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Drosophila melanogaster knockdown (kdn), transcript variant A,


LOCUS       NM_132091               2510 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_132091
VERSION     NM_132091.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 2510)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2510)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2510)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 2510)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 2510)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 2510)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 2510)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 2510)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 2510)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 2510)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 2510)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 2510)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 2510)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 2510)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 2510)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 2510)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 2510)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 2510)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 2510)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 2510)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 2510)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 2510)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 2510)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_132091.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2510
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..2510
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /note="knockdown"
                     /map="5F2-5F4"
                     /db_xref="FLYBASE:FBgn0261955"
                     /db_xref="GeneID:31579"
     CDS             156..1550
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /EC_number="2.3.3.-"
                     /EC_number="2.3.3.1"
                     /note="CG3861 gene product from transcript CG3861-RA;
                     CG3861-PA; kdn-PA; citrate synthase; lethal (1) G0030"
                     /codon_start=1
                     /product="knockdown, isoform A"
                     /protein_id="NP_572319.2"
                     /db_xref="FLYBASE:FBpp0070872"
                     /db_xref="GeneID:31579"
                     /db_xref="FLYBASE:FBgn0261955"
                     /translation="MSLYRISARKLSEAQKLPNVGAYVRMIAADGKSLRDVLAAKVPQ
                     EQERVKNFRKQHGATKMGETTIDMMYGGMRGIKALVTETSVLDADEGIRFRGLSIPEC
                     QKVLPAADGGTEPLPEGLFWLLLTGEVPTKSQVQQLSREWAERAALPQHVVTMLNNMP
                     TTLHPMSQFAAAVTALNHDSKFAKAYSDGVHKSKYWEYVYEDSMDLIAKLPVVAATIY
                     CNTYRGGKGSRSIDSSLDWSANFVKMLGYDNAPFTELMRLYLTIHSDHEGGNVSAHTV
                     HLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLRKLQKEAGNNPSEEQLKEYIW
                     KTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPEDETFQLVSKIYKVVPPILTET
                     GKVKNPWPNVDAHSGVLLQYYGMKEMNYYTVLFGVSRALGVLASLVWDRALGLPIERP
                     KSFSTDLLVKMVQK"
     misc_feature    255..1538
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /note="Saccharomyces cerevisiae (Sc) citrate synthases
                     Cit1-2_like. Citrate synthases (CS) catalyzes the
                     condensation of acetyl coenzyme A (AcCoA) with
                     oxaloacetate (OAA) to form citrate and coenzyme A (CoA),
                     the first step in the citric acid cycle (TCA or...;
                     Region: ScCit1-2_like; cd06105"
                     /db_xref="CDD:99858"
     misc_feature    order(369..374,381..401,654..656,666..668,675..677,
                     951..953,966..968,975..980,987..992,999..1007,1017..1019,
                     1038..1043,1050..1058,1200..1202,1491..1517)
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:99858"
     misc_feature    order(375..377,951..953,963..965,1053..1064,1068..1070,
                     1077..1079,1179..1202,1209..1211,1224..1226,1347..1349,
                     1356..1358,1362..1364,1428..1430,1440..1442,1491..1493,
                     1500..1502)
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /note="active site"
                     /db_xref="CDD:99858"
