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Drosophila melanogaster topoisomerase related function 4-1,


LOCUS       NM_132262               4238 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant I (Trf4-1), mRNA.
ACCESSION   NM_132262
VERSION     NM_132262.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4238)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4238)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4238)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4238)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4238)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4238)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4238)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4238)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4238)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4238)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4238)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4238)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4238)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4238)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4238)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4238)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4238)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4238)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4238)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4238)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4238)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4238)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4238)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_132262.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4238
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4238
                     /gene="Trf4-1"
                     /locus_tag="Dmel_CG11265"
                     /gene_synonym="AAF46390; CG11265; Dmel\CG11265; DmTRF4-1;
                     dTrf4-1; Trf4"
                     /note="Topoisomerase related function 4-1"
                     /map="7F4-7F4"
                     /db_xref="FLYBASE:FBgn0030049"
                     /db_xref="GeneID:31795"
     CDS             551..3556
                     /gene="Trf4-1"
                     /locus_tag="Dmel_CG11265"
                     /gene_synonym="AAF46390; CG11265; Dmel\CG11265; DmTRF4-1;
                     dTrf4-1; Trf4"
                     /EC_number="2.7.7.-"
                     /EC_number="2.7.7.19"
                     /note="CG11265 gene product from transcript CG11265-RI;
                     CG11265-PI; Trf4-1-PI"
                     /codon_start=1
                     /product="topoisomerase related function 4-1, isoform I"
                     /protein_id="NP_572490.2"
                     /db_xref="FLYBASE:FBpp0304113"
                     /db_xref="GeneID:31795"
                     /db_xref="FLYBASE:FBgn0030049"
                     /translation="MDPFVGWFQKEQEGPSLCTWLKIWETNAQEMGALLNQQLQQATT
                     INGSTSSSSSSSNSGNNNNNNNNNIINNTITNTTNNTGNNSSAKPYLSRPYSSLNRVL
                     NFRADSLEILQQQQQQQQLNGTTQRNSTNINTTSGGSTSSSADSTTNRDNNSPANSSS
                     TNGPGAGTGTSTGAGGTGTNSPATTASSTAATTTGPATSMSDTSNNPPQSTTTPASRT
                     NSIYYNPSRKKRPENKAGGAHYYMNNHMEMIAKYKGEPWRKPDYPYGEGVIGLHEEIE
                     HFYQYVLPTPCEHAIRNEVVKRIEAVVHSIWPQAVVEIFGSFRTGLFLPTSDIDLVVL
