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Drosophila melanogaster C3G guanyl-nucleotide exchange factor


LOCUS       NM_132122               6467 bp    mRNA    linear   INV 26-DEC-2023
            (C3G), transcript variant H, mRNA.
ACCESSION   NM_132122
VERSION     NM_132122.5
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6467)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6467)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6467)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6467)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6467)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6467)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6467)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6467)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6467)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6467)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6467)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6467)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6467)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6467)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6467)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6467)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6467)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6467)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6467)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6467)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6467)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6467)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6467)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_132122.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6467
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6467
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="C3G guanyl-nucleotide exchange factor"
                     /map="6D1-6D2"
                     /db_xref="FLYBASE:FBgn0259228"
                     /db_xref="GeneID:31618"
     CDS             814..5529
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="CG42328 gene product from transcript CG42328-RH;
                     CG42328-PH; C3G-PH; C3G ortholog"
                     /codon_start=1
                     /product="C3G guanyl-nucleotide exchange factor, isoform
                     H"
                     /protein_id="NP_572350.2"
                     /db_xref="FLYBASE:FBpp0289753"
                     /db_xref="GeneID:31618"
                     /db_xref="FLYBASE:FBgn0259228"
                     /translation="MPQFDESFLSDCALADRWHFYSYTVKQLPPHPSPKPNRNRNPYP
                     SGASHDDHQHQLHHHHHQQHHHNHHRLWKTQRQSWSPRDTNNNHSLTSNNCNCNSSNT
                     CNSISATGNTLHSIKFHRRRKYKKLARLALSTPAIPLQMDVDVDVNVTVDREFDMEMD
                     TPVPLKNAVCHGSISSPSTPGTCSSGIGVGGGGCSSSSNNSINSGSYSTACTPPPPTH
                     QHHSQHQQLQGTPGGSSRVGGAGAGGGGGVPPAPPSAGSSGHKNSLKGTKLARRARSF
                     KDDLIEKISLMRTTNNTLGRSHSPHSPRTKHGTKAPPTTEEVLRSTQTLETHVKDISN
                     ALKHFRDVILKKKLEVLPGNGTVILETIASMYSVIQTYTLNENSAIMSSATLQVYQSL
                     GKLIKLCDEVMLSEDSGECASLSNENVREVIDLLEDAVRNLVTLAQGKLKEQDQCAFR
                     YSGSGLGGIGAAAEIMGAVTASPGASVPGTGVMRVSAAESAAQRTSLPDIALTPKERD
                     ILEQHNVNPMRGSHSTESILRDTSPPPKPPLPNRASNPPPLPPKRRSQPSASAGTVGV
                     GCSSSTSTSNQASPLPYAQSHNISLNSDLDCSSNISLLNYGVDRLSVRSRSPDENSQC
                     SFDSALNHSREEEDQQQQHQHLRSFPKLAAMMDEDMDKMVSYSAAIDDKTQTPLSTGG
