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Drosophila melanogaster activating transcription factor 3,


LOCUS       NM_138988               7025 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant A (Atf3), mRNA.
ACCESSION   NM_138988
VERSION     NM_138988.4
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 7025)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7025)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7025)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 7025)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 7025)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 7025)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 7025)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 7025)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 7025)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 7025)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 7025)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 7025)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 7025)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 7025)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 7025)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 7025)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 7025)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 7025)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 7025)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 7025)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 7025)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 7025)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 7025)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_138988.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7025
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..7025
                     /gene="Atf3"
                     /locus_tag="Dmel_CG11405"
                     /gene_synonym="A3-3; atf3; ATF3; CG11405; dATF3; DM11;
                     Dmel\CG11405; EG:33C11.1"
                     /note="Activating transcription factor 3"
                     /map="1E5-1F1"
                     /db_xref="FLYBASE:FBgn0028550"
                     /db_xref="GeneID:43867"
     CDS             1409..3250
                     /gene="Atf3"
                     /locus_tag="Dmel_CG11405"
                     /gene_synonym="A3-3; atf3; ATF3; CG11405; dATF3; DM11;
                     Dmel\CG11405; EG:33C11.1"
                     /note="CG11405 gene product from transcript CG11405-RA;
                     CG11405-PA; Atf3-PA; A3-3"
                     /codon_start=1
                     /product="activating transcription factor 3, isoform A"
                     /protein_id="NP_620473.1"
                     /db_xref="FLYBASE:FBpp0070234"
                     /db_xref="GeneID:43867"
                     /db_xref="FLYBASE:FBgn0028550"
                     /translation="MFNSNIPASSLLSIDSGGLLMGGHTPKTPEILNSLIAMTNPLEN
                     FSYSSAAAAAAAVSVASSSASCSAASTPVVTVRHFNGHPNGQSHSQDSSHSSCSGSPL
                     DSPAGTATTPSVQQTCSRLIKEGLKLSIQSKRKLSTCDSSSGSEQPHSKYSRRSSNHN
                     GHSGSSNNYSGSMSNANDLDDDCEESSDDDSETKSQPKGLTPEDEDRRRRRRERNKIA
                     ATKCRMKKRERTQNLIKESEVLDTQNVELKNQVRQLETERQKLVDMLKSHGCQRAGGC
                     QLPSQLLQSPAQKYLSELELETVSIDGPNSGNNNQRLQSIPSMATFKYGSKTAAAMAQ
                     QLPNGYCKPSPSAQEFEHAGYQQQQQQQQQQQPQSLNPAGNNVIDQQHANPSPSLLSD
                     YVPNCDGLTGSASNHPSHNNNNNNNNSSGASSNTSNNNSNISSHSSNATSSTTPTATS
