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Drosophila melanogaster histone deacetylase 4, transcript variant D


LOCUS       NM_132640               6312 bp    mRNA    linear   INV 26-DEC-2023
            (HDAC4), mRNA.
ACCESSION   NM_132640
VERSION     NM_132640.6
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6312)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6312)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6312)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6312)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6312)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6312)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6312)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6312)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6312)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6312)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6312)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6312)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6312)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6312)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6312)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6312)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6312)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6312)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6312)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6312)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6312)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6312)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6312)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_132640.5.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6312
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6312
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Histone deacetylase 4"
                     /map="11E8-11E9"
                     /db_xref="FLYBASE:FBgn0041210"
                     /db_xref="GeneID:32278"
     CDS             461..4219
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /EC_number="3.5.1.98"
                     /note="CG1770 gene product from transcript CG1770-RD;
                     CG1770-PD; HDAC4-PD; histone deacetylase 4"
                     /codon_start=1
                     /product="histone deacetylase 4, isoform D"
                     /protein_id="NP_572868.3"
                     /db_xref="FLYBASE:FBpp0290513"
                     /db_xref="GeneID:32278"
                     /db_xref="FLYBASE:FBgn0041210"
                     /translation="MSSPDDRIPIHDLPSEAGSDERLLHITPATLTLDFKPHPAVDID
                     QQIMELKKSQELQKQRLINSFQEQSKQMELEHKLQLEHKYQFAVNSHGAFQELRNESM
                     VTAAAAAVAQEQHRQQLHQQQQQHQQQQQQQQHQQQQQQQQARGRDGMKLKQNCSANA
                     SPEVKQILNCFILSRKSQAAASNGTTTTSPYRNRGVVKSSSGESLPAGTVTSAHPYKI
                     PQPPPSLLKYESDFPLRKTASEPNLLKIRLKQSVIERKARIGGPAGARRHERLLQAAQ
                     RRQQKNSVLTNCNSTPDSGPNSPPSAAALAVGVVGSRGSPTSAPIQEENEEGSQYQPG
                     QRSSINDLPLFSSPSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMF
                     AALAAAQGGCGQPGYYNPLGMAFVGRQPAPLAMIPATGIAPQQPSPVVRSASATSTSS
                     SQASLVGDVAPPQAHAASTILPSSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAAAGS
                     LPPTNSHGHGHGSHAHPHPHAHGHGHGHGHGIYAGHQHNVPITDAQVAQVHLHKQGHR
