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Drosophila melanogaster GTPase activating protein and VPS9 domains


LOCUS       NM_132476               5830 bp    mRNA    linear   INV 26-DEC-2023
            1 (Gapvd1), mRNA.
ACCESSION   NM_132476
VERSION     NM_132476.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5830)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5830)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5830)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5830)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5830)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5830)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5830)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5830)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5830)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5830)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5830)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5830)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5830)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5830)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5830)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5830)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5830)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5830)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5830)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5830)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5830)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5830)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5830)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_132476.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5830
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5830
                     /gene="Gapvd1"
                     /locus_tag="Dmel_CG1657"
                     /gene_synonym="CG1657; Dmel\CG1657; FBpp0073304; GAPVD1"
                     /note="GTPase activating protein and VPS9 domains 1"
                     /map="10B3-10B3"
                     /db_xref="FLYBASE:FBgn0030286"
                     /db_xref="GeneID:32070"
     CDS             149..5287
                     /gene="Gapvd1"
                     /locus_tag="Dmel_CG1657"
                     /gene_synonym="CG1657; Dmel\CG1657; FBpp0073304; GAPVD1"
                     /note="CG1657 gene product from transcript CG1657-RA;
                     CG1657-PA; Gapvd1-PA"
                     /codon_start=1
                     /product="GTPase activating protein and VPS9 domains 1"
                     /protein_id="NP_572704.1"
                     /db_xref="FLYBASE:FBpp0073304"
                     /db_xref="GeneID:32070"
                     /db_xref="FLYBASE:FBgn0030286"
                     /translation="MEPPAAGNLLEIMDLARTLRQEQLFIQQEQAAFAQLTGAFESNA
                     GTITKLAFVCAQQRQILNELLLARTDQDPLLFCRRASAYDSAQFVDAKQLLPYEHALA
                     YEDLFNYLYNTPYLLALSLATADRLSLLSASQLGQIINTIATGLYGNAINTKDVELLL
                     KLLRELIEIQLLTSEQPRRLLRTNSSSFARLYQRLVESLFSARIFLTAALHAPLMGVL
                     SEHEIWLDLDPHKLMQTFTPKEREKRFGREGDEEYQRNVARFHAETLGKLHSHVQEFV
                     KSLQQSWALFPSSLRWLLQTLSQQLRQSLRHEEQEIRQLLTDLVFTHFISPAIASADL
                     LGIIDVNVSERMRHNLNQIVKLLQRLALNDEDSELVQLMELLMLGQTGEDVVAILPQQ
                     SDFERSQLAINQRELAQLVEFFRLLTARDEYDISVEERQRLQRILGRIPKQQVQQQQQ
                     TPKDAPDSRESPEKSKKSNKSLMSLGKAKKKLAKGMSFSSGSSNHNPVPVSEPLTNGQ
                     ANTSNGSGGLGADLEHCSSHSGSNTSLSSCGANMPTTNDPLDMSTSSDPVLVFSLYNA
                     GAKSKLKPLTEEEVLKMNSIGQDGSNLLPAVVTTAPLAPSSNNDDVSSLEAMRRPQDD