                     SAIEFVKNELVDSQSPYTTALSAERFLFEPSDGFPDIKHACVLPSPCGINGLNMASVV
                     NTNGSTGNNNNSHHNNNNNNNNHLMDFHQGLQHGNIGTGVGVGVGVGVGVGVGVGVMT
                     PYDDEQLLLLKNGCFATDLLSQLVEEGGEYVDLDSATAFMNNGSCLA"
     misc_feature    2051..2212
                     /gene="Atf3"
                     /locus_tag="Dmel_CG11405"
                     /gene_synonym="A3-3; atf3; ATF3; CG11405; dATF3; DM11;
                     Dmel\CG11405; EG:33C11.1"
                     /note="Basic leucine zipper (bZIP) domain of Activating
                     Transcription Factor-3 (ATF-3) and similar proteins: a
                     DNA-binding and dimerization domain; Region: bZIP_ATF3;
                     cd14722"
                     /db_xref="CDD:269870"
     misc_feature    2051..2203
                     /gene="Atf3"
                     /locus_tag="Dmel_CG11405"
                     /gene_synonym="A3-3; atf3; ATF3; CG11405; dATF3; DM11;
                     Dmel\CG11405; EG:33C11.1"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:269870"
     misc_feature    order(2084..2086,2093..2098,2105..2110,2114..2119,
                     2126..2131,2135..2140,2147..2152,2156..2161,2168..2173,
                     2177..2182,2189..2194,2198..2203)
                     /gene="Atf3"
                     /locus_tag="Dmel_CG11405"
                     /gene_synonym="A3-3; atf3; ATF3; CG11405; dATF3; DM11;
                     Dmel\CG11405; EG:33C11.1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:269870"
ORIGIN      
        1 cgtcaaccgg actcgaacgc aacgccgcca cagcgagccg acgctccacc aacccaccct
       61 tttccgctcc accccgtttc acaggcacag ccacatccac atccactgac actggcactg
      121 ccgttcttat tagattttat ggcggctccg acttagaaca caaacaacaa gcacaagcac
      181 agcacatcga cggtcggtcg gtcggccgcg cctttggccg tttcagttgc catccgtttc
      241 ttcgttctcg cgccgttaga atcgcactgt ggcgcagtcg ctcctctgcc gacgtcgctg
      301 ccgctggctg acttattggc tttaagcgaa tttgaacgtc gctcgaactt ttattcaacg
      361 tgttggattc atcgtgtgag caactctgaa tcgctacaaa tgcgcagcgg aaactaaaaa
      421 ctgaaataca caaaccaaaa acacaaatcg aaaatacaaa atccccctta aaaatacaaa
      481 ctaagccccc caaaaaaaat ccgcgatacg caagtgttaa atgcgatatt gaagaaaaac
      541 gtacatagta atacatataa ttaatatcgc cttaaaatct aagagattta ataatatttt
      601 tttgaagtgt tgaacccatt aagtgcttta aacgacaaca acaacaacaa ctaccaaaat
      661 gccttgcaaa agcatcacgc tttagtggta caaaaccaag tgttacaagt ccccccaccc
      721 ttttcgcaaa gaccccattc aaaactgata gcaagggagg cccaaacagg tgtccgcctg
      781 ccgaaaggcc aacgaaacgc accagcgaca atcagatggg cagaactgct cttggagcga
      841 gagagagatt ttccagcagc tcagctcaga gctcagtgtg gtgcagacca gcgaatcttg
      901 catttattga ttcgatgccg atgtgaaggg aggtgccggc tgttcgacgt tcaacgcatt
      961 gcattcgctc ggccttagcg ctctgagcaa caacaaaagt cggggatctg agccgatgga
     1021 accgatggat cgatcttact cctctgccgc cgacccccta agaaccccaa tcccaattga
     1081 accgaaagaa acaacactct agacagcgaa gactcttcga gtttgacatg tgataagcaa
     1141 aaaagtgaaa agtgtgtgcc tctaaaattc aatatataat atatatacaa atacacatat
     1201 acacaagaga tatagaacaa acaactttgt gaacagtcca acaaaacaaa tgcaacgcgt
     1261 aggcctttaa ctgtgattta acaatatata gcaagcaaac aaaaaaaaaa aaaaaaacaa
     1321 aaaaaaaaaa caccagtttg ttacgattaa ttttagttcg gtttagtttt cgttttattt
     1381 accgtgcgtg taaccgtcaa cgtcgaccat gttcaattcc aacataccgg cctcctcgct
     1441 gctgagcatc gacagcggcg gcctcctgat gggcggccat acgcccaaga cgccagagat