     misc_feature    order(375..377,1053..1061,1068..1070,1077..1079,
                     1179..1202,1209..1211,1347..1349,1356..1358,1362..1364,
                     1491..1493)
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /note="coenzyme A binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:99858"
     misc_feature    order(375..377,951..953,963..965,1056..1061,1179..1184,
                     1188..1202,1224..1226,1356..1358,1440..1442)
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /note="citrylCoA binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:99858"
     misc_feature    order(951..953,963..965,1059..1064,1197..1202,1224..1226,
                     1362..1364,1428..1430,1440..1442,1500..1502)
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /note="oxalacetate/citrate binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:99858"
     misc_feature    order(1059..1061,1197..1199,1362..1364)
                     /gene="kdn"
                     /locus_tag="Dmel_CG3861"
                     /gene_synonym="BEST:GM01832; CG 3861; CG3861; CS; csyn;
                     Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033;
                     l(1)G0159"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:99858"
ORIGIN      
        1 attcagttgc cgcgcagctg ctagacgaga gacccacgaa aagaacactt cacttccaga
       61 aaaaggaaag caaatttttt tctgtgtgtg tgtttttttc tagccaaggc gaaagtgttt
      121 ttcttctact cgcagccgta cgtaatcgca ttgccatgtc gctctatcgc atttccgcac
      181 ggaaattgtc cgaggcacag aaactgccaa atgtgggagc ctatgttcgc atgatcgccg
      241 ccgatggcaa gagcctgcgc gacgtgctgg ccgccaaggt gccccaggag caggagcgcg
      301 taaagaactt ccgcaagcag catggcgcca ccaagatggg cgagacgacc atcgacatga
      361 tgtacggcgg catgcgcggc atcaaggccc tggtcaccga gacctcggtg ctggatgctg
      421 acgagggtat ccgcttccgc ggcctctcca ttcccgagtg ccaaaaggtt ctgccagccg
      481 ccgatggcgg cactgagccc ctgcccgagg gtctcttctg gctgctgttg accggcgagg
      541 tgcccaccaa gtcccaggtg cagcagctgt cccgcgaatg ggccgagcgc gccgccctgc
      601 cccagcacgt ggtcaccatg ttgaacaaca tgcccaccac cctgcacccg atgtcgcagt
      661 ttgctgccgc cgtcactgcg ctgaatcacg acagcaaatt cgccaaggca tactcggatg
      721 gtgtgcacaa gagcaagtac tgggagtacg tctacgagga cagcatggac ctgatcgcca
      781 agctcccagt ggtggcggcc accatctact gcaacaccta tcgcggcggc aagggctccc
      841 gttcgattga ctccagcctg gattggtcgg cgaactttgt gaagatgctc ggctacgaca
      901 acgccccctt caccgagctg atgcgtctct atctgaccat ccacagtgac cacgagggtg
      961 gcaacgtgtc tgcccacacc gttcacttgg tgggctccgc cctcagcgat ccctacctct
     1021 cctttgccgc cggcctgaac ggtctggctg gtcccctgca cggcctggcc aaccaggagg
     1081 tgctcgtgtg gctgcgcaag ctgcagaagg aggccggcaa caacccgtcg gaggagcagc
     1141 tcaaggagta catctggaag accctcaagt ccggacaggt ggttcccggc tacggacacg
     1201 ccgtgctccg caagaccgat ccccgctaca cctgccagcg tgagttcgcg ctgaagcacc
     1261 tgcccgagga cgagacgttc cagctggtgt cgaagatcta caaggtggtg ccaccaattc
     1321 tgaccgagac cggcaaggtg aagaacccct ggcccaatgt agatgcccat tccggtgtgc
     1381 tgctgcagta ctacggcatg aaggagatga actactacac cgtgttgttc ggcgtttccc
     1441 gtgccctcgg cgtgctggcc tccctcgtct gggatcgcgc cctcggcctg cccatcgagc
     1501 gccccaagtc attctccacc gatctgctgg tcaaaatggt ccagaagtaa gcaactggag
     1561 caggaggagc gggaggagct ggagttcaac cttttgtagc cggaggacga tggacgtaaa
     1621 atgcagaagc tgtagattgt aattgacgag ggaagaggca gaaagagaga gatagagaga
     1681 gagagagaat cgatcggatt ggattaggat gagatgggat tggattggat ggatatcgat
     1741 atgacgacgc tgatattgag ggagttggag atgtgtagtt gaggagaaga gcaaccaaat
     1801 acgaaccaat aggacaaaaa cgaaaaccag aagaaaactg caacacactg caactgcaaa
     1861 acaataagtt ggaaataagg cagaaacata tttttagtag taaaataatt aacgaagggc
     1921 aaccgacaag caaccactta attatttgta taagctatat atatatataa atatatatat
     1981 atatatatat atatatatat acgattgact atatatatag ggacaggcag agagagtaaa
     2041 atgtttgcgc ctattgttta tgttcagcat ttcccccacc cgaaaccgcc cacgataccc
     2101 actctttatt aagtttgtta tgtttatatt ttgttcatct tagccgatcg atggactaac
     2161 cacgacacga ccttaatgat ttatccccca aaaagcccgc ccgacccacc agcacccacc
     2221 ccgcctgaaa aacctaaaaa aaaattacta acttgataac attttacttt taatttaact
     2281 ataatttatt atgcaaacaa gatacaaaca aacaagtgta aagaaaccaa caaaaacatt
     2341 tgaaaaaaac tcaataaaaa aacagaacaa taaataatat aatgcataga gagtagttat
     2401 tgtcaactcc accagtggaa gctgcaaacg cgttcgttca tcgccgtgca agtgtattcg
     2461 agaaagcaaa acccacaata aatcttagca aacttgaatc gcagatcgtt