Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]

Drosophila melanogaster synaptotagmin 12, transcript variant A


LOCUS       NM_132650               4823 bp    mRNA    linear   INV 26-DEC-2023
            (Syt12), mRNA.
ACCESSION   NM_132650
VERSION     NM_132650.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4823)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4823)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4823)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4823)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4823)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4823)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4823)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4823)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4823)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4823)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4823)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4823)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4823)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4823)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4823)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4823)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4823)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4823)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4823)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4823)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4823)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4823)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4823)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_132650.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4823
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4823
                     /gene="Syt12"
                     /locus_tag="Dmel_CG10617"
                     /gene_synonym="CG10617; Dmel\CG10617; dsyt12; Syt 12;
                     syt-12; syt12; SYT12"
                     /note="Synaptotagmin 12"
                     /map="11F1-11F1"
                     /db_xref="FLYBASE:FBgn0261085"
                     /db_xref="GeneID:32290"
     CDS             242..2605
                     /gene="Syt12"
                     /locus_tag="Dmel_CG10617"
                     /gene_synonym="CG10617; Dmel\CG10617; dsyt12; Syt 12;
                     syt-12; syt12; SYT12"
                     /note="CG10617 gene product from transcript CG10617-RA;
                     CG10617-PA; Syt12-PA; syt12; synaptotagmin 12"
                     /codon_start=1
                     /product="synaptotagmin 12, isoform A"
                     /protein_id="NP_572878.1"
                     /db_xref="FLYBASE:FBpp0073598"
                     /db_xref="GeneID:32290"
                     /db_xref="FLYBASE:FBgn0261085"
                     /translation="MMSFTITLALLLLAVLILGILFACHCLGPRAANWMRMRSSKEEK
                     IGLSNHKQKLFHANGYMASIQSGSEFLLSTSGSFKRFDTIDKEDYNRSQQTHQTHLFL
                     MNGGGAVSITGSSSALQATTAMWHLPRSGIKIPPPPDRPAPSPNSAAAAGKTVTFSLS
                     QVNEVIMPGEQVTSNDQERRSCLRQNGGTAGGAGGGGVLPQPLEAPPPPRLTASTSVN
                     LSGTAIPRPIAKRQVSTQPANNSGCQPEQTVVTPMREGERKAPALKRRNSSTNPFLCE
                     STEQIPSNPISEPLNATVASLEKTTISTSECTPITAPLETPNGPISTDTPSTIHHNGN
                     PFVERESLSSRLLKIHNTTNPFTGLSQRVKGPHLLQKTISEDYLFRKLGVNCPMANGN
                     GTGPGSGHVNGNGNGTWSFGRSLLRQDSTLSLGMGLGRRNSSQVSLDSHAGSVPGSMD
                     GINLERAISCDSVTSDSTLFLDQLDQPYTQITGYLCVGLNYDQMSISNEGMELTVSVL
                     EAKGLICPFSVESLDTFVRIYLVPDHPGAMQTKVVKGTLTPSYNESFDFWLHKRQARH