                     PLGRTQSAPLPLGHPMLTGAVQLNVVQTHYENSEAERQAYEHQVVNQKVRQTVLTRSG
                     AAAAAAAAAGVSVVREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTSTIATSTSQNLPE
                     ALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELAKSLM
                     RPLSRTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMS
                     TLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWAR
                     LNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRL
                     SCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEAN
                     LAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHR
                     HDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSF
                     NPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAA
                     ICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTV
                     GLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQDETK"
     misc_feature    587..>751
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Glutamine-rich N-terminal helical domain of various
                     Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9);
                     Region: ClassIIa_HDAC_Gln-rich-N; cl25407"
                     /db_xref="CDD:421006"
     misc_feature    order(599..601,611..613,623..625,632..634,644..646,
                     653..655,665..670,677..682,689..691,701..703)
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="dimer interface A, D [polypeptide binding]; other
                     site"
                     /db_xref="CDD:259829"
     misc_feature    2918..4042
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Histone deacetylases, class IIa; Region:
                     HDAC_classIIa; cd11681"
                     /db_xref="CDD:212544"
     misc_feature    order(3359..3364,3386..3391,3476..3478,3482..3484,
                     3758..3760,3878..3880)
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="active site"
                     /db_xref="CDD:212544"
ORIGIN      
        1 agatatcgat gtggttccag ctctaatagt cgtggatttc ggaacattaa tttgtatttt
       61 ttgcgtcgcg tcgccccaga aagtccaatc caacagcaaa tcgcgcgttt tccaaagaac
      121 aacaaccccg aaaaattcga aaataataat tttcttgttt tttttttctg ttttcctgcg
      181 gcaaaaattc caattttttt cgtaacatct aaacaacaac aacaaaaaaa gtgcgtgcgc
      241 gtgcagaagc gaaaaaaacc gaataaattg tgggcgaatc aacaagcaaa agagaatgag
      301 cgatgatgag gagaagaggc aaaaaaagca gaggcagttg tcgtagtact agtaccaaaa
      361 agaaactgcg aaaactgcta aagtgacaaa aacaacaaca gcaagtaacg aaagagaaaa
      421 gcaaaagaag gttccgccct cccccaattc catatgcaaa atgtctagtc ccgacgatag
      481 aataccaata cacgatctgc catcagaagc cggaagcgat gagcgattgc tgcacataac
      541 gccggccact ctgacattgg acttcaagcc ccatcccgcc gtggatatcg atcagcagat
      601 catggagctc aagaagagcc aggagctgca aaagcagcgg cttatcaact cgtttcagga
      661 gcaatcgaag caaatggaat tggagcataa acttcaattg gagcacaagt atcaatttgc
      721 ggtgaattca catggcgctt tccaggaatt gcgaaacgag agcatggtga cagccgccgc
      781 tgctgcggtg gctcaggagc aacatcgcca acagttgcat caacagcagc agcaacatca
      841 gcagcagcag cagcagcagc aacatcaaca gcagcagcag cagcaacagg cacgcggcag
      901 ggatggcatg aaactcaagc agaactgtag tgccaatgcc agtcccgagg tcaaacagat
      961 tctcaactgc ttcatcctga gcagaaagtc ccaggcggcg gcatcgaatg gcacaacgac