                     GLWEKLPLRTLEFELVSRGIAEACTVRVLDKASVPIIKLTDRETQVKVDISFNMQSGV
                     QSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLNEVFTGGISSYSLILMCISFLQMHPR
                     GIYHDTANLGVLLLEFFELYGRRFNYMKIGISIKNGGRYMPKDELQRDMVDGHRPSLL
                     CIEDPLTPGNDIGRSSYGVFQVQQAFKCAYRVLALAVSPLNLLGIDPRVNSILGRIIH
                     ITDDVIDYREWIRENFEHLVVVDRISPLPTAAPTAYATANGAPKYVIMPSGAVVQQLY
                     HHPVQVPTAHGHSHAHSHSHGHAHPGAHLCQPYVTGTTVSAVTTTTTMAVVTVGVSAG
                     GVQQQQQQQNATAHTHSQQQTQNQSQSRHRRGSTSSGDDSEDSKDGDVVETTSSAQEV
                     VDIALSTPNGLANMSMPMPVHAVGMPASNSWSGNGNGNGNSSSSTGSSPEIAHIAAQE
                     MDPELEDQQQQQQHQETSGGNGFIRPGDVGTGSNRGGGDGSGGRNYNQRNNHNSSGYY
                     HQQYYVPPPMQQQLSKSNSSSNYHQQHHHSHSHGNHSHRQQHHHQQQHHHQQRPQHLR
                     VGGGNRYQKSLGGSPIISAGNASNSSSNCSNSSSSSGSNNSRLPPLRGTLVNSSSAIS
                     IISISSESSIASSSSSSSRSGQDQQRDER"
     misc_feature    1361..>2299
                     /gene="Trf4-1"
                     /locus_tag="Dmel_CG11265"
                     /gene_synonym="AAF46390; CG11265; Dmel\CG11265; DmTRF4-1;
                     dTrf4-1; Trf4"
                     /note="DNA polymerase sigma [Replication, recombination
                     and repair]; Region: TRF4; COG5260"
                     /db_xref="CDD:227585"
ORIGIN      
        1 ctcatcaatc gattcgtgaa ccagctctat cgcgaaacgg tcgcgtgttc gcacgcaaat
       61 tgcaatataa atccacagaa attgacaggg aacgttgcta aagggcgaaa aacaatcgtg
      121 ccgcgattga ggcctgcgat ctgcacagga aatgcacaat tgcgaagcgc aatttgataa
      181 attcggtaat gttcgattct cgaaagaacc agtcgtgtgc gtctgtatgt gcttcaaatg
      241 tcactctgtg tgcgggtgtg tggggagtgc ataaaaggca tagaggcagc aaggagtgaa
      301 agagagagct ccatcggcag cgcaacgaaa cacttgaatg ctgacagcat tcaaagaggt
      361 ttagtcccgg cagcgacttt aattaatttt tccctgtgga gcacaaagat cacatcggat
      421 ctatatagag tcacgtctat atattcagac caccaggacg cagaggatag aggtgaaagg
      481 acgaagcgaa ggagagacgc gcgcccccct cgtttcccgc ccagccaaca gccgtgtgaa
      541 cccgtcttga atggatccat ttgttggctg gtttcagaag gaacaggagg gaccatcgct
      601 gtgcacatgg ttaaagattt gggagacgaa tgcccaagag atgggcgcat tgcttaatca
      661 acagctacag caggcgacga cgatcaacgg gagcacgagc agcagcagca gcagcagcaa
      721 tagtggtaac aacaacaaca acaacaacaa taacatcatc aataacacta tcaccaacac
      781 gaccaataac actggtaaca attcatcggc caaaccctac ttatcgcgac cctacagctc
      841 gctaaatcgg gtgctcaatt tccgagcgga ttccctggag atcctgcagc agcaacaaca
      901 acagcagcag ctcaacggga ccactcagcg caacagcacc aacatcaata ccacaagcgg
      961 cggcagcact agctcgtcgg cagattccac cacgaatcgg gacaataact cacccgccaa
     1021 tagcagttca accaacggac ccggagcagg aacgggaacg tcaacaggag caggaggtac
     1081 cggtacaaat agtccggcga cgacagcgtc aagcacagct gcgaccacga ctggtccagc
     1141 cactagtatg agcgacacca gcaacaaccc gccacaatca acgaccacgc ccgccagccg
     1201 cacgaacagc atctactaca atccatcgcg gaagaaacga ccggagaaca aggctggcgg
     1261 agcccactac tatatgaaca accatatgga gatgatcgcc aagtacaagg gcgaaccgtg
     1321 gcgcaagccg gactatccgt atggcgaggg cgttatcggg ctgcacgagg agatcgagca
     1381 tttctatcag tacgtcctgc ccacgccctg cgaacacgcc atccgcaacg aggtggtcaa
     1441 gcgtatcgag gccgttgtcc attccatctg gccacaggca gtagtcgaga tctttggctc
     1501 ctttcgcact ggcctctttt tgcccacctc cgacatagat ctcgttgtgt taggtttgtg
