgt tcctcgagga gttcgagggc aatgcgtgtg
     2161 ccaacggaac acccggtgac tatgtggaag agtccaaggc cctgtaccag ctggatcagt
     2221 ttgccaagca cgtgcaggag tggaataagc tgcgggcgga atgcgtacag ctggcgctgc
     2281 agaagtgggt cattccggat ctgatcaagg agctgcgctc aactctgcac gaggaggctc
     2341 agcaatttgt gctgcgttcc tgcacgggta agctgtataa gtggctaaag gtggcaccct
     2401 ataaaccgca actgcccccc gactttggct acgaggagtg gagcacgctg aggggcatac
     2461 gggtgctggg tctggcctac gatcccgatc actcagtggc cgctttctgt gcggtgacta
     2521 ccgtggaggg cgacatctcc gactacctgc gactgccgaa cattctgaag cgcaagaatt
     2581 cttacaacct tgaggagaag gcccagaagt tggccgacct tcgaaagctg agtgacttta
     2641 tcaaaatgaa gaagccacac attgttgtca tcggagcgga atcgcgcgat gcccagaaca
     2701 tccaggcaga cattaaggag attctgcatg aactcgagac ctccgaacaa tttccgccca
     2761 tcgaggtgga gataatcgac aacgagctgg ccaagatcta tgccaactcg aagaagggcg
     2821 agtctgactt taaggagtat cctcctctgc tgaagcaggc tgcttcgctg gcccgcaaga
     2881 tgcaggatcc gctagtggaa tactcacagc tgtgtgatgc ggacgacgag attctctgcc
     2941 tgcgctacca tccgctacag gagcgtgtgc cgcgcgaaca gctgctggag cagctcagcc
     3001 tgcagtttat caatcgaacg agcgaggtgg gtctggacat taacctgatg gtgcagaact
     3061 cacggaccat caacctgctg cagtacatct gtggcttggg tccgcgcaag ggtcaggctt
     3121 tacttaaact tcttaagcag agcaaccagc ggttggagaa ccgcacccag ctggtcaccg
     3181 tgtgtcatct ggggcccagg gtctttatca actgcagcgg tttcattaag atcgatacct
     3241 catcgctggg cgacagcaca gaggcgtatg tcgaggtgct ggacgggtcg cgtgtgcatc
     3301 cagaaacgta cgagtgggcc agaaagatgg ccatcgatgc catggagtac gacgacgagg
     3361 agaccaatcc ggccggtgcc cttgaggaaa ttctcgagtc gccagagcgc cttaaggatc
     3421 tcgatctgga cgcattcgct gtggaactgg agcgccaggg attcggcagc aagagcataa
     3481 ccttgtacga cataaggaac gagttgagct gcctgtacaa ggactaccgc actccgtaca
     3541 caaagcccag tgcggaggag ctcttcgata tgctgaccaa ggagacgccc gactcgtttt
     3601 atgtgggcaa gtgcgtcacg gccatggtca ccggtttcac ctaccgtcgg ccgcagggcg
     3661 atcagctaga cagcgcaaat ccggtgcgtc tagattccaa cgaaagctgg cagtgcccct
     3721 tctgccacaa ggacgacttc ccagagctgt ccgaggtgtg gaatcacttt gacgcgaacg
     3781 cgtgccctgg ccagccatct ggtgtgcgtg tgcgtctgga gaacggcctg cctggcttta
     3841 tacacatcaa gaacttgtcc gatagacagg ttcgcaatcc cgaagaacgt gtgcgcgtct
     3901 cacagatgat tcatgttcgc atcattaaga tagacattga ccggttctca gtcgaatgct
     3961 cttcgaggac cgctgatctt aaggatgtga acaatgagtg gcggccgcgt cgcgacaact
     4021 actatgatta tgtgactgag gagcaggaca atcggaaagt gagcgatgcc aaggccaggg
     4081 ctctgaagcg caaaatttac gcgcgtcgcg taatcgccca tcccagcttc ttcaacaagt
