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Drosophila melanogaster meckel syndrome, type 1 (Mks1), mRNA.


LOCUS       NM_132576               2203 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_132576
VERSION     NM_132576.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 2203)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2203)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2203)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 2203)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 2203)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 2203)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 2203)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 2203)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 2203)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 2203)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 2203)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 2203)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 2203)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 2203)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 2203)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 2203)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 2203)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 2203)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 2203)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 2203)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 2203)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 2203)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 2203)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_132576.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2203
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..2203
                     /gene="Mks1"
                     /locus_tag="Dmel_CG15730"
                     /gene_synonym="CG15730; Dmel\CG15730; dMks1; mks1; MKS1"
                     /note="Meckel syndrome, type 1"
                     /map="11A12-11A12"
                     /db_xref="FLYBASE:FBgn0030395"
                     /db_xref="GeneID:32200"
     CDS             37..2136
                     /gene="Mks1"
                     /locus_tag="Dmel_CG15730"
                     /gene_synonym="CG15730; Dmel\CG15730; dMks1; mks1; MKS1"
                     /note="CG15730 gene product from transcript CG15730-RA;
                     CG15730-PA; Mks1-PA; meckel syndrome, type 1 homologue"
                     /codon_start=1
                     /product="meckel syndrome, type 1"
                     /protein_id="NP_572804.1"
                     /db_xref="FLYBASE:FBpp0073500"
                     /db_xref="GeneID:32200"
                     /db_xref="FLYBASE:FBgn0030395"
                     /translation="MQKSRDIKRTGVYRVSGNIGDLQLELKLRHISEWLPVPKFEYAG
                     AQSTNAYGDHYPGSEEDIWQDCYIHVPQGDDSCGGKTGLGYNCSYYNVGIGYTGRRRR
                     SPISQHEGEMEKDKNEGEITDLESQSNRSWSILSDNSRPPAGDLFYKRNKELCNGAIA
                     TIRISWQQKHFSQAELEQYINNPGSCASKLQRRYHRWALETLKLQQRYLRKLENLEDA
                     ETVEDPEPITIRRRIRKPKAKQRGCSAAAHPTITSLSSANMSEVSILDDPNFAARTCL
                     IHTLLDNDSESLMPAEASEFHKKGYQLMYIYADLQQDTLLVSIRYDPEQGLLYVYPDF
                     SSSAQDLDYVIQIERNNDCRQLYAFGFENVTPLEAYDDDGFSEEADGEDEQELGDGLP
                     IEEDLPEEASAEEILEFYRRRREAASERRSLLQFEMPPKRMKRVSLLLELQEGQNFEN
                     PNIHVRYYLKAPANTFYEGTPGVDTMQGATATCRNAGDWRSAHLGHCWQVTLLLEEQH