     1561 ggagaagctg ccgctgagaa cgctggagtt cgagctagtg agccgtggta tcgccgaggc
     1621 ttgtacggtg cgtgttctgg acaaggcatc agtgcccatc atcaagctga cggaccggga
     1681 aacgcaagtg aaggtagaca tatcgttcaa catgcagagt ggtgttcagt cggcggagct
     1741 gattaagaag tttaagcgcg actatccagt gctggagaag ctagtgcttg tgctgaagca
     1801 gttcttacta cttcgcgatc tcaacgaggt gttcacgggc ggcatctcct cctactcgct
     1861 gatccttatg tgcatcagct tcctgcagat gcatccgcgc ggtatctacc acgatacagc
     1921 caatctgggg gtgcttctcc tcgagttctt cgaactttat ggacgtcgct tcaactacat
     1981 gaagatcggc atctccataa agaacggtgg ccgctacatg cccaaggatg agctgcagcg
     2041 tgacatggtc gatggccatc gaccctcgct cctgtgcatc gaggatccgc tgacgccagg
     2101 caatgatatc ggtcgaagca gctacggcgt cttccaggtg caacaggcat tcaagtgcgc
     2161 ctaccgcgtg ctcgcccttg ccgtcagtcc gctcaacctt ctcggcatcg atccgcgcgt
     2221 caactcgata ctgggtcgaa tcattcacat caccgacgac gtgatcgatt atcgcgaatg
     2281 gatccgcgag aacttcgaac atctggtggt ggtggatcgt atctcgccgc tgcccactgc
     2341 cgctcccact gcgtacgcca ccgccaatgg ggcgccaaaa tatgtgatta tgccctcggg
     2401 cgccgttgtc cagcagctgt accatcatcc ggtgcaggtg cccaccgctc acgggcacag
     2461 ccatgcgcac agccacagtc acgggcacgc gcatcctggc gcccatctgt gccagccgta
     2521 tgtgaccggg accactgtat ctgctgtaac gacgactaca acgatggcgg tggtgaccgt
     2581 gggcgtgtca gccggcggag tccaacagca gcaacagcaa cagaatgcga cggcccatac
     2641 ccactcgcaa cagcagacac agaaccaatc gcagtcgcgc catagacgcg gcagcacctc
     2701 gtcgggcgat gactccgagg atagcaagga cggcgatgtt gtcgagacga cgtcgagtgc
     2761 tcaggaggtc gttgacatcg cgctatcgac gccaaatggc ctggccaaca tgtccatgcc
     2821 catgccagtg catgctgtcg gaatgcctgc gtcgaacagt tggagcggta atggcaatgg
     2881 aaacggaaac agcagctcat ccacgggctc gtcgccggaa atcgcacaca tcgctgccca
     2941 ggaaatggac cccgagcttg aggatcaaca gcaacaacag cagcaccaag agacttctgg
     3001 aggtaatggc ttcatccgac cgggtgacgt cggcaccggt tccaacaggg gaggcggtga
     3061 cggcagtggc ggccgcaatt acaaccagcg gaacaaccac aactccagcg gctactacca
     3121 ccagcagtac tacgtgccac cgccgatgca acagcagctg agcaagtcca actcctcctc
     3181 caactatcac cagcaacacc atcacagcca cagccatggc aatcatagtc accgacaaca
     3241 gcatcaccac cagcagcagc accaccacca gcagcggccg cagcatctgc gtgtgggcgg
     3301 cggcaatcga taccagaaat cgttgggcgg atcgcccatc atcagtgctg gcaatgcgtc
     3361 gaacagcagc agtaattgca gcaacagcag cagcagcagc ggcagcaaca acagccgact
     3421 gccgccgcta aggggcacgc tggtcaactc atcgtcagca atatcaatca tttccatatc
     3481 ctcagaatca tccattgcta gcagcagctc cagttcgtca agatccggtc aggatcagca
     3541 gcgtgacgag cgataggaat aggatgtagg aagatattgt gtatgtctat gacacagaga
     3601 gaaagagagt gcgacacaga gggacagaga atgagagaga aagagatagt tacggtgtta
     3661 gcaatattta tgggttacat ttctttctca ggttaattgt aaactacgct gcatttttct
     3721 aataaatatc attgaccccc ccgccccccc gcctctacct aatccgaaag catctcctca
     3781 accaatgtaa ctgcgatcag attttctttt acactgctgt cttgcttaaa ttgggagagc
     3841 gacgcagacc tactaagcct agtgttagga actttgcctc tgatcgcgct aaatgtattt
     3901 cagtttgttt ctaaaataaa catgaaagca aagaatatat atatatatat atatatatat
     3961 ttatatatat agatatatat taaattaaat taaattgtac cataagcata actgttagct
     4021 cataagtaga ttgtaagggt ttaaaagatc gataaactga agtatgaaat tatgctaatc
     4081 tcttttccca tacccccccc cccccctttt tatccatcat catgcgcatt caagcttcta
     4141 aagtattttg tagtttctga aatgctctcc gtctagtgca atggtaaaca tttttgcaaa
     4201 cgtaactaat tccctatcca ccccatttcc tgccatac