     1021 aacgtcgccc tacaggaatc gcggcgtggt gaagagctcc tcgggcgaat ccctcccagc
     1081 tggaaccgtg accagtgcgc atccgtacaa aatacctcag ccgccaccct cactgctcaa
     1141 atatgaatct gattttccgc tgaggaagac agcatccgaa ccgaacctgc tgaagatccg
     1201 gctgaagcag agcgtcatcg agcgcaaggc ccgcatcgga ggaccggcgg gagcccggcg
     1261 ccacgaacga ctcctccagg cggcgcagcg taggcagcaa aagaactcgg ttctcacaaa
     1321 ctgcaacagt acaccggatt ctggacccaa ttcaccgccc tcggcagctg cgttggcggt
     1381 gggcgtggtc ggtagccgtg gatcaccgac aagtgcaccc attcaggagg aaaacgagga
     1441 gggcagccaa tatcagccgg gccagaggag cagcatcaac gatttgccat tgttcagttc
     1501 accatcgctg ccgaatattt cgctcgggcg accgcattta cccaactcgg cgcaggcgca
     1561 tgcccaggtg aatgcccagg ttgctgccca ggctcaggca caggcccagg cacaggcaca
     1621 ggcgcatgcc atgttcgcgg cactggctgc cgcccagggt ggctgcggac agccgggcta
     1681 ctataatcca ctgggcatgg cattcgttgg ccggcaacca gcaccgctgg ccatgattcc
     1741 ggccacgggg atagcaccgc agcaaccgtc gccggtggtg cgcagtgcat cggccacttc
     1801 gacatcgtcg tcgcaggcct cgctggtggg cgatgtggcg ccaccgcagg ctcatgccgc
     1861 ctccaccatt ctgccctcgt catcgtccta catgcagcaa ctgggcagtg tggccggttc
     1921 gggtgttaat ctccatgccg ccgccgttgc tgcagcggca gcagcagcag ccgccgccgg
     1981 ttcactgcca ccgaccaata gccatggtca cggacacggt tcccacgcac atccacatcc
     2041 acatgcccat ggacacgggc atggccatgg ccatggtatc tacgctggcc accagcacaa
     2101 tgtgcccata acggacgccc aggtggcgca ggtgcatctg cacaaacagg gccatcggcc
     2161 gctgggacga acgcagtcgg caccactgcc ccttggacat ccgatgctaa ccggagctgt
     2221 gcaactgaat gtggtccaaa cgcactacga gaatagtgag gcggagcgcc aggcgtacga
     2281 gcaccaggtg gtgaaccaga aagtccgcca gaccgtcctg actcgcagcg gagctgctgc
     2341 agcagccgct gctgccgccg gcgtgagcgt ggtgcgtgag gcacagttga aggaggagga
     2401 tgacgactcg gccgccgagg tgatggacct cacagataag aaaaaaccgc cgaagacggt
     2461 gctaaccagc acgatagcca ccagtacgtc ccagaatctg cccgaagctt tggcggcggc
     2521 ggcggcggca gccgcctacc gtgccccgca caacgcgtcc agtaactccg cctccgccac
     2581 aaagtccggt attaagctgc gggaccagga gtatttgcaa cagcagcggg agcaactatt
     2641 gctccttcag caggaggagg aactggcgaa gagcctaatg cgtccgctat cgcgaacgct
     2701 tagcagtccg ctggtgccgc tggggccaca tggtcttagt cagattcccg acactggaca
     2761 acagccggca ccgatagcca catcctcgtc ggccgatcat ataccgcccg ttaacctctc
     2821 gctgccgcat cgccagcacc gccagctaat gagcacacta tacgccagcc aattgcgtaa
     2881 ccaccagcca tcggcgagtg gttcaccgcc gcacaaggtc accaccggtt tggcctacga
     2941 tccgcttatg ctgaagcatt cgtgtatttg cggagacaat gcccagcatc cggagcacag
     3001 tggtcgactg cagagcgtgt gggcacggtt aaatgaaacg gatctggtga agcgttgcga
     3061 tcgcctgcgc gctcgcaagg cgacacagga ggagctgcag actgtgcaca ccgaagcgca
     3121 tgccatgctc ttcggttcga atcagtgcca gctcagcagg cccaagttgg aaaacacgtt
     3181 gtcggccagc tttgtgcgtt tgtcgtgcgg cggcttgggt gtggatctgg ataccacgtg
     3241 gaatgagcac catacggcaa ccgctgcacg aatggcagcc ggttgtgtta tcgatttggc
     3301 actgaagacg gccaagggtg acctgcggaa tggctttgcc gttgtccggc cgccgggcca
     3361 tcatgcggag gccaatttgg ccatgggctt ttgtttcttc aattcgatag ccattgcggc
     3421 caagctgctg cgtcagcgga tgcccgaggt gcggcgcatc ctgatcgtcg attgggatgt
     3481 gcatcacggc aatggcacac agcaagcatt ctaccaaagt cccgacattc tatatctttc
     3541 catacatcga cacgatgacg gtaacttctt tcccggcaca ggtggaccca cagagtgcgg
     3601 ctccggtgct ggtctcggct ttaacgtgaa catctcatgg tctggggcac ttaatccgcc
