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Drosophila melanogaster chromatin assembly factor 1, p180 subunit


LOCUS       NM_132267               4043 bp    mRNA    linear   INV 26-DEC-2023
            (Caf1-180), mRNA.
ACCESSION   NM_132267
VERSION     NM_132267.5
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4043)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4043)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4043)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4043)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4043)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4043)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4043)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4043)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4043)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4043)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4043)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4043)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4043)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4043)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4043)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4043)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4043)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4043)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4043)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4043)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4043)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4043)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4043)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_132267.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4043
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4043
                     /gene="Caf1-180"
                     /locus_tag="Dmel_CG12109"
                     /gene_synonym="CAF-1 p180; Caf-180; Caf1; caf1-180;
                     CAF1-180; CAF1-p180; CAF1p180; CG12109; dCAF-1-180;
                     dCAF-1-p180; Dmel\CG12109; NURF; p180; P180"
                     /note="Chromatin assembly factor 1, p180 subunit"
                     /map="7F8-7F8"
                     /db_xref="FLYBASE:FBgn0030054"
                     /db_xref="GeneID:31801"
     CDS             117..3668
                     /gene="Caf1-180"
                     /locus_tag="Dmel_CG12109"
                     /gene_synonym="CAF-1 p180; Caf-180; Caf1; caf1-180;
                     CAF1-180; CAF1-p180; CAF1p180; CG12109; dCAF-1-180;
                     dCAF-1-p180; Dmel\CG12109; NURF; p180; P180"
                     /note="CG12109 gene product from transcript CG12109-RB;
                     CG12109-PB; Caf1-180-PB; CAF-1 large subunit; CAF1 large
                     subunit; large subunit of CAF-1"
                     /codon_start=1
                     /product="chromatin assembly factor 1, p180 subunit"
                     /protein_id="NP_572495.1"
                     /db_xref="FLYBASE:FBpp0071172"
                     /db_xref="GeneID:31801"
                     /db_xref="FLYBASE:FBgn0030054"
                     /translation="MHAGVVKTPLSGRKKDAAVPAKSAEKTASGGKKFVQTRLPFKLL
                     TPGGGAVPTSSSSSSSPATIGSGPVTVILDEDDPAPRKRKLSYDDESPSEGTGCSTGQ
                     LRRSTSKENLDLASSIATKKVKTTDSVVEDVIELDEDEADKEIEDQDQLVEAKSSKEV
                     KLKPKKSEGKKGSPAPIQIKLPLVNKRSKRRKSLKKSEEPLETSTADVAKGDSESSDD
                     IEIIAEELNPQKRQKVQTPREKSPENSSTSGKHTEEVMQKNGKDSKKQEESMKAVKES
                     KKEEPKTAEQNKKNDQATIDLFMGKKMETNKKDKPEVKTTAKDNKKDPLIAEDSKPKE
                     VPKKETSKTGGKGKKEGAKPAEKSKKEEKEDSTTKSKKEKADSPANNQKEQQIGVKKK
                     TSEPEDASNSHKSVTAKKDSKKDEASTQVKSDNESPEAAEISMILSTSEANSSSSEHE
