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Drosophila melanogaster phosphodiesterase 9, transcript variant B


LOCUS       NM_132606               6579 bp    mRNA    linear   INV 26-DEC-2023
            (Pde9), mRNA.
ACCESSION   NM_132606
VERSION     NM_132606.5
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6579)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6579)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6579)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6579)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6579)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6579)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6579)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6579)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6579)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6579)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6579)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6579)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6579)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6579)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6579)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6579)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6579)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6579)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6579)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6579)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6579)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6579)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6579)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_132606.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6579
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6579
                     /gene="Pde9"
                     /locus_tag="Dmel_CG42276"
                     /old_locus_tag="Dmel_CG32648"
                     /old_locus_tag="Dmel_CG3754"
                     /gene_synonym="CG1627; CG32648; CG3754; CG3761; CG3765;
                     CG42276; Dmel\CG42276; PDE9"
                     /note="Phosphodiesterase 9"
                     /map="11C2-11D1"
                     /db_xref="FLYBASE:FBgn0259171"
                     /db_xref="GeneID:32233"
     CDS             1384..5964
                     /gene="Pde9"
                     /locus_tag="Dmel_CG42276"
                     /old_locus_tag="Dmel_CG32648"
                     /old_locus_tag="Dmel_CG3754"
                     /gene_synonym="CG1627; CG32648; CG3754; CG3761; CG3765;
                     CG42276; Dmel\CG42276; PDE9"
                     /EC_number="3.1.4.-"
                     /EC_number="3.1.4.17"
                     /EC_number="3.1.4.35"
                     /note="CG42276 gene product from transcript CG42276-RB;
                     CG42276-PB; Pde9-PB"
                     /codon_start=1
                     /product="phosphodiesterase 9, isoform B"
                     /protein_id="NP_572834.2"
                     /db_xref="FLYBASE:FBpp0288910"
                     /db_xref="GeneID:32233"
                     /db_xref="FLYBASE:FBgn0259171"
                     /translation="MYQDSGCSSSSSRRGSSSAAAATSTAATAAETAAAAAATTTSSS
                     DEETLETLTIITTTITDSDIHATTTTTTVIASGTATTAAAAATTATLATLATLASNSD
                     IEDSSPVESEDSEECEYIEIDCQTTAQEGTSPSGGSSSSGNAVLLQRSSNNLQQQQQQ
                     QQQQQQHLQLQLQQADERLLRKIGYIASRVRCLSKYYGDFRLVNPYSARRQRRQLQEI
                     LLRHSIFDPGKEHQRAIVLAAATAAIAGPLAAIDCVCGSSSISLEAVSSRSRSSELED
