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Drosophila melanogaster tomosyn, transcript variant J (Tomosyn),


LOCUS       NM_132591               4687 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_132591
VERSION     NM_132591.5
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4687)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4687)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4687)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4687)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4687)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4687)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4687)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4687)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4687)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4687)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4687)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4687)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4687)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4687)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4687)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4687)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4687)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4687)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4687)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4687)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4687)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4687)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4687)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_132591.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4687
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4687
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /map="11B6-11B7"
                     /db_xref="FLYBASE:FBgn0030412"
                     /db_xref="GeneID:32217"
     CDS             684..4448
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="CG17762 gene product from transcript CG17762-RJ;
                     CG17762-PJ; Tomosyn-PJ; tomosyn ortholog"
                     /codon_start=1
                     /product="tomosyn, isoform J"
                     /protein_id="NP_572819.4"
                     /db_xref="FLYBASE:FBpp0300334"
                     /db_xref="GeneID:32217"
                     /db_xref="FLYBASE:FBgn0030412"
                     /translation="MKKFTFKGVLDGFRQSVQPQATRQEQEIQEQLKADHFTLKKTFR
                     HGFPYSPTSFAFDPVQKLLAIGDKSGYIRILGRPGVDAHAKHEGESECAVLFAQFLVN
                     EGALVTVTADDTIHLWSIRQKTPRIVQSLKFQRERVTCIHLPVGSKWLYVGTEKGNIH
                     VVHIDTFALSGYIINWNKAIEVVRTSHPGAVIALCDNPLDANKLLIAFECGLLVLWDL
                     KAKCAELRWQAAEAVKSLAWHYEGKYFVSSHTDGSICSWPTKPQAKPQSQVCPHAKIN
                     KDGNAEKCKPIYKVDLKSSATGETFTIFSGGMPSEKGSKSNCITVMVGKATTVLEMEH
                     AVCDFITLCENPWPCETQEPYAIAVLLQYDLVLIDLLTPGFPCFESPYPMDLHESPVT
                     CCTYLTDCPSDLVPAFYSVGRTTTSKKSCFSEREWPISGGEWSPASCSYSEIVITGHQ
                     DGSLKFWDSGAGTLQILYKLKTAKMFEKPRSHVAHSHPESDNPLAVHLIFLCSESRRL
                     CVAGAMGQVMLFKFRKVESTSEVLVLEIPILYENFDDIYGTSPECDFLTGHQVQKAES
                     SDSDKTAECSLKVRNGAQRKPPGFQSQLVCLTTGPNRRNVQVTSLCISSSYGLMAYGT
                     EYGLVIIDIIQKICLLSVACPDLYGAHDPYSRTPKSPKRIENKEEQSRSPSSDQINGS
                     GVATAAPQQQQQQQQQLQQSQQQQQQQLQQQQQQQQQQQQQQQQQQQSLGGDPGDHAT
                     STSAGAATLAGSSIYGADDADKLDGTFSRSRSSSMSSIDMSSSESVTCLAFIESYAKR
                     NDILTLVPTLWIGTSFGSILTLFITMPERDVRKSQPVLITINGGPVVRLKGSITSMSF
                     LDSYGSIIPYTFETWRDEKRDNKDRTPTKSSSRTSPTFTPTTANTLSNTSVAGGASAG
                     GGAGGGGGAGGGAASGGAAAGGPAGGGAGAGSAAGAAGGVGSGVTSGGGMSSSSASSS
