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Drosophila melanogaster Upf1 RNA helicase (Upf1), transcript


LOCUS       NM_132539               5187 bp    mRNA    linear   INV 26-DEC-2023
            variant A, mRNA.
ACCESSION   NM_132539
VERSION     NM_132539.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5187)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5187)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5187)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5187)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5187)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5187)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5187)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5187)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5187)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5187)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5187)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5187)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5187)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5187)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5187)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5187)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5187)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5187)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5187)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5187)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5187)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5187)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5187)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_132539.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5187
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5187
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /note="Upf1 RNA helicase"
                     /map="10F4-10F4"
                     /db_xref="FLYBASE:FBgn0030354"
                     /db_xref="GeneID:32153"
     CDS             403..3945
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /EC_number="3.-.-.-"
                     /EC_number="3.6.4.13"
                     /note="CG1559 gene product from transcript CG1559-RA;
                     CG1559-PA; Upf1-PA; up-frameshift suppressor 1"
                     /codon_start=1
                     /product="Upf1 RNA helicase, isoform A"
                     /protein_id="NP_572767.1"
                     /db_xref="FLYBASE:FBpp0073433"
                     /db_xref="GeneID:32153"
                     /db_xref="FLYBASE:FBgn0030354"
                     /translation="MSVDTYAPSSALSFLDMDDNELLPGADTQPTQYDYRDFTMPSTS
                     QSQTQNDQLEIAQRCSAGDSHPRLASITNDLADLQFEEEDDEPGSSYVKELPPHACKY
                     CGIHDPATVVMCNNCRKWFCNGRGSTSGSHIINHLVRAKHREVTLHGEGPLGETILEC
                     YSCGVRNVFVLGFIPAKADSVVVLLCRQPCAAQNSLKDMNWDQEQWKPLIADRCFLAW
                     LVKQPSEQGQLRARQISAAQINKLEELWKENIEATFQDLEKPGIDSEPAHVLLRYEDG
                     YQYEKTFGPLVRLEAEYDQKLKESATQENIEVRWDVGLNKKTIAYFTLAKTDSDMKLM
                     HGDELRLHYVGELYNPWSEIGHVIKVPDNFGDDVGLELKSSTNAPVKCTSNFTVDFIW
                     KCTSFDRMTRALCKFAIDRNSVSNFIYSRLLGHGRADSNDEVLFRGPQPKLFSAPHLP
                     DLNRSQVYAVKHALQRPLSLIQGPPGTGKTVTSATIVYQLVKLHGGTVLVCAPSNTAV
                     DQLTEKIHRTNLKVVRVCAKSREAIDSPVSFLALHNQIRNMETNSELKKLQQLKDETG
                     ELSSADEKRYRNLKRAAENQLLEAADVICCTCVGAGDGRLSRVKFTSILIDESMQSTE
                     PECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIRPFRLEVQ
                     YRMHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDFPWPQPERPMFFLVTQGQEEIAGS
                     GTSFLNRTEAANVEKITTRFLKAGIKPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLY
                     QEIEIASVDAFQGREKDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIIIVGNP
                     KVLAKQQLWNHLLNFYKDRKVLVEGSLNNLKESLIHFQKPKKLVNSMNIGAHFMSTII
                     ADAKEVMVPGSIYDRSGGYGQGRQMVGQSMNGGQYGGSGGGPYGNSPLGYGTPSSNSM
                     VGFGLGNGGNGAAGGNNNFGGAGPSWAAAHLHHDSIGYISNEHGAAALGNMPVPVGMF