     3661 actgggcgac gccgagtata tcgctgcatt ccgtaccgtt gtgatgccca tcgcgcggag
     3721 ctttaatccg gacattgtgc tggtatcctc cggcttcgat gcggccaccg gccatccggc
     3781 accgctgggt ggctaccatg tctctccggc ctgctttggg ttcatgaccc gcgaactcct
     3841 tcagttggcc aacggcaaag tggtgctggc cctcgagggc ggctacgatc tggccgccat
     3901 ctgtgattcc gcccaggagt gtgtgcgggc gctgctcggc gatcccgctg ctcccattgc
     3961 caaggccgag ctggagcgcc cgccttgcca gaatgccatc aatacgctcc agaagacgat
     4021 agccatacag caaacgcatt ggccctgcgt gaggatgctg gagcacacgg ttggcttgtc
     4081 tgcgctggag acgctcaagg tggagcacga cgagtccgag acgatcaacg ccatggctgg
     4141 cctctcgatg cagtcgatgc acagaactct atcccgcgat gattccgagg agccgatgga
     4201 tcaggatgaa accaaataga aggcgatgca gacgtatatt gcggaagagg aggcggtggg
     4261 cgtggcgagg tttttgtgga cctggtagag tgggaatggc aggagggggc gtggccgcaa
     4321 gctgctcaat gcacatttag ttatttgttg tagttgaatt gattgttgtt gctgttgttg
     4381 ttgtggcgct cgcttgcaat tgttgtcgtt gtcattgatc gtctatagcc acatctatct
     4441 ctctcactcg atcgattata gcatcccaat tccccgcccc gccaaaaaaa acaaaaagaa
     4501 gagaaacatc gaaaatatag gggaacatgt ctaaaagaag cagaacaggg cctaaagttc
     4561 aaaatggtgg ctgtgcctcc aaaagaagaa ataattataa taattagaaa agaatccttt
     4621 caaaaaaaaa ggagatttta tatgaatata tatatatatg aatatatatg tagcttaagc
     4681 tcagaattta gttgtagaag tcatcgagat tttttttttt tgttttaagg tgagagcaga
     4741 ggtattttaa cgcacacaca aacacacgca actcaatgta tcttattatt attatttaag
     4801 taagtgtgtc aaaaggatat agaaccacta acgtactggt gaacatcatc agtaagctat
     4861 aaagataatg tttaaagagg tcgggtgcaa gaagcatgtg ttttttttta taaggtaagg
     4921 ttcaacctca aagttcccaa gtctagaccc caccacgccc acttatccgc catcgcttac
     4981 agagatcgag tggggagttg attacatgtt atgtagaatg ctttagttga taataagata
     5041 tgagaaaaaa aaaacttaac aactaactag ttggatgaaa agcgaaaaaa ctgagaaatc
     5101 tttttgtaca atttatagtt tagtgcaagt ttcaagtaca acatgctatt atttaaagaa
     5161 ttctatatat atacatatat atatatatat atacaaaaaa aatatatatt gtgcaataaa
     5221 tgtgagaaaa tgaaaatcgc cacacaaaac agaaactaaa acgaataaga gaaaatttgt
     5281 tgttaaatgt tgccgagatc ttatatacgt atgtatacct aataactgtt acaataataa
     5341 ccctttatat atataactat ataaatgcac atgtgtattc accatgtgtg taacgataac
     5401 gatgttcaac aaatgtctga aatgaagtaa aactattatt atatgtaaat aaaacacaaa
     5461 aaacaaagag aacaatttta ataaaaaaaa agcaacaata aaatacaaaa tcaaagaaaa
     5521 tatccacgct cacacacaca catacacaca caaacatata tacgtcctgg gcaggacccg
     5581 agaggcgtga atcgggaaaa attctgaaat aaccgttcaa tcgctaaccg ttaactgtaa
     5641 aaccgctgta actgtatttg tactcgtgta cctttagctg tctatagccg tctctctcta
     5701 actcgctacc taactgtaaa ggagcacctc aataacgaaa gaagaaggag caacagacaa
     5761 ggatcaaaaa tatatagcaa gtgaaaagga tgatggaaag aaggaggagg aggaggagaa
     5821 acaagaaaaa taagcacaac gagagatgga ccgattggct ccaactggat gaaacaattg
     5881 ttaacaaaac gaaacagaaa ctaaaaacta tccttaaaaa aaaatgaaat cacaaatgta
     5941 actattaatc taagcgaagc atatgccctt gccattttta ttttcttatt attcacctgt
     6001 tttctctttt caatacagca gattttttga aaaacatact tttgaacata agctgtttcg
     6061 tatgcaagcc acgtaattgc tgttacttag gaatatatat atacgaattt ttcttgggtt
     6121 ccaaaagcgt tacaatacgc tctgtgttaa atctgtgctt ttattttaat tttctattta
     6181 taatttggca aattggcgat ctccccttac cttacctttt tttatctttc ctgaatttgt
     6241 ttttttttta ccaaaacacg aattatgaag aggattctac taacaagatg aaatattatt
     6301 gttgcgcact gc