                     GIAGVAGGTGGAGEGVAAAASGDGETNSNRHSNESGFVSMREFRTSTQTTDYSVQSST
                     KSSSSNSEIAFSISESTAVGSSSEYQQISQLVSHSQRHISSSSSSCTTTTTSSSTTTG
                     YGSSEVEQLQQQQQQQTTTTPADLAPALPPKSIQRSSLTRHDSPGVGDELDEVQSSSG
                     WASHRSSQSEVAELRQLSPLHHLNHHPHTASAGQLQQWHSKHHSLIEGPRLQLAGSGS
                     CSAFDQRHLDQEPPPLPIKKKHILAYMEICSASTRSIEQHRHTMHACNISRNISHSQT
                     MNIMPMSKELSPELEMPPALPPKNYKQRKATSMVASPTLQPVIVTTPPPSPKPTLGEN
                     GSTGRPDSRMATVCEELNDAVASEDAMPEPRSPVLDSNENVSAVDDGQTFYCHSHQLP
                     AAEMEMSEDASSADNQPITTPQVLEEQEEPTAESRPLVAVHESVKPANVDEDEEAERA
                     DMLINMLEEVNITRYLILKKREEDGPEVKGGYIDALIVHASRVQKVADNAFCEAFITT
                     FRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAAKETFALLVRVVNDLTSTDLTSQLLS
                     LLVEFVYQLVCSGQLYLAKLLRNKFVEKVTLYKEPKVYGFVGELGGAGSVGGAGIAGS
                     GGCSGTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKSPNL
                     NKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALD
                     SGPIRRLEWQKGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTFV
                     HVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRFFDNFKDFMGEE
                     EMWQISEKIKPRGRRPVNY"
     misc_feature    4321..4731
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; Region: RasGEFN; smart00229"
                     /db_xref="CDD:214571"
     misc_feature    order(4378..4380,4513..4515,4525..4530,4537..4539,
                     4546..4551,4648..4650,4657..4659)
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:100121"
     misc_feature    4816..5487
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; Region: RasGEF; cd00155"
                     /db_xref="CDD:238087"
     misc_feature    order(4915..4923,4945..4950,4954..4962,4966..4971,
                     4978..4983,4990..4992,5089..5091,5098..5103,5107..5115,
                     5119..5130,5134..5139,5191..5193,5206..5214,5221..5223,
                     5260..5268,5275..5283,5287..5295,5299..5310,5353..5355,
                     5365..5367,5467..5469,5476..5481)
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Ras interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238087"
ORIGIN      
        1 gagtggcagg ccaaaagtgt tagcttatcg cttatcggcg attgaatcaa tcagccgaag
       61 cctgttgaaa tttcaagttc agaaatgcaa aagtgactgt gcggcgaatg gaaagctatt
      121 ggggaaaatt gcggaaatcg cacttgaaat ataagtaaag caaaagacaa gtggctttgg
      181 agttgattac cttcaattta ccacaatcgg gcaggcagta agaaacggaa attagggctt
      241 gatggctttt aaacattaaa gaaaataata tacggaaatc actatggcca attgaagtga
      301 tctctaagct ggcatacttg tatttcagtc aaacaaagag tgtccagaac aattcttgcg
      361 gttgccacag gaagcttgaa tcggtaatcg cttgaattgc ctatcggact atcgaacgaa
      421 ttgcaaaagt gaacgaacat gatgagaaag caattgaaat ctacttcctg ctggcagagc
      481 acatcggata tagcttttat cagtgcttaa aactttttcc gaaaacactg aaacaaccga
      541 aaactgaaag tgaaataatc aatgtaaaac atgccgaaac agaaaaatga attgatgttg
      601 taatcgcgac ggcaatcgct taaatcaaca atcttatacg aaaacgatgt tgctgctatc
      661 gcttatcgct atttggagaa atcagttagg ccaacgtgtg tgtcttttgg ccaagcatat
      721 ttaagccaca acaaattgtt gttatgcgtg ttgctgtcgc tgttgctgct gttgttattg
      781 ctgctgctgc tgctgctgtc attatgcaac attatgccgc agtttgatga atcttttttg
      841 agcgactgtg cgctcgccga ccgctggcat ttctattcgt acacggtcaa gcaattgccg
      901 ccacatccga gtccgaaacc gaatcggaat cggaatccgt atcccagcgg tgccagccac