                     MNMSNIPPRFYNQHQQAIMAVKQNRAIQQQTGNFSPGNSGPGVTGVGVGRSATPGGNK
                     KTNKLGKSRVTGGGTGGAPLTQGSSVCNAAPYSQHPMPLSLQMTQPSGFALSQQPELS
                     QDFGQISQMDGLLSQDVAFNASGERSLNQFSQPY"
     misc_feature    694..1149
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /note="RNA helicase (UPF2 interacting domain); Region:
                     UPF1_Zn_bind; pfam09416"
                     /db_xref="CDD:401391"
     misc_feature    1306..1572
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /note="1B domain of eukaryotic UPF1 RNA helicase and
                     related proteins; Region: 1B_UPF1-like; cd21407"
                     /db_xref="CDD:394815"
     misc_feature    order(1408..1416,1468..1470)
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /note="nucleic acid substrate binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:394815"
     misc_feature    1465..3042
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /note="DNA helicase, putative; Region: TIGR00376"
                     /db_xref="CDD:273041"
     misc_feature    1753..2454
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /note="DEXXQ-box helicase domain of UPF1; Region:
                     DEXXQc_UPF1; cd18039"
                     /db_xref="CDD:350797"
     misc_feature    order(1753..1761,1768..1770,1825..1845,2338..2340,
                     2449..2454)
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350797"
     misc_feature    order(1909..1917,1981..1992,2143..2145,2191..2193,
                     2197..2199,2350..2352,2356..2358)
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:350797"
ORIGIN      
        1 gatagacccc tcgtgagtca aatgcaaact gacgtatatt tattactggc aaaacaggcc
       61 gggcaaattt gttgaacaag caagaaagtt ttcgcttttt ttaatcctac attccccgca
      121 atagcgtggg aatctcgtac agactcaatt taaaacacac aacagccaca gtttcgaaag
      181 agtgccgaac ggcgggctcc cgaacacgga aagcgcgaaa cgcacacacg acaccatcgc
      241 cataccataa tcatcgcggc cacgctccaa gcttaggaat ttttcaattc cggaaacact
      301 gaccaagcga tccgtggtct aggagcaggt actatagatc tcatcgcgat ccctgcggaa
      361 acgcagcata atcaccttgg gtgagaagaa acaacaggcg ccatgagcgt ggacacgtac
      421 gcgcccagct cggcgctctc gttcctggac atggacgaca acgagctgct tccgggagcg
      481 gatactcaac ccacgcagta cgattaccgc gactttacca tgccctccac ctcgcagagc
      541 cagacccaga acgatcagct ggagattgcc caacgctgct ctgccggaga ctcgcatcca
      601 cgactggcca gcatcaccaa cgatctggcc gatctgcagt tcgaagagga ggacgacgag
      661 cctggcagct cgtatgtgaa ggagctgccg ccgcatgcgt gcaagtattg cggcatccat
      721 gatccagcca cggtggtcat gtgcaacaac tgccgcaaat ggttttgcaa cggtcgtgga
      781 agcacttccg gttcgcacat catcaaccat ctggtgaggg ccaagcatcg cgaggtgacg
      841 ctccacgggg aaggtcccct gggcgagaca atcctggagt gctactcctg tggtgtgcgc
      901 aacgtctttg tgctgggctt cattccggcc aaggccgatt ctgtggtcgt gctgctctgc
      961 cgtcagccgt gtgccgccca gaattcgcta aaggatatga actgggacca ggaacagtgg
     1021 aagcctctaa ttgcagaccg ctgctttttg gcctggctgg taaagcaacc cagcgaacag
     1081 ggacagctgc gagctcgcca aatctcagcc gctcagatca acaagctgga ggagctatgg
     1141 aaggagaata ttgaggccac gtttcaggat ctggagaagc caggcattga ctcggagcca
     1201 gcacatgtgc tactccgcta cgaggatggc tatcagtacg agaagacctt tgggccgctg
     1261 gtccgccttg aggccgaata cgaccaaaaa ctgaaggagt ctgccacgca ggagaacatc
     1321 gaagtacgct gggacgtcgg cctcaacaaa aagaccattg cctactttac gctggcgaag
     1381 accgattcgg acatgaagct catgcatggc gacgagctgc gcctgcatta tgtgggcgag
     1441 ctgtacaatc cgtggagcga gatcggccac gttatcaagg tgccggacaa tttcggcgat
     1501 gacgtcggcc tggagctgaa atcctcaacg aatgccccgg ttaagtgcac cagtaacttt
     1561 acggtggact tcatctggaa gtgcacgtca tttgatcgca tgacacgtgc tctgtgcaaa
     1621 ttcgccatcg atcgcaattc agtgtcgaac ttcatctact cgcgcctgtt gggccacggt
     1681 cgtgcggatt ccaacgacga ggtgctgttc cgcggcccac aacccaagct cttcagtgcc
     1741 ccgcatctgc cggatttgaa tcgcagccag gtgtatgccg tgaaacacgc gcttcagcgt
     1801 ccgctctcgc taatccaagg gccgcctggc acgggcaaaa ccgtgacctc ggcgaccatc
     1861 gtttaccagc tggtcaagct ccatggtggc acagtgctgg tgtgcgctcc cagcaacacg