     1501 cctcaactcg ctaattgcca tgaccaatcc gctggagaac tttagctaca gttcagcagc
     1561 ggcggcggcg gcggcagttt ccgtcgcatc ctcatctgca tcctgcagtg ccgcctccac
     1621 gccggtggtc accgtgcgcc acttcaacgg ccatcccaat ggtcagtcgc actcgcagga
     1681 cagcagtcat tccagttgct ccggatcacc gctcgactcc ccagcgggca cggctaccac
     1741 acccagcgtg caacagacct gttcgcgcct gatcaaggag ggcctgaagc tgtccatcca
     1801 gagcaagcgt aagctgtcca cctgcgactc aagctccgga tcggagcagc cgcactccaa
     1861 gtactcgcgc cgcagtagca accacaacgg gcacagcggc agcagcaaca actatagcgg
     1921 cagcatgagc aacgccaacg atttggacga cgactgcgag gagtccagcg atgacgacag
     1981 cgaaaccaag tcacagccca agggactcac cccggaggac gaggacagac ggcgaaggcg
     2041 ccgcgagcgg aataagattg cggccaccaa gtgccgaatg aagaagcgcg aacgcacaca
     2101 gaatctgatc aaggagtcgg aggtcctgga tacccaaaac gtagagctaa agaaccaagt
     2161 acgtcagctg gaaaccgaac gccaaaagtt ggtggacatg ctgaaatcgc acggctgcca
     2221 gcgagccgga ggctgccaat tgcccagcca actgctccaa tcgccggccc agaaatatct
     2281 cagcgaactg gaactggaaa cggtgagcat cgacggtccc aactccggta acaacaacca
     2341 gcggctgcag agcataccct cgatggccac cttcaagtat ggctccaaaa cggcggcggc
     2401 catggcccaa caactgccca atggctactg taaaccttcg cccagcgccc aggaattcga
     2461 gcacgccggc taccagcaac agcagcagca gcagcagcaa cagcagccac agtccctgaa
     2521 tcccgccggc aacaacgtga ttgaccagca gcatgccaat cccagtccca gtctgctttc
     2581 cgactacgtt cccaactgcg acggcctaac tggcagtgcc agcaaccatc ccagtcacaa
     2641 caacaacaac aacaacaaca acagcagcgg cgccagcagc aacaccagca ataacaacag
     2701 caacatcagc agccacagca gcaacgccac tagcagtaca acgcccaccg ccaccagcag
     2761 cgccattgag ttcgtgaaga atgagctggt ggactcgcag agtccctaca ccaccgccct
     2821 cagtgcggaa aggttcttgt tcgagcccag cgatggcttt ccggacatca agcacgcctg
     2881 tgttttgccc tcgccctgcg gcatcaatgg cctcaacatg gccagcgtgg taaacacgaa
     2941 cgggagcacc ggcaacaata ataacagcca ccataataat aataacaaca acaacaatca
     3001 cctgatggac ttccaccagg gcctgcagca tggcaacatt gggaccggag tgggcgttgg
     3061 cgtcggagtt ggtgtgggag tgggagtcgg agtgggcgtg atgacgccct acgatgacga
     3121 gcaattactg ctgctgaaga atggatgctt tgccaccgat ctgctgtcgc aactggtgga
     3181 ggagggcggc gagtatgtcg acctggactc agccactgcc ttcatgaaca acggcagttg
     3241 cctggcgtga ggaagggcgc cggacaggga gcgggatcga gaccgcgacc tgctgcttcc
     3301 agccttcgaa cagccaaaca ctcagcaaca gcaagcagtc caatacccgg ccgggaagga
     3361 agagccaccg gccagtccac agcttgatgg gcaggtgcaa ctcgaactcg aaatggagct
     3421 gcaactcgga gaggatcagg atccggcttg gactcatgta gactactggt gctagggcta
     3481 gggcatcatc atcatcacat actaatgtta atcttaaacg ccactcgact aagcaggagt
     3541 acagaaaaat aagccgcagt tcccccttta aaccccaaca accaatccgt agcgaagatc
     3601 ccatttcatg caatgcgatc cctgttatca gttatataac taaagcattc tttctttcaa
     3661 aatcaaagcc acacatttct tcctagccta caactttctt acatagaatt gaaagcagac
     3721 cacagatatt tttttgagcc acttgctttt cggattcttt tatcctaagc aaactttaaa
     3781 ccgctacatt ttaacacaag caatccaagt tcttccaata gcagagttcc cctcaaaggt
     3841 ctggatcccg cgattcaatc aaggaccact cgaataaaat ccccaacccg agatacatcc
     3901 ccgcccccaa gaaaccccca taccttgatc ccaagtccgc ctggagccgg catccagcct
     3961 gtggcttgac tacctcatga agcaagaagc agaaacaatt aacaagtaac tatcattaaa
     4021 gagctgtaag gagtaaggtg taaagaaaaa tggacaaaag gcagaaacag aagcagaagc
     4081 agagaagcag aaacgagagc acacaaacac acgcgcagcg gtgaaagaaa cacttgcaca
     4141 actgtacata accaaatttt tatacattaa ctaggtatat cgattaacat tccattgcaa
     4201 gcctgcgaga aaaacaagtc gagggaagaa gagcagtaat caactgctag cagtcacatc