                     ASIGNSDNLEAISEAAHSVASSLDLEEQQERDVHENEDNLSDMVSANVSGRGTPNISG
                     RDTPSSQVTDGDGAGGDLGHHHGVHARAAANPQMQKMLLSKARSDIEDKFCKFELKKF
                     EGDENVSIISDTWSTDVLASDSENTLDATVSERGDRDRNFSTPLIPSAVVLPGDNNFV
                     VEALARAGRVSGVHGPQLDASDQRSESNWSTDVLASDSEKLAEIDTDDNVSITTKSDT
                     TAPQAAVLDDDDEDEQTPGSSGDGEPDPDRGNGSERSQEDSAFFDAVNSYEDANLYHG
                     ASSLARSSVRTSYHVLGGESSFQQQYKCSGADSSGRKTTPLMGTSCMRRQTSAESSIS
                     NQSLNLEEPPPPMGKHHHHHREHHHRDYHHHHRERERERERERSALKKKKHQQQEKEH
                     RDLIDFSDCSEDKEELARNRDEEQPPGLVQQLLDMINQDEQTGAVSSSSPNVEHRRIS
                     IEQRSAIIDGRRNGILAGSMRRHQSLNYENHEIMLNSMLPKTDDDKQEMLLCVQTQQL
                     QLEERRGSAGLRPEVDGASGIAAAGGSGLKPPTKATGAIPKSISFDASADKDKQTYHR
                     DGERDRERDRERERDRERDRERDRERDRERDHHGAGIFNKLRQGIFKNRRGASAKNAS
                     NSSNQSNPAASTSSVQADIRSVSFDPSAGCDNFGTHYCDTSEDILAKYRRKVSSSSEA
                     TNSDSTGNGHGVGSTGSVGAAAHLHKHMNGGHIPGVVFGCVKQKLRTVLSRTDLHSGD
                     FRQTSTTSTTMATPLQIYLQIQLAQCISLQRLPQISHVAEALRCLAQLERPQHGQLLA
                     ELQRDLERRQSYLQYLMRHRQQLLLRSEQLEQLEARLRGEARSSQRCLLQALVRMYLA
                     WSRQQEKLEQFQAEFAQLRASDERVELTEEFVESLLQELRSSADLQDEWQVDAARVAI
                     ERMLLEQMYEQVMFPNEDADVSRDEVLSAHIGKLQRFVHPAHPALCIAQEYLGEAPWT
                     FAQQQLCHMAAYKTPREKLQCIINCISSIMSLLRMSSGRVPAADDLLPVLIYVVIMAN
                     PPYLLSTVEYISCFLGKKLEGEDEFYWTLFGSVVKFIKTMDYLD"
     misc_feature    416..1528
                     /gene="Gapvd1"
                     /locus_tag="Dmel_CG1657"
                     /gene_synonym="CG1657; Dmel\CG1657; FBpp0073304; GAPVD1"
                     /note="Ras-GTPase Activating Domain of Rab5-activating
                     protein 6; Region: RasGAP_RAP6; cd05129"
                     /db_xref="CDD:213331"
     misc_feature    order(563..565,680..682,686..688,692..697,713..715,
                     722..724,734..736,1088..1090,1112..1117,1124..1129,
                     1136..1138,1199..1201,1208..1213,1220..1222,1232..1234,
                     1238..1240,1250..1255)
                     /gene="Gapvd1"
                     /locus_tag="Dmel_CG1657"
                     /gene_synonym="CG1657; Dmel\CG1657; FBpp0073304; GAPVD1"
                     /note="putative Rab5 interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:213331"
     misc_feature    <1784..2878
                     /gene="Gapvd1"
                     /locus_tag="Dmel_CG1657"
                     /gene_synonym="CG1657; Dmel\CG1657; FBpp0073304; GAPVD1"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     Region: MSCRAMM_ClfA; NF033609"
                     /db_xref="CDD:468110"
     misc_feature    4382..>4768
                     /gene="Gapvd1"
                     /locus_tag="Dmel_CG1657"
                     /gene_synonym="CG1657; Dmel\CG1657; FBpp0073304; GAPVD1"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; Region: YhaN; COG4717"
                     /db_xref="CDD:443752"
     misc_feature    4973..5275
                     /gene="Gapvd1"
                     /locus_tag="Dmel_CG1657"
                     /gene_synonym="CG1657; Dmel\CG1657; FBpp0073304; GAPVD1"
                     /note="Vacuolar sorting protein 9 (VPS9) domain; Region:
                     VPS9; pfam02204"
                     /db_xref="CDD:460489"
ORIGIN      
        1 attgtttttg ttgttttcct tttgggagac gcgtgtgtgt gttttgcgtg tgataattta
       61 tttattttcc cgttccgttt gtttatgcac tgtaatttag attcagtttt tagcacaggc