     1921 gccgtggatc agctaactga gaagatccac cgaacaaacc ttaaagtggt gcgtgtttgc
     1981 gccaagagcc gtgaggccat cgatagcccg gtaagcttcc tggcgctgca caaccaaatc
     2041 cgtaacatgg agaccaactc ggagctaaag aagctgcagc agctgaaaga cgagaccggc
     2101 gagctgagct cagcagacga aaagcgatac cgcaacctga aacgtgccgc cgagaaccaa
     2161 ctgctggagg ctgccgacgt tatctgctgc acatgcgtag gcgccggcga tggtcgtcta
     2221 tcgcgagtca agttcacctc gatcctgatc gatgagtcta tgcagtcgac ggagccggag
     2281 tgcatggtgc cagtggtgct gggcgctaag cagctgatcc tcgtgggcga tcactgccag
     2341 ctgggaccgg ttgttatgtg caagaaagca gctcgtgccg gcctctcgca aagtttgttc
     2401 gagcgcctgg tggttctggg catccgtccg ttccggctgg aggtgcaata tcgcatgcac
     2461 cccgagctgt cccagttccc gtccaacttc ttctacgagg gatcgctgca aaacggcgtc
     2521 tgcgcggagg atcgtcgcct taagcttgat ttcccctggc cacagccgga gagaccgatg
     2581 ttctttctgg taacacaggg acaggaggag attgccggct ccggcacctc tttcctcaac
     2641 cgcacagagg cggccaacgt ggaaaagatt acgacgcgat tccttaaggc aggcatcaag
     2701 ccggaacaaa ttggaatcat cacgccttac gaaggtcagc gcgcttacct ggtgcagtac
     2761 atgcaatacc agggcagcct gcactctcgt ctataccagg agatcgagat cgccagtgtg
     2821 gacgcgttcc agggacgtga gaaggacatc attatcatgt cttgcgtgcg atctaacgaa
     2881 cgtcaaggca tcggcttttt gaacgaccca cgtcgcctta atgttgccct tacacgggcc
     2941 aagttcggga tcatcattgt gggcaatccc aaagtgctcg ccaagcagca gctgtggaac
     3001 catctgctca acttctacaa ggaccgtaag gtgctcgtcg agggatctct gaataacctt
     3061 aaggagtcgc taatccactt ccagaagccc aaaaagcttg tcaacagcat gaacattggg
     3121 gcacacttta tgtccaccat tattgccgat gccaaggaag tgatggtgcc aggctccatt
     3181 tacgaccgca gtggcggtta cggccaaggt cgccaaatgg tgggacagtc aatgaatggc
     3241 ggacagtacg gtggcagtgg aggtggtccc tacggaaact cacccctcgg ctacggtact
     3301 cccagctcca attccatggt gggctttggc ctgggcaacg gaggcaatgg cgcggccggt
     3361 ggcaacaaca acttcggagg ggctggaccc agttgggcgg ctgcccacct ccaccacgac
     3421 tccattggct atatatccaa cgagcatgga gcagcagcac tgggcaacat gccagttccg
     3481 gttggcatgt tcatgaacat gagcaatatt ccgccgcgtt tctacaacca gcaccagcag
     3541 gcgatcatgg cggtcaagca gaatcgcgcc attcaacaac agacgggtaa tttctctccc
     3601 ggtaactcgg gtcctggagt cactggagtc ggagtcggac gaagcgccac cccaggcggc
     3661 aataagaaga ccaacaagct gggaaaatcg cgcgtaacgg gcggtggaac tggcggggca
     3721 ccgctaacac aaggaagctc ggtatgcaat gctgctccat acagtcagca cccgatgcct
     3781 ttgtcgctgc agatgaccca gcccagcgga tttgctctgt cccagcagcc ggaactttca
     3841 caggactttg ggcaaatatc gcagatggac ggtttgctat cccaggatgt tgcctttaac
     3901 gcgtcgggcg agcggagctt gaatcagttc tcacagcctt attgagaatc cggttggagg
     3961 tgcaacaact acaaacgata acaagcaaca caaacgaaac aacaacaaac tcaactttga
     4021 agtcatcatc aaggagtagc atcagtaggc agcaggaaaa agcagagagg accatcacgg
     4081 gaacaacgac agatgcggga aacaatgcga cctaagaaca ttaggacaaa gcgggacatt
     4141 aaaagatggc aaatcgagac gaggcagcgt gatagatgga gacggatatg gcaagatgtg
     4201 gagttacaaa gtaataaaga agactgagac gggagagaga tgtcgaaaga tcgaaatatc
     4261 gagagcaaat cactgtaggc tgccaggatg cacagctgca gttgctgttt ccgtagcgcc
     4321 gcgggccatg gagtcatagc caggcgacat gccattggcc accggccatt ggccattggt
     4381 cacgagtgcg ctcccgagac ggagttcgcc cacggatgag ccaatctgcc agcaaggcgc
     4441 cacacaagat ggacaacttc tcgacacgtt tcttttctct tttgccagcc caggattcgc
     4501 agccggagcc taacaaagac gcaatcactc ccgcccagga catgtattca ccaagtggct
     4561 tatcttctaa ccttcttctg gcctctagtg cagcagccaa tctttagctc ctgttttaac
     4621 attttcccac ccaaagcggt ttataccgat ccccatatat gtatgcccac tgttgtacat
     4681 ttttggactc ttttttgatg catttgttat cctaacaaac acgaaaacaa aatcaaacaa
     4741 aaacaaggaa aatcacgcaa acaaagaatc aagacgaaac aaaatcaaat ttaaaaaaca
     4801 tggatacacc atttataatc gctcgggaac gctggcggat ccccccaagc ggatgcaggc
     4861 ttccagcgca gttcggatat cgaatggttg ataggaaaac gcattgcgat ttaccgatct
     4921 acataggtac actacaaaaa aaaaaacacc acaaaaaaac aggcgaacat taacaaactg
     4981 aaccaacgga gtaaatgatc aggatcagaa aaggttagtt attaataata ttaatgcagt
     5041 tacagatgcc tgatcattgt ttttaaaacg acatgaaaat cgtatatatt ttctatatat
     5101 tgtcagttaa ttcttcctcc atgcgactct ttgtatcaag aaaatggaac attttgtttg
     5161 aaattcaaaa taaagaattc ccttgcg