                     HPADLLHLYFEVISIDSWQRERCEGYAHYAIPLTSALPTDSIRLQCIRPLGNWLDALN
                     RYFIGGRQLFDFESFFDVHRQSEMHSRLNFNSDRPMTTTGTLSLRLQKLQQRQIDTSD
                     QFHHHFHLELGNDSSDDGDSNDDDVRSSSNPDTSRATTLDEVMAAFVEARKRIELLLG
                     NSSETASPSSAYYQAEF"
     misc_feature    1342..1881
                     /gene="Mks1"
                     /locus_tag="Dmel_CG15730"
                     /gene_synonym="CG15730; Dmel\CG15730; dMks1; mks1; MKS1"
                     /note="Ciliary basal body-associated, B9 protein; Region:
                     B9-C2; pfam07162"
                     /db_xref="CDD:462108"
ORIGIN      
        1 taaaaattta ctgggcaaaa taatcatcgg cgaatcatgc aaaaaagcag agacataaag
       61 cgcactggag tttatcgcgt gagcggaaac ataggagatc tgcaattgga actgaagctg
      121 cgacacatca gtgaatggct gccggtcccc aaatttgaat acgcgggagc gcaatcgacg
      181 aacgcatatg gtgaccacta tcccggatcg gaggaagata tctggcagga ttgctatatt
      241 catgtccccc agggcgatga ttcgtgtgga gggaagactg gcttgggcta caactgcagt
      301 tattataatg tgggaattgg ttacaccggc aggagacgaa ggagtccaat atctcagcat
      361 gagggggaaa tggaaaagga taagaacgag ggagaaataa cggatctgga gtcccaaagt
      421 aatcggtcgt ggagcattct cagtgataat agtcgtcctc ccgctggtga tctcttctat
      481 aaacggaata aggaactctg caatggtgct atagccacaa tacgcatatc ctggcagcaa
      541 aagcacttta gtcaagcgga actggagcaa tatataaaca atcctggaag ttgcgcttcg
      601 aaactacagc ggcgctatca caggtgggcc ttggaaacct tgaagctaca acagcgatat
      661 ctaaggaaac tggagaatct ggaagatgca gagacggtgg aggatcctga gcctattaca
      721 attcgtcgcc ggatacgaaa gcccaaggcg aagcagagag gctgctctgc cgcagctcac
      781 ccgactatta ccagtctgtc ctcggcgaat atgtcggagg tttcaatact ggatgacccc
      841 aattttgccg ccagaacgtg cctcatacac accttattgg ataatgattc cgagagtctt
      901 atgcccgccg aagcaagtga attccataaa aagggctatc agctaatgta catctatgcc
      961 gatctgcagc aggacacact gttggttagt atacgatatg atcccgaaca gggtctgctc
     1021 tatgtctatc cggatttcag tagcagtgcc caggatctgg attatgtgat tcagatcgag
     1081 cggaataacg attgccgaca gttgtatgcc tttggctttg agaatgtcac accgctagag
     1141 gcctacgacg atgatggttt ctctgaggag gcggatggcg aggatgagca ggaactgggc
     1201 gatggtttac ccatcgaaga agatctgccc gaagaagcct ccgccgagga gatactcgag
     1261 ttttatcgca gacggcgaga agcagccagc gagaggagaa gtctcctcca gttcgaaatg
     1321 ccgcccaaga ggatgaagcg ggtcagcctg ctgctggaac tacaggaagg ccagaacttt
     1381 gagaacccca acatacatgt aagatactat ctgaaagcac cagcaaatac cttttatgag
     1441 ggtacacctg gggtggatac catgcaggga gcgacggcca cgtgcaggaa tgccggcgac
     1501 tggaggagtg cccatttggg tcactgctgg caggtgaccc tgctgctgga ggaacaacat
     1561 catccggctg atctactgca tctatatttt gaagtgatca gcatagatag ctggcagcgg
     1621 gagcgatgtg agggatatgc tcactatgcg ataccgttaa catccgccct gccaacggac
     1681 tccatacggc tgcagtgcat ccgaccactg ggcaactggc tggatgccct caatcggtat
     1741 ttcataggcg gtcgtcagct gttcgacttt gagtccttct tcgatgtaca tcggcaatcg
     1801 gaaatgcatt cccgtttgaa cttcaactct gacaggccaa tgaccaccac gggaacactt
     1861 tcgctccggc ttcaaaagct tcagcagcgc caaatagaca catctgatca gttccatcac
     1921 cacttccatc tggaactcgg caacgatagt agcgacgatg gcgatagcaa tgatgacgat
     1981 gtcagatcca gttcaaatcc ggatacttcg agggccacca ctctggacga agtaatggcc
     2041 gcctttgtgg aggccaggaa acggatcgag ctgctcctgg gaaatagttc agaaacagcc
     2101 tcaccatcat ctgcatacta ccaggctgag ttttaagccc ttcaatgagt acaataatat
     2161 gatgacaaat aatttttttt tatataaact ataatatttg tat