                     DHHEQDQVQEEQEQEQHQGDTEDNEEEQEHPSEKPERTDIEEEPPPAIAVTTTTTATV
                     RRKSSSSSTISGTATVSGSVSVSASASQSFCSNNINLLEELLIQFYEEQDHRSNLTVI
                     RHHHHQQHQQHQQQQRITNNNNNNNNCNSIQNNNNMSNPAATAAATATPSVEQPATSG
                     TTNIHLQPTSLPDGSDNPRRRRASDCSAVQAALQNQLHCITLKNNNCGKAMPFHRGSC
                     GAAGEHLLAANSIANRATIILSKSCSNVDGDATATAATALSSTVGGGIGGIGGSIKMR
                     ASATDIETNALNGARDAIVASNNGNNGNNGNNGNNEYSILQLNNTIIQCHFNDDDFRA
                     LVKDLKRKVEYTERMNWLCLSKRPLGPPHRKSSLPKHQEVKRRFLEICDTTFSEEVRA
                     ALRLPAFDSYEWSDADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYNEVPFH
                     NFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTE
                     LALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARH
                     NEILTQFMEITPIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFA
                     QSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELVPELTELIIIPVR
                     IALEYYRRLNDAQTKTRKSVADSNTSATSDSNSGTIDSNAAMVSTPGGASDKLSLDKG
                     QGNSQGSGGGGGGGGGGGAGGGTGSGCGSNAAGSVSPQMPRSGSGISVKSRRSIPSQK
                     SASRTSVDEPGGMASELHDLPEGSESGDSETATEVDVAEKTSKFKVDTEGSSNRSKSS
                     HSTSRKSSREKRPSMIGELCSSGGGQRIRNSYGNIHGYHSNRCHFGNNRAVSLDQYSS
                     AGNNRRLSDGLPQVISDSNVFYGRHNRSSTETTVAVGNPQDTNANTNHPVGCQLKELL
                     ARTEADSDGEGDGNGREDKKIPLVIPSMPQLATSSNGNISPTLVVTEQILPSNGSTRS
                     SASSGRGGSGVPGGSGGSGMPGPSAGSGSSWKSRLRQFSDYFSFSFDKSNKRFGSTRS
                     SPCPGSNSSSGRTNNNANGLGENQDGLGAGGGIKPGMCCTTITNSSGSTVKGETRGGT
                     AGAGGGALTTMTTGNDAHQRHRAYSLDVPGMMRYSSNDSSRHPSNNTLQSAGGGAGLT
                     TGLEVTAQRVPPSLSVEMGLASGSSSEAGPKI"
     misc_feature    3598..4284
                     /gene="Pde9"
                     /locus_tag="Dmel_CG42276"
                     /old_locus_tag="Dmel_CG32648"
                     /old_locus_tag="Dmel_CG3754"
                     /gene_synonym="CG1627; CG32648; CG3754; CG3761; CG3765;
                     CG42276; Dmel\CG42276; PDE9"
                     /note="3'5'-cyclic nucleotide phosphodiesterase; Region:
                     PDEase_I; pfam00233"
                     /db_xref="CDD:459723"
ORIGIN      
        1 ctgcgcgcgc ggattacggt taattttcag ttggtttaca aactttacaa acggcgtacg
       61 cttatcgcga tcgcttttaa tcaacaaacc gaattagttg ccaaaataac gggaatgaca
      121 caggaaatgt gctgccggtg ctcaaatgct agcttaattg agtgaaaaag tgcaagtgat
      181 cgaactgcaa cggttacaaa aaaaacggtt gtttttctct ttatttttgt tttataaact
      241 aagaaatcgt tctataaatt gcatttattt gaatatctgt aagcccgcgt ttatctcaaa
      301 tgtacttgtg cgcgccacct gttttttaat taatatttta ctacaatcgg cgtgataaaa
      361 agtgtatgaa attcgttatt ttttttattt ttttggtttt tgttgagagt gcaagatcgt
      421 gcagcttgtg cgtgtgtgtg cgttcagtgt gcttgtgagg aagttatagt ttaatgttgg
      481 ttagcttcaa ttgtcgagca acagagaaaa aaagaaataa ataaataaaa cagcagcagc
      541 aacaacaacg atgtgatgct gattgatgtc acacacacca cgaaggaaaa aaaaataaaa
      601 aataaataaa ttatcacctt gaaggggttt atcaattttg ccagcacata aagatgttat
      661 cttggaaaac cgtttagaga tttgccagcg ctcacaaacg gaaacggaag tgacgcccga
      721 aaggaaaagg gggaagagga agtggtagcg caggacaaac ggctgaataa tgcaaattaa
      781 aacacaataa aatgtaaaac acaaatgaca acggagaaca cgagctgcaa aaggctaaag
      841 gagctaaaaa caaaaacaaa aaaaaaaaaa tagcaaaagg cgaatcggtt gacatgccaa
      901 aaaaaaatgc gagtggcggc aacttttcca ctgaattgat ttgattttca gtcaggagta