                     GISGSVSTGLETLTDRQYIVIASEKQTKVFDVANQCCINRIQLSEMDFAVKAETITMK
                     DGSCLATYLSNGHLMVHSLPSLKLLLDTDFLPLMELSFQTKCKQGIVDPMLSIWGQQI
                     IVHEDTTQISKIFCFSHKGHGLYMASPTEIQKFTISSEFCQFILEMMGELYTVHEMPE
                     QPKEGFFKGLFGGGAKLLDREELFGEQSGKPNRSVARHIPGPNLEQLGQRASTAASEI
                     SRAHQLAMERGEKLNLLEERAERMANTAQDFSGTAHQLMLKYKDKKWYQL"
     misc_feature    <804..1454
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    966..1082
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1095..1235
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1257..1361
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1485..1811
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="LLGL2; Region: LLGL; pfam08366"
                     /db_xref="CDD:462446"
     misc_feature    4242..4424
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="SNARE domain of STXBP5, STXBP6 and related
                     proteins; Region: R-SNARE_STXBP5_6; cd15873"
                     /db_xref="CDD:277226"
     misc_feature    order(4251..4253,4260..4265,4269..4271,4281..4286,
                     4290..4298,4302..4307,4311..4316,4323..4328,4332..4349,
                     4353..4370,4374..4391,4395..4403,4407..4412,4419..4421)
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="heterotetramer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:277226"
     misc_feature    4323..4325
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="zero layer; other site"
                     /db_xref="CDD:277226"
ORIGIN      
        1 gcccagtcgt cgaagttttc acagctctaa cagttgagac aacattttga gaaattgtcg
       61 tttgttttgt cgtgcttttt gtttaaacat tgcgttgtgt tttttgttta tcgcccccgt
      121 gtcgatctga tctgattcgg ttcgccaatc caattggatt gggcaagcgc cacaaacgtt
      181 caacagcgga gtgaatcgcc atgaaacagt gaagaagctg caggaggagc ataagatgaa
      241 gatgtagcta acatcaaata tttcgaccac tgttaaccta gtttcacatc tcaaaaataa
      301 aaccaaacaa caaggacgaa ctcagaccag cactggctcc tctgtcttca attacgcaca
      361 gctctaccag tatctagaga ataacgagta aaggctacca aggactcgag ggaagagaat
      421 cgcctggggc agaggaagaa gccaatcccc atacttttcg gttctcctcg gaccagaatc
      481 atcacctccc ccatcccgac cccggcacta ccttcccgct gaaccacata cactctgtcc
      541 actatccact attcgacacc accacactct gtgcatccaa ctatttggcc aaccattaat
      601 ccttgggcga gaccagagca gccccatcgc ataactgtgg atagcagagc agccggagca
      661 cgaggacgac tcatgttaca aaaatgaaaa agttcacatt caaaggagtt ctagatggat
      721 ttcgacaaag cgttcagccc caagccacac gacaggagca ggagattcag gagcaactca
      781 aggccgatca ctttacgtta aagaaaacct ttcgccatgg ctttccatac tcgcccacat
      841 ccttcgcctt cgatccagta caaaagctac tagcgattgg cgacaaatcg ggctacattc
      901 gcattttggg acgacctggc gtcgatgccc atgccaaaca cgagggcgaa tccgagtgcg
      961 ccgtgctctt tgcccagttc ctggtcaacg agggcgcatt ggtcaccgtc accgccgatg
     1021 acaccattca cttgtggagc attcgccaaa agacaccgcg cattgtgcag agtctgaagt
     1081 ttcagaggga gcgcgtgact tgcatacacc tgcctgtggg cagcaaatgg ctgtacgtgg
     1141 gcaccgagaa gggaaacata cacgttgttc acatagatac atttgcactt agtggttata
     1201 ttattaactg gaataaagca attgaagtgg ttagaactag tcatccaggt gctgtgattg
     1261 cgttatgtga taatccattg gatgcaaaca agttgcttat tgcatttgag tgcgggctgc
     1321 ttgtgctgtg ggatctgaag gcgaaatgcg ctgagctgcg atggcaggcg gccgaggccg
     1381 tcaagtccct ggcctggcac tacgagggca aatattttgt gtcctcgcac acggatggct
     1441 ccatttgctc ctggcccacg aagccgcagg ctaagccgca gtcgcaggtc tgtccgcatg
     1501 ctaaaatcaa caaggatggc aatgcggaga aatgcaagcc gatatataaa gttgacttga
     1561 agtccagcgc aactggggaa accttcacaa ttttctcggg cggcatgccc tcggagaagg
     1621 gctccaagtc caactgcatc acggtgatgg tgggcaaggc caccacggtg ctggagatgg
     1681 agcacgccgt ttgcgatttc ataacactct gcgagaatcc ctggccctgc gagacccagg