                     MDADTDTAATDRPSAQKETRLNRKSLPEVTGAPKGLTPKQQRLMEQRKKAREEKEQKL
                     AEERRLKQQDKEHREQQKKQERDEKEQQRKLERDQKEQQRKMEKEEKERKRQAEVDSK
                     NEEKRKRNEAKEEVQRKKDEERRKKEQEREEAEQKKKRAAESFSKFFVPKQPKCGSGS
                     NNTSYLEHEQSSCDSSKASSQTLAFRPFQIKDDMLLAPIVRNSLGQEQRSQLDGLFRH
                     RDEEADDEEEEEEQDIVRRKPPNRANLYLSELSSGRRKPLKMQRDVKLQRRTKDEEDD
                     DDVQVIDYLSPAGLPIEVEQPKQLTRMKAKYLHFADNRRPPYYGTWRKKSSSISARRP
                     LAQDKVLFDYEVDSDCEWEEEEPGESLSASEDEKEKESEEESEEEYNEWYVPHGHLSD
                     EELQNDGDGMEDGHTREAQKAKLQVLQQEFAQEMKKQTKKIKARLLGPVWLDENGNKS
                     ELFPAIFAHTIDMYACWQVEPLSLEPPPEPERQDQTPEQPVPLQLDDRLMQQLVRLTH
                     GNRNSKTFLINEYLEYLKTQATAEANQTTLPSKAVLREKFDELASWKTVELSTPEAAA
                     ASANSAKKGRKPKKRLCWVVASDMLEKFQLPDLQLQNQWNYTLTPKVSDGPDAAQQEQ
                     SPPADAVPAASPASNQTTNSAPTTPISGQTQAGQGVKKRATLIMSVPRDQPIPSATKN
                     KLISQFLQRQSDASKPKEKMQEKPPPIVFDDVVMLSD"
     misc_feature    <507..1925
                     /gene="Caf1-180"
                     /locus_tag="Dmel_CG12109"
                     /gene_synonym="CAF-1 p180; Caf-180; Caf1; caf1-180;
                     CAF1-180; CAF1-p180; CAF1p180; CG12109; dCAF-1-180;
                     dCAF-1-p180; Dmel\CG12109; NURF; p180; P180"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    2424..>2555
                     /gene="Caf1-180"
                     /locus_tag="Dmel_CG12109"
                     /gene_synonym="CAF-1 p180; Caf-180; Caf1; caf1-180;
                     CAF1-180; CAF1-p180; CAF1p180; CG12109; dCAF-1-180;
                     dCAF-1-p180; Dmel\CG12109; NURF; p180; P180"
                     /note="Chromatin assembly factor 1 subunit A; Region:
                     CAF1A; pfam12253"
                     /db_xref="CDD:463507"
     misc_feature    2955..>3497
                     /gene="Caf1-180"
                     /locus_tag="Dmel_CG12109"
                     /gene_synonym="CAF-1 p180; Caf-180; Caf1; caf1-180;
                     CAF1-180; CAF1-p180; CAF1p180; CG12109; dCAF-1-180;
                     dCAF-1-p180; Dmel\CG12109; NURF; p180; P180"
                     /note="CAF1 complex subunit p150, region binding to
                     CAF1-p60 at C-term; Region: CAF1-p150_C2; pfam15539"
                     /db_xref="CDD:434777"
ORIGIN      
        1 ccatcgctag tgtgttttca ccgccttttt tattaagcga ataacaagtg aagatttgct
       61 gggggaaaac aggagccgca ggaaacagga aacaggcaga cagagagtac agcagaatgc
      121 acgctggcgt tgttaagacg ccgctcagcg gcaggaaaaa agatgcggct gtgccggcca
      181 aatcagcgga aaagacggcc agcggtggca agaagttcgt gcagacgcgt ttgcccttta
      241 agttattaac gccaggcggt ggggcggtgc ccacatcctc ctcctcctca tcgtcccccg
      301 ccactatcgg ctctggcccc gtcactgtaa tcctggatga ggacgatccc gctccgcgca
      361 agcgaaaact ttcgtacgac gatgagtcgc catcggaggg cactggctgc tctacggggc
      421 aactgcgacg ttcgaccagc aaggagaatc tggatctggc cagttccata gccactaaaa
      481 aggtcaagac cacggattcg gtagtggaag atgtcataga actggatgag gacgaggccg
      541 acaaggagat agaggaccag gatcagttgg tagaggccaa gtcctccaag gaggtcaagt
      601 tgaagcccaa gaagtcggag ggcaagaaag gctcgccggc acccatacaa atcaagctgc
      661 cattggtcaa caaacgatca aagcgcagaa aatccctgaa gaaatctgag gaaccgctgg
      721 agacttcgac cgcggatgtt gccaaggggg acagcgagtc cagcgatgac atagagatta
      781 tcgccgaaga actgaacccc cagaagaggc aaaaagtaca aacgccgcgt gagaaatccc
      841 cagaaaacag ctctacaagc ggcaagcaca cggaggaggt catgcagaag aatggaaagg
      901 actcaaagaa gcaggaggag tccatgaagg cggtcaagga gtcgaagaag gaagagccaa
      961 agaccgcaga acaaaataaa aagaacgatc aggccacaat agatctcttt atgggaaaga
     1021 aaatggaaac taataagaag gataaaccgg aggtcaagac cacagctaaa gacaacaaga