      961 cagccggaat acggagcgta tgcgcgatac gtatacgcga tatttagggc gccgggggag
     1021 cggcggaaat ttgcataact ttgctggcgt ggcataaaca tcaaaaaaca aattgcaagt
     1081 aacaaaggga agcaatggtc ataaaaacgg cgccagcctc gtaaaaaata cgttacaaaa
     1141 aaaaaaaaaa gaataagttc tcgcaaaacc cccgctcttt aagtgaaaat taatttatgc
     1201 agcaaatcaa atacggatag ggaagaaata taaaagtaat cgctggccgt aacaattaag
     1261 acagccgtgg gcagtgagga aaagtcggga aaagctgggt gaacgctgga aaaatcaagt
     1321 gcagcagcag ccgaaaaagg aaacacagag tcgaagaaac cggttagcaa gggttgctta
     1381 taaatgtacc aagacagcgg ctgcagcagc agtagcagtc gacgcggcag cagcagtgca
     1441 gcagcagcaa catctacagc agcaactgca gcagaaactg cagcagcagc agcagcaaca
     1501 acaaccagca gcagcgacga ggaaacactc gagactctga cgattataac gaccaccatc
     1561 accgatagcg atatccatgc gaccacaaca actacgacgg ttatagccag cggtacggcg
     1621 acaacagcgg cagcggcagc gacaacagca acacttgcca cacttgcaac actcgccagc
     1681 aacagcgaca tcgaggacag cagtccggtg gagagcgagg atagcgagga gtgcgagtat
     1741 atcgagatcg attgccagac gaccgcccag gaaggcactt cgccaagtgg cggcagcagc
     1801 agcagcggca atgcggtctt gctgcaacgc agcagcaata acctccagca gcagcagcag
     1861 caacaacagc agcagcaaca acatttgcaa ctgcagctgc agcaggcgga cgagcgattg
     1921 ttgcgcaaaa tcggctatat tgcatcgcgt gtgcgctgcc tgtccaagta ctacggtgac
     1981 ttccgcctgg tgaatccgta cagtgcccgc cggcagaggc gccaattgca ggagatcctg
     2041 ctgcggcact cgatcttcga tcctggcaag gagcaccagc gggcgattgt cttggccgcg
     2101 gcaacagcgg caattgccgg tcctctggcg gccatcgatt gcgtctgcgg cagcagtagc
     2161 atcagtttag aggcagtcag cagcagaagt cgcagcagtg agctggagga cgatcatcac
     2221 gagcaggatc aggtgcagga ggagcaggag caggagcagc atcaggggga taccgaggat
     2281 aacgaagagg agcaagagca tccgagtgaa aagccagaga gaacagacat tgaggaggag
     2341 ccaccgccgg cgattgcagt gaccaccacc acaacggcca ccgtgcgccg gaagtcctcg
     2401 agcagttcca caatcagtgg cacggccacc gtttccggtt ccgtttcggt atcggcctcc
     2461 gcctctcaat ccttttgctc caacaacatc aatctgctcg aggagctgct cattcagttc
     2521 tacgaggagc aggatcatcg cagcaaccta acggtgatcc gacatcatca tcatcagcag
     2581 caccagcagc accagcagca gcaaagaatc accaacaata ataacaacaa taacaattgc
     2641 aacagcatac agaacaacaa caacatgtcg aatcctgcgg ctacagcggc agcaacagca
     2701 acgccatcag tggaacaacc ggcaacatcg ggcaccacca acatccactt gcaacccacc
     2761 tccctgcccg atggcagcga taatccgcgc cgccgccggg ccagcgattg ctcagcggtg
     2821 caggccgctc tccagaatca gctgcactgc atcacgctga agaacaacaa ttgcggcaag
     2881 gcgatgccct tccatcgcgg cagttgcggc gccgccggtg agcatctgtt ggccgccaat
     2941 tcgatagcta atcgtgccac cattattttg agtaaatcat gcagcaatgt ggatggtgat
     3001 gccactgcca cagcggcaac ggcactaagt tcaacggttg gcggcggcat cggtggcatt
     3061 ggtggcagta taaaaatgcg tgccagtgcc acagatatcg agacgaatgc attgaacggt
     3121 gcccgggatg ccattgttgc atcgaataac ggtaataacg gcaataacgg aaataacggg
     3181 aacaacgagt acagcatcct gcagctgaac aacacgatca tccagtgcca cttcaacgac
     3241 gatgactttc gcgccctggt caaggacctc aagcgcaagg tcgagtacac ggagcgcatg
     3301 aactggctat gtctctccaa acgaccgctg ggcccgccgc atcgtaaaag cagtctacca
     3361 aagcatcagg aggtgaagcg tcgcttcctg gaaatttgtg atacgacctt ctcggaggag
     3421 gtgagggccg ccctacgcct gccggccttc gattcctacg agtggagcga tgccgatgtc
     3481 atccatctca tgcagaccat gttcgtcgag ctgggattca ttgagaagtt cagcattccg
     3541 gtggacacgc tgcgcgagtg gctctatgag gtctacaagc actacaacga ggtgcccttc
     3601 cacaactttc ggcactgctt ctgcgttgcc cagatgatgt atgccataac gcgccaggcg
     3661 aacttgctga gtcgcctggg cgacctagag tgtctgatcc tgttggtgtc ctgcatttgc
     3721 cacgacctcg accatcctgg ctacaataat atctaccaga tcaatgcccg caccgagctg
