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Drosophila melanogaster nostrin, transcript variant D (Nost), mRNA.


LOCUS       NM_132287               2735 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_132287
VERSION     NM_132287.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 2735)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2735)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2735)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 2735)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 2735)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 2735)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 2735)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 2735)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 2735)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 2735)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 2735)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 2735)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 2735)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 2735)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 2735)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 2735)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 2735)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 2735)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 2735)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 2735)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 2735)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 2735)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 2735)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 31, 2011 this sequence version replaced NM_132287.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2735
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..2735
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /old_locus_tag="CG4040"
                     /old_locus_tag="Dmel_CG15364"
                     /old_locus_tag="Dmel_CG33224"
                     /old_locus_tag="Dmel_CG4040"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="Nostrin"
                     /map="8C3-8C4"
                     /db_xref="FLYBASE:FBgn0259734"
                     /db_xref="GeneID:8673992"
     CDS             666..2693
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /old_locus_tag="CG4040"
                     /old_locus_tag="Dmel_CG15364"
                     /old_locus_tag="Dmel_CG33224"
                     /old_locus_tag="Dmel_CG4040"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="CG42388 gene product from transcript CG42388-RD;
                     CG42388-PD; Nost-PD; nostrin"
                     /codon_start=1
                     /product="nostrin, isoform D"
                     /protein_id="NP_572515.2"
                     /db_xref="FLYBASE:FBpp0292037"
                     /db_xref="GeneID:8673992"
                     /db_xref="FLYBASE:FBgn0259734"
                     /translation="MSQFRDNSWGQNGFEELRRYVKQGGDFSKELIFVLQERADSELI
                     YSKSLSKLANKLNKAGREIPGSVADAWRGVATEMESRSDIHRQLAASLTDELVKPLKI
                     VVEGHHKARKAVESNVDKAARVLGEWRASEAKAKKASHTAARENEKLQDAMLDVRIQK
                     SPSIALLHQGPNKQAAEKELKSAEKDCVKLDNKRKKAEEAVKRADVEYYTLCVRSERA
                     RVDWEMAVLRGSAQLQSSEQQRLGNMHNFAQQYARLISDMNPILGGLSTRLQPQLDAC
                     NVAKDMQVVRHIRRNSEGPSEQLLPDFYCEHTTLAMNRERRKHALIKLLQLVKTDLER
                     ERRSRDGLRGLSQSLNHQEHQNITDKLYHIRSMLTYLEGARLKLHSALLELDHKPRAT
                     HPLAQHIHITRDRTGLQQSILKVPNWLKNNDKSQTQQSTSMLAHDITDITTNHEDELP
                     DENCSHLHSSSHSNNNSNGSCTDVSSVVKPFNRSKSNIETNFTSQPKIISTTNAAIAV
                     SVKSKTLANLQDGHHNNQQHHHHHHNHHSDRGQADGGSNQQDSDFDEFSSQDEDDEPQ
                     QPQQQPQPLQSQQQQQQPLLQNPTINGQVQTQHFYQNAQELQKGQKNGSVPILGRCKA
                     LYSYTPKLYDELELSPGDIIEVHAKQDDGWWLGALRNHIGIFPATYVEECA"
     misc_feature    690..1424
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /old_locus_tag="CG4040"
                     /old_locus_tag="Dmel_CG15364"
                     /old_locus_tag="Dmel_CG33224"
                     /old_locus_tag="Dmel_CG4040"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="The F-BAR (FES-CIP4 Homology and
                     Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase
                     TRaffic INducer (NOSTRIN); Region: F-BAR_NOSTRIN; cd07658"
                     /db_xref="CDD:153342"
     misc_feature    order(702..704,711..713,732..734,741..746,753..755,