     1081 aagatccact gattgcagag gattccaaac caaaagaagt ccctaagaag gaaacaagca
     1141 aaaccggagg aaaaggcaag aaggagggag caaaaccagc tgaaaagagt aagaaagaag
     1201 agaaggaaga cagcacaaca aagtcaaaga aagagaaagc agactcacct gcaaataatc
     1261 aaaaagaaca acaaattgga gtcaagaaaa agacttctga accagaagat gcatcgaact
     1321 cacacaaatc ggtgacggcc aaaaaggatt ccaagaaaga cgaggcatct actcaagtta
     1381 agtcggacaa cgaatctccg gaagcagcag aaatctcgat gatcctctcg accagcgagg
     1441 ccaacagttc cagcagcgag cacgagatgg atgcggatac ggacaccgcg gccaccgaca
     1501 gaccctccgc ccaaaaggag actcgcctga acaggaagag tctgccggaa gtaaccggcg
     1561 ccccgaaggg tcttacgccc aaacagcaac gactcatgga gcaaaggaaa aaggctcgcg
     1621 aggagaagga acaaaagctg gcggaggagc gtcgcctcaa gcaacaggat aaggagcacc
     1681 gcgagcagca aaagaaacag gagcgcgacg aaaaggaaca gcagcggaag ctggagaggg
     1741 atcagaagga gcagcagagg aagatggaaa aggaggagaa ggagcgcaag cgacaggcgg
     1801 aggtggactc caagaacgag gagaagcgca agcgcaacga ggccaaggag gaggtgcaac
     1861 gcaaaaagga cgaggagcgt cgcaagaagg agcaggagcg tgaggaggcc gagcaaaaga
     1921 agaagcgcgc cgccgagtcc ttctccaagt tcttcgtgcc caagcagccc aagtgcggca
     1981 gcggatccaa caacacatcc tacctggagc acgagcaaag cagctgcgac agctccaagg
     2041 ccagcagcca aacgctggcc tttcgaccat ttcagatcaa ggacgacatg ctgctagcac
     2101 cgatcgtgcg caactcgctc ggccaggagc agcgctccca gctagatgga ctttttcgac
     2161 accgggacga ggaagctgac gacgaggagg aagaggagga gcaggacatc gtcagacgaa
     2221 agccgccgaa tcgggctaat ctctatctta gtgagttgag cagcggacgg cgcaagccgc
     2281 tcaagatgca gcgcgatgtg aagctccaaa gacgcaccaa ggacgaggag gatgatgacg
     2341 atgttcaagt gatagattac ctttcaccgg cgggtctgcc catcgaggtg gagcagccca
     2401 agcagctgac ccgaatgaag gccaagtatc tgcatttcgc cgacaaccgg aggccaccgt
     2461 actacggcac ctggcgtaaa aagagcagca gcatctccgc ccgacgcccg ctggcacagg
     2521 ataaggtgct cttcgactac gaagtggact ccgattgcga gtgggaggag gaggagccgg
     2581 gggaatcgtt gagcgctagc gaggacgaga aagagaagga gtccgaggag gaatcggaag
     2641 aggagtacaa cgagtggtac gtgccgcacg gacatctcag cgacgaggaa ctgcaaaacg
     2701 acggcgacgg aatggaagac ggccacacgc gggaggcgca gaaggccaaa ctccaggtgc
     2761 tgcagcagga gttcgctcag gaaatgaaga agcagacgaa aaagatcaag gcgcgcctgt
     2821 tgggtcccgt ttggctggac gagaacggca acaagtccga gctattccca gctatctttg
     2881 cccacaccat cgacatgtac gcctgttggc aggtggagcc actcagccta gagcctccgc
     2941 cagaaccgga gcgtcaggat cagacgccag agcagccggt gccgctgcag ctggacgatc
     3001 gtctcatgca gcagctggtg cgccttaccc acggcaatcg gaactcgaag acgttcctga
     3061 tcaacgaata tttagagtac ctgaaaaccc aagcgaccgc cgaggccaat caaacaacgc
     3121 tgccctcaaa ggctgtgctg cgcgagaaat tcgacgagct tgccagctgg aagaccgtgg
     3181 agctgagcac acccgaagcc gctgccgcca gtgccaacag cgccaaaaag ggcaggaaac
     3241 cgaagaagcg cctctgctgg gtggtcgcca gcgatatgct ggaaaagttc cagctgccgg
     3301 atctccagtt gcagaatcaa tggaactaca cgttgacgcc caaggttagc gacggaccag
     3361 atgcagcgca gcaagagcaa agtccaccag cggatgcggt accagccgcc tcgcccgctt
     3421 ccaaccagac cacaaactcg gcacccacaa cgcccatcag tggacagacg caggcgggtc
     3481 agggcgtcaa gaagcgggcc accctgatca tgtccgtgcc cagggatcag ccgattccct
     3541 cggccaccaa gaacaagctg attagccagt ttctgcaacg ccagagcgat gccagcaaac
     3601 ccaaggagaa gatgcaggag aagccaccgc ccattgtctt cgatgatgtg gtgatgctct
     3661 cggattaaga ctaggattaa gctagatccc ctaaggatct tccgcttcct gctaagcgag
     3721 tattttaaga atacacattt tttttgtcgc tagtttcact cgtaagttga tttaatttta
     3781 aatgttccga tgtacgttcg acttgtatgt ccttctcagc caacccatcc ccaccagggt
     3841 cacccctgcc ccaaccagca tcccacccac tcgatcgcaa agtttttaag aagttgagca
     3901 acagaagctc gcaggattgc aattttcatt gagccaacta aacatatata gtatatatgc
     3961 aataatacac tacctacctg atgatgatct ttcatttgat ggcgattttg ggttcgcatt
     4021 ggaaatatat agacacaata cat