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Drosophila melanogaster programmed cell death 4, transcript variant


LOCUS       NM_132690               2368 bp    mRNA    linear   INV 26-DEC-2023
            A (Pdcd4), mRNA.
ACCESSION   NM_132690
VERSION     NM_132690.4
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 2368)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2368)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2368)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 2368)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 2368)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 2368)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 2368)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 2368)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 2368)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 2368)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 2368)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 2368)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 2368)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 2368)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 2368)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 2368)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 2368)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 2368)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 2368)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 2368)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 2368)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 2368)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 2368)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_132690.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2368
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..2368
                     /gene="Pdcd4"
                     /locus_tag="Dmel_CG10990"
                     /gene_synonym="CG10990; Dmel\CG10990; pdcd4"
                     /note="Programmed cell death 4"
                     /map="12B4-12B10"
                     /db_xref="FLYBASE:FBgn0030520"
                     /db_xref="GeneID:32337"
     CDS             703..2232
                     /gene="Pdcd4"
                     /locus_tag="Dmel_CG10990"
                     /gene_synonym="CG10990; Dmel\CG10990; pdcd4"
                     /note="CG10990 gene product from transcript CG10990-RA;
                     CG10990-PA; Pdcd4-PA; programmed cell death 4 ortholog"
                     /codon_start=1
                     /product="programmed cell death 4, isoform A"
                     /protein_id="NP_572918.1"
                     /db_xref="FLYBASE:FBpp0073671"
                     /db_xref="GeneID:32337"
                     /db_xref="FLYBASE:FBgn0030520"
                     /translation="MEVESNNKRATNGGRHFTPPSDSDSKESSVERELNEEIEAVELN
                     GSGGGGHSNGHVKKLMAVEDGRIKRKAKRLIQRQNSGSGGSANQTNGNGAAGAGGAHG
                     ASVMPLGINRIMPSPGGYVVPHRRWKNSRRSRTINRGRGLPKKGGGGGKGVWGLPGSE
                     ALAEVYEDENDPNYDSECNDRNVELREVITEITREEFFKLAEPIVLEYYEHGDPHEVA
                     LSFDEILQAPMREHVTSILVEIAMDHKDSQREMTSVLISDLYGRVITGKDIEKGFNML
                     LANLPDLVLDTPEAPIMLGNFMARAVADDCIPPKFVAKSGEELRHLGLGEHAEQALRR
                     ADSLIYKHVWAHLDNVWGMGGPLRPVKTITMQMELLLKEYLSSRDVAEAQRCLRALEV
                     PHYHHELVYEAIVMTLESLSQTTEEAMCELLKQLDLTCLVLPAGMEQGFLRAFDDMAD
                     IVLDVPLAYIILDRFVERCNRAGFLTDKIINNVPSRGRKRFVSEGDGGHVKPTTFTMR
                     D"
     misc_feature    1291..1626
                     /gene="Pdcd4"