                     762..767,774..779,786..788,798..800,807..809,819..821,
                     894..896,903..905,1224..1226,1236..1238,1311..1313,
                     1323..1325,1332..1334,1341..1346,1353..1355,1365..1367,
                     1374..1376,1386..1388,1398..1400,1407..1412,1419..1421)
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:153342"
     misc_feature    2526..2684
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /old_locus_tag="CG4040"
                     /old_locus_tag="Dmel_CG15364"
                     /old_locus_tag="Dmel_CG33224"
                     /old_locus_tag="Dmel_CG4040"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="Src homology 3 domain of Nitric Oxide Synthase
                     TRaffic INducer; Region: SH3_Nostrin; cd11823"
                     /db_xref="CDD:212757"
     misc_feature    order(2541..2543,2547..2549,2556..2558,2568..2570,
                     2622..2627,2664..2666,2670..2675)
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212757"
ORIGIN      
        1 ctcgtttagt tcgccgtttc gtagaagagc gacgagagcg catgcggctt ttccagcgcg
       61 gtttttccac caaaacttcg gcgacctgtg tactattatt tatattttta ttacattttt
      121 ttttattgtt ttttctttct acctgcgaac gctttgctcg ccttgaactg gagtgcttcg
      181 tttttgagta gtgcatctct gccttttgct ggcgagtgct acaattgtcg cacgtaatcg
      241 tgctggcagt tacgcctcag aaagcagcca aaaaaaaaag aaaaaaaaac gcagatacaa
      301 gatacaaaag tatctcgaac acatgcgtta cgctcagctg actcgtcgtg tgtgtgagtg
      361 tatcgtagtg tcgttgtgtg tgtgtgctaa caaattggtt agataaatta aacaaaaact
      421 gtgaaattcg cgaatcaaaa aaaaaaaaaa aacaaaagta aaataaaagt tacacaaacg
      481 aaatacgcga aggaaaagcg acgagctgaa actgaaagca aacaatcagc cgggctgacc
      541 agtagtaaat gctttaaact tcaattataa aatttaaatt gaaaaaaata aaaaaaacac
      601 atatagttca caataccgca tcataatatc ctacccgcat cctaaccccc gccgctggcc
      661 aaaatatgtc acaattccgc gataattcat ggggacagaa cggcttcgag gaactccggc
      721 gatatgtgaa gcagggcggt gattttagca aggagctcat ctttgtcctg caggagagag
      781 ccgattcgga gctgatctac tccaagtcgc tatcgaaact ggccaacaag ctgaacaaag
      841 cgggcaggga aattcccggg agcgtggccg acgcctggcg tggagtggct acggagatgg
      901 agagccgcag cgacatccat cgccagttgg cagcctcgct aacggatgag ctggtcaagc
      961 cgctcaagat cgtcgtcgaa ggacatcaca aggcgcgcaa ggcggtggaa agcaacgtgg
     1021 acaaggcggc gcgagtactg ggcgaatggc gagccagcga ggcgaaagcc aagaaggcct
     1081 cccatacggc ggcgcgcgag aacgagaagc tgcaggacgc aatgctggac gtgcgcatcc
     1141 agaagtcacc atcgattgcc ctgctccacc agggacccaa caagcaggcc gcagaaaagg
     1201 agctcaagtc agcggagaag gattgcgtca agctggataa caagcgcaag aaggccgagg
     1261 aggcggtgaa gcgtgcggat gtggaatact acaccctgtg cgtgcgttcg gagcgagcac
     1321 gcgtagactg ggagatggcc gtgctccggg gaagtgccca actgcagagc agcgaacagc
     1381 agcggctggg caatatgcac aactttgccc agcagtatgc acgcctcatc tcggacatga
     1441 atccgatact cggtggcctg agcacacgcc tgcagccgca actcgatgct tgcaatgtgg
     1501 ctaaggatat gcaagtggtg cgccacatcc gccgcaattc ggagggaccc agtgagcaac
     1561 tcctaccgga cttttactgc gaacacacca cgctggccat gaatcgggag cgtcgcaagc
     1621 acgctctgat caagctgctg cagctggtca agacggatct ggagcgggag cgacgatccc
     1681 gcgacggatt gaggggactg tcgcaatcgc ttaaccatca ggagcatcag aacatcaccg
     1741 ataagctgta ccacattcgt tccatgctga cctatttgga gggcgcccgt ctcaagctgc
     1801 actctgccct cttggagctg gaccacaagc ccagagccac tcacccactg gcccagcaca
     1861 ttcatatcac ccgtgaccgc actggtttgc agcagagcat cctgaaggtg cccaactggc
     1921 tgaagaacaa cgacaagtcg cagacgcagc aatcgaccag tatgctggcc cacgacatca
     1981 ccgacataac cactaaccac gaggatgagc ttcccgacga gaactgctcc cacctgcaca
     2041 gcagtagcca tagcaacaat aatagcaacg gctcctgcac agatgtcagt tcggtggtga
     2101 agccttttaa ccgaagcaaa agcaacatcg agaccaattt caccagtcaa ccaaagataa
     2161 tctcgacgac aaatgccgcg attgccgtgt ccgttaagtc caaaaccctg gccaatctgc
     2221 aggatggcca tcacaataac caacagcacc atcatcatca tcataatcat cacagcgatc
     2281 gcggccaggc ggatggtgga tccaatcagc aggactctga tttcgatgag ttcagctcgc
     2341 aggacgagga cgacgagccg cagcagccgc agcaacaacc gcagccgttg caatcgcagc
     2401 agcagcaaca gcagccgttg ctgcaaaatc caaccatcaa tggccaagtg cagacgcagc
     2461 atttctatca gaatgcgcag gaactgcaga agggccaaaa gaacggatcc gttccgatac
     2521 tgggacgctg caaggcactg tatagctaca ccccgaagct ctacgacgag ctggaactga
     2581 gtcccggcga catcatcgag gtgcatgcca aacaggacga cggctggtgg ctgggcgccc
     2641 tgcgcaatca catcggcatc tttccggcca cctatgtgga ggagtgcgcc tagttctagt
     2701 tgggaaacgc cctgccagct tccctccata gctat