      961 gatgaccatc agcaccaact ccatcatcat catcatcaac agcaccatca caatcatcat
     1021 cgtctttgga agactcagcg gcagtcgtgg tcgccgcgcg acaccaacaa caatcatagc
     1081 ctcacaagca acaactgcaa ctgcaacagc agtaacacct gcaacagcat cagtgccacc
     1141 ggcaacacgt tgcatagcat caaattccac agacgtcgca aatacaaaaa gctggcacga
     1201 ttggcgctat caacgccagc gattccactg cagatggatg tggatgtcga tgtgaatgtg
     1261 accgtggata gggagttcga tatggagatg gacacacctg tgccgctcaa gaatgcggtg
     1321 tgccacggca gcatcagttc tccatccacg cccggcacct gttccagtgg catcggagtg
     1381 ggcggtggcg gctgcagcag cagcagcaac aatagcatca acagcggcag ctactccacc
     1441 gcctgcactc cgccaccacc cacgcatcag catcactcgc agcaccagca gctgcagggc
     1501 acgccgggag gatctagtcg ggtaggggga gcaggagcag gcggaggtgg tggtgtacca
     1561 ccggcaccac ccagtgccgg atcctcgggc cacaagaaca gtctcaaggg caccaagcta
     1621 gcgcgccggg cgcgttcctt taaggacgac ctcatcgaga agatttccct gatgcgaacc
     1681 accaacaata cactgggtcg ctcccactcg ccgcacagtc cgcgcaccaa gcacggcaca
     1741 aaggcaccgc ccaccaccga ggaggtgcta cggtccaccc aaaccctgga gacgcacgtc
     1801 aaggacattt cgaatgccct gaagcacttc cgggatgtta tactcaagaa gaagctggag
     1861 gtgttgccgg gcaacggaac ggtcattctg gaaaccatag ccagcatgta ctccgtgatc
     1921 caaacctata ccctgaatga aaacagtgcc atcatgagca gcgccacgct gcaggtttac
     1981 cagagcctgg gcaagctcat caagctctgc gacgaggtga tgctctccga ggacagcggc
     2041 gagtgcgcct ccctgagcaa cgagaatgtg cgggaagtca ttgatcttct cgaggatgct
     2101 gtgcggaatc tcgttacgct ggcgcagggc aagctgaagg agcaggatca gtgcgccttt
     2161 cgctacagtg gatctggctt gggcggcatt ggagcggcgg cggagatcat gggtgcggtc
     2221 accgcctcgc cgggagcgag tgttcccggt actggagtca tgcgcgtttc ggccgccgaa
     2281 tcagctgccc agcgtacttc gttgccggac atagcgctca cgcccaagga gcgcgacata
     2341 ctggagcagc acaatgtgaa cccgatgcgc ggctcccaca gcaccgaaag tatcctgcgc
     2401 gacacgagtc caccgccgaa gccaccgcta cccaataggg ccagtaatcc gccgccgttg
     2461 ccaccaaagc gacgcagcca gccgagcgca tcagctggta cagtgggcgt aggctgctca
     2521 tcgtcgacat ccacctccaa tcaggccagt ccactgccct acgcccagtc ccataatatt
     2581 agtctgaact cggacctgga ctgcagttcc aatatctcgc tgctgaatta tggcgtggat
     2641 cgcctatccg tgcgttcacg gtcaccggat gagaatagtc agtgctcctt tgactcggcg
     2701 ttgaatcact cacgcgagga ggaggaccag caacagcaac atcagcatct gaggtcattt
     2761 ccaaagttgg ctgcgatgat ggacgaagac atggacaaga tggtcagcta cagcgccgca
     2821 atcgacgaca aaacgcagac accactttcg actggtggtg gtatagctgg tgttgctggt
     2881 ggaactggag gagcaggcga aggtgtagct gctgcagcgt ctggtgacgg ggaaactaac
     2941 agcaatcgcc actcaaacga atcgggtttc gtgtcgatgc gtgagtttcg cacttccaca
     3001 cagacgacgg actacagtgt ccagtcctcc acgaagtcgt ccagcagcaa ttcggagatt
     3061 gcgttcagca tcagtgagtc gacggcggtc ggcagcagta gcgagtacca gcagattagc
     3121 cagttggtgt cgcacagcca gcgtcatata tcctcgagca gtagcagctg caccaccacg
     3181 accaccagca gcagcacaac caccggctat ggcagcagcg aagtggagca gctgcagcag
     3241 cagcagcagc agcagacgac gacgacgccg gccgatctgg cgcccgcctt gccgccaaag
     3301 agcatccaac ggagcagcct aacccgccac gactcgcccg gagttggcga tgagctggac
     3361 gaggtgcagt cctcctccgg ctgggccagc catcggagca gccagtcgga ggtggccgag
     3421 ctgcgtcagc tgtcgccgct ccatcacctc aatcaccatc cgcatactgc gtccgccggt
     3481 caactgcagc agtggcactc caagcaccac agcctgatcg agggaccccg cctccagctg
     3541 gcggggagtg gcagctgcag tgcgttcgat cagcgacact tggatcagga gccaccgccg
     3601 ctgccaataa aaaagaagca cattctggcg tacatggaaa tctgttcggc gtccacgcga
     3661 tccattgagc agcatcgtca cacaatgcac gcctgcaaca taagtcgcaa catctcgcac
