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Drosophila melanogaster Upf2 (Upf2), mRNA.


LOCUS       NM_132206               5078 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_132206
VERSION     NM_132206.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5078)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5078)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5078)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5078)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5078)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5078)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5078)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5078)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5078)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5078)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5078)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5078)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5078)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5078)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5078)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5078)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5078)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5078)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5078)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5078)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5078)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5078)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5078)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_132206.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5078
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5078
                     /gene="Upf2"
                     /locus_tag="Dmel_CG2253"
                     /gene_synonym="CG2253; Dmel\CG2253; smg-3; upf2; UPF2"
                     /map="7D5-7D5"
                     /db_xref="FLYBASE:FBgn0029992"
                     /db_xref="GeneID:31724"
     CDS             312..4037
                     /gene="Upf2"
                     /locus_tag="Dmel_CG2253"
                     /gene_synonym="CG2253; Dmel\CG2253; smg-3; upf2; UPF2"
                     /note="CG2253 gene product from transcript CG2253-RA;
                     CG2253-PA; Upf2-PA; up-frameshift suppressor 2"
                     /codon_start=1
                     /product="Upf2"
                     /protein_id="NP_572434.1"
                     /db_xref="FLYBASE:FBpp0071072"
                     /db_xref="GeneID:31724"
                     /db_xref="FLYBASE:FBgn0029992"
                     /translation="MLANDSATTDSEVSTPPSSRKDLADGVAEGDNDNDIDTGDTDAN
                     ADEDVDAAAAIALEAEEREELQQFISELREKIESKRQLRLQNSTIELPGEEYFAKLDS
                     NLKKNTAFVKKLKLFTATQLDGLLREISALNLSKYISEICAALVEAKLKMTDVPAVVT
                     LASRLHCTYADFDVHFLEAWQKALNIKATEKIGNPSKLRVDLRLFAELVSSGVIQMKP
                     GLAQLGVVLVHLIALDKDDHSNFSIILSFCRHCGEEYAGLVPQKMQQLATKYGVEVPK
