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Drosophila melanogaster DNA ligase 4 (DNAlig4), mRNA.


LOCUS       NM_132679               3040 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_132679
VERSION     NM_132679.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3040)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3040)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3040)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3040)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3040)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3040)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3040)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3040)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3040)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3040)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3040)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3040)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3040)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3040)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3040)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3040)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3040)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3040)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3040)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3040)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3040)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3040)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3040)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_132679.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3040
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3040
                     /gene="DNAlig4"
                     /locus_tag="Dmel_CG12176"
                     /gene_synonym="CG12176; Dmel\CG12176; lig4; Lig4; LIG4;
                     ligase IV; ligaseIV; ligIV; RE37186"
                     /note="DNA ligase 4"
                     /map="12B2-12B2"
                     /db_xref="FLYBASE:FBgn0030506"
                     /db_xref="GeneID:32322"
     CDS             72..2828
                     /gene="DNAlig4"
                     /locus_tag="Dmel_CG12176"
                     /gene_synonym="CG12176; Dmel\CG12176; lig4; Lig4; LIG4;
                     ligase IV; ligaseIV; ligIV; RE37186"
                     /EC_number="6.5.1.1"
                     /note="CG12176 gene product from transcript CG12176-RA;
                     CG12176-PA; DNAlig4-PA; ligase 4; ligase4; DNA ligase IV"
                     /codon_start=1
                     /product="DNA ligase 4"
                     /protein_id="NP_572907.1"
                     /db_xref="FLYBASE:FBpp0073678"
                     /db_xref="GeneID:32322"
                     /db_xref="FLYBASE:FBgn0030506"
                     /translation="MSVDIASTIKFRDICSLFEKIKATQKVANKEEVLKSYYESFCRH
                     RESFRRQTGLNNDQPEDGASSFYSVLRLLLPGADTGRDTYGLQITALGRLYIRVLQLP
                     TDSSDAIRLQHRNGNMYRDYGDVVYSVLKPRCFNPPSNLRLKEIHQMLDTIANEDTEV
                     KQQQLIRFTEQASPEEQKWLIRLLLKSLGLGIGEQKIFGVLHPKAQDIYQRCSDLGHV
                     CNLLADRTTDLDASSSKDSKAAVKFVNLNSVIRPFHQIRPMLCERFPGDIQELMQSDV
                     LYLETKMDGERFQLHIDRGRFMYISRNGVDYTRNFGHSYDHGTLTPKLRGLLPLGLES
                     IILDGEMMVWDTNKLRFREKGENTDVKSLKPEGSWQPCFVVYDLLYFNGQSLLDHTYI
                     QRAYKLQKLIVEQSGVLQLMRARKIGSVQEFNELFQQALDSHAEGIVLKKQGSRYQPG
                     VRLGGGWYKDKADYIKGLITEFDVLIIGAFYNRKRTFVDSFLLGVLQPAPPGSSNRPE