                     SLWFHLYHNGPAHTLIGEAEMEIGEMPRPITTWIPLSDSRKCNARWGELMFSLSYLPT
                     AERLTIVVVKARNLKLDGEQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSLKRKDRS
                     PIFNESMIFSVPPPSLTTTQLRVTVFGVTTSGVTPLGHIVAGSCAVGKGLRHWHQMLS
                     SLRKPVAMWHVLRRAVNQPIFTGGAEAVVAAMQNTLQRSTAKRNSIV"
     misc_feature    1748..2047
                     /gene="Syt12"
                     /locus_tag="Dmel_CG10617"
                     /gene_synonym="CG10617; Dmel\CG10617; dsyt12; Syt 12;
                     syt-12; syt12; SYT12"
                     /note="C2 domain; Region: C2; pfam00168"
                     /db_xref="CDD:425499"
     misc_feature    2075..2500
                     /gene="Syt12"
                     /locus_tag="Dmel_CG10617"
                     /gene_synonym="CG10617; Dmel\CG10617; dsyt12; Syt 12;
                     syt-12; syt12; SYT12"
                     /note="C2 domain second repeat present in Synaptotagmin
                     12; Region: C2B_Synaptotagmin-12; cd08406"
                     /db_xref="CDD:176051"
ORIGIN      
        1 ccagttggcc gcgagttttg gcaccgaacg gtctacgaaa atgagcgaat tttccgcccg
       61 cacttccgct tcctgctctt cctctttccg cagcgttact acttgttatt atttgtattg
      121 ttaaatcaga gtgataaact aatatatttg ccatttaaat gtggccaaat gatcagcaag
      181 gataagtaag aagaacggag agatgcatca cgattggtaa acgaatggca ctcgttcgga
      241 tatgatgagc ttcaccatta ccttggcgct actgctcctg gcagttctga tcctgggcat
      301 cttgttcgcc tgccactgtc ttggtccgcg ggccgccaac tggatgcgta tgcgatccag
      361 caaggaggaa aagatcggac tatccaatca caagcaaaag ctcttccatg ccaatggtta
      421 tatggccagt atacaatccg gctccgagtt cctgctgagc accagtggta gtttcaagcg
      481 tttcgatacc atcgacaagg aggactacaa tcgctcccag cagacgcatc agacgcatct
      541 gttcctgatg aacggcggcg gtgcggtttc gataaccgga tcatccagtg ccctgcaggc
      601 caccacggcc atgtggcatc taccgcgttc gggtattaag attccaccac cgcccgatcg
      661 accagctcca tctccgaata gtgctgcagc agccggcaaa acggttacct tctctttgag
      721 ccaggtaaac gaggtcatca tgcccggcga gcaggtgaca tccaacgatc aggaacgtcg
      781 ctcctgcctg cgacaaaatg gtggaactgc gggcggtgct ggcggcggtg gtgtgctgcc
      841 gcagccactg gaggcaccac ctccgccacg actcaccgca tcgacgtcgg tgaacttatc
      901 gggtacggcg attccaaggc ccattgccaa gcggcaagtg tccacgcagc cggccaacaa
      961 tagcggatgc cagccggagc agaccgtggt gaccccgatg cgggagggtg agagaaaagc
     1021 gcctgccttg aagcgtagaa actccagcac taatcccttc ctgtgcgaat caacggagca
     1081 gatacccagt aatcccattt ctgaacctct gaatgccacg gtggcttctc tggaaaaaac
     1141 gactatttca acaagtgaat gtactcctat aactgctcct ctagagactc caaatgggcc
     1201 tatttcaacg gatactccat ccaccataca tcacaatggc aatcccttcg tggagagaga
     1261 aagtctgtcc agcagactcc tgaagatcca taacacaacg aatcctttca cgggactctc
     1321 gcaacgcgtc aagggtccgc atctactgca aaagaccatt tcggaggatt atctatttcg
     1381 gaaattgggt gtcaattgtc cgatggccaa tggcaatggt acgggaccag gatctggtca
     1441 tgtcaacgga aatggcaatg gaacttggtc ctttggacgc tccctgttgc gacaggactc
     1501 cacattgagt ctgggcatgg gcttgggcag aaggaacagc tcccaggtat ccctggattc
     1561 acatgcggga tcggtgcccg gttcaatgga tggcatcaat ttggagcgag ccatctcctg
     1621 cgattcggta acctcggact ccactctatt cctggatcaa ttggatcagc cctacactca
     1681 gataaccgga tatttatgcg ttggccttaa ctacgatcag atgagtatta gcaacgaggg
     1741 catggaactg actgttagtg tcctggaggc caagggactc atatgtccat tcagcgttga
     1801 atccctggac acctttgtgc gcatctactt ggtgccggat catccgggag ctatgcaaac
     1861 taaggtggtc aagggaacac tgacacccag ctacaacgaa agtttcgatt tctggctgca
     1921 caagcgacag gcgcgccatt cgctgtggtt ccatctgtac cacaatggac ccgcccacac