     1741 agccgtatgc tattgccgtg ctgttgcaat acgacttagt attaatagac ttattaacac
     1801 ccggttttcc atgttttgaa tcgccttatc caatggactt acacgaatca cctgttacat
     1861 gttgcacata tttaaccgat tgcccatcgg atttggttcc tgctttctat tcagttggtc
     1921 gcacaacgac aagtaaaaag agctgcttct cggagcgcga atggccgata tccggtggcg
     1981 agtggtcgcc ggcgtcgtgc agctattcgg agatcgtgat caccggacac caggacggca
     2041 gcctcaagtt ctgggattcc ggtgccggca cactgcagat cctctataag ctgaagacag
     2101 ccaagatgtt cgagaagccg cgctcccacg tcgcccactc gcatccggaa agcgacaatc
     2161 cgctggcggt gcacctaatc ttcctttgct cggaatcgcg acgcctgtgt gtggccggcg
     2221 ccatgggaca ggtgatgctc ttcaagttcc gcaaagtgga gtccacgtcg gaggtactgg
     2281 tgctggagat acccatactc tatgagaatt ttgatgacat ttatgggaca agtcccgagt
     2341 gcgattttct aacgggccat caagtgcaga aggctgagtc gagtgattcg gataagacgg
     2401 ccgagtgttc gctaaaggtg cgcaatgggg cgcaacgcaa gccgccgggc ttccagtcgc
     2461 agctggtctg cctcaccacc ggaccaaatc gccggaacgt gcaggtcacc tcgctgtgca
     2521 tcagctccag ttatggccta atggcttatg gtaccgaata tggacttgtc ataattgata
     2581 taatccaaaa aatttgccta ttgagtgttg catgccccga tctgtatggc gcacatgatc
     2641 cttactcgcg aacaccaaaa agtccaaaac gtattgaaaa caaagaggag caaagccgat
     2701 cgcccagctc agatcagatc aacggcagcg gagttgcaac tgcagcaccg cagcagcaac
     2761 agcagcagca gcaacagttg cagcaatcac agcaacaaca gcagcagcag ctacagcagc
     2821 aacagcagca gcagcaacaa caacagcagc agcagcaaca acaacaacaa tcgttaggtg
     2881 gtgatcctgg tgatcatgca acatcgacgt cagcgggagc agcaacattg gcgggatcct
     2941 ccatttacgg tgcagatgat gcagataaat tggatggaac tttctcaaga tccagatcat
     3001 cgtcaatgtc cagcattgat atgtcttcct ctgaatctgt tacctgttta gcttttatcg
     3061 agagttatgc aaaacgaaat gatattttga cacttgttcc tactttgtgg attggaacta
     3121 gtttcggttc gatactgaca ttgttcatca ccatgcccga gcgagatgtg cgcaaatctc
     3181 agccagtatt gataacaata aatggtggcc ccgtggtacg actcaaagga tccataactt
     3241 ccatgtcttt tttagactca tacggttcga tcatacccta tacgtttgag acctggcgtg
     3301 acgagaagag ggacaacaaa gatcgcacac caacaaagag cagcagccgc accagtccca
     3361 cattcacacc gacaactgcc aatacattat caaacacttc ggtcgcgggt ggtgcgtccg
     3421 caggcggagg agctggcggc ggtggtggtg ccggcggtgg tgcggccagc ggtggcgcag
     3481 ccgcaggagg gccagccggc ggtggtgccg gagcaggatc ggcggctgga gcggccggcg
     3541 gcgttggaag cggtgtaacc agcggcgggg ggatgagcag cagcagcgcc agcagcagcg
     3601 gcatcagcgg aagtgtgagc accggcctgg aaactctcac cgatcgacaa tacatcgtta
     3661 tcgcaagcga gaagcaaaca aaagtcttcg atgtcgccaa ccagtgctgc atcaaccgca
     3721 tacaattatc ggaaatggat tttgcagtca aggcagaaac tatcacgatg aaagatggct
     3781 cttgcttagc aacctatctt tcgaatggcc atctaatggt acatagtctt cctagtctaa
     3841 aactgttatt ggatactgat ttcttaccac ttatggaact aagttttcaa acaaaatgta
     3901 aacagggaat tgtggatcca atgctttcga tatggggtca acagatcatt gttcatgaag
     3961 atacaactca aatatcaaaa atattttgct ttagtcataa aggtcatgga ttgtacatgg
     4021 catcgcccac cgaaattcaa aaattcacga tatcatcgga attttgtcaa tttattttgg
     4081 agatgatggg tgaactatat acggtacacg aaatgcccga acagccgaag gagggtttct
     4141 tcaagggtct atttggtggt ggcgccaaac tcctggatcg cgaggagcta tttggcgagc
     4201 agagcgggaa accgaatcga tcggtggcac ggcacatacc cggccccaat ttggagcagc
     4261 tcggccagag ggcttccacc gccgcatcgg agatcagccg ggcgcaccag ctggccatgg
     4321 agcgcggcga gaagctaaat ttgctggagg agcgcgccga gcgcatggcc aacactgctc
     4381 aagatttcag cggcactgcg catcaattaa tgcttaaata taaagacaag aagtggtatc
     4441 agttgtaaaa tatctatttt aggagccaat tctaccacag ttattgtaat attgctttta
     4501 taacactttc tactacatta cgagtaaagt acacttattt aatttctgtt ttcaagtcgt
     4561 cacgttattt acaaaaaccg aaaaccaaca aaaaaaaaca acaaaaaccg aaaattcaca
     4621 aaaacaaaaa aactgaaaga gaaaacccaa ccaaaaaaaa actgttttta ataaaaatat
     4681 atagacc