                     SDFLTADKQLNLRTMLKGYFKALCKHVLAEQAELMNMTKNIRRTMECKGEISTEKREK
                     CELMQAGFDKLLASAQSLSELLGEPLPELAKESEGCNPGTVIDNMLDSASFGVLDPWG
                     DEETRAFYTDLPDLRQFLPNFSAPKVDLETLEEPSELTEEAIDANLDAEMDLDDPPST
                     TSDTTPENPIEEQPTTPVAAAEDLKPQKMGNALMELGRQQQQQSQLNQNPIQIQNQMR
                     QQFDGFLVNLFNCVNKELIDSAAIEFLLNFNTKHQRKKLTRTIFSVQRTRLDILPYLS
                     RFVAIVHMCNTDVATDLAELLRKEFKWHIHKKNQLNIETKLKIVRFIGELVKFGLFKK
                     FDALGCLKMLLRDFQHHQIEMACAFVEVTGVYLYNCRDARLLMNVFLDQMLRLKTATA
                     MDSRHAAQIESVYYLVKPPESSKREPMVRPAMHEYIRYLIFEELCKQNVDRCIKMLRR
                     IDWQDPETNCYAIKCLSKAYLLRFQLIRCLADLVSGLSSYQPRAVTIVIDNVFEDIRA
                     GLEIHSPRMAQRRIAMAKYLGEMYNYKLVESTNILNTLYSIISLGVSNDQNVVSPLDP
                     PDSLFRLKLACMLLDTCAPYFTSQATRKKLDYFLVFFQHYYWFKKSHPVFSKTENTSD
                     LFPILMDHTYRDCLLNVRPKLKIYKSLEQAKAAIDHLQEKLYPQLKTTNNAQDPSLGT
                     ISEISEIDEGGTDEDSGSSNDQRERQVSGQEQDQSNDWTENEAEPPLPPLPPPEKSKE
                     DLEFEQLYEKMTTDSYQERLKEPIKATAKDIPVPMMARLQKKSYDQITGAQTIGPGIN
                     NMSQISKSVPNQDGTPGSPGADSPDGNGKSGGGVGGSDVGAAGAAGASGATSVPFVLM
                     VRGHKGGKQQFKSFVAPSDSHLATNLKRQEQMIREEKEKVKRLTLNITERIEEEDYQE
                     SLMPPQHRNFTQSYYQKPNKHKFKHQKGAPDADLIFH"
     misc_feature    621..1211
                     /gene="Upf2"
                     /locus_tag="Dmel_CG2253"
                     /gene_synonym="CG2253; Dmel\CG2253; smg-3; upf2; UPF2"
                     /note="MIF4G domain; Region: MIF4G; pfam02854"
                     /db_xref="CDD:397130"
     misc_feature    1863..2414
                     /gene="Upf2"
                     /locus_tag="Dmel_CG2253"
                     /gene_synonym="CG2253; Dmel\CG2253; smg-3; upf2; UPF2"
                     /note="Middle domain of eukaryotic initiation factor 4G
                     (eIF4G); Region: MIF4G; smart00543"
                     /db_xref="CDD:214713"
     misc_feature    2457..3113
                     /gene="Upf2"
                     /locus_tag="Dmel_CG2253"
                     /gene_synonym="CG2253; Dmel\CG2253; smg-3; upf2; UPF2"
                     /note="MIF4G domain; Region: MIF4G; pfam02854"
                     /db_xref="CDD:397130"
     misc_feature    3396..3887
                     /gene="Upf2"
                     /locus_tag="Dmel_CG2253"
                     /gene_synonym="CG2253; Dmel\CG2253; smg-3; upf2; UPF2"
                     /note="Up-frameshift suppressor 2; Region: Upf2;
                     pfam04050"
                     /db_xref="CDD:461146"
ORIGIN      
        1 aaaacatcgc cctcctcaac ccccccgcat gtaaatcgtg gcggaaaaac gtgggaaaaa
       61 caaagcaatg acagttattt aaagaacata atatcaaata tataattcgt ccgaacagtt
      121 ccagcaactg atcaacctaa ggtgactatt tcacattaaa aactatgccc aatcacactc
      181 agccttagct ctccaagaac aaaatagttc ccgattcgca tacctttgcc agcaggtcca
      241 gtttcaaaac atagccaccg cgcatcaagt cgcgccaacg tgaatccgtt cacggaactt