      121 gcaggaccag cgaaggctgc acctagccat ggagccccca gctgctggca atctgctgga
      181 gatcatggac ctggcccgca ctctccgcca ggagcagctc ttcatccagc aggagcaggc
      241 ggcctttgcc cagctcactg gagcctttga gagcaatgca gggaccataa ccaagttggc
      301 ctttgtgtgt gcccagcagc ggcagatact caatgagctg ctcctggcgc gcacagatca
      361 ggatccgctg ctcttctgcc gccgagcgag tgcctacgat agtgcccaat tcgtggacgc
      421 caagcagttg ctgccctatg agcacgcctt ggcctacgaa gatctgttca actacttgta
      481 taatacaccc tatttgttgg ccctatccct ggccaccgcg gatcgcttat ccctgctctc
      541 ggccagccag cttggccaaa ttattaatac catagcgacg ggactgtatg gcaatgccat
      601 caataccaag gatgtggaac tgctgcttaa attgctgcgg gaactgattg aaatccaatt
      661 gctgaccagc gaacagccca gacgtttgct gagaaccaat agcagctcct ttgcccgact
      721 gtatcagcga ttggttgaga gtctgttctc ggcgagaatt ttcctaaccg ccgcgctcca
      781 tgcgccgctc atgggtgtgc tgagtgagca cgagatttgg ctggatctgg atccgcacaa
      841 actaatgcag accttcacgc ccaaggagcg ggagaagcgc tttggtcgcg agggtgatga
      901 ggaataccag cgaaatgtgg ctcgctttca tgcggagact ttgggcaagc tgcactccca
      961 tgtccaagag tttgtgaaga gcttgcaaca gagttgggcg ctatttccca gctctcttag
     1021 atggctactc caaacactga gccaacagct ccggcagtcg ttgcgccacg aggagcagga
     1081 gatccgccag ctgctcaccg acctggtgtt cacacacttc atttcaccag ccattgccag
     1141 tgctgatctc ctgggcatca tcgatgttaa tgtgagtgaa cggatgcggc acaatcttaa
     1201 tcagattgtg aaattgcttc agcgactggc actgaacgat gaggatagcg aactggtgca
     1261 gctgatggag ctcttgatgc tgggacagac tggcgaagat gtggtggcca tattgccgca
     1321 acaaagcgac ttcgagcgtt cccaattggc catcaatcaa agggagctgg cacagctcgt
     1381 ggagttcttt cgtttactaa cggccagaga cgaatatgac atatccgtcg aagagaggca
     1441 gcggctgcag aggattctcg gcaggatacc caagcagcag gtgcagcagc aacagcaaac
     1501 acccaaggat gcgccagatt cccgagaaag tccggagaag agcaaaaaaa gcaacaagag
     1561 tctgatgagc ctaggcaaag ccaaaaagaa actggcgaaa ggcatgagtt tcagcagtgg
     1621 cagtagtaac cataatccgg ttccagtctc agagccactg accaatggcc aggccaacac
     1681 ctcgaatggc agcggaggac tgggtgctga tctcgagcac tgttcctcgc acagcggcag
     1741 caacaccagc ttgagttcct gcggagctaa catgccaact acaaatgatc ccctggacat
     1801 gtccacctcg tcggatcccg tgttggtatt cagtctctat aatgcgggag caaaaagtaa
     1861 gctgaaaccg ctgacagagg aggaggtctt gaagatgaac agcatcggtc aggatggcag
     1921 taatctgctg ccagcggtgg tcaccactgc tcctttggcg ccatcttcga acaacgacga
     1981 tgtgagtagt ctggaggcta tgcggcggcc gcaggatgat gcatcgatag gaaattcgga
     2041 taatctggag gctatcagtg aggcggcaca ttcagttgcc agttcgcttg acttggagga
     2101 gcagcaggag cgagatgttc acgaaaacga ggacaatctc tccgatatgg tttcggccaa
     2161 tgtgtcgggc aggggaacac cgaacatcag tggtcgcgat acaccatcat cgcaggtaac
     2221 tgatggtgat ggcgctggcg gggatttggg ccatcatcat ggtgttcacg cccgggcagc
     2281 tgccaatccg caaatgcaaa agatgctgct atccaaggcc agatccgaca tcgaggataa
     2341 gttctgtaaa ttcgaactga agaaattcga gggcgacgag aatgtgagca tcatatccga
     2401 tacatggtcc acggatgtgc tggcctccga ttcggaaaac acattggatg ccacagtgag
     2461 cgaacgtggg gatagggata gaaatttctc cacaccccta ataccctccg ccgtcgtcct
     2521 gcccggcgat aacaatttcg ttgtcgaggc tttggccaga gctggtcgcg tctcgggcgt
     2581 ccatggacca cagttggatg catccgatca gcgatcggag agcaactgga gcactgatgt
     2641 cttggccagc gattcggaga agctggctga aatagacacc gatgacaatg tttccattac
     2701 gaccaaatcg gatacgacgg cgccacaggc agcggtcctc gacgacgacg atgaggatga
     2761 gcagacgccc ggcagcagtg gcgatggtga gcccgatccg gatcggggaa acggcagcga
     2821 gcgtagccag gaggattcgg cctttttcga tgccgtcaac tcgtatgagg atgccaatct
     2881 gtatcatggc gcatcttcgt tagccagaag ctcggtgcgg accagctatc atgttctggg
     2941 cggcgagagc agtttccagc agcagtacaa gtgcagcgga gcagattcca gtggtcgcaa