     3781 gcactcagat ataatgacat ctcaccgctg gagaatcacc attgttcgat agcgttccgc
     3841 ctgctggaac atcccgaatg caatatattc aagaacttta gccgcgacac cttcaataac
     3901 attcgcgagg gcatcatccg gtgcattttg gccacggaca tggcccgtca caatgaaatc
     3961 ctcacgcagt ttatggagat aacgcccatc ttcgactata gcaatcgtgc ccacatcaat
     4021 ttgctctgca tgatcctgat caaagtggcg gacatttcga acgaggcgcg acccatggac
     4081 gtggccgagc cctggctgga ccgcctgctc caggagttct ttgcccagag cgcagccgag
     4141 aagtccgagg gattgccggt gacgccgttc atggatccgg acaaggtcag caagccgggc
     4201 tcgcaggtgc gcttcatcgg actcgttctc ctgccactat tcgaggctct aggcgaactg
     4261 gtgccggagc taaccgagct catcatcata cccgtgcgca tcgccctaga gtactacagg
     4321 cgcctcaacg atgcccagac aaaaacgcgc aaatcggtgg cggacagcaa tacgtccgca
     4381 acctccgata gcaacagcgg caccatcgat tccaatgcgg cgatggtcag cacaccggga
     4441 ggcgccagcg ataagctcag cttggacaag ggacagggca attcgcaggg ctccggcggc
     4501 ggaggaggcg gaggaggagg aggaggtgcc ggtggtggga caggatctgg atgcggcagc
     4561 aatgccgctg gtagcgtatc gccacaaatg ccacgctccg gatccgggat cagtgttaag
     4621 tcgcgacgca gcattccatc gcaaaagtcc gcctcgagga cgtccgtgga tgagcccgga
     4681 ggaatggcgt cggagctcca cgatttgccg gagggcagcg agagcggtga ttcggaaacg
     4741 gccaccgaag ttgatgtggc cgagaagacg tccaagttca aggtggacac cgagggcagc
     4801 agcaaccgga gcaagtcctc gcactcgacc tcccggaagt cctctcgcga gaagcgtccc
     4861 tcgatgatcg gtgaactgtg cagcagtggc ggtggccagc gaatccggaa ctcgtacggc
     4921 aacatccacg gctatcacag caatcgctgt cattttggca acaatcgggc ggttagcctg
     4981 gatcagtata gtagtgccgg taacaatcgc cgcctctcgg acggactgcc gcaggtgatc
     5041 tcggacagca atgttttcta cggccggcac aatcggagca gcacggagac cactgttgct
     5101 gttggcaatc cgcaggatac caatgcgaat accaatcatc cggtcggatg tcagctgaaa
     5161 gagctattgg cccgcaccga agcggactcg gatggtgagg gcgatggcaa tggcagagag
     5221 gacaaaaaga ttccattggt cataccgtcg atgccgcagc tggccacatc atcgaacggt
     5281 aacatatcgc cgacactggt ggtcaccgag caaatcctgc ccagcaacgg cagtacacgg
     5341 agcagcgcca gcagtggccg tggcggctcc ggcgtacctg gaggatcggg tggctctggg
     5401 atgcctggac catcggccgg ttctggtagt tcatggaaat cgagactgcg ccagttctcc
     5461 gattacttta gcttcagctt tgataagagc aacaagcgct ttggcagcac acgtagtagt
     5521 ccgtgtcccg gttccaattc cagttcggga cggaccaata acaatgccaa tggattgggt
     5581 gaaaatcagg acggattggg agcaggaggc ggtataaagc cgggcatgtg ctgcaccacc
     5641 atcaccaata gctcaggatc cacggtaaaa ggcgagacga gaggaggtac cgccggtgca
     5701 ggcggcggtg ctctgaccac catgaccacc ggaaatgatg cccatcaacg ccatcgcgcc
     5761 tatagcctgg atgtgcccgg catgatgaga tactcctcca acgacagcag tcgccatccc
     5821 agcaacaata cgcttcagag tgcgggtggc ggtgctggtt tgaccaccgg attagaggtc
     5881 actgcccaac gagtgccgcc cagtttgagc gttgaaatgg gcctggccag cggctcatca
     5941 tcagaggcgg gcccaaagat ttgacaacag gggagcacca ggcaggatgc ggtagccatt
     6001 agcaagggct acgacggggc cgttgagcaa caggaggagg aggaggagga ggaggatgag
     6061 caggaggacg atgacgagga tgagggacgc gaggagcacc gccagctgca gcggcatcag
     6121 cagcagccgg acgcttcgtc cagctgcgag gtgtcctcca tgtcgatgac cgtgtggtcg
     6181 gcgattggtc agcgtttgaa cgccctcgtc tgccattgct gcgaacgcaa attaccggaa
     6241 ccagaaaatg tctaagtggg tggaaagtag ggccaggttt aacccagaac ccatcgccac
     6301 ccatttaaga tgcaatcaaa tgcccccatc ccctgtcctc atttttagca gctgggggat
     6361 tccttggctt tcacagtcat tgacttttgc ctggtagctt aggtttacgt ttaactccta
     6421 gcaaattaca ttaggtttcc actgatttta ctctcttgtt ttgttttttt tttttttttt
     6481 aattattatt ttatattttt atcttgttac cttttaagta tttttattta tgtacatgcg
     6541 catacacaca cacacaaata tatatatata tatacatct