                     VFSIGVVANNTKQRGVLNHTLKPHWHDVVNEPPPLWFHYKPKERSGCPDLWIEPQNSV
                     ILQVKAADLAPNGAFFTRKSLHFPRTEMKRDDKTWSECMTLKEFNDLCGGPLAIKKLN
                     KRQLRLEDVTTKRKQMRMTPSERSRLGLAVYEKRYDASTSASTSKLFDGLSFCILSGS
                     AGRHSKHQLQELAVKNGGCIVENPLPNDPKCFCIAGDETFLVKRLILQQPRTCDIVRM
                     EWLLRVCQKQELELKPRDLIAATEPLQQDLAECFDRHGDSYTKDIANVEELQDLLQGI
                     ELTADNVAGITASNLNALEDQLLDGKKNLNMFRNLNAFFYSPHGDEVAKLLFLQNGGR
                     IVDDSDPQLNLGFICMSSDIDNDHFEHWLHNHSKLTTDKVLNSAWIHQCHREGILLPM
                     HSFV"
     misc_feature    321..1910
                     /gene="DNAlig4"
                     /locus_tag="Dmel_CG12176"
                     /gene_synonym="CG12176; Dmel\CG12176; lig4; Lig4; LIG4;
                     ligase IV; ligaseIV; ligIV; RE37186"
                     /note="DNA ligase I, ATP-dependent (dnl1); Region: dnl1;
                     TIGR00574"
                     /db_xref="CDD:273147"
     misc_feature    816..1469
                     /gene="DNAlig4"
                     /locus_tag="Dmel_CG12176"
                     /gene_synonym="CG12176; Dmel\CG12176; lig4; Lig4; LIG4;
                     ligase IV; ligaseIV; ligIV; RE37186"
                     /note="Adenylation domain of DNA Ligase IV; Region:
                     Adenylation_DNA_ligase_IV; cd07903"
                     /db_xref="CDD:185713"
     misc_feature    order(909..920,924..932,975..977,1089..1091,1122..1124,
                     1197..1199,1377..1379,1386..1388,1392..1394,1440..1442,
                     1446..1448)
                     /gene="DNAlig4"
                     /locus_tag="Dmel_CG12176"
                     /gene_synonym="CG12176; Dmel\CG12176; lig4; Lig4; LIG4;
                     ligase IV; ligaseIV; ligIV; RE37186"
                     /note="active site"
                     /db_xref="CDD:185713"
     misc_feature    order(915..917,924..932,972..980,984..986,990..992,
                     1134..1139,1146..1154,1377..1379,1446..1448,1452..1454)
                     /gene="DNAlig4"
                     /locus_tag="Dmel_CG12176"
                     /gene_synonym="CG12176; Dmel\CG12176; lig4; Lig4; LIG4;
                     ligase IV; ligaseIV; ligIV; RE37186"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:185713"
     misc_feature    2079..2351
                     /gene="DNAlig4"
                     /locus_tag="Dmel_CG12176"
                     /gene_synonym="CG12176; Dmel\CG12176; lig4; Lig4; LIG4;
                     ligase IV; ligaseIV; ligIV; RE37186"
                     /note="C-terminal domain of the breast cancer suppressor
                     protein (BRCA1) and related domains; Region: BRCT;
                     cl00038"
                     /db_xref="CDD:469589"
     misc_feature    2559..2822
                     /gene="DNAlig4"
                     /locus_tag="Dmel_CG12176"
                     /gene_synonym="CG12176; Dmel\CG12176; lig4; Lig4; LIG4;
                     ligase IV; ligaseIV; ligIV; RE37186"
                     /note="BRCT domain, a BRCA1 C-terminus domain; Region:
                     BRCT_2; pfam16589"
                     /db_xref="CDD:465186"
ORIGIN      
        1 gtcacattgc ttgaacagat gttcacagtg atgaaattgt ttacaacagt atattgtttt
       61 taaacaacaa aatgagcgta gatatagcca gcacgatcaa gttccgggat atttgcagcc
      121 tgttcgagaa gattaaggcc acgcaaaagg tggctaacaa ggaggaggtc ctcaagagct
      181 actacgagtc cttctgtcgc caccgcgaat cctttcgccg gcaaaccgga ttaaacaacg