      301 ccaccaacgc catgctagcc aacgattctg caacgactga cagcgaggtg tccacaccgc
      361 cgtcgtcgag gaaagatttg gcagatggtg ttgccgaggg tgacaacgac aacgacatcg
      421 ataccggcga cacggacgca aatgcggatg aagatgtgga tgcggctgct gccattgccc
      481 tggaggccga agagcgcgag gagctgcaac agttcataag cgagctgcgc gagaagatcg
      541 agagcaagcg acagctgcgc ctccaaaact ccacaatcga gctgcccggt gaggagtact
      601 tcgccaaact ggactccaat ctcaaaaaga acacggcatt cgtcaagaaa ctgaaactat
      661 tcacggccac acagctggac ggactattgc gtgagatatc tgctctaaac ctgagcaaat
      721 acatctcgga aatatgcgcc gcgctggtcg aggccaaact gaaaatgact gatgtgccgg
      781 cggtggtgac gctggcctct cggctgcact gcacatatgc cgacttcgat gtccattttc
      841 tggaggcctg gcaaaaggca ctgaacatca aggccaccga gaagattggc aatccgagca
      901 aactgcgcgt ggatcttcgc ctgttcgccg aactagtcag ctctggtgtg atccaaatga
      961 agcccggatt ggcccaactg ggtgttgttc tggtgcattt gattgccctg gacaaggatg
     1021 accacagcaa cttctcgatc atcctctcat tctgccggca ctgcggcgag gagtacgccg
     1081 gcctagtgcc gcaaaagatg caacagttgg ccaccaaata cggggtggag gtgccgaaat
     1141 ccgacttcct gactgccgac aagcagctca atctgcgcac catgcttaag ggttacttca
     1201 aggccctgtg caagcatgtc ctggccgagc aggccgaact gatgaacatg accaagaaca
     1261 ttcggcgcac catggagtgc aagggtgaga tatccacgga gaagcgcgag aagtgtgaac
     1321 tgatgcaggc cggattcgat aagctgctgg cctccgctca atcgctgtcg gaactgctgg
     1381 gtgaaccact gcccgagctg gccaaggagt ctgagggctg taatccgggc acagtcatcg
     1441 acaacatgct ggacagtgcc tcctttggtg tgctggatcc gtggggcgac gaggagaccc
     1501 gagccttcta cacggatttg cccgatttga gacagtttct gccaaacttt tcggcaccca
     1561 aagtcgattt ggaaacgtta gaggagccca gtgaactaac cgaagaagcg atcgatgcca
     1621 atctagatgc cgaaatggat ctagatgatc caccgtccac cacttcggat acgactccgg
     1681 agaatccaat cgaagagcag ccaacgacgc cagttgccgc tgcggaggat ctcaagccgc
     1741 agaagatggg taacgctcta atggaactgg gtcgccagca gcagcagcaa agtcagctca
     1801 accagaatcc gatccagatc caaaaccaga tgcgtcagca gttcgatggc ttcctggtca
     1861 acctattcaa ctgtgtgaac aaggagctga tcgattcggc ggccatcgag ttcctgctta
     1921 acttcaatac caagcatcaa cgcaagaagc tgacgcgtac gatattctcg gtgcagcgta
     1981 cgcgtctgga tatcctgccc tatctctccc gcttcgtggc cattgtgcat atgtgcaata
     2041 ccgatgtggc caccgatttg gccgaactgc tgcgcaagga gttcaagtgg cacattcaca
     2101 agaagaacca gctgaatatc gagacgaagc ttaagattgt gcgattcatt ggtgaactgg
     2161 ttaagtttgg tttgtttaaa aagttcgatg ccttaggatg tctgaagatg ctgctaaggg
     2221 actttcagca tcatcaaatc gagatggcct gtgcctttgt ggaagtcacc ggcgtctatc
     2281 tgtacaattg ccgggatgcc cgtctgctga tgaatgtgtt cctggaccag atgctgcgct
     2341 tgaaaacagc cacggcaatg gactcgcgac atgcggcgca gattgagagc gtgtactatt
     2401 tggtaaagcc gccggaatcg tccaagcgag agcccatggt tcggccggca atgcatgagt
     2461 acatccgtta cttgatcttc gaggagcttt gcaaacagaa cgttgatcgt tgtatcaaaa
     2521 tgctgcgccg catcgattgg caggatccgg agacaaattg ttatgccatt aagtgcctca
     2581 gcaaggcgta tctgctgcgc ttccagctca tccgctgtct ggccgatctc gtatccggac
     2641 tgagctccta tcagccacga gcggttacca tcgtgatcga taatgtgttt gaggatatac