     4141 cgtacgcgga ggtggtggcc atgctagcgg aggccgatca gggcgaggtg gccctgcgtc
     4201 cgagcagcaa gtccaaggac catctgacag ccacctggaa ggtggccgac gacatcttcc
     4261 agcacatcga tgtgcgcgag gagggtaaag agaacgattt cagcctgggc agaagtctgt
     4321 ggatcggcac cgaggagttc gaggatctgg acgagatcat cgcccgccac atcatgccga
     4381 tggccttggc tgcccgcgaa ctgatacagt acaagtacta caagccaaac atggtgaccg
     4441 gcgatgaaaa tgaacgggat gtcatggaaa agttgctgcg cgaggagaag gcaaatgatc
     4501 cgaagaagat acactacttt tttacggcct cacgcgccat gccgggcaag ttcctgctgt
     4561 cctatctgcc caagacgaag gtgcgtcacg agtatgtgac ggtcatgccg gagggctatc
     4621 gtttccgtgg ccagattttc gatacggtta acagtctgct gcgttggttt aaggaacact
     4681 ggctggatcc aacggccacg ccggccagcg cctcggcgtc caacttaacg ccactgcact
     4741 tgatgcgtcc gccgccgacg atctcgtcgt catcccagac ctccttgggc ccccaggcgc
     4801 cctacagcgt cactggcagc gtgactggtg gaacgccgcg cagtggcatc agcagtgccg
     4861 tcggcggtgg cggttccagc gcctactcca ttacgcaatc catcactggc tacggcacgt
     4921 cgggcagttc tgctccaggg gctggagtat cttcctccca ctatggcagc tcatcgacgc
     4981 cgtcgtttgg cgccatcaat acgccataca cgcccagtgg acagactccg ttcatgacgc
     5041 cctacacgcc gcatgcctca cagacgcctc gctatggtca caatgtgccc agtcccagct
     5101 cgcaatcatc gagcagtcag aggcatcact acggcagcag ttccggaacg ggcagcacgc
     5161 ccaggtatca cgatatggga ggaggaggcg gtggcggcgt tggtggtggt ggtggttcca
     5221 atgcctacag catgcagccg catcaccagc aacgtgccaa agagaacctc gactggcagc
     5281 tggccaacga tgcctgggca agacgcagac cgcagcagca tcagtcacat cagtcgtatc
     5341 acgcccagca gcagcatcat cactcgcagc agcaacccca tatgggcatg agcatgaaca
     5401 tgggcattac aatgtcactg ggacgtggca ccggtggcgg cggaggaggt ggctatggat
     5461 cgacgcctgt caatgattac agcaccggag gcggtcataa tcggggtatg tcctcgaagg
     5521 cgtctgtgcg cagtacgccg cgcaccaacg cctcgccgca ctccatgaat ctgggcgatg
     5581 ccacgcccct ctacgacgag aactaggggc ggcgaagtga atggaaaccg aaaaccaaca
     5641 caagctgcaa aggatgcact atgcacacac catatgctac tatatacata cactatacta
     5701 caaaaacgag aacagaaccg aacagaacag aaaagtctac aattatatat aattcatgca
     5761 cgcgcagctg gcgaagatcc agttgcacta atcttagtac tttggagtgc gattccgcat
     5821 tgatcctcaa cgatatttag gtttaagtca agtccataac tgatccgcag ttcacaccac
     5881 atatataaat atatattatc tatgtataat tgaaaattgc ggaacgcctg ccgttggagt
     5941 gggtgcatca cctggcggtg ggggagtagg agtagaacgg ctgggcagga gctgagacgc
     6001 cggtgggccg gggagcaatc aggtttgtga cgacggaaga atgaaaaata aatttcaatt
     6061 ttttctgacc agaaatatac cgccagctct tcttactaat gggaattcaa gattggtttt
     6121 atccgcagct tttatgaata aaacgcccga gttgtgtaat ttaagc