     3001 gaccaccccg ctgatgggta catcctgcat gcgccgccaa acgtccgcgg agagcagcat
     3061 tagtaatcag agcctgaact tggaggaacc gccaccgccg atgggcaagc atcatcacca
     3121 ccatagagag caccatcatc gcgactacca tcatcatcac cgagagaggg agcgggagcg
     3181 ggagcgggaa cggtcggcac ttaagaagaa gaaacaccag cagcaggaga aggagcatcg
     3241 cgatctaatc gatttcagcg actgcagcga ggacaaagaa gagctggcga ggaataggga
     3301 tgaggagcag ccgcctggct tggtgcaaca actgctggat atgattaacc aggatgaaca
     3361 gaccggcgca gtttcaagtt cctcgcccaa tgtggaacac cgtcgcatct ccatcgaaca
     3421 acgatcggcc atcatagatg gtcgtcgaaa tggcattctg gcgggcagta tgcgccgcca
     3481 tcagagcttg aactacgaga atcacgagat tatgctgaac tccatgttgc ccaaaaccga
     3541 cgatgacaag caggagatgc tactttgtgt gcagacgcag caattgcagc tggaggagcg
     3601 aagaggatcc gccggattga ggccagaggt ggatggagct agcggaatag cagcggctgg
     3661 aggatcgggc ctgaagccac ccaccaaggc gaccggagcc ataccaaaga gcattagttt
     3721 cgacgccagc gcggacaagg acaagcagac gtatcatcgg gacggggaac gggatcgcga
     3781 aagggacagg gaacgggaac gtgatcgaga aagagatcgg gagcgagatc gtgaacggga
     3841 tcgggagcga gatcaccacg gtgctggcat attcaacaag cttaggcagg gtattttcaa
     3901 gaatcgccgc ggagccagcg ccaaaaatgc aagcaactcc agtaaccaat cgaatccggc
     3961 ggccagcact tctagtgtcc aagcggatat tcgcagcgtt agcttcgatc ccagtgccgg
     4021 atgcgataac ttcggcaccc actactgtga tacgagcgag gacatcctgg ccaagtaccg
     4081 ccgcaaggtg agcagctcca gcgaggcaac caactccgat tccacgggca atggccatgg
     4141 cgtagggtcg acgggatccg ttggagcagc tgcccatctg cataagcaca tgaacggagg
     4201 gcatattcct ggcgtggtct ttggctgtgt gaagcagaag ctgcgcacgg tgctttcccg
     4261 gacggatttg cacagtggcg atttccgcca aacctcgacc acatcgacaa cgatggccac
     4321 accgctacag atctacctgc agattcagtt ggcgcagtgc atcagcctgc agcgattacc
     4381 acagatctcg cacgtggccg aggccctgcg ctgtttggcc caattggagc gaccacagca
     4441 tggccagctt ctggccgaac tgcagcggga tctggagcga cgacaaagct acctgcagta
     4501 cctgatgcga cacaggcaac agctcctgct gcgatcggag caattggagc agctggaggc
     4561 gcgattgcgt ggcgaggcgc gcagcagcca gagatgtctg ctgcaagcac tggtccggat
     4621 gtatctggct tggtcccgtc agcaggagaa gctggagcag tttcaagcgg agttcgccca
     4681 gctgcgggcc agcgacgaac gcgtcgagct caccgaggaa tttgtggagt ccctgctgca
     4741 ggagctgcgc tccagtgccg atctacagga cgagtggcag gtggatgctg cacgcgtggc
     4801 catcgagcga atgctgctgg agcagatgta cgagcaggtg atgttcccca acgaggatgc
     4861 cgatgtgtcg cgggacgagg tgctctcggc gcatattggt aaactgcagc gctttgtaca
     4921 tcccgcccac ccggcgctgt gcatcgccca ggagtatttg ggcgaggctc cgtggacgtt
     4981 tgcccagcaa cagctgtgcc acatggccgc ctacaagacg ccacgcgaga agctgcagtg
     5041 catcatcaac tgcatctcga gcatcatgag cctgctgcgc atgtccagtg gtcgggtgcc
     5101 cgcagccgat gatctgctgc ccgtgctcat atacgtagtg ataatggcca atcccccgta
     5161 tctgctatcc accgtggagt atatcagctg ctttctgggc aaaaagctgg agggcgagga
     5221 cgagttctat tggacgctct tcggatccgt ggtcaagttc atcaagacca tggactatct
     5281 agactagcga tatttgttaa gggcttaggc ggatgtatct gtagatttct ttatcgcttt
     5341 gttgtaggca ttacaccaat ctcccatccc actctctcct ccagtcgata ttttccatat
     5401 ttatatatgt atatgtatgt ctgtgtctga tatttgtgta aaaatttgtt aaaaccatag
     5461 tctaagtgca aaaactgcgg cagatgtgcg aagcgatcca agtcaaatcg aagtggaaac
     5521 ggaacaccaa tcagtgggag atgccgatgc tgaagctgaa gtggagatat ctaggttaag
     5581 cttaacattg aacgctagaa ggcctcgcct tacggatatc cacgatatat atatatatat
     5641 atatatatat atataaagtg aactagagag catattcttc tatttatata tacacgtacc
     5701 atacatacat acctagatat atgcatgttt atcggatcgg tctagccact gtcataagta
     5761 tgtttcggaa acgaactgca acttaatatt ccttattgtg taacacaaaa ttaaaagcca
     5821 atattatttc