                     /locus_tag="Dmel_CG10990"
                     /gene_synonym="CG10990; Dmel\CG10990; pdcd4"
                     /note="Domain in DAP-5, eIF4G, MA-3 and other proteins;
                     Region: MA3; smart00544"
                     /db_xref="CDD:214714"
     misc_feature    1789..2130
                     /gene="Pdcd4"
                     /locus_tag="Dmel_CG10990"
                     /gene_synonym="CG10990; Dmel\CG10990; pdcd4"
                     /note="MA3 domain; Region: MA3; pfam02847"
                     /db_xref="CDD:397128"
ORIGIN      
        1 ctctggttca gtcgagttga gttttcacgg cgtgaacaac agtgtgcgtt attggttcct
       61 tattctgcgg ttcttcaatc ctttttgttc caatcctact gaaaaagaaa tcaaaagttc
      121 acatcgttaa gcggcaaaaa caacaaaagc gaaggtgaat aaggcataaa aaacagcaca
      181 cgcaactgaa tagttgtggg tgtgcgagtg tgtgtatgcg cgtgtgaagg agccttttag
      241 taaacactca cacacttgtg tatttttttt ctgtgagaca caagatattt gagtgcattt
      301 tttgccattt gccttgccaa cccctctccc ccgcacgcat ataagaagag aaagagaggc
      361 agggaaaaaa taaaggagcc cacgaagaaa agcaacaact attaaacagg ctcctcatcg
      421 tataaaagca gcgcagccgc cgtcaacgtc aactgcagtg ggccaacgtc gttgcagtcg
      481 tgtcgttagt ttttgttctt gttgcagcag cagcatcaaa gacagaagta gagagagcga
      541 gcgaaacagc cggagagaca aaacaaaaag cacttagaaa agaaaagaag ccacgcacct
      601 ggtgccagag tacaaaaccc aaacatctac aatatccgag ctgtgcattc caaggagata
      661 acgaggaacg tatatatcga agagtttgag aacatcgtca ggatggaagt ggaatcgaat
      721 aacaaacgcg ccaccaacgg cggccgtcac ttcactccac cgtcggactc cgattccaag
      781 gagagttccg tcgagcggga gctgaacgaa gagatcgagg cggtggagct aaatgggagt
      841 ggtggtggcg gccactcgaa cggccatgtt aagaagctga tggctgtcga ggatggcagg
      901 attaagcgta aggccaagcg gttaatccaa agacagaata gtggttctgg cggcagtgcc
      961 aatcaaacta atggcaatgg agctgctggc gctggtggag cacatggagc aagtgtaatg
     1021 ccgctgggaa tcaacagaat tatgccgtcg cccggtggct atgtggtgcc acatcgacgc
     1081 tggaagaata gccggcgttc gcgaaccatc aatcgtggtc gaggactgcc caaaaagggt
     1141 ggtggcggcg gcaagggcgt ctggggattg cccggttccg aggctctggc cgaggtctat
     1201 gaggacgaga atgatcctaa ctacgatagt gagtgcaacg atcgtaatgt ggagctgcgc
     1261 gaggtgatca ctgagataac acgcgaggag ttctttaagc tggcggagcc cattgtcttg
     1321 gagtactacg agcacgggga tccgcatgag gtggcactga gctttgatga gatactgcag
     1381 gcaccgatgc gcgagcacgt caccagcatt ctcgtggaga tcgccatgga tcacaaggat
     1441 tcgcagcgcg agatgacctc ggtgctgatc tccgatctct acggacgcgt tattaccggc
     1501 aaggatattg agaagggatt caatatgctg ttggccaatc tgccggatct cgtcctggac
     1561 actccagagg cgccaatcat gctcggcaat tttatggccc gcgccgtggc cgatgactgc
     1621 attccgccca agtttgtggc caagtcgggg gaggagctaa gacatttggg actgggcgaa
     1681 catgccgaac aggcccttcg ccgtgctgac tcgcttatct acaagcatgt gtgggcccat
     1741 ttggacaatg tctggggcat gggtgggcca ctgcgtccag tgaagacaat caccatgcag
     1801 atggagctgc tgctcaagga gtacttatca tcgcgtgacg tagccgaggc acagcgctgt
     1861 ctgcgtgccc tcgaggtgcc acactatcat cacgagcttg tctacgaggc gattgtcatg
     1921 acactggagt cacttagcca gaccaccgag gaggccatgt gcgagctgct caagcagcta
     1981 gatctcacct gcctggtgct gcccgcgggc atggagcagg gtttcttgcg cgccttcgac
     2041 gacatggccg acatcgtttt ggatgtgccc ctggcctata taatactcga tcgcttcgtc
     2101 gagcgctgca atcgcgccgg attcctaacc gacaagatta taaacaatgt gccatcgcgc
     2161 ggacgcaagc gtttcgtttc ggagggcgac ggcggccacg tgaagccgac taccttcacc
     2221 atgcgtgatt aaatcatagg gacaacgggg acgttatatg ctgcacatgc ttatatgacc
     2281 actgccccca gccacccaat gacaactaga ggagcaacaa gagagaagca aacattaaac
     2341 aaaaacaaaa aaaaaaacac caaattac