     3721 agccagacca tgaacattat gcccatgagc aaggaactgt cgccggagct cgagatgcca
     3781 cctgccctgc cgccaaagaa ctacaagcag cgcaaggcga caagcatggt agcatcaccc
     3841 acgctgcagc ccgtcattgt gaccacgcca ccgccgagtc cgaagccgac gctgggcgag
     3901 aatgggtcga cgggcaggcc ggacagccgg atggccaccg tatgcgagga gctgaacgat
     3961 gcagtggcca gcgaggatgc gatgccggag ccccgttcgc ccgtgctgga cagcaatgag
     4021 aatgtgagcg ccgtcgatga tggacagact ttctactgtc actcacatca gttgcccgcc
     4081 gccgaaatgg agatgagcga ggatgcgagc agtgccgaca accagccaat aaccacgccc
     4141 caagtgctcg aggagcagga ggagccaacg gcggagtccc gaccactggt cgctgtgcac
     4201 gagtcggtta agccagcgaa cgtcgacgag gatgaggagg cggagcgagc ggatatgctg
     4261 atcaacatgc tggaagaggt caacatcaca cggtacctga tactcaagaa gagagaggag
     4321 gacgggcccg aggtgaaggg cggctacatc gatgccctca tcgtgcacgc cagccgtgtc
     4381 caaaaggtcg ccgacaatgc attctgcgag gccttcatca ccacctttcg caccttcatc
     4441 cagccgatcg acgtgatcga gaagctgacc catcgctaca catacttctt ctgtcaagtg
     4501 caggacaaca agcagaaggc cgctaaggag acctttgcgc tgctggtccg agtcgtcaac
     4561 gatctaacgt cgacggatct aaccagccag ctgttgagcc tgctggtgga gttcgtctat
     4621 cagttggttt gctctgggca attgtacttg gccaagttgc tgcgcaacaa gttcgtggag
     4681 aaggtgacgc tgtacaagga gcccaaggtg tacggctttg ttggggagtt gggcggagcc
     4741 ggtagtgtcg gcggagcagg aatcgccggc agtggtggat gcagtggtac agctggtggt
     4801 ggaaaccagc ctagtctgct cgacctcaag tcgctggaga ttgccgaaca gatgacgctg
     4861 ctggatgcgg agctgttcac gaagatcgag atacccgaag tattactatt tgccaaagat
     4921 cagtgcgagg agaagtcgcc caacctaaac aagttcaccg agcacttcaa caagatgtcc
     4981 tactgggcgc gctccaaaat cctgcgcctg caggatgcca aggagcggga gaagcatgtg
     5041 aacaagttta tcaaaatcat gaagcatcta cgcaagatga acaactacaa ctcgtatctg
     5101 gcgttgttgt cggccctcga ttcgggtccc ataagaagat tggagtggca aaaaggcatc
     5161 accgaggagg tgcgatcatt ctgcgccctc atcgattcca gctccagttt tcgcgcctat
     5221 cgacaggcgc tggccgaaac taatccgccc tgcataccct acatcggcct aattctgcag
     5281 gatctaacgt ttgtgcatgt gggcaaccag gactacttgt ccaagggcgt cataaacttc
     5341 tccaagcgct ggcagcagta caacataatt gacaacatga aacgttttaa gaaatgtgcc
     5401 tatccatttc gacgcaacga gcgcattata cgcttctttg ataacttcaa ggactttatg
     5461 ggcgaggagg agatgtggca gatatcggag aagatcaagc cgcgtggacg ccgccccgtt
     5521 aactattagt cttcaagcag caacagcaaa acaccaatat tatatatgat aaagtatata
     5581 caccgtatta attaaacagt tcaaaacggt tgccacgtct aggaggagga tcagcatcgg
     5641 gagcagccaa caactattct aatgggtctg agcaataatg ttcgctattc tctgtctata
     5701 tatatacaat tatacaagat atttagctgt aattaccagc cgatgccgaa tcggaaatac
     5761 atatacatac ttacttaaga tgtagcgatt cagatacgga tacggataca tgtagccgcg
     5821 tacaaataac gagccgatct gtagtttaac tattaagctc tatgagtcat tgggtcgatg
     5881 gacctaacct cagctaactc cccaccaata ttcgaatccg aatccctgtc tgcgagtccc
     5941 aaaaactttt tcccggactt ttgccagcac tagaacacca aactaactaa ctaacttact
     6001 taccaccaga gacaaccaat caagaaatca gcaattttcg cttttgtttt gagatctctt
     6061 ttttacacaa gaacacaacg aattttgaaa gcaagctacg tgaacgtaga ggccaaccga
     6121 caaactatat tcgacgatat atgtagcgat atctcggact ataaatcgat gcaatccacg
     6181 agcagaacac caagcgaacc ctagcacaaa gcgcgttata tgcaattctc tctccaaaca
     6241 accaatatta aatacccgtg tgtgtgtatg tgtgttagaa gttattcaaa ttgaaattga
     6301 actcaaaatc aaaatcagag atttcagagt gcacgaaaca gaaaacagaa ggcggtatct
     6361 atcgatcaaa tcaatcaatc aatgaaatca atcaaaaatt cattttgcga ctcaattaat
     6421 tgaagaaact tttaaagtta caaaacaaaa caaaatacaa aaaatac