     1981 gctcattggc gaggcggaga tggaaattgg tgagatgcca cgccccatta ccacatggat
     2041 accactgtcc gattcgcgca agtgcaacgc ccgctggggc gagctaatgt tctctctaag
     2101 ctatctgccc acggcggaaa gactaaccat cgtcgtggtc aaggcacgga atctcaagct
     2161 ggacggtgag caaccggctc cggaatccgc ggaaacggtg cacagcgtct tcgttaaggt
     2221 ctacctgatg gacaaggatc gcaaggtgct aaagaagcgc acctcactga agcgcaagga
     2281 tcgcagtccg atcttcaacg aatcgatgat cttcagtgtg ccgccaccca gtttgaccac
     2341 cacccagctg cgggtgaccg tgttcggggt gacaactagt ggggtgaccc cgttgggtca
     2401 catcgtggcc ggcagctgtg cggtgggcaa gggattgcgc cattggcacc agatgctctc
     2461 gtcgcttagg aaaccggtgg ccatgtggca tgtcctgcgg cgtgcggtca atcagccgat
     2521 tttcacgggc ggcgccgagg cggtggtggc cgccatgcaa aacaccctgc aacgctccac
     2581 cgccaagcgg aacagcatcg tctagataga agtctcgcga agatcacaga cggcgacgac
     2641 ggcggcggct cacatcaacg gcgaaatttt ctgcctcact gacgacacta actgcaccgc
     2701 ccttttaatt tggaaaaacc cctttcgtag aagagatata ccttttttgg gggggagaag
     2761 aagaaaagaa gagaacgacg aaaaaaacag aagaaaacct tgtggaaaat tgcatttacc
     2821 acactctagc catgagactt tcttactttt ctactgctta cgaacacaca cacaaccaga
     2881 agtattatta tgtaatctaa aaacccgcac caaaggacaa acgatccact taactagtaa
     2941 cctagctacc catatttgag cgcactaatt gttatgaacc gatttttatt gaaccgagta
     3001 tatcttatat gatgatgcaa cctcgatctg aaaaacgaaa acaaaagagt ccacacactt
     3061 gttgaaattt gtcgcataca gcgagcgaaa taattgcata aactggcatt atctatctat
     3121 tagatattat ttctatatag catatttatt tccattcttg tttatggaaa cagaacattt
     3181 gtagatgtgt gtcccaaaaa gggcctgttt atcttacttg gctacatttc agagctctca
     3241 tattatttta ccatttcaaa tcatctgcca cttggcagct caaatttccc actttaagtt
     3301 ccattctcgt tgggtaaatc caatgaaaac tgatagatag agatcgtaat ggagtaaaat
     3361 caataatgat agcattgata aagccaatgg aaatacaatt atttcgcgag ctgtatggtt
     3421 tagcctagcg accagtgagc ctgttatatt agaactctat agatagatcg tcgtttggca
     3481 atcaaacgtt gttgaatttg aagcccaaat cgaaatcgag aacaaaactc gataaccgat
     3541 aatcgataat cgagaatcga gaagcggcga gccctttaag cattgtgata tgatataata
     3601 gcaaacgaag tgaattcaga gtgcgtctgt gtcaagagcg gagaatcgta tcgaaggaaa
     3661 tcaaagtatt tacgatagct acaatccata gtcgatataa aatattaata ataatactaa
     3721 taatattatt gatgatatat aggtaccata tgtaatgttt gtacttttgt gatttgtgtt
     3781 cgttcaaatt ttttgtaggg ccgcgtgttt tgtaatttag atttagttgg ttcaaggatc
     3841 aaaacttttt taagcgaatg ttatatatat acacgcaccg ttaatacaca catagatttc
     3901 aatttagaga acgtttttta aacagtaaag gacaataact ttgcaagcat ttaccatatg
     3961 attccatgtt aaacacaagt aattataatt accaaacatt aaacaaaagt tcgttgttgg
     4021 tcccgtttta acatgaaccg attgtccgct acaaccttat aatatatgat gatcataatg
     4081 tatatgatcc tgagaccata atagaacgca ctcgaataca cgaatagtac tttcctagtc
     4141 gcacctgcat tttgaccaac caaccaatcg aatcgaaaac ctggcacatt tctagctcaa
     4201 gctttaatca atgtaatcct ctaatagaac tcagtaacgt ttttgaatca cacttactaa
     4261 atggatataa aatacatata tgtatgcaga gggacagtgc gtttcacaat tgtatgaagt
     4321 gagataatag catttattca ttcggttcga agaacacaat ttcccatttg acaacttttt
     4381 gcggtaagtt cgattacata tcctaattaa aaacagctgg ctgaattcga aattatttga
     4441 caatcgccaa cagttggcca tcatttgttc cgaaatttaa aagattgtta cttgtgaaac
     4501 gcgctgcacc gtatatataa gcatatatgt atatatttac acaaaaaata tataaagaag
     4561 gcatttaaaa ggcattaaat ggaaagtcct ttcacctaaa aacttctagt atataaatcg
     4621 ctgagaattt ttttttcttt tttttacgta ctattagcta atgaaacgat atggctaaac
     4681 tcgagttgaa tttgtattta tacggaaata tatatataca tatatatata tgtgtgtacg
     4741 tgctatataa gataatgaat gctacaaatt gttatacacg taaaccgaaa ttgactcaaa
     4801 taaacgaata aagatattaa acg