     2701 gcgctggcct cgagattcat tcgccacgca tggcacagcg gcgcatcgcg atggccaagt
     2761 atctgggcga gatgtacaac tacaagctgg tggagtccac gaacattctt aatacgctgt
     2821 actccatcat ctcgctgggc gtatcgaatg accaaaatgt cgtctcgcca ctggatccgc
     2881 ccgatagcct gttccgactg aagcttgcct gtatgctact ggacacgtgt gcaccctact
     2941 tcaccagcca ggccacgcga aaaaaactgg actactttct ggtcttcttc caacactact
     3001 attggttcaa gaaatcccat cccgtgttca gcaaaacgga gaacacctcc gatttgttcc
     3061 ccatcctaat ggatcacacc tatcgcgact gtctactcaa tgtgcggccc aagctgaaga
     3121 tttacaagag tctagagcag gccaaggcgg cgattgatca tctgcaggag aagctctatc
     3181 cgcagctaaa gactaccaat aatgctcagg atccgtcgct gggcacaatc agtgaaataa
     3241 gcgagataga cgagggcggc actgatgagg attctgggtc atcgaatgat cagcgagagc
     3301 gccaagtgtc gggccaagag caggaccaga gcaacgactg gacagagaac gaggcggagc
     3361 caccgctgcc gccgctcccg ccgccagaaa agtccaagga ggacctggag ttcgagcaat
     3421 tgtacgaaaa aatgaccaca gactcgtacc aagaacggct taaggagccg ataaaggcta
     3481 cggccaagga tatacctgtg ccgatgatgg cgcgcctgca aaaaaaatcg tacgatcaga
     3541 taacaggtgc tcagaccatc ggccctggga tcaacaatat gtcacagatc tcaaagtcgg
     3601 tccccaatca ggacggaacg cctggctctc caggtgcaga ttcaccagat ggcaacggca
     3661 aatccggcgg cggtgtaggt ggtagcgatg ttggtgctgc tggtgctgct ggtgcttctg
     3721 gtgctacatc tgtacccttt gtgctaatgg tgcgcggcca caagggcgga aagcagcaat
     3781 ttaagtcatt tgtggcacca tccgactcgc acttggccac caacctaaag cggcaggagc
     3841 agatgatacg cgaggagaag gagaaggtca agcgccttac gcttaacata actgagcgca
     3901 ttgaggagga ggactaccag gagtcgttga tgccgccgca gcatcgaaac ttcacccaga
     3961 gctactacca gaagcccaat aagcacaagt tcaagcacca aaagggtgcg cccgatgcgg
     4021 acctcatatt tcactgaaac gttgcccccg ctaacggatc cgaaaacagc cggtgccggt
     4081 gagtgcggta gctcgctggt tttttaggtg acagccactt gtgcgtttcc cagcctcctt
     4141 ctggccgtcg tattaatacc actgtgctgt tgctgttgct gctgctgctg cagctgcagc
     4201 tgctgtaagg cctaaagact gcgattgcga taccacggaa gcgaaataat acgatgcgga
     4261 gagtaacgct ccaagagcca acgactctcc gccaacggaa gaagctccgg aaattgcgcg
     4321 atcccaaaca caagagacac accaacctca agctgtactt aagtcaaaca attcacaaaa
     4381 caacaggcca acatgttaag ccagccactc aatccaaacc aatccaagcc aaccaatata
     4441 caacaacagg ccaacatgcc aacatactaa cataccaagc cactcaatcg cagtcgtggc
     4501 agctgaagcc catccaaatg gaccctggga cctcgtcctc gatattatcg tgtatatatg
     4561 tagaagtgct gctacgatcc cgatccgtaa acgtatattt taacactact tagtacgtaa
     4621 aaatgcctag acttgtttcg aaaacacaac ccaattgaat aacaaagcat atatacaacg
     4681 atatatacag attgttatat aatgttacat acacacacac acacacacac acacacgcat
     4741 tcgataatgc catccgatga tccattcaca tttttgaatc aaatgcagaa tgcagtcgga
     4801 agtgaattcg tctccattgg gaaagctgtt tggatgagca aatggaaaga tcccccgcca
     4861 ctgagtttct tctggggatg cagtgagtcc agcaagtctc gaacttagct cgcttgtgta
     4921 ttggagtttt aattgaataa ttctcggatg cccttttgca ttgatgctag gtactttatc
     4981 tcatgttgta taagaaataa taacttgtaa acaattgatc caaatttctg tactcaaatt
     5041 tcgcattatt tccatccgat gaataaataa gatacacg