     4261 cgcatcagta attattaatt ttaatttgtt cgattctttt caagcataca tagatttgtt
     4321 tgctctttgc taccatcaaa gccttaacca ttacatatat taatatgctt ataaatgtat
     4381 aaacaatcga gagattagag agaaatattc gagatgagaa gcaaaagcag taacagaaat
     4441 aggaagccca tgcgatatga tgtttgatat ttttttctaa aacctaggct tagtcagtga
     4501 taaacccaat atgtatatat accgcatata tatacagact tatatataca tttatgaatt
     4561 tttgtttttt tttttttgtg tccatgaata gtaagctatg tttaaaaaat aagtaaaatt
     4621 gccttactca aacattaaat cgacaaaaaa aaagatcttt gaattgacca ctaaacctaa
     4681 attactaatc ttcactttgt taaatctttt gcaaaactaa tctatatata ccagagcaac
     4741 aaaatatata aatataatat atatacaaga gatatatgga gaaagaaatg tattatgtat
     4801 aaattggtgg aatcgaagac cttaaagtgc tgctaaaatt gaaactttgc aactccttct
     4861 aacgtgcgcc ttataacaat tttgtaattt atactatata catatggtag gaaaagtcga
     4921 agtatatata tatgtacata tatatatata tatatatata tatatacaag cgtgtactaa
     4981 atcgaggtta aacttatata tttgtgtgtt tattgcttga tcaacgagat atatacataa
     5041 ttatacacag ataaagcagt taattatata tacaaagtgt gtgtacaaac agctgtgaac
     5101 accaaaaagt ggcctaaagg agaatccaaa caaaacccaa acaaaagtaa ttcccccaac
     5161 aagtgctttg aaattatttc gtatttgtaa ttgcctcgag ctgaaaagag ttaaccaacg
     5221 ataccgataa acgataagcg atataagtat atctatgtta aatacgcaaa ctatttataa
     5281 catgtaacga acccgatgag cttgtcaagc tttttgagca ccgccttttt ctcttgatct
     5341 accaagtcta ccataatgtt atgtcaccac gatacttctc aaataacact cacaacacaa
     5401 tgagtgccta attgtacgat attcacgcat gcaaccgaca aaaagccttt ccattggaaa
     5461 tggaacgtta agattaaaaa ttgtattgag cataccttaa gaaaagttta cctcacacac
     5521 acagaaacac tcgcacacaa cacgacacaa caaacttaca cacacataga aggaacccta
     5581 gaaaattgta gagtgggact tcgctcgccg acaattgata ttacatacat acgttcagct
     5641 tccaacaaaa ttacccaaaa tatacaaaaa caagacaaaa aaaatacttt aacaaagttt
     5701 aacaactcag gtctggcgag tggagcgctg ccagggttgc caccacattc gatgttaaat
     5761 gtaattcgta actgtaaatg ttaactgtaa ctgtaatggc aaaatgcaat caagtccatg
     5821 atgttagccc cgcttgtaaa gattatttta tttatttttg tattatttcc caagttgttc
     5881 tttgttttcg attaatgttc tctaatatat atatctaaaa tatgaccata acgagtggcg
     5941 tttcagttct tgagttttgg gattggggac tctcttctgc cagcagctga aataatagtg
     6001 gaaatatctt ttaactaata gagcattgta ggagtagatc aacatcatcg gaacaacaca
     6061 acaccatcat ctatcgctct catccacgca ggactcatcg attcttaagt ggcgcatctg
     6121 catttacccc accttgacct cgacctctga ccttgacctg agcccggacc ctcattttta
     6181 gcttttagtt ttaggttaca taaagttttt tcgaagaaaa ctaaataact taaacacaac
     6241 atgcgctaca aaagtacctg gaaaaatgta acgatacacg ataaacaata acaatagatc
     6301 agtctttgtt attacactga aaaacgaaat cgatacccga actcagctgc aggcagaaac
     6361 gggaaacaca atccaatccc catgaaaacc caaaaaaaaa gccccgacaa aaaggtccgt
     6421 ttaattgtat agctctaggc ctataatata tatccatgta tattgctaaa gatattgata
     6481 taattaatga aatttaaatg tgtatatgtc ccggaaaccg caagagcaaa caacaaagaa
     6541 acctcccaca aactgtgcta aaacaaacgt aagaaataat aatactaaaa aaaaaagtgt
     6601 cgggatagtc cagatgatat ttgtgtaatt ttgaccagag caaaactata cgagaaatag
     6661 atctagctga ctaacgatgt gaaagccaaa caagaggatc aagagcaaaa cagcaaaaca
     6721 gcaaaacagc taagcagcta aacagcaaaa ccgcaacgaa gcccaatcaa atctatgtgt
     6781 aacagaagga tagttgatag tcgataatgt taactctctc tcatcaccca agtccatcaa
     6841 tccatacacc gtgtgtttca ttttattccg tagcctacct atctacgttt gtatctctaa
     6901 cgctcgctgt atctacatac aatgtatctg tatctctaac tgtatctgta aaccatcacc
     6961 gatccgacca caaccgatca cactctaaaa gaacaacaat aaattcaagt ttaatattca
     7021 acaat