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LOCUS NM_132346 5407 bp mRNA linear INV 26-DEC-2023 variant D (Hecw), mRNA. ACCESSION NM_132346 VERSION NM_132346.3 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 5407) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 5407) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 5407) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 5407) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 5407) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 5407) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 5407) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 5407) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 5407) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 5407) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 5407) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 5407) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 5407) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 5407) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 5407) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 5407) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 5407) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 5407) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 5407) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 5407) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 5407) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 5407) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 5407) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jan 16, 2013 this sequence version replaced NM_132346.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..5407 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..5407 /gene="Hecw" /locus_tag="Dmel_CG42797" /old_locus_tag="Dmel_CG3003" /old_locus_tag="Dmel_CG3099" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="Hecw ubiquitin protein ligase" /map="8F1-8F2" /db_xref="FLYBASE:FBgn0261931" /db_xref="GeneID:31905" CDS 353..4633 /gene="Hecw" /locus_tag="Dmel_CG42797" /old_locus_tag="Dmel_CG3003" /old_locus_tag="Dmel_CG3099" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="CG42797 gene product from transcript CG42797-RD; CG42797-PD; Hecw-PD" /codon_start=1 /product="hecw ubiquitin protein ligase, isoform D" /protein_id="NP_572574.2" /db_xref="FLYBASE:FBpp0292725" /db_xref="GeneID:31905" /db_xref="FLYBASE:FBgn0261931" /translation="MEPPAAPVPLQPLAASSACLADRSPVDPIAVRLQQEEQAEGDDE EEEEEEEDDDDDPKEEEAFYEARNGNESDELEQAFQSALTLTNDVHVSVSEVEEHEPP LASRNQEVAEVEEQQQQLGACALPQPSEASLTGSKETREPRHHQTLLSTKSCETPANN ATLSPTNSYNGSIGSDGGSSVGGGARRKSWTLSPQSGGSTPLSGAKKKTKTGAPTTTL SNANGDGFNLWVARECFETVPAEMVDTLSMAEVDEEVDEEEDEEAAAVESLLGAAAAL QASAHVQRRQQQQHHQHLRQPSPPQHRPLERSWPPRAVGRDLKLQGDVFQFDILDTDE RLAEEMAQGSGSSNNSPLATPPVRFKPLLKKKIGPDSYINTISTQKVPVHQSYEFPTF PSSSAVGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPP SGCSTRSASPLDISLSPEQHSPTRGRGVGGALQDAVPPGTPTFHGQRPQQRLLKRVGG GAGAGATGGATGSPLVCPPTPTHHARRHARLQAVTANSSLASGGAIPSDPPAVSSQLD YIYLQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTV SGSSGAGAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHH RQQLDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCR PDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSR ELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYY PDLVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAI SCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHT MSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLN SRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSA NKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVS PLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNE FHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLER MIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTE YRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFC IEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE" misc_feature <1583..2038 /gene="Hecw" /locus_tag="Dmel_CG42797" /old_locus_tag="Dmel_CG3003" /old_locus_tag="Dmel_CG3099" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="large tegument protein UL36; Provisional; Region: PHA03247" /db_xref="CDD:223021" misc_feature 2264..2353 /gene="Hecw" /locus_tag="Dmel_CG42797" /old_locus_tag="Dmel_CG3003" /old_locus_tag="Dmel_CG3099" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="WW domain; Region: WW; pfam00397" /db_xref="CDD:459800" misc_feature 2564..2734 /gene="Hecw" /locus_tag="Dmel_CG42797" /old_locus_tag="Dmel_CG3003" /old_locus_tag="Dmel_CG3099" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="Helical box domain of E3 ubiquitin-protein ligase HECW1; Region: HECW1_helix; pfam18436" /db_xref="CDD:465766" misc_feature 3554..4624 /gene="Hecw" /locus_tag="Dmel_CG42797" /old_locus_tag="Dmel_CG3003" /old_locus_tag="Dmel_CG3099" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; Region: HECTc; cd00078" /db_xref="CDD:238033" misc_feature order(3572..3574,3665..3667,3698..3700,3881..3883, 4409..4411,4514..4519,4526..4540,4598..4600,4619..4621) /gene="Hecw" /locus_tag="Dmel_CG42797" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="catalytic cleft [active]" /db_xref="CDD:238033" misc_feature order(3965..3967,3974..3979,3983..3988,3995..3997, 4019..4021,4025..4027,4037..4039,4043..4045,4061..4063, 4076..4078,4127..4129,4139..4141) /gene="Hecw" /locus_tag="Dmel_CG42797" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="E2 interaction site [active]" /db_xref="CDD:238033" ORIGIN 1 ccattgacat ctggtcacat tgcactagac ccgaaatata tattttattt agcttttgca 61 atatccttaa attaacaatt gatcaactaa agccacggcc ttgcgggcag tgagcacagc 121 acagcacggc ccagaactgg actcaatggc tggaggacgc gaaatgctcc ggtcggaagg 181 cagcaaacat cagaacgcca aagtagagca actgcagctg taactgtaac tgttaaccct 241 gggttggtcg cgggggcggg gtggcagtgg tggttgtgga ccaggaagag gaagagcaag 301 ggtgctggga aagaggaaga gcacatcttg aggccaggag gcaaacgagc caatggagcc 361 accagctgca ccggtacccc tacagccact ggcagcatct tccgcctgcc tggcggacag 421 gagtccagtg gatcccattg cagtcagact gcagcaggag gagcaggcag aaggagatga 481 cgaggaggag gaggaggaag aggaggacga tgatgatgat cccaaagaag aggaggcctt 541 ctacgaggcg cgcaacggca acgaaagtga cgagctggaa caggccttcc agagtgccct 601 taccctgacc aacgatgtcc atgtgagtgt cagcgaagtg gaggaacatg aaccgccctt 661 ggcatcgaga aatcaggagg tggcagaggt ggaggagcag cagcagcagc tgggggcctg 721 cgcactgccg cagcccagcg aagcctctct tacaggctca aaggagacca gggaaccgcg 781 ccaccaccag acgctgcttt ccaccaaatc ttgcgagacg ccggccaata atgccacgct 841 ctcgccgacc aactcctaca atggcagcat tggcagcgac ggcggcagca gtgtgggcgg 901 tggcgcccgc cgcaagtcct ggaccctgtc gccgcaaagc ggtggctcca cgcccctgag 961 cggagccaag aagaagacca agacgggtgc gccaaccaca acactgtcca atgctaatgg 1021 cgacggtttt aatctgtggg tggcacgtga gtgcttcgaa acagtgcccg ctgaaatggt 1081 ggatactctg agcatggctg aagtggacga ggaggtggat gaggaggagg acgaggaggc 1141 ggctgccgtg gagagtcttc tgggagccgc tgctgccctc caggccagtg cccatgtgca 1201 gcgccgtcag cagcagcagc atcaccagca tcttcgccag ccctcgccac cacagcatcg 1261 tccgctggaa cgatcttggc cgccgcgtgc cgttggtcgg gatctgaagc ttcagggcga 1321 tgtctttcag ttcgacatcc tggacacgga cgagcgactg gccgaggaga tggcacaggg 1381 cagtgggagt tcgaataatt cacccctggc cacgccgcct gtgcgcttta agccgctgct 1441 gaagaaaaag attggacccg atagctacat caacacaatt agcacacaaa aggtgccggt 1501 ccaccagagc tatgagttcc ccacctttcc aagttcctcg gcagttggat cgtcatcttc 1561 gtcgccgaat agtctgcaat ttccgtatct gcgccagcac cgtccgctca cccgtgccct 1621 ttccaatggc aaggccagtt catcggagga gcaagcctcc ccacgccttc tgctctcacc 1681 aaaacgtccg cgaagtcctc cttccggttg ttccacgcgc agtgcctctc cattggatat 1741 cagcctgagt ccagagcagc actcgcccac cagaggcaga ggagtgggtg gtgctctgca 1801 ggatgcggtg ccgcccggaa ctccaacatt ccatggtcag cgaccgcagc agcggctgct 1861 caaacgtgta ggcggtggag caggagctgg tgctacggga ggcgcaaccg gctcgccatt 1921 ggtatgtcca ccaacgccta ctcaccatgc ccgtcggcat gcccgcctcc aagccgtcac 1981 tgccaattcc agcctcgcca gcggaggagc gatcccctcg gatccgccag ccgtctctag 2041 tcaattggat tacatatatc tgcaagatgg