      241 accagccgga ggacggtgcc agtagcttct attccgtgct gcgactgctg cttccgggtg
      301 cggacactgg tcgggatacc tatggattgc agatcaccgc gctgggcagg ctctacatca
      361 gggtgctcca gctacccacg gactccagcg atgccatcag gctgcagcac cgcaacggaa
      421 acatgtaccg ggactacggt gatgttgttt attccgtgct taagccaagg tgctttaatc
      481 cgcccagcaa tttgagactg aaagaaatcc atcagatgct ggacaccatt gccaacgagg
      541 acacagaagt taagcagcag caactcatcc ggtttacgga gcaggcctcg cctgaggaac
      601 agaagtggct aattcggttg ctgcttaaga gcctcgggct ggggatcggt gagcaaaaga
      661 ttttcggtgt gctgcacccc aaggcgcagg atatctacca gcgctgctcc gatctgggac
      721 atgtgtgcaa tctgctggca gaccgaacca ccgacctaga cgccagcagc agcaaggaca
      781 gcaaggcggc ggtcaagttt gtaaacctga attccgtcat acggccattc caccagatac
      841 gtcccatgct gtgcgaacga ttccccggtg acatccagga gctgatgcag tcggatgtgc
      901 tctatctgga gaccaaaatg gatggcgaac gctttcagct gcacatcgat cggggtcgtt
      961 tcatgtacat ttcccgcaat ggagtggact acaccagaaa ctttggtcac agctacgatc
     1021 acggcacctt aacgccaaag ctgaggggac ttctgccgct gggtctggag tctatcatac
     1081 tcgacggcga gatgatggtg tgggatacca acaaactgcg ctttcgggaa aaaggcgaga
     1141 atacggacgt gaagagcctg aagccggagg gcagctggca gccatgtttc gtggtgtacg
     1201 atctgctata ttttaatggc cagagtctgc tggaccatac ctacattcag cgggcgtaca
     1261 aattgcagaa actcatagtt gaacagtcgg gtgtgctgca gttgatgcgt gcacgcaaaa
     1321 tcggttccgt tcaagagttc aacgagctgt tccagcaggc actcgactcc cacgccgagg
     1381 gcattgtgct aaagaagcag ggatcaagat atcagcctgg cgttagactg ggcggtgggt
     1441 ggtacaagga caaggctgat tacatcaaag ggctgatcac cgagttcgat gtgctgatca
     1501 tcggggcatt ctacaatcgc aagcgcacct ttgtggactc atttttactg ggcgttctcc
     1561 agccggcgcc gccaggcagc tctaatcgtc ccgaagtctt cagtattgga gtggttgcca
     1621 acaatacgaa acagcgcgga gtgctaaatc acacactgaa accacattgg catgatgtag
     1681 tcaatgagcc accgccattg tggtttcact acaagcccaa ggagaggtcc ggatgccccg
     1741 atctgtggat tgaaccgcag aactcggtaa ttttgcaggt gaaagctgct gatctggcgc
     1801 ccaatggagc atttttcacc cgaaaatcgt tgcactttcc gcgcactgag atgaaacggg
     1861 atgataagac ctggagcgag tgtatgacac ttaaggagtt taacgatctc tgcggaggtc
     1921 ctttggccat caagaagtta aacaagcggc aactgcgact agaggatgtg accaccaagc
     1981 ggaaacagat gcgtatgacg ccctcggagc gaagccgact gggattggcc gtctatgaga
     2041 agcgctatga cgctagcacc tccgctagca cttccaaact tttcgacggt ctgagctttt
     2101 gcattctgag cggatctgcc ggacgacaca gcaagcatca gctgcaggag ctggctgtta
     2161 aaaacggtgg ctgcatcgtg gaaaatcccc tgcccaatga tccaaagtgt ttttgcatcg
     2221 caggcgatga gacgttttta gttaagcggc tcatccttca acagccacgc acctgtgaca
     2281 ttgtgcgcat ggagtggcta cttagggtct gtcagaagca ggagcttgaa ctaaagccta
     2341 gagatcttat tgcggccact gaaccactgc agcaggatct ggctgaatgt tttgatcggc
     2401 acggtgatag ctacaccaaa gacattgcca acgtggagga gctgcaggat ctgcttcaag
     2461 gcattgagtt gacagctgat aatgtggctg gcataaccgc atctaatctc aatgctctgg
     2521 aggatcagct tctggatggg aaaaagaatc tgaacatgtt ccgcaacctt aatgcgttct
     2581 tctacagtcc gcatggtgat gaagtggcta agcttctgtt tcttcaaaac ggcggccgga
     2641 tagtcgacga ttccgatccg caactaaatc tgggatttat ctgtatgtct tctgacatcg
     2701 ataacgacca cttcgagcac tggctgcaca atcattccaa gttgaccact gacaaggtct
     2761 taaactcggc gtggatacat cagtgccatc gcgaaggcat cctacttcct atgcattctt
     2821 tcgtctaact caatgagttt ttcacgcttt atagttttgt acaaaaatta cctgttatcc
     2881 ttgttataaa attgttgttt cattgacatt tttcttacca taaaaagctt taaacagaag
     2941 tcattccgaa tttaatgtta tatcaaaaag attttcatgg ataatttgct tcaataaagt
     3001 gaaacataga ataacaatag tagaatgaca ataagtacgc