tggccaggag cagggtcagg agcagtcaga 2101 cgaagttgtg cacataagca gcacccgcct gccctccatt ccagaacgca gtgcagccgc 2161 agcagcggcg gcggcggcag cagcagctgg agccgctctc atggaacccg gaacgggtac 2221 ggtatccggg tctagtggag ctggagccgc tggagagcca ccattgccgc ctgcttggga 2281 ggcgcgtatg gacagccacg gacgcatctt ctacatcgat cacacaacgc gaacaacctc 2341 atggcaacga ccaggagcgg cgccaagtgg aggaccagca ggcagagagc aacatcatcg 2401 ccagcagctg gataggcggt atcaaagcat ccgacgcacc attaccaatg agagtagagc 2461 tgcgcagctt tacaacctgc caacctcggc gaatagtaat gccaattcca cagctccagc 2521 tgctcctccg cccgccacgg ctatacatcc agccatcctg atgctctgcc gcccggattt 2581 ctactcccta ctgcacacca acgaagctgc actggccatc tacaatcgca atgccgcact 2641 aaagcacatg gtcatgcgca tccgacgcga tccgccgtgc ttccagcggt atcagtacaa 2701 caaggatctg gtggcgctgg ttaacacatt cgcccagatg agcagggaac tgccctcgtg 2761 ctgggagacc aagctggatc aatcgggcaa gcagttcttt attgatcacc agcatcgtcg 2821 cacctcattc atggatcctc gtctgccggt ggagtgtcct cgtgtggtac gccatcgcca 2881 gcagcattcg cagcaacagt ccagtgtggg ctactactat ccggatctgg tggatggcaa 2941 ctgcctgtcc gccaccagtg ggcatattaa cgccagtcca gcatcatcgg tctccggtgt 3001 accgccctta cctccaccga gaccctcatc gtcgtcctcc tcgtccagaa gtagccatgg 3061 acatggccac aactgcaaca caacgtcagc catctcctgt gccctcaacg ccgaccgttc 3121 ggcgtatggt gccgctggaa tggccagcgc tggagccact gcagccgggt acgaagatgt 3181 gcccatcgcc tacaacgaaa aggtcattgc cttcctgcgc cagccgaaca tcctggagat 3241 cctgcgagag cgccagggcc agcacacaat gtcccgccag ttgcgtgaga aaatcaatat 3301 actgcgagtg gagggtgttc ccgcactcga aagattgggc catgacctac aactgaccat 3361 tttgctgagc ctgttcgagc aggagatcat gggctttgtt cctattgaag agcgcagtcc 3421 gcagggatcg ccggtcctca actcccggat gccacagcgt gcgccgccac catttcgcag 3481 agatttcgag gccaaactgc gcagtttcta tcgcaaacta gagtccaagg gctacggaca 3541 aggaccacac aagcttaaac tgcacattcg tcgcagccat ttgctggagg acgccttccg 3601 gcgcatcatg tccgccaaca agaaggacct gcaacgcggc cgactcgccg tgctctggga 3661 tacggaggag ggcctggact atggcggacc atcacgcgag ttcttcttcc tactttcgcg 3721 cgaactgttt aatccgtact acggactgtt cgagtactca gccaacgata cgtacaccgt 3781 gcaggtgtca ccattgtcgg cgttcgtgga taattgccac gattggttcc gctttagtgg 3841 acgagttttg ggattggcac tggtacatca gtatctactg gacgcattct ttacgcgtcc 3901 cttttacaag gcgctgctgc gcctgcccgt ggctctcagt gatttggagt cgctggacaa 3961 tgagttccat cagtcgctcc aatggatacg cgacaatgac atcggcacgg gcgtggatct 4021 tggcctaacg ttctgtgtca cagaggagct gcttggcagt gtggtggaca gggaactgaa 4081 gcccggtggc aagaatatca tcatcaacga gaagaacaaa aaggagtact tggagcgcat 4141 gattaagtgg cgtctggagc gcggtgttca ggagcagacc gagtcgctgg tgcgcggctt 4201 ttacgaggtg atcgactcgc gcctcgtttc cgtctttgat gcccgagagt tggagctggt 4261 tattgccggc actgcagaaa tagacacaaa cgattggcgc ctgaacacag agtatcgttc 4321 tggttaccat gataaccacc aggtgatcgt ttggttctgg caggttatcg agcgctttag 4381 caacgagcag cgtcttcgtc tgcttcagtt cgtgactggc acgtcgagca taccgtacga 4441 aggattctcg gcattacgcg gatcgactgg cccgaggcgt ttctgcatcg agaagtgggg 4501 caagccaaat gcactgcccc gtgcccacac atgcttcaat cggctggatt tgccgccgta 4561 tccaacaccc gaactgctgt acgagaagct gctgctggcc gtcgaggaga ccaacacgtt 4621 cggcattgag tagacacgtg atattgcacc cacatacaca tacacaaaca aaaacacata 4681 cacatacaca tacagataca caaaacacgc gcctaaacgc tttatttcga ttttagaagt 4741 ttttataact tgcctaagtc tagaaattcg cgagctatgc agaaatccta gggatttgga 4801 cacaacaagt tgcagttttt attgaatagc aatgcattct ttgtaaatta gttttaaagt 4861 tcaatttaat tttttcttct taatatgaac cgttattggt tatattagtt tgcgatgatt 4921 attcttaaaa atagaacttg ttacgattaa atttaggtaa acgagttagt taatacttcg 4981 aatttgttag ctatttttag gcacctaaat gctattaaaa tccactggga tttctgcaac 5041 cctcataatt gtactgtagt tatttatata cgtaggtggt cccccttccg aaaatgaaca 5101 aaattgtaaa gcaaataaat gcctagccat agacagactt gctactttag gcatggcatc 5161 ccactagttt gtagacaatt tgccttcgcc ttcgtttgcc gttcattgaa tggaagttac 5221 ctcaagagca aaacggcttg ccagcgccgc cagtcattag tcctaagatc tacacgcccc 5281 cggataattt ctaagcctaa gtatccttcg cttgactctg cctgatttac actcgaaacg 5341 ttgccaactg ccctctagag aaaattacga cgcgtaaacg ctgttccaga